Cited by 460Cell Image Analysis TechniquesAdvanced Neural Network ApplicationsAI in cancer detection

Deep learning in microscopy image analysis: a survey

Xing, Fuyong, Xie, Yuanpu, Su, Hai, Liu, Fujun, Yang, Lin·2018·IEEE Transactions on Neural Networks and Learning Systems

Abstract

Computerized microscopy image analysis plays an important role in computer aided diagnosis and prognosis. Machine learning techniques have powered many aspects of medical investigation and clinical practice. Recently, deep learning is emerging as a leading machine learning tool in computer vision and has attracted considerable attention in biomedical image analysis. In this paper, we provide a snapshot of this fast-growing field, specifically for microscopy image analysis. We briefly introduce the popular deep neural networks and summarize current deep learning achievements in various tasks, such as detection, segmentation, and classification in microscopy image analysis. In particular, we explain the architectures and the principles of convolutional neural networks, fully convolutional networks, recurrent neural networks, stacked autoencoders, and deep belief networks, and interpret their formulations or modelings for specific tasks on various microscopy images. In addition, we discuss the open challenges and the potential trends of future research in microscopy image analysis using deep learning.

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Crossref · 10.1109/tnnls.2017.2766168

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192 of 192 references verified0 citation errors · 0 not checkable

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  • Several review articles on deep learning in medical image analysis focus on the whole field of medical image analysis or on other single-imaging modalities such as MRI and microscopy.

    “Several review articles have been written to date on the application of deep learning to medical image analysis; these articles focus on either the whole field of medical image analysis [11][12][13][14][15] or other single-imaging modalities such as MRI [53] and microscopy [54].”

    From Deep Learning in Medical Ultrasound Analysis: A Review (2019) · cites this paper as [54]

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Authors
Xing, F., Xie, Y., Su, H., Liu, F., & Yang, L.
Affiliations
  • University of Colorado Denver (US)
  • University of Florida (US)
Venue
IEEE Transactions on Neural Networks and Learning Systems
Published
2018-10
Volume
29
Issue
10
Pages
4550-4568
ISSN
  • 2162-237X (ISSN-L)
  • 2162-2388
OpenAlex
W2768673271
Cited by
460
References
192
Citations by year
2026: 35 · 2025: 55 · 2024: 54 · 2023: 70 · 2022: 70 · 2021: 67 · 2020: 60 · 2019: 31 · 2018: 17
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • IEEE Transactions on Neural Networks and Learning Systems (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
Keywords
microscopy image analysis, deep learning, convolutional neural networks, fully convolutional network, recurrent neural networks, stacked autoencoder, deep belief network, cell detection, image segmentation, image classification, computer-aided diagnosis, medical image analysis
MeSH terms
Deep Learning, Algorithms, Diagnosis, Computer-Assisted, Female, Humans, Image Processing, Computer-Assisted, Male, Microscopy, Surveys and Questionnaires, Neural Networks, Computer

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