Cited by 60Glaucoma and retinal disordersComplement system in diseasesRetinal Diseases and Treatments

The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma

Rosen, Allison M., Stevens, Beth·2010·Advances in Experimental Medicine and Biology

Abstract

Glaucoma is one of the leading causes of vision loss worldwide, yet the signals that initiate the progressive degeneration of optic nerve axons and the selective loss of retinal ganglion neurons (RGCs) remain elusive. Reactive gliosis, release of inflammatory cytokines, and complement upregulation all occur in the early stages of glaucoma in several disease models. Recent work has implicated the classical complement cascade in the elimination of excess synaptic connections in the developing visual system and in early synapse loss associated with glaucoma, suggesting that mechanisms of developmental synapse elimination may be aberrantly re-activated in glaucoma. This review describes current evidence in support of this "synaptic" hypothesis and places complement in the context of other well-described mechanisms of neurodegeneration occurring in the glaucomatous eye.

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Crossref · 10.1007/978-1-4419-5635-4_6

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  • Abnormal microglia function and complement cascade activation have been associated with neurodegeneration of the CNS.

    “Consistent with this idea, abnormal microglia function and complement cascade activation have been associated with neurodegeneration of the CNS (Alexander et al., 2008; Beggs and Salter, 2010; Rosen and Stevens, 2010; Schafer and Stevens, 2010; Stephan et al. 2012).”

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Authors
Rosen, A. M., & Stevens, B.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Stevens, Beth
Venue
Advances in Experimental Medicine and Biology
Published
2010
Volume
703
Pages
75-93
ISSN
0065-2598 (ISSN-L)
OpenAlex
W96660166
Cited by
60
References
110
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 7 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 8 · 2012: 8
FWCI
35.03
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Richard and Susan Smith Family Foundation
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords
glaucoma, synaptic pruning, retinal ganglion cell death, visual system development, reactive gliosis, neuroinflammation, neurodegeneration
MeSH terms
Animals, Complement Pathway, Classical, Disease Models, Animal, Glaucoma, Humans, Models, Neurological, Nerve Degeneration, Neuroglia, Retina, Retinal Ganglion Cells, Risk Factors, Synapses, Neuroimmunomodulation, Signal Transduction, Cell Death, Mice

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