Long-lasting consequences of early life stress on brain structure, emotion and cognition.
Abstract
During the perinatal period, the brain undergoes substantial structural changes, synaptic rearrangements, and development of neuronal circuits which ultimately determine brain function and behavior. Environmental factors-such as exposure to adverse experiences-have major impact on brain function and structure during this sensitive period. These alterations can be long-lasting, and have been implicated in psychopathology such as cognitive decline and emotional dysfunction. Here we briefly review how early postnatal adversity determines structure and function of the hippocampus, amygdala, and prefrontal cortex (PFC) areas, which are crucial for proper cognitive and emotional function.
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Early life stress is known to impair (non-stressful) learning and memory.
“ELS – using a variety of models (Krugers and Joëls, 2014; Tractenberg et al., 2016) – is known to impair (non-stressful) learning and memory.”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Krugers and Joëls, 2014
Cites
Sensitivity and attachment: A meta-analysis on parental antecedents of infant attachment
De Wolff, M. S., & van Ijzendoorn, M. H. (1997) · Child Development · doi:10.1111/j.1467-8624.1997.tb04218.x · Cited by 2,526 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus
Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074 · see citing works
Childhood poverty: specific associations with neurocognitive development
Farah, M. J., Shera, D. M., Savage, J. H., Betancourt, L., Giannetta, J. M., Brodsky, N. L., Malmud, E. K., & Hurt, H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.072 · Cited by 835 · see citing works
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1243 · Cited by 721 · see citing works
Infant–mother attachment: Factors related to its development and changes over time
Egeland, B., & Farber, E. A. (1984) · Child Development · doi:10.2307/1130127 · Cited by 652 · see citing works
Teicher, M. H., Anderson, C. M., & Polcari, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115396109 · Cited by 639 · see citing works
Sticks, stones, and hurtful words: relative effects of various forms of childhood maltreatment
Teicher, M. H., Samson, J. A., Polcari, A., & McGreenery, C. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.993 · Cited by 634 · see citing works
Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood
Kim, P., Evans, G. W., Angstadt, M., Ho, S. S., Sripada, C. S., Swain, J. E., Liberzon, I., & Phan, K. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308240110 · Cited by 610 · see citing works
Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects
Nederhof, E., & Schmidt, M. V. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.008 · Cited by 363 · see citing works
Early-life stress mediated modulation of adult neurogenesis and behavior
Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.037 · Cited by 194 · see citing works
Self-citationOpposite effects of early maternal deprivation on neurogenesis in male versus female rats
Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0003675 · Cited by 190 · see citing works
Self-citationBock, J., Gruss, M., Becker, S., & Braun, K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh181 · Cited by 175 · see citing works
Bagot, R. C., Tse, Y. C., Nguyen, H.-B., Wong, A. S., Meaney, M. J., & Wong, T. P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.016 · Cited by 65 · see citing works
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Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268 · see citing works
Kentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works
“Corticosterone overexposure caused by depriving rats or mice from maternal care once for 24 h, or repeatedly for 3 h per day in the first two postnatal weeks is known to alter HPA-axis functionality and stress reactivity later in life and quite consistently causes deficits in cognitive and emotional behavior (for revi…”
BackgroundMethodSelf-citationKentrop, J., van der Tas, L., Loi, M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00122 · Cited by 16 · see citing works
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- Authors
- Krugers, H. J., & Joëls, M.
- Affiliations
- University of Amsterdam (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Krugers, Harm J.
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer Berlin Heidelberg
- Published
- 2014
- Volume
- 18
- Pages
- 81-92
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W1953637450
- Cited by
- 35
- References
- 14
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2
- FWCI
- 20.83
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- early life stress, perinatal adversity, hippocampus, amygdala, prefrontal cortex, brain structure, emotions, cognition, cognitive decline, emotional dysfunction, neural circuit development, psychopathology
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