Ovarian Function and Obesity—Interrelationship, Impact on Women’s Reproductive Lifespan and Treatment Options

Rachoń, Dominik; Teede, Helena

doi:10.1016/j.mce.2009.09.026

Cited by 161Ovarian function and disordersReproductive Biology and FertilityDiabetes, Cardiovascular Risks, and Lipoproteins

Ovarian Function and Obesity—Interrelationship, Impact on Women’s Reproductive Lifespan and Treatment Options

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Rachoń, Dominik, Teede, Helena·2010·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2009.09.026

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Abstract

Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution. Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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Higher circulating levels of insulin increase ovarian androgen production, which has a strong influence on PCOS symptoms.
“Higher circulating levels of insulin increase ovarian androgen production, which has a strong influence on PCOS symptoms [84,85].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [85]
The public health impact of early identification and targeted prevention in high-risk, young, reproductive-age women with PCOS is likely to be very significant.
“The public health impact of early identification and targeted prevention in high-risk, young, reproductiveage women with PCOS is likely to be very significant; 93-96”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [93]
Excess weight increases the risk of developing PCOS.
“Excess weight increases the risk of developing PCOS”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [93]
Excess weight increases the clinical severity of PCOS by exacerbating both androgen and insulin levels.
“and increases the clinical severity of the condition by exacerbating both androgen and insulin levels. 93,102”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [93]

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Authors: Rachoń, D., & Teede, H.
Affiliations: Gdańsk Medical University (PL)
Jean Hailes (AU)
Corresponding author: Rachoń, Dominik
ORCID: Rachoń, Dominik
Teede, Helena
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2010-03
Volume: 316
Issue: 2
Pages: 172-179
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2009.09.026
OpenAlex: W2064410014
Cited by: 161
References: 129
Citations by year: 2026: 5 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 4
FWCI: 1.08
Type: journal article
Language: en
Open access: green
hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: ovarian function, obesity, insulin resistance, polycystic ovary syndrome, subfertility, early menarche, menopause, estrogen, body fat distribution, type 2 diabetes, prediabetes, cardiovascular disease, obesity treatment
MeSH terms: Animals, Cardiovascular Diseases, Contraceptives, Oral, Diabetes Mellitus, Type 2, Female, Humans, Infertility, Insulin Resistance, Menarche, Menopause, Obesity, Ovary, Polycystic Ovary Syndrome, Reproduction, Risk Factors, Women's Health, Disease Progression, Hormone Replacement Therapy, Risk Reduction Behavior

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Ovarian Function and Obesity—Interrelationship, Impact on Women’s Reproductive Lifespan and Treatment Options

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