Deep learning in microscopy image analysis: a survey
Abstract
Computerized microscopy image analysis plays an important role in computer aided diagnosis and prognosis. Machine learning techniques have powered many aspects of medical investigation and clinical practice. Recently, deep learning is emerging as a leading machine learning tool in computer vision and has attracted considerable attention in biomedical image analysis. In this paper, we provide a snapshot of this fast-growing field, specifically for microscopy image analysis. We briefly introduce the popular deep neural networks and summarize current deep learning achievements in various tasks, such as detection, segmentation, and classification in microscopy image analysis. In particular, we explain the architectures and the principles of convolutional neural networks, fully convolutional networks, recurrent neural networks, stacked autoencoders, and deep belief networks, and interpret their formulations or modelings for specific tasks on various microscopy images. In addition, we discuss the open challenges and the potential trends of future research in microscopy image analysis using deep learning.
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Several review articles on deep learning in medical image analysis focus on the whole field of medical image analysis or on other single-imaging modalities such as MRI and microscopy.
“Several review articles have been written to date on the application of deep learning to medical image analysis; these articles focus on either the whole field of medical image analysis [11][12][13][14][15] or other single-imaging modalities such as MRI [53] and microscopy [54].”
From Deep Learning in Medical Ultrasound Analysis: A Review (2019) · cites this paper as [54]
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Deep learning for cellular image analysis
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Automated segmentation of insect anatomy from micro‐CT images using deep learning
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- Authors
- Xing, F., Xie, Y., Su, H., Liu, F., & Yang, L.
- Affiliations
- University of Colorado Denver (US)
- University of Florida (US)
- Venue
- IEEE Transactions on Neural Networks and Learning Systems
- Published
- 2018-10
- Volume
- 29
- Issue
- 10
- Pages
- 4550-4568
- ISSN
- 2162-237X (ISSN-L)
- 2162-2388
- OpenAlex
- W2768673271
- Cited by
- 460
- References
- 192
- Citations by year
- 2026: 35 · 2025: 55 · 2024: 54 · 2023: 70 · 2022: 70 · 2021: 67 · 2020: 60 · 2019: 31 · 2018: 17
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Neural Networks and Learning Systems (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Keywords
- microscopy image analysis, deep learning, convolutional neural networks, fully convolutional network, recurrent neural networks, stacked autoencoder, deep belief network, cell detection, image segmentation, image classification, computer-aided diagnosis, medical image analysis
- MeSH terms
- Deep Learning, Algorithms, Diagnosis, Computer-Assisted, Female, Humans, Image Processing, Computer-Assisted, Male, Microscopy, Surveys and Questionnaires, Neural Networks, Computer
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