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Dissociable functions in the medial and lateral orbitofrontal cortex: Evidence from human neuroimaging studies

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Elliott, R.·2000·Cerebral Cortex
DOI 10.1093/cercor/10.3.308
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Abstract

Recent imaging studies show that the orbitofrontal cortex (OFC) is activated during a wide variety of paradigms, including guessing tasks, simple delayed matching tasks and sentence completion. We suggest that, as with other regions of the prefrontal cortex, activity in the OFC is most likely to be observed when there is insufficient information available to determine the appropriate course of action. In these circumstances the OFC, rather than other prefrontal regions, is more likely to be activated when the problem of what to do next is best solved by taking into account the likely reward value of stimuli and responses, rather than their identity or location. We suggest that selection of stimuli on the basis of their familiarity and responses on the basis of a feeling of 'rightness' are also examples of selection on the basis of reward value. Within the OFC, the lateral regions are more likely to be involved when the action selected requires the suppression of previously rewarded responses.

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  • Several previous studies identified different MDD subtypes with different functional connectivity patterns in DMN areas.

    “Consistent with the distinct DMN alterations in our study, several previous studies focusing on the local functional connectivity of the DMN or based on a small-sample dataset identified the different MDD subtypes with different functional connectivity patterns in the DMN areas [15, 54].”

    From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [54]

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  1. Baddeley A (1986) Working memory. Oxford: Clarendon Press.
  2. Diamond A (1991) Guidelines for the study of brain-behaviour relationships during development. In: Frontal lobe function and dysfunction (Levin HS, Eisenberg HM, Benton AL, eds), pp. 339-380. Oxford: Oxford University Press.
  3. Petrides M, Pandya DN (1994)Comparative architechtonic analysis of the human and macaque frontal cortex. In: Handbook of neuro- psychology, Vol. 9 (Boller F, Grafman J, eds), pp. 17-58. Amsterdam: Elsevier Science BV.

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Authors
Elliott, R.
Affiliations
University of Manchester (GB)
Corresponding author
Elliott, R.
ORCID
Elliott, R.
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2000-03-01
Volume
10
Issue
3
Pages
308-317
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/10.3.308
OpenAlex
W2156777444
Cited by
887
References
73
Citations by year
2026: 5 · 2025: 14 · 2024: 14 · 2023: 14 · 2022: 15 · 2021: 28 · 2020: 35 · 2019: 40 · 2018: 33 · 2017: 39 · 2016: 37 · 2015: 38 · 2014: 34 · 2013: 44 · 2012: 43
FWCI
2.67
Type
journal article
Language
en
Open access
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
orbitofrontal cortex, medial orbitofrontal cortex, lateral orbitofrontal cortex, reward value, decision-making, prefrontal cortex, response selection, response suppression, delayed matching-to-sample, sentence completion
MeSH terms
Animals, Frontal Lobe, Humans, Neural Pathways, Neuropsychological Tests, Tomography, Emission-Computed

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