Cited by 65Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeural and Behavioral Psychology Studies

Depression and antisocial personality disorder: two contrasting disorders of 5HT function

Deakin, J. F. W.·2003·Journal of Neural Transmission. Supplementa

Abstract

Impaired 5HT functioning has been implicated in two very different psychiatric syndromes: antisocial personality disorder and depression. In both, reduced csf concentration of 5HIAA and blunted circulating hormone responses to 5HT drug challenge have been described. The paradox can be resolved by the theory that the two main ascending 5HT pathways mediate adaptive responses to future and current adversity. Projections of the anterior group of raphe 5HT cells (dorsal raphe nucleus) oppose the action of dopamine and mediate avoidance of threats. Impaired function sensitises the dopamine system resulting in impulsivity and drug addiction. Posterior 5HT cells (median raphe nucleus) innervate hippocampus and cingulate gyrus and suppress memory and awareness of current and past adversity. Impaired function results in low mood, low self-esteem, hopelessness and pessimism. Modern imaging methods are providing startling corroboration of these ideas.

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Crossref · 10.1007/978-3-7091-6020-6_5

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  • Serotonergic activity is crucially involved in risk aversion and self-regulation.

    “Serotonergic activity is thus crucially involved in risk aversion and self-regulation (Cools et al., 2008; Deakin, 2003; Fairbanks, 2009; Tops et al., 2009)”

    From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Deakin, 2003

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Authors
Deakin, J. F. W.
Affiliations
University of Manchester (GB)
Corresponding author
Deakin, J. F. W.
Venue
Journal of Neural Transmission. Supplementa
Published
2003
Issue
64
Pages
79-93
ISSN
0303-6995 (ISSN-L)
OpenAlex
W2294684135
Cited by
65
References
57
Citations by year
2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
6.71
Type
book chapter
Language
en
Open access
closed
Locations
  • Journal of neural transmission. Supplementum (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
depression, antisocial personality disorder, serotonin, dorsal raphe nucleus, median raphe nucleus, dopamine, impulsivity, drug addiction, avoidance behavior, memory, pessimism, self-esteem, hopelessness
MeSH terms
Antisocial Personality Disorder, Brain Chemistry, Depressive Disorder, Humans, Serotonin

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