Opposite effects of early maternal deprivation on neurogenesis in male versus female rats
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BACKGROUND: Major depression is more prevalent in women than in men. The underlying neurobiological mechanisms are not well understood, but recent data shows that hippocampal volume reductions in depressed women occur only when depression is preceded by an early life stressor. This underlines the potential importance of early life stress, at least in women, for the vulnerability to develop depression. Perinatal stress exposure in rodents affects critical periods of brain development that persistently alter structural, emotional and neuroendocrine parameters in adult offspring. Moreover, stress inhibits adult hippocampal neurogenesis, a form of structural plasticity that has been implicated a.o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring. PRINCIPAL FINDINGS: We show that 24 h of maternal deprivation (MD) at PND3 affects hippocampal structural plasticity at PND21 in a sex-dependent manner. Neurogenesis was significantly increased in male but decreased in female offspring after MD. Since no other structural changes were found in granule cell layer volume, newborn cell survival or proliferation rate, astrocyte number or gliogenesis, this indicates that MD elicits specific changes in subsets of differentiating cells and differentially affects immature neurons. The MD induced sex-specific effects on neurogenesis cannot be explained by differences in maternal care. CONCLUSIONS: Our data shows that early environment has a critical influence on establishing sex differences in neural plasticity and supports the concept that the setpoint for neurogenesis may be determined during perinatal life. It is tempting to speculate that a reduced level of neurogenesis, secondary to early stress exposure, may contribute to maladaptation of the HPA axis and possibly to the increased vulnerability of women to stress-related disorders.
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Some other studies failed to show that maternal separation stress reduces adult neurogenesis in the rat hippocampus.
“Previous work showed maternal separation stress reduced adult neurogenesis in the rat hippocampus (37; 62–64), although other studies failed to show this (65).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [65]
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- Authors
- Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Lucassen, Paul J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-01-29
- Volume
- 4
- Issue
- 1
- Pages
- e3675
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2629844
- OpenAlex
- W2105673253
- Cited by
- 190
- References
- 126
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 12 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 9
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion, cc-by)
- UvA-DARE (University of Amsterdam) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal deprivation, early life stress, hippocampal neurogenesis, sex differences, structural plasticity, perinatal stress, hypothalamic-pituitary-adrenal axis, astrocytes, gliogenesis, maternal care
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Astrocytes, Behavior, Animal, Cell Differentiation, Cell Survival, Corticosterone, Female, Male, Maternal Deprivation, Neuroglia, Neuronal Plasticity, Sex Factors, Weight Loss, Rats, Wistar, Dentate Gyrus, Cell Proliferation, Rats, Neurogenesis
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