CoChat
Sign Up
Cited by 40

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Host Defenses Against Human Papillomaviruses: Lessons from Epidermodysplasia Verruciformis

Orth, G.·2008·Current Topics in Microbiology and Immunology
DOI 10.1007/978-3-540-75203-5_3
Open this paper in CoChat — free account

Abstract

Epidermodysplasia verruciformis (EV) is a rare, autosomal recessive genodermatosis associated with a high risk of skin carcinoma (MIM 226400). EV is characterized by the abnormal susceptibility of otherwise healthy patients to infection by specific, weakly virulent human papillomaviruses (HPVs), including the potentially oncogenic HPV-5. Inactivating mutations in either of the related EVER1/TMC6 and EVER2/TMC8 genes cause most EV cases. New insights in EV pathogenesis have been gained from the following recent observations: (1) EV-specific HPVs (betapapillomaviruses) are defective for an important growth-promoting function encoded by an E5/E8 gene present in other HPVs, and inactivation of EVER proteins may compensate for the missing viral function; (2) the transmembrane viral E5/E8 and cellular EVER proteins interact both with the zinc transporter ZnT1, and are likely to modulate zinc homeostasis. EV may thus represent a primary deficiency in intrinsic, constitutive immunity to betapapillomaviruses, or constitute a primary deficiency in innate immunity (or both). Keratinocytes, the home cells of HPVs, are likely to play a central role in both cases. An important issue is to establish which cellular genes involved in intrinsic and innate antiviral responses play a part in the outcome of infections with other HPV types, such as genital oncogenic HPVs.

Overview

Integrity signals

Registry

Crossref · 10.1007/978-3-540-75203-5_3

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 4 references

Research works printed but not linked: 135

  1. Akgül B, Köse O, Safali M, Purdie K, Cerio R, Proby C, Storey A (2007) A distinct variant of epidermodysplasia verruciformis in a Turkish family lacking EVER1 and EVER2 mutations. J Dermatol Sci 46:214–216 · DOI
  2. Al-Gurairi FT, Al-Waiz M, Sharquie KE (2002) Oral zinc sulfate in the treatment of recalcitrant viral warts: randomized placebo-controlled clinical trial. Br J Dermatol 146:423–431 · DOI
  3. Alonso I, Fuchs E (2003) Stem cells of the skin epithelium. Proc Natl Acad Sci USA 100:11830–11835 · DOI
  4. Andrews GK, Wang H, Dey SK, Palmiter RD (2004) Mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis 40:74–81 · DOI
  5. Androphy EJ, Dvoretzky I, Lowy DR (1985) X-linked inheritance of epidermodysplasia verruciformis: genetic and virologic studies of a kindred. Arch Dermatol 121:864–868 · DOI
  6. Antonsson A, Forslund O, Ekberg H, Sterner G, Hansson BG (2000) The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. J Virol 74:11636–11641 · DOI
  7. Antonsson A, Karanfilovska S, Lindqvist PG, Hansson BG (2003) General acquisition of human papillomavirus infections of skin occurs in early infancy. J Clin Microbiol 4:2509–2514 · DOI
  8. Archard HO, Heck JW, Stanley HR (1965) Focal epithelial hyperplasia: an unusual oral mucosal lesion found in Indian children. Oral Surg Oral Med Oral Pathol 20:201–212 · DOI
  9. Astori G, Lavergne D, Benton C, Hockmayr B, Egawa K, Garbe C, de Villiers EM (1998) Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 110:752–755 · DOI
  10. Barr BB, Benton EC, Mc Laren K, Bunney MH, Smith IW, Blessing K, Hunter JA (1989) Human papillomavirus infection and skin cancer in renal allograft recipients. Lancet 1:124–129 · DOI
  11. Beaudenon S, Praetorius F, Kremsdorf D, Lutzner M, Worsaae N, Pehau-Arnaudet G, Orth G (1987) A new type of human papillomavirus associated with oral focal epithelial hyperplasia. J Invest Dermatol 88:130–135 · DOI
  12. Berthelot C, Dickerson MC, Rady P, He Q, Niroomand F, Tyring SK, Pandya AG (2007) Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod. J Am Acad Dermatol 56:882–886 · DOI
  13. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K (2006) Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol 24:353–389 · DOI
  14. Bieniasz PD (2004) Intrinsic immunity: a front-line defense against viral attack. Nat Immunol 5:1109–1115 · DOI
  15. Blanpain C, Horsley V, Fuchs E (2007) Epithelial stem cells: turning over new leaves. Cell 128:445–458 · DOI
  16. Bos JD (ed) (2005) Skin immune system. Cutaneous immunology and clinical immunodermatology. 3rd edition, Boca Raton, CRC Press
  17. Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55:244–265 · DOI
  18. Boxman ILA, Berkhout RJM, Mulder LHC, Wolkers MC, Bouwes Bavinck JN, Vermeer BJ, ter Schegget J (1997) Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers. J Invest Dermatol 108:712–715 · DOI
  19. Brash DE (1997) Sunlight and the onset of skin cancer. Trends Genet 13:410–414 · DOI
  20. Bruinsma JJ, Jirakulaporn T, Muslin AJ, Kornfeld K (2002) Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev Cell 2:567–578 · DOI
  21. Bruton OC (1952) Agammaglobulinemia. Pediatrics 9:722–728 · DOI · Paper page
  22. Carré D, Dompmartin A, Verdon R, Comoz F, Le Brun E, Freymuth F, Leroy D (2003) Epidermodysplasia verruciformis in a patient with HIV infection: no response to highly active antiretroviral therapy. Int J Dermatol 42:296–300 · DOI
  23. Casanova JL, Abel L (2004) The human model: a genetic dissection of immunity to infection in natural conditions. Nat Rev Immunol 4:55–66 · DOI
  24. Casanova JL, Abel L (2007) Primary immunodeficiencies: a field in its infancy. Science 317:617–619 · DOI
  25. Casanova JL, Fieschi C, Bustamante J, Reichenbach J, Remus N, von Bernuth H, Picard C (2005) From idiopathic infectious diseases to novel primary immunodeficiencies. J Allergy Clin Immunol 116:426–430 · DOI
  26. Cockayne EA (1933) Inherited abnormalities of the skin and its appendages. Oxford University Press, London, p 156
  27. Coleman N, Birley HDL, Renton AM, Hanna NF, Ryait BK, Byrne M, Taylor-Robinson D, Stanley MA (1994) Immunological events in regressing genital warts. Am J Clin Pathol 102:768–774 · DOI
  28. Cooper KD, Androphy EJ, Lowy D, Katz SI (1990) Antigen presentation and T-cell activation in epidermodysplasia verruciformis. J Invest Dermatol 94:769–776 · DOI
  29. Cousins RJ, Liuzzi JP, Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281:24085–24089 · DOI
  30. de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H (2004) Classification of papillomaviruses. Virology 324:17–27 · DOI
  31. DiMaio D, Mattoon D (2001) Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene 20:7866–7873 · DOI
  32. Fausch SC, Da Silva DM, Rudolf MP, Kast WM (2002) Human papillomavirus virus-like particles do not activate Langerhans cells: a possible immune escape mechanism used by human papillomaviruses. J Immunol 169:3242–3249 · DOI · Paper page
  33. Favre M, Orth G, Majewski S, Baloul S, Pura A, Jablonska S (1998) Psoriasis: a possible reservoir for human papillomavirus type 5, the virus associated with skin carcinomas of epidermodysplasia verruciformis. J Invest Dermatol 110:311–317 · DOI
  34. Favre M, Majewski S, Noszczyk B, Maienfisch F, Pura A, Orth G, Jablonska S (2000) Antibodies to human papillomavirus type 5 are generated in epidermal repair processes. J Invest Dermatol 114:403–407 · DOI
  35. Feltkamp MCW, Broer R, di Summa FM, Struijk L, van der Meijden E, Verlaan BPJ, Westendorp RGJ, ter Schegget J, Spaan WJM, Bouwes Bavinck JN (2003) Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer. Cancer Res 63:2695–2700
  36. Fischer A (2004) Human primary immunodeficiency diseases: a perspective. Nat Immunol 5:23–30 · DOI
  37. Fischer WC, Black RE (2004) Zinc and the risk for infectious disease. Annu Rev Nutr 24:255–275 · DOI
  38. Frank M, Kemler R (2002) Protocadherins. Curr Opin Cell Biol 14:557–562 · DOI
  39. Frazer IH, Thomas R, Zhou J, Leggatt GR, Dunn L, McMillan N, Tindle RW, Filgueira L, Manders P, Barnard P, Sharkey M (1999) Potential strategies utilised by papillomavirus to evade host immunity. Immunol Rev 168:131–142 · DOI
  40. Friedewald WF (1944) Certain conditions determining enhanced infection with the rabbit papilloma virus. J Exp Med 80:65–76 · DOI
  41. Fuchs E, Tumbar T, Guasch G (2004) Socializing with the neighbors: stem cells and their niche. Cell 116:769–778 · DOI
  42. Fuchs PG, Pfister H (1996) Papillomaviruses in epidermodysplasia verruciformis. In: Lacey C (ed) Papillomavirus reviews: current research on papillomaviruses, vol 2 (The papillomaviruses). Leeds University Press, Leeds, pp 253–261
  43. Garcia-Vallvé S, Alonso A, Bravo IG (2005) Papillomaviruses: different genes have different histories. Trends Microbiol 13:514–521 · DOI
  44. Genther Williams SM, Disbrow GL, Schlegel R, Lee D, Threadgill DW, Lambert PF (2005) Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene. Cancer Res 65:6534–6542 · DOI · Paper page
  45. Glinski W, Jablonska S, Langner A, Obalek S, Haftek M, Proniewska M (1976) Cell-mediated immunity in epidermodysplasia verruciformis. Dermatologica 153:218–227 · DOI
  46. Glinski W, Obalek S, Jablonska S, Orth G (1981) T-cells defect in patients with epidermodysplasia verruciformis due to human papillomavirus types 3 and 5. Dermatologica 162:141–147 · DOI
  47. Gober MD, Rady PL, He Q, Turker SB, Tyring SK, Gaspari AA (2007) Novel homozygous frameshift mutation of EVER1 gene in an epidermodysplasia verruciformis patient. J Invest Dermatol 127:817–820 · DOI
  48. Gorlin RJ, Gelb B, Diaz GA, Lofsness KG, Pittelkow MR, Fenyk JR (2000) WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies. Am J Med Genet 91:368–376 · DOI
  49. Guess JC, McCance DJ (2005) Decreased migration of Langerhans precursor-like cells in response to human keratinocytes expressing human papillomavirus type 16 E6/E7 is related to reduced macrophage inflammatory protein-3a production. J Virol 79:14852–14862 · DOI
  50. Harry JB, Wettstein FO (1996) Transforming properties of the cottontail rabbit papillomavirus oncoproteins LE6 and SE6 and the E8 protein. J Virol 70:3355–3362 · DOI
  51. Harwood CA, Proby CM (2002) Human papillomaviruses and non-melanoma skin cancer. Curr Opin Infect Dis 15:101–114 · DOI
  52. Howley PM, Lowy DR (2007) Papillomaviruses. In: Knipe DM, Howley PM, Griffin DE, et al (eds) Fields virology, 5th edn. Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, pp 2299–2354
  53. Hu J, Han R, Cladel NM, Pickel MD, Christensen ND (2002) Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits. J Virol 76:6453–6459 · DOI
  54. Jablonska S, Formas I (1959) Weitere positive Ergebnisse mit Auto- und Heteroinokulation bei Epidermodysplasia verruciformis Lewandowsky-Lutz. Dermatologica 118:86–93 · DOI
  55. Jablonska S, Orth G (1985) Epidermodysplasia verruciformis. Clin Dermatol 3(4):83–96 · DOI
  56. Jablonska S, Dabrowski J, Jakubowicz K (1972) Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis. Cancer Res 32:583–589
  57. Jablonska S, Orth G, Jarzabek-Chorzelska M, Rzesa G, Obalek S, Glinski W, Favre M, Croissant O (1979) Epidermodysplasia verruciformis versus disseminated verrucae planae: is epidermodysplasia verruciformis a generalized infection with wart virus? J Invest Dermatol 72: 114–119 · DOI
  58. Karagas MR, Nelson HH, Sehr P, Waterboer T, Stukel TA, Andrew A, Green AC, Bouwes Bavinck JN, Perry A, Spencer S, Rees JR, Mott LA, Pawlita M (2006) Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst 98:389–395 · DOI
  59. Kawashima M, Favre M, Obalek S, Jablonska S, Orth G (1990) Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses. J Invest Dermatol 95:537–542 · DOI
  60. Keresztes G, Mutai H, Heller S (2003) TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics 4:24–35 · DOI
  61. Khattar JA, Musharrafieh UM, Tamim H, Hamadeh GN (2007) Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. Int J Dermatol 46:427–430 · DOI
  62. Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, Hirano T (2006) Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol 7:971–977 · DOI
  63. Koranda FC, Dehmel EM, Kahn G, Penn I (1974) Cutaneous complications in immunosuppressed renal homograft recipients. J Am Med Assoc 229:419–424 · DOI
  64. Koromilas AE, Li S, Matlashewski G (2001) Control of interferon signaling in human papillomavirus infection. Cytokine Growth Factor Rev 12:157–170 · DOI
  65. Kröncke KD (2007) Cellular stress and intracellular zinc dyshomeostasis. Arch Biochem Biophys 463:183–187 · DOI
  66. Kupper TS, Fuhlbrigge RC (2004) Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 4:211–212 · DOI
  67. Kurima K, Peters LM, Yang Y, Riazuddin S, Ahmed ZM, Naz S, Arnaud D, Drury S, Mo J, Makishima T, Ghosh M, Menon PSN, Deshmukh D, Oddoux C, Ostrer H, Khan S, Riazuddin S, Deininger PL, Hampton LL, Sullivan SL, Battey JF, Keats BJB, Wilcox ER, Friedman TB, Griffith AJ (2002) Dominant and recessive deafness caused by mutations of a novel gene TMC1 required for cochlear hair-cell function. Nat Genet 30:277–284 · DOI
  68. Kurima K, Yang Y, Sorber K, Griffith AJ (2003) Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Genomics 82:300–308 · DOI
  69. Laffort C, Le Deist F, Favre M, Caillat-Zucman S, Radford-Weiss I, Debré M, Fraitag S, Blanche S, Cavazzana-Calvo M, de Saint Basile G, de Villartay P, Giliani S, Orth G, Casanova JL, Bodemer C, Fischer A (2004) Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gamma cytokine receptor subunit or JAK-3 deficiency. Lancet 363:2051–2054 · DOI · Paper page
  70. Lazarczyk M, Pons C, Mendoza JA, Cassonnet P, Jacob Y, Favre M (2008) Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med 205:35–42 · DOI · Paper page
  71. Lebre MC, van der Aar AM, van Baarsen L, van Capel TMM, Schuitemaker JHN, Kapsenberg ML, de Jong EC (2007) Human keratinocytes express functional Toll-like receptor 3, 4, 5 and 9. J Invest Dermatol 127:331–341 · DOI
  72. Lewandowsky F, Lutz W (1922) Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). AMA Arch Derm Syphilol 141:193–203 · DOI
  73. Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci USA 102:6843–6848 · DOI · Paper page
  74. Longworth MS, Laimins LA (2004) Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68:362–372 · DOI
  75. Lutz WA (1946) A propos de l’épidermodysplasie verruciforme. Dermatologica 92:30–43 · DOI
  76. Lutzner MA (1978) Epidermodysplasia verruciformis: an autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis. Bull Cancer 65:169–182
  77. Lutzner MA, Croissant O, Ducasse MF, Kreis H, Crosnier J, Orth G (1980) A potentially oncogenic human papillomavirus (HPV5) found in two renal allograft recipients. J Invest Dermatol 75:353–356 · DOI
  78. Lutzner MA, Orth G, Dutronquay V, Ducasse MF, Kreis H, Crosnier J (1983) Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lancet 2:422–424 · DOI
  79. Lutzner MA, Blanchet-Bardon C, Orth G (1984) Clinical observations, virologic studies, and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific human papillomaviruses. J Invest Dermatol 83:18s–25s · DOI
  80. Majewski S, Jablonska S (1992) Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancers: the role of local immunosurveillance. Am J Med Sci 304:174–179 · DOI
  81. Majewski S, Jablonska S (1995) Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Arch Dermatol 131:1312–1318 · DOI
  82. Majewski S, Skopinska-Rozewska E, Jablonska S, Wasik M, Misiewicz J, Orth G (1986) Partial defects of cell mediated immunity in patients with epidermodysplasia verruciformis. J Am Acad Dermatol 15:966–973 · DOI
  83. Majewski S, Malejczyk J, Jablonska S, Misiewicz J, Rudnicka L, Obalek S, Orth G (1990) Natural cell-mediated cytotoxicity against various target cells in patients with epidermodysplasia verruciformis. J Am Acad Dermatol 22:423–427 · DOI
  84. Majewski S, Hunzelmann N, Nischt R, Eckes B, Rudnicka L, Orth G (1991) TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis. J Invest Dermatol 97:862–867 · DOI
  85. Majewski S, Jablonska S, Orth G (1997) Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression. Clin Dermatol 15:321–334 · DOI
  86. Majewski S, Jablonska S, Favre M, Ramoz N, Orth G (1999) Papillomavirus and autoimmunity in psoriasis. Immunol Today 20:475–476 · DOI
  87. Marcotti W, Erven A, Johnson SL, Steel KP, Kros CJ (2006) Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. J Physiol 574:677–698 · DOI
  88. Maufort JP, Williams SM, Pitot HC, Lambert PF (2007) Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis. Cancer Res 67:6106–6112 · DOI
  89. Mendoza JA, Jacob Y, Cassonnet P, Favre M (2006) Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor b signaling pathway by binding to SMAD3. J Virol 80:12420–12424 · DOI
  90. Miller LS, Modlin RL (2007) Human keratinocyte Toll-like receptors promote distinct immune responses. J Invest Dermatol 127:262–263 · DOI
  91. Münger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M, Huh KW (2004) Mechanisms of human papillomavirus-induced oncogenesis. J Virol 78:11451–11460 · DOI · Paper page
  92. Nickoloff BJ (2007) Cracking the cytokine code in psoriasis. Nat Med 13:242–244 · DOI
  93. Nonnenmacher M, Salmon J, Jacob Y, Orth G, Breitburd F (2006) Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. J Virol 80:4890–4900 · DOI
  94. Obalek S, Favre M, Szymanczyk J, Misiewicz J, Jablonska S, Orth G (1992) Human papillomavirus (HPV) types specific of epidermodysplasia verruciformis detected in warts induced by HPV3 or HPV3-related types in immunosuppressed patients. J Invest Dermatol 98:936–941 · DOI
  95. Oliveira WRP, Carrasco S, Neto CF, Rady P, Tyring SK (2003) Nonspecific cell-mediated immunity in patients with epidermodysplasia verruciformis. J Dermatol 30:203–209 · DOI
  96. Orth G (1987) Epidermodysplasia verruciformis. In: Howley PM, Salzman NP (eds) The papovaviridae. Vol 2 The papillomaviruses. Plenum Publishing, New York, pp 199–243 · DOI
  97. Orth G (2004) Human papillomaviruses and the skin: more to be learned. J Invest Dermatol 123:xi–xiii · DOI
  98. Orth G (2005) Human papillomaviruses associated with epidermodysplasia verruciformis in non-melanoma skin cancers: guilty or innocent? J Invest Dermatol 125:xii–xiii · DOI
  99. Orth G (2006) Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses. Semin Immunol 18:362–374 · DOI · Paper page
  100. Orth G (2008) General features of human papillomaviruses. In: Mahy B, Van Regelmortel M (eds) Encyclopedia of virology, 3rd edn. Elsevier, Oxford (in press)
  101. Orth G, Jablonska S, Favre M, Croissant O, Jarzabek-Chorzelska M, Rzesa G (1978) Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis. Proc Natl Acad Sci USA 75:1537–1541 · DOI
  102. Orth G, Jablonska S, Jarzabek-Chorzelska M, Rzesa G, Obalek S, Favre M, Croissant O (1979) Characteristics of the lesions and risk of malignant conversion as related to the type of the human papillomavirus involved in epidermodysplasia verruciformis. Cancer Res 39:1074–1082
  103. Orth G, Favre M, Breitburd F, Croissant O, Jablonska S, Obalek S, Jarzabek-Chorzelska M, Rzesa G (1980) Epidermodysplasia verruciformis: a model for the role of papillomaviruses in human cancer. Cold Spring Harbor Conf Cell Prolif 7:259–282
  104. Orth G, Favre M, Majewski S, Jablonska S (2001) Epidermodysplasia verruciformis defines a subset of cutaneous human papillomaviruses. J Virol 75:4952–4953 · DOI
  105. Ostrow RS, Bender M, Niimura M, Seki T, Kawashima M, Pass F, Faras AJ (1982) Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis. Proc Natl Acad Sci USA 79:1634–1638 · DOI
  106. Palmiter RD, Findley SD (1995) Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J 14:639–649 · DOI
  107. Pass F, Reissig M, Shah KV, Eisinger M, Orth G (1977) Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. J Natl Cancer Inst 59:1107–1112 · DOI
  108. Pfister H (2003) Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 31:52–56 · DOI
  109. Pfister H, Gassenmaier A, Nürnberger F, Stüttgen G (1983) Human papillomavirus 5-DNA in carcinoma of an epidermodysplasia verruciformis patient infected with various human papillomavirus types. Cancer Res 43:1436–1441
  110. Prawer SE, Pass F, Vance JC, Greenberg LJ, Yunis EJ, Zelickson AS (1977) Depressed immune function in epidermodysplasia verruciformis. Arch Dermatol 113:495–499 · DOI
  111. Ramoz N, Rueda LA, Bouadjar B, Favre M, Orth G (1999) A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus. J Invest Dermatol 112:259–263 · DOI
  112. Ramoz N, Taieb A, Rueda LA, Montoya LS, Bouadjar B, Favre M, Orth G (2000) Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21–p24 and 17q 25. J Invest Dermatol 114:1148–1153 · DOI · Paper page
  113. Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M (2002) Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet 32:579–581 · DOI
  114. Rink L, Haase H (2007) Zinc homeostasis and immunity. Trends Immunol 28:1–4 · DOI
  115. Schiffman M, Kjaer SK (2003) Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr 31:14–19 · DOI
  116. Spahl DU, Berendji-Grün D, Suschek CV, Kolb-Bachofen V, Kröncke KD (2003) Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release. Proc Natl Acad Sci USA 100:13952–13957 · DOI
  117. Stanley M (2006) Immune responses to human papillomavirus. Vaccine 24 [Suppl 1]:S16–S22 · DOI
  118. Stark S, Petridis AK, Ghim S, Jenson AB, Bavinck JNB, Gross G, Stockfleth E, Fuchs PG, Pfister H (1998) Prevalence of antibodies against virus-like particles of epidermodysplasia verruciformis-associated HPV8 in patients at risk of skin cancer. J Invest Dermatol 111:696–701 · DOI
  119. Storey A (2002) Papillomaviruses: death-defying acts in skin cancer. Mol Med 8:417–421
  120. Sun XK, Chen JF, Xu AE (2005) A homozygous nonsense mutation in the EVER2 gene leads to epidermodysplasia verruciformis. Clin Exp Dermatol 30:573–574 · DOI
  121. Tagami H, Aiba S, Rokugo M (1985) Regression of flat warts and common warts. Clin Dermatol 3(4):170–178 · DOI
  122. Tate G, Suzuki T, Kishimoto K, Mitsuya T (2004) Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. J Hum Genet 49:223–225 · DOI
  123. Ullrich SE (2005) Mechanisms underlying UV-induced immune suppression. Mutat Res 571:185–205 · DOI
  124. von Bülow V, Rink L, Haase H (2005) Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1beta production in monocytes by elevation of guanosine 3c, 5,-cyclic monophosphate1. J Immunol 175:4697–4705 · DOI
  125. Vreugde S, Erven A, Kros CJ, Marcotti W, Fuchs H, Kurima K, Wilcox ER, Friedman TB, Griffith AJ, Balling R, Hrabé de Angelis MH, Avraham KB, Steel KP (2002) Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet 30:257–258 · DOI
  126. Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J (2002) A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet 71:66–73 · DOI · Paper page
  127. Weissenborn SJ, Höptl R, Weber F, Smola H, Pfister HJ, Fuchs PG (1999) High prevalence of a variety of epidermodysplasia verruciformis-associated human papillomaviruses in psoriasis skin of patients treated or not treated with PUVA. J Invest Dermatol 113:122–126 · DOI
  128. Wellinghausen N, Kirchner H, Rink L (1997) The immunobiology of zinc. Immunol Today 18:519–521 · DOI
  129. Woodworth CD (2002) HPV innate immunity. Front Biosci 7:2058–2071 · DOI
  130. Yamasaki S, Sakata-Sogawa K, Hasegawa A, Suzuki T, Kabu K, Sato E, Kurosaki T, Yamashita S, Tokunaga M, Nishida K, Hirano T (2007) Zinc is a novel intracellular second messenger. J Cell Biol 177:637–645 · DOI
  131. Yamashita S, Miyagi C, Fukada T, Kagara N, Che YS, Hirano T (2004) Zinc transporter LIV1 controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 429:298–302 · DOI
  132. Yang R, Murillo FM, Cui H, Blosser R, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB (2004) Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88. J Virol 78:11152–11160 · DOI
  133. Yang R, Murillo FM, Delannoy MJ, Blosser LR, Yutzy WH, Uematsu S, Takeda K, Akira S, Viscidi R, Roden RB (2005) B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174:7912–7929 · DOI
  134. Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ (2004) Abrogation of nuclear factor-κB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-a production and liver injury. Am J Pathol 164:1547–1556 · DOI
  135. Zuo YG, Ma D, Zhang Y, Qiao J, Wang B (2006) Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis. J Dermatol Sci 44:153–159 · DOI

Cited by

See all 40

Metadata

Authors
Orth, G.
Venue
Current Topics in Microbiology and Immunology
Publisher
Springer Berlin Heidelberg
Published
2008
Pages
59-83
ISSN
0070-217X
DOI
10.1007/978-3-540-75203-5_3
Cited by
40
References
4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Host Defenses Against Human Papillomaviruses: Lessons from Epidermodysplasia Verruciformis. https://app.cochat.ai/papers/10.1007/978-3-540-75203-5_3
The paper
Orth, G. (2008). Host Defenses Against Human Papillomaviruses: Lessons from Epidermodysplasia Verruciformis. Current Topics in Microbiology and Immunology. https://doi.org/10.1007/978-3-540-75203-5_3