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Cited by 117Phytochemicals and Antioxidant ActivitiesChromatography in Natural ProductsAnalytical chemistry methods development

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Extraction and Isolation of Phenolic Compounds

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Santos-Buelga, Celestino, Gonzalez-Manzano, Susana, Dueñas, Montserrat, Gonzalez-Paramas, Ana M.·2012·Methods in Molecular Biology
DOI 10.1007/978-1-61779-624-1_17
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Abstract

Phenolic compounds constitute a major class of plant secondary metabolites that are widely distributed in the plant kingdom and show a large structural diversity. These compounds occur as aglycones or glycosides, as monomers or constituting highly polymerized structures, or as free or matrix-bound compounds. Furthermore, they are not uniformly distributed in the plant and their stability varies significantly. This greatly complicates their extraction and isolation processes, which means that a single standardized procedure cannot be recommended for all phenolics and/or plant materials; procedures have to be optimized depending on the nature of the sample and the target analytes, and also on the object of the study. In this chapter, the main techniques for sample preparation, and extraction and isolation of phenolic compounds have been reviewed-from classical solvent extraction procedures to more modern approaches, such as the use of molecularly imprinted polymers or counter-current chromatography.

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Metadata

Authors
Santos-Buelga, C., Gonzalez-Manzano, S., Dueñas, M., & Gonzalez-Paramas, A. M.
Affiliations
Universidad de Salamanca (ES)
ORCID
Dueñas, Montserrat
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2012
Volume
864
Pages
427-464
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
DOI
10.1007/978-1-61779-624-1_17
OpenAlex
W2406454033
Cited by
117
References
5
Citations by year
2026: 5 · 2025: 15 · 2024: 17 · 2023: 7 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 2
FWCI
16.37
Type
book chapter
Language
en
Open access
Licence
Locations
  • Methods in molecular biology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
Keywords
phenolic compounds, extraction, isolation, plant secondary metabolites, sample preparation, solvent extraction, molecularly imprinted polymers, countercurrent chromatography, extraction optimization
MeSH terms
Countercurrent Distribution, Hydrolysis, Microwaves, Phenols, Plant Extracts, Plants, Solvents, Sound, Chromatography, Supercritical Fluid, Solid Phase Extraction

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