The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The xCELLigence System for Real-Time and Label-Free Monitoring of Cell Viability
Abstract
We describe here the use of the xCELLigence system for label-free and real-time monitoring of cell -viability. The xCELLigence system uses specially designed microtiter plates containing interdigitated gold microelectrodes to noninvasively monitor the viability of cultured cells using electrical impedance as the readout. The continuous monitoring of cell viability by the xCELLigence system makes it possible to distinguish between different perturbations of cell viability, such as senescence, cell toxicity (cell death), and reduced proliferation (cell cycle arrest). In addition, the time resolution of the xCELLigence system allows for the determination of optimal time points to perform standard cell viability assays as well as other end-point assays to understand the mode of action. We have used the WST-1 assay (end-point viability readout), the cell index determination (continuous monitoring of viability by xCELLigence), and the DNA fragmentation assay (end-point apoptosis assay) to systematically examine cytotoxic effects triggered by two cytotoxic compounds with different cell-killing kinetics. Good correlation was observed for viability readouts between WST-1 and cell index. The significance of time resolution by xCELLigence readout is exemplified by its ability to pinpoint the optimal time points for conducting end point viability and apoptosis assays.
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Aswad, H., Forterre, A., Wiklander, O. P. B., Vial, G., Danty-Berger, E., Jalabert, A., Lamazière, A., Meugnier, E., Pesenti, S., Ott, C., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3337-2 · Cited by 185
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Self-citationLiberio, M. S., Sadowski, M. C., Soekmadji, C., Davis, R. A., & Nelson, C. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112122 · Cited by 85
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Metadata
- Authors
- Ke, N., Wang, X., Xu, X., & Abassi, Y. A.
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2011
- Volume
- 740
- Pages
- 33-43
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W96287323
- Cited by
- 411
- References
- 17
- FWCI
- 88.84
- Type
- book chapter
- Language
- en
- Open access
- closed
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- Ke, N., Wang, X., Xu, X., & Abassi, Y. A. (2011). The xCELLigence System for Real-Time and Label-Free Monitoring of Cell Viability. Methods in Molecular Biology. https://doi.org/10.1007/978-1-61779-108-6_6
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