Cited by 403AI in cancer detectionCutaneous Melanoma Detection and ManagementImage Retrieval and Classification Techniques

A Deep Learning Architecture for Image Representation, Visual Interpretability and Automated Basal-Cell Carcinoma Cancer Detection

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Cruz-Roa, Angel Alfonso, Arevalo Ovalle, John Edison, Madabhushi, Anant, González Osorio, Fabio Augusto·2013·Lecture Notes in Computer Science

Abstract

This paper presents and evaluates a deep learning architecture for automated basal cell carcinoma cancer detection that integrates (1) image representation learning, (2) image classification and (3) result interpretability. A novel characteristic of this approach is that it extends the deep learning architecture to also include an interpretable layer that highlights the visual patterns that contribute to discriminate between cancerous and normal tissues patterns, working akin to a digital staining which spotlights image regions important for diagnostic decisions. Experimental evaluation was performed on set of 1,417 images from 308 regions of interest of skin histopathology slides, where the presence of absence of basal cell carcinoma needs to be determined. Different image representation strategies, including bag of features (BOF), canonical (discrete cosine transform (DCT) and Haar-based wavelet transform (Haar)) and proposed learned-from-data representations, were evaluated for comparison. Experimental results show that the representation learned from a large histology image data set has the best overall performance (89.4% in F-measure and 91.4% in balanced accuracy), which represents an improvement of around 7% over canonical representations and 3% over the best equivalent BOF representation.

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  1. Montavon, G.: A machine learning approach to classification of low resolution histological samples. Master's thesis (2009)

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Authors
Cruz-Roa, A. A., Arevalo Ovalle, J. E., Madabhushi, A., & González Osorio, F. A.
Affiliations
Case Western Reserve University (US)
Venue
Lecture Notes in Computer Science
Published
2013
Volume
16
Issue
Pt 2
Pages
403-410
ISSN
  • 0302-9743 (ISSN-L)
  • 1611-3349
OpenAlex
W1932469787
Cited by
403
References
15
Citations by year
2026: 4 · 2025: 17 · 2024: 21 · 2023: 35 · 2022: 46 · 2021: 55 · 2020: 33 · 2019: 62 · 2018: 42 · 2017: 41 · 2016: 24 · 2015: 12 · 2014: 8 · 2013: 2
FWCI
9.90
Type
conference paper
Language
en
Open access
Locations
  • Lecture notes in computer science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) (528–2011)
  • Universidad Nacional de Colombia
  • National Institutes of Health (5r03ca143991-02)
  • National Cancer Institute (R03CA143991-01, R01CA140772, R01CA136535)
  • National Institute of Biomedical Imaging and Bioengineering (R43EB015199)
Topics
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Image Retrieval and Classification Techniques
Keywords
basal cell carcinoma, skin cancer detection, histopathological image classification, image representation learning, visual interpretability, saliency maps, bag of visual words, discrete cosine transform, Haar wavelet transform, skin histology
MeSH terms
Algorithms, Artificial Intelligence, Biopsy, Basal Cell Carcinoma, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Microscopy, Pattern Recognition, Automated, Sensitivity and Specificity, Skin Neoplasms, Reproducibility of Results

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