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Cited by 201Probiotics and Fermented FoodsRespiratory viral infections researchPediatric health and respiratory diseases

Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

de Vrese, Michael, Winkler, Petra, Rautenberg, Peter, Harder, Timm, Noah, Christian, Laue, Christiane, Ott, Stephan, Hampe, Jochen +3 more·2006·Vaccine
DOI 10.1016/j.vaccine.2006.05.048
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Abstract

To investigate the effect of long-term consumption of probiotic bacteria on viral respiratory tract infections (common cold, influenza), a randomized, double blind, controlled intervention study was performed during two winter/spring periods (3 and 5 month). Four hundred and seventy-nine healthy adults were supplemented daily with vitamins plus minerals with or without probiotic lactobacilli and bifidobacteria. The intake of the probiotic had no effect on the incidence of common cold infections (verum=158, control=153 episodes, influenza was not observed), but significantly shortened duration of episodes by almost 2 days (7.0+/-0.5 versus 8.9+/-1.0 days, p=0.045), reduced the severity of symptoms and led to larger increases in cytotoxic T plus T suppressor cell counts and in T helper cell counts.

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Crossref · 10.1016/j.vaccine.2006.05.048

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  • Clinical studies have shown that although probiotics do not influence the incidence of respiratory tract infection, they do reduce the severity of symptoms and duration of the illness.

    “clinical studies have shown that although probiotics do not influence the incidence of respiratory tract infection, they do reduce the severity of symptoms and duration of the illness”

    From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [57]

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Authors
de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S., Hampe, J., Schreiber, S., Heller, K., & Schrezenmeir, J.
Affiliations
Christian-Albrechts-Universität zu Kiel (DE)
ORCID
Venue
Vaccine
Publisher
Elsevier BV
Published
2006-11
Volume
24
Issue
44-46
Pages
6670-6674
ISSN
0264-410X (ISSN-L)
DOI
10.1016/j.vaccine.2006.05.048
OpenAlex
W2022579357
Cited by
201
References
25
Citations by year
2025: 1 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 19 · 2020: 13 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 19 · 2012: 19
FWCI
17.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
  • OpenAgrar (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
Keywords
probiotics, common cold, respiratory viral infections, influenza, lactobacilli, Bifidobacterium, symptom duration, symptom severity, vitamin and mineral supplementation, T cells, cytotoxic T lymphocytes, T helper cells, healthy adults
MeSH terms
Adolescent, Adult, Aged, Common Cold, Double-Blind Method, Female, Humans, Immunity, Cellular, Male, Middle Aged, Respiratory Tract Infections, Severity of Illness Index, Cytokines, Probiotics

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