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Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
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“Peak concentrations and metabolism of nicotine occur rapidly, hence the use of nicotine’s primary metabolite, cotinine, as a biomarker.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [7]
In the citing paper
“Nicotine is structurally similar to acetylcholine and is a nicotinic acetylcholine receptor (nAChR) agonist.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [7]
In the citing paper
“Ethnic differences in nicotine metabolism have also been observed with African- and Chinese-Americans exhibiting slower clearance than Hispanic and Caucasian Americans [7].”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [7]
In the citing paper
“Given the high degree of hepatic extraction, any physiological event that perturbs/reduces liver blood flow (e.g. meals, posture, exercise, etc.) will likely affect the rate of nicotine clearance and, therefore, reduce and/or delay the maximal effect observed [7].”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [7]
In the citing paper
“Consumption of menthol or grapefruit will likely inhibit cytochrome P450 2A6, the primary enzyme responsible for the oxidation of nicotine and cotinine [7].”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [7]
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Biochemical verification of tobacco use and cessation
Benowitz, N. L., III, P. J., Ahijevych, K., Jarvis, M. J., Hall, S., LeHouezec, J., Hansson, A., Lichtenstein, E., Henningfield, J., Tsoh, J., et al. (2002) · Nicotine & Tobacco Research · doi:10.1080/14622200210123581 · Cited by 1,800 · cited 1×
“Nicotine and cotinine metabolism among Chinese–Americans, Latinos, and whites has been compared (Benowitz et al. 2002b).”
BackgroundSelf-citationBenowitz, N. L., Porchet, H., Sheiner, L., & Jacob, P. (1988) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1988.107 · Cited by 619
Self-citationRisks and Benefits of Nicotine to Aid Smoking Cessation in Pregnancy
Dempsey, D. A., & Benowitz, N. L. (2001) · Drug Safety · doi:10.2165/00002018-200124040-00005 · Cited by 346 · cited 1×
“Nicotine crosses the placental barrier easily, and there is evidence for accumulation of nicotine in fetal serum and amnionic fluid in slightly higher concentrations than in maternal serum (Dempsey and Benowitz 2001).”
BackgroundSelf-citationNicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers
Benowitz, N. L., & Jacob III, P. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.27 · Cited by 232 · cited 1×
“However, we found that the clearance of nicotine was significantly slower in cigarette smokers than in nonsmokers (Benowitz and Jacob 1993).”
BackgroundSelf-citationNicotine metabolism and elimination kinetics in newborns
Dempsey, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.106129 · Cited by 112
Site of nicotine absorption from a vapour inhaler - comparison with cigarette smoking
Lunell, E., Molander, L., Ekberg, K., & Wahren, J. (2000) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050007 · Cited by 94
Schoedel, K. A., Sellers, E. M., Palmour, R., & Tyndale, R. F. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.96 · Cited by 64
Research works printed but not linked: 136
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Cited by
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Petrick, J. L., Campbell, P. T., Koshiol, J., Thistle, J. E., Andreotti, G., Beane-Freeman, L. E., Buring, J. E., Chan, A. T., Chong, D. Q., Doody, M. M., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0007-z · Cited by 257
McEvoy, C. T., Schilling, D., Clay, N., Jackson, K., Go, M. D., Spitale, P., Bunten, C., Leiva, M., Gonzales, D., Hollister-Smith, J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5217 · Cited by 217
Current advances in research in treatment and recovery: Nicotine addiction
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Self-citationThirdhand smoke causes DNA damage in human cells
Hang, B., Sarker, A. H., Havel, C., Saha, S., Hazra, T. K., Schick, S., Jacob, P., Rehan, V. K., Chenna, A., Sharan, D., et al. (2013) · Mutagenesis · doi:10.1093/mutage/get013 · Cited by 171
Self-citation
Metadata
- Authors
- Benowitz, N. L., Hukkanen, J., & Jacob, P.
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Pages
- 29-60
- ISSN
- 0171-2004
- Cited by
- 1,179
- References
- 7
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.