Function of TopBP1 in Genome Stability

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385 · see citing works

Transcriptional regulation and transformation by Myc proteins

Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,122 · see citing works

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works

Polygenic susceptibility to breast cancer and implications for prevention

Pharoah, P. D. P., Antoniou, A. C., Bobrow, M., Zimmern, R. L., Easton, D. F., & Ponder, B. A. J. (2002) · Nature Genetics · doi:10.1038/ng853 · Cited by 898 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1212 · Cited by 666 · see citing works

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 629 · see citing works

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

Jackman, M. R., Lindon, C., Nigg, E. A., & Pines, J. (2003) · Nature Cell Biology · doi:10.1038/ncb918 · Cited by 614 · see citing works

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

Zegerman, P., & Diffley, J. (2007) · Nature · doi:10.1038/nature05432 · Cited by 555 · see citing works

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Syljuåsen, R. G., Sørensen, C. S., Hansen, L. T., Fugger, K., Lundin, C., Johansson, F., Helleday, T., Sehested, M., Lukas, J., & Bártek, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3553-3562.2005 · Cited by 550 · see citing works

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y., & Araki, H. (2007) · Nature · doi:10.1038/nature05465 · Cited by 530 · see citing works

Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy.

Dittmer, J. (2003) · Molecular Cancer · doi:10.1186/1476-4598-2-29 · Cited by 498 · see citing works

Regulation of the c-Abl and Bcr–Abl tyrosine kinases

Hantschel, O. D., & Superti‐Furga, G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1280 · Cited by 491 · see citing works

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 454 · see citing works

TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 368 · see citing works

Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H., & Karnitz, L. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.032 · Cited by 342 · see citing works

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

Herold, S., Wanzel, M., Beuger, V., Frohme, C., Beul, D., Hillukkala, T., Syväoja, J. E., Saluz, H., Haenel, F., & Eilers, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00633-0 · Cited by 305 · see citing works

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

Sangrithi, M. N., Bernal, J. A., Madine, M. A., Philpott, A., Lee, J.-K., Dunphy, W. G., & Venkitaraman, A. (2005) · Cell · doi:10.1016/j.cell.2005.05.015 · Cited by 305 · see citing works

E2F – at the crossroads of life and death

Polager, S., & Ginsberg, D. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.003 · Cited by 300 · see citing works

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

Dutertre, S., Cazalès, M., Quaranta, M., Froment, C., Trabut, V., Dozier, C., Mirey, G., Bouché, J., Theis‐Febvre, N., Schmitt, E., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01108 · Cited by 284 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

Araki, H., Leem, S., Phongdara, A., & Sugino, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11791 · Cited by 273 · see citing works

Holliday Junctions Accumulate in Replication Mutants via a RecA Homolog-Independent Mechanism

Zou, H., & Rothstein, R. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80316-5 · Cited by 256 · see citing works

HPV: from infection to cancer

Stanley, M., Pett, M. R., & Coleman, N. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351456 · Cited by 237 · see citing works

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

Mäkiniemi, M., Hillukkala, T., Tuusa, J. T., Reini, K., Vaara, M., Huang, D., Pospiech, H., Majuri, I., Westerling, T., Mäkelä, T. P., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102245200 · Cited by 217 · see citing works

A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replicationPreprint

Kubota, Y., Takase, Y., Komori, Y., Hashimoto, Y., Arata, T., Kamimura, Y., Araki, H., & Takisawa, H. (2003) · Genes & Development · doi:10.1101/gad.1070003 · Cited by 200 · see citing works

The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication

Matsuno, K., Kumano, M., Kubota, Y., Hashimoto, Y., & Takisawa, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02267-05 · Cited by 194 · see citing works

Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

Masumoto, H., Sugino, A., & Araki, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2809-2817.2000 · Cited by 184 · see citing works

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo, L. I., Murga, M., Gutierrez-Martinez, P., Soria, R., & Fernandez-Capetillo, O. (2008) · Genes & Development · doi:10.1101/gad.452308 · Cited by 183 · see citing works

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

Yamane, K., Wu, X., & Chen, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.555-566.2002 · Cited by 181 · see citing works

Poly ADP-ribose polymerase-1: An international molecule of mystery

Woodhouse, B. C., & Dianov, G. L. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.009 · Cited by 179 · see citing works

Identification and functional analysis of TopBP1 and its homologs

Garcia, V., Furuya, K., & Carr, A. M. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.04.001 · Cited by 158 · see citing works

Specificity in the activation and control of transcription factor E2F-dependent apoptosis

Hallstrom, T. C., & Nevins, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831408100 · Cited by 152 · see citing works

A Sliding Clamp Model for the Rad1 Family of Cell Cycle Checkpoint Proteins

Thelen, M. P., Venclovas, Č., & Fidelis, K. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80587-5 · Cited by 150 · see citing works

The BRCA1 C-terminal domain: structure and function

Huyton, T., Bates, P. A., Zhang, X., Sternberg, M. J. E., & Freemont, P. S. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00034-3 · Cited by 147 · see citing works

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survivalPreprint

Liu, K., Luo, Y., Lin, F., & Lin, W.-C. (2004) · Genes & Development · doi:10.1101/gad.1180204 · Cited by 147 · see citing works

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

Hatten, R. A. V., Tutter, A., Holway, A. H., Khederian, A. M., Walter, J., & Michael, W. (2002) · Journal of Cell Biology · doi:10.1083/jcb.200207090 · Cited by 145 · see citing works

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

Wilsker, D. F., Petermann, E., Helleday, T., & Bunz, F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806917106 · Cited by 140 · see citing works

Xenopus Cut5 is essential for a CDK‐dependent process in the initiation of DNA replication

Hashimoto, Y., & Takisawa, H. (2003) · EMBO Journal · doi:10.1093/emboj/cdg238 · Cited by 140 · see citing works

The emerging role of E2F-1 in the DNA damage response and checkpoint control

Stevens, C., & Thangue, N. B. L. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.034 · Cited by 136 · see citing works

Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

Saka, Y., Fantes, P. A., Sutani, T., McInerny, C., CREANOR, J., & Yanagida, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06866.x · Cited by 133 · see citing works

Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1

Liu, K., Lin, F., Ruppert, J. M., & Lin, W.-C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3287-3304.2003 · Cited by 132 · see citing works

Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1.

Roussel, M. F., Jn, D., Jl, C., Ghysdael, J., & Hiebert, S. W. (1994) · PubMed · Cited by 121 · see citing works

A DNA‐Topoisomerase‐11–Binding Protein with Eight Repeating Regions Similar to DNA‐repair Enzymes and to a Cell‐Cycle Regulator

Yamane, K., Kawabata, M., & TSURUO, T. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00794.x · Cited by 119 · see citing works

Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM

Yoo, H. Y., Kumagai, A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701770200 · Cited by 118 · see citing works

PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1

Xu, Z., Timanova-Atanasova, A., Zhao, R., & Chang, K.-S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4247-4256.2003 · Cited by 114 · see citing works

A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1

Boner, W., Taylor, E. R., Tsirimonaki, E., Yamane, K., Campo, M. S., & Morgan, I. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202163200 · Cited by 106 · see citing works

Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response

Honda, Y., Tojo, M., Matsuzaki, K., Anan, T., Matsumoto, M., Ando, M., Saya, H., & Nakao, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104347200 · Cited by 105 · see citing works

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival

Liu, K., Paik, J. C., Wang, B., Lin, F., & Lin, W.-C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601355 · Cited by 102 · see citing works

A Role for the Phosphorylation of hRad9 in Checkpoint Signaling

St.Onge, R. P., Besley, B. D. A., Pelley, J. L., & Davey, S. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303134200 · Cited by 99 · see citing works

Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA

Yamane, K., & Tsuruo, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202922 · Cited by 92 · see citing works

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

Yang, S., Lin, F., & Lin, W. (2008) · EMBO Reports · doi:10.1038/embor.2008.128 · Cited by 89 · see citing works

The papillomavirus E2 protein: a factor with many talents

Ham, J., Dostatni, N., Gauthier, J. M., & Yaniv, M. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90172-r · Cited by 88 · see citing works

TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint

Perera, D., Pérez-Hidalgo, L., Møens, P. B., Reini, K., Lakin, N. D., Syväoja, J. E., San-Segundo, P. A., & Freire, R. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0444 · Cited by 88 · see citing works

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

Herold, S., Hock, A., Herkert, B., Berns, K., Mullenders, J., Beijersbergen, R. L., Bernards, R., & Eilers, M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.200 · Cited by 81 · see citing works

Checking Out the Centrosome

Krämer, A., Lukas, J., & Bártek, J. (2004) · Cell Cycle · doi:10.4161/cc.3.11.1252 · Cited by 78 · see citing works

The role of CDK in the initiation step of DNA replication in eukaryotes

Tanaka, S., Tak, Y., & Araki, H. (2007) · Cell Division · doi:10.1186/1747-1028-2-16 · Cited by 77 · see citing works

hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.

Greer, D. A., Besley, B. D. A., Kennedy, K. B., & Davey, S. K. (2003) · PubMed · Cited by 73 · see citing works

Initiation of eukaryotic DNA replication: Regulation and mechanisms

Nasheuer, H., Smith, R. W., Bauerschmidt, C., Große, F., & Weißhart, K. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)72067-9 · Cited by 72 · see citing works

Human TopBP1 Ensures Genome Integrity during Normal S Phase

Kim, J., McAvoy, S., Smith, D. I., & Chen, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10907-10915.2005 · Cited by 72 · see citing works

The Drosophila mus101 Gene, Which Links DNA Repair, Replication and Condensation of Heterochromatin in Mitosis, Encodes a Protein With Seven BRCA1 C-Terminus Domains

Yamamoto, R., Axton, M., Yamamoto, Y., Saunders, R. D. C., Glover, D. M., & Henderson, D. S. (2000) · Genetics · doi:10.1093/genetics/156.2.711 · Cited by 70 · see citing works

Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.

Yamane, K., Chen, J., & Kinsella, T. J. (2003) · PubMed · Cited by 66 · see citing works

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

Parrilla-Castellar, E. R., & Karnitz, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300418200 · Cited by 65 · see citing works

TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with Chromatin

Donaldson, M., Boner, W., & Morgan, I. M. (2007) · Journal of Virology · doi:10.1128/jvi.02353-06 · Cited by 65 · see citing works

Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.

Choi, J.-H., Lindsey-Boltz, L. A., & Sancar, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706013104 · Cited by 64 · see citing works

The phosphorylated C‐terminal domain of Xenopus Cut5 directly mediates ATR‐dependent activation of Chk1

Hashimoto, Y., Tsujimura, T., Sugino, A., & Takisawa, H. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00998.x · Cited by 63 · see citing works

The Chromatin Structure of the Dual c-myc Promoter P1/P2 Is Regulated by Separate Elements

Albert, T., Wells, J. M., Funk, J.-O., Pullner, A., Raschke, E. E., Stelzer, G., Meisterernst, M., Farnham, P., & Eick, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100265200 · Cited by 63 · see citing works

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling

Yan, S., Lindsay, H. D., & Michael, W. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200601076 · Cited by 56 · see citing works

Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation.

de Nigris, F., Mega, T., Berger, N., Barone, M. V., Santoro, M. M., Viglietto, G., Verde, P., & Fusco, A. (2001) · PubMed · Cited by 56 · see citing works

DNA Replication-Dependent Formation of Joint DNA Molecules in Physarum polycephalum

Bénard, M., Maric, C. A., & Pierron, G. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00237-4 · Cited by 52 · see citing works

Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor

Yoshida, K., & Inoue, I. (2004) · Oncogene · doi:10.1038/sj.onc.1207829 · Cited by 51 · see citing works

The Radioresistance to Killing of A1–5 Cells Derives from Activation of the Chk1 Pathway

Hu, B., Zhou, X.-Y., Wang, X., Zeng, Z., Iliakis, G. E., & Wang, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009340200 · Cited by 49 · see citing works

TopBP1 associates with NBS1 and is involved in homologous recombination repair

Morishima, K., Sakamoto, S., Kobayashi, J., Izumi, H., Suda, T., Matsumoto, Y., Tauchi, H., Ide, H., Komatsu, K., & Matsuura, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.086 · Cited by 48 · see citing works

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis

Reini, K., Uitto, L., Perera, D., Møens, P. B., Freire, R., & Syv�oja, J. E. (2004) · Chromosoma · doi:10.1007/s00412-004-0277-5 · Cited by 47 · see citing works

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

Choi, J.-H., Lindsey‐Boltz, L. A., & Sancar, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1075 · Cited by 46 · see citing works

Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer

Karppinen, S.-M., Erkko, H., Reini, K., Pospiech, H., Heikkinen, K., Rapakko, K., Syväoja, J. E., & Winqvist, R. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.05.030 · Cited by 42 · see citing works

Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2

Boner, W., & Morgan, I. M. (2002) · Virus Research · doi:10.1016/s0168-1702(02)00145-4 · Cited by 38 · see citing works

Characterization of the interaction between the human DNA topoisomerase IIβ-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

Schmidt, U., Wollmann, Y., Franke, C., Große, F., Saluz, H., & Hänel, F. (2007) · Biochemical Journal · doi:10.1042/bj20070872 · Cited by 37 · see citing works

Aberrant expression of TopBP1 in breast cancer

Going, J. J., Nixon, C., Dornan, E. S., Boner, W., Donaldson, M. M., & Morgan, I. M. (2007) · Histopathology · doi:10.1111/j.1365-2559.2007.02622.x · Cited by 35 · see citing works

Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ERα and p53

Morris, J. S., Nixon, C., King, O. J. A., Morgan, I. M., & Philbey, A. (2008) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.10.025 · Cited by 34 · see citing works

Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition

Jeon, Y., Lee, K. Y., Ko, M. J., Lee, Y. S., Kang, S., & Hwang, D. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609116200 · Cited by 33 · see citing works

Phosphorylation ofXenopusRad1 and Hus1 Defines a Readout for ATR Activation That Is Independent of Claspin and the Rad9 Carboxy Terminus

Lupardus, P. J., & Cimprich, K. A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0865 · Cited by 33 · see citing works

BRIT1/MCPH1: A Guardian of Genome and an Enemy of Tumors

Chaplet, M., Rai, R., Jackson-Bernitsas, D., Li, K., & Lin, S. (2006) · Cell Cycle · doi:10.4161/cc.5.22.3471 · Cited by 32 · see citing works

Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53

Morris, J. S., Nixon, C., Bruck, A., Nasir, L., Morgan, I. M., & Philbey, A. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.01.006 · Cited by 31 · see citing works

The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription

Sjøttem, E., Rekdal, C., Svineng, G., Sagen-Johnsen, S., Klenow, H., Uglehus, R. D., & Johansen, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm739 · Cited by 27 · see citing works

Coupling of DNA replication and mitosis by fission yeast rad4/cut5

Saka, Y., Fantes, P. A., & Yanagida, M. (1994) · Journal of Cell Science · doi:10.1242/jcs.1994.supplement_18.8 · Cited by 23 · see citing works

The DNA topoisomerase IIβ binding protein 1 (TopBP1) interacts with poly (ADP‐ribose) polymerase (PARP‐1)

Wollmann, Y., Schmidt, U., Wieland, G. D., Zipfel, P. F., Saluz, H., & Hänel, F. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21292 · Cited by 20 · see citing works

TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains

Wright, R. H. G., Dornan, E. S., Donaldson, M., & Morgan, I. M. (2006) · Biochemical Journal · doi:10.1042/bj20060831 · Cited by 18 · see citing works

Identification of TopBP1 as a c-Abl-interacting Protein and a Repressor for c-Abl Expression

Zeng, L., Hu, Y., & Li, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503016200 · Cited by 17 · see citing works

Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork

Nasheuer, H., Pospiech, H., & Syväoja, J. E. (2006) · Springer eBooks · doi:10.1007/7050_016 · Cited by 16 · see citing works

Geminin organizes the molecular platform to balance cellular proliferation and differentiation

Yoshida, K. (2007) · Frontiers in bioscience · doi:10.2741/2288 · Cited by 5 · see citing works

The transcription factor Egr-1 is a regulator of the human TopBP1 gene

Usskilat, C., Skerka, C., Saluz, H., & Hänel, F. (2006) · Gene · doi:10.1016/j.gene.2006.05.025 · Cited by 5 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation

Landeghem, L. V., Santoro, M. A., Krebs, A. E., Mah, A. T., Dehmer, J. J., Gracz, A. D., Scull, B., McNaughton, K. K., Magness, S. T., & Lund, P. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00519.2011 · Cited by 139 · see citing works

Engagement of the ATR-Dependent DNA Damage Response at the Human Papillomavirus 18 Replication Centers during the Initial Amplification

Reinson, T., Toots, M., Kadaja, M., Pipitch, R., Allik, M., Ustav, E., & Ustav, M. (2012) · Journal of Virology · doi:10.1128/jvi.01943-12 · Cited by 138 · see citing works

Congenital microcephaly

Alcantara, D., & O’Driscoll, M. (2014) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31397 · Cited by 136 · see citing works

The role of BRCA1 in DNA double-strand repair: Past and present

Caestecker, K. W., & Van de Walle, G. R. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.013 · Cited by 108 · see citing works

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Moudrý, P., Watanabe, K., Wolanin, K., Bártková, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Oestergaard, V. H., Lisby, M., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201507042 · Cited by 87 · see citing works

Papillomavirus-associated squamous skin cancers following transplant immunosuppression: one Notch closer to control

Connolly, K., Manders, P., Earls, P., & Epstein, R. J. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.08.005 · Cited by 78 · see citing works

Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic

Priya, B., Ravi, S., & Kirubakaran, S. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103662 · Cited by 75 · see citing works

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Bigot, N., Day, M., Baldock, R. A., Watts, F. Z., Oliver, A. W., & Pearl, L. H. (2019) · eLife · doi:10.7554/elife.44353 · Cited by 59 · see citing works

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

Laine, A., Nagelli, S. G., Farrington, C., Butt, U., Cvrljevic, A. N., Vainonen, J. P., Feringa, F. M., Grönroos, T. J., Gautam, P., Khan, S., et al. (2020) · doi:10.1101/2020.08.27.269902 · Cited by 54 · see citing works

Clinical perspectives of BET inhibition in ovarian cancer

Andrikopoulou, Α., Liontos, M., Koutsoukos, K., Dimopoulos, M. A., & Zagouri, F. (2021) · Cellular Oncology · doi:10.1007/s13402-020-00578-6 · Cited by 50 · see citing works

Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy

Zhao, Y., Huang, X., Zhu, D., Wei, M., Luo, J., Yu, S., Tian, Y., & Zheng, X. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01036-6 · Cited by 50 · see citing works

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

Sokka, M., Rilla, K. J., Miinalainen, I., Pospiech, H., & Syväoja, J. E. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv371 · Cited by 45 · see citing works

Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk

Alemi, F., Sadigh, A. R., Malakoti, F., Elhaei, Y., Ghaffari, S. H., Maleki, M., Asemi, Z., Yousefi, B., Targhazeh, N., & Majidinia, M. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30573 · Cited by 41 · see citing works

The NF-Y/p53 liaison: Well beyond repression

Imbriano, C., Gnesutta, N., & Mantovani, R. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.11.001 · Cited by 38 · see citing works

High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

Parplys, A. C., Seelbach, J. I., Becker, S., Behr, M., Wrona, A., Jend, C., Mansour, W. Y., Joosse, S. A., Stuerzbecher, H.-W., Pospiech, H., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1055996 · Cited by 36 · see citing works

Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing

Jaramillo-Lambert, A., Fuchsman, A. S., Fabritius, A. S., Smith, H. E., & Golden, A. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.017038 · Cited by 23 · see citing works

Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front

Jeffrey, J. D., Jeffries, K. M., & Suski, C. D. (2019) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2019.100614 · Cited by 23 · see citing works

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

Gao, L., Li, D., Ma, K., Zhang, W., Xu, T., Fu, C., Jing, C., Jia, X., Wu, S., Sun, X., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005346 · Cited by 22 · see citing works

Comparative analysis of the molecular mechanisms controlling the initiation of chromosomal DNA replication in yeast and in mammalian cells

Sacco, E., Hasan, M. M., Alberghina, L., & Vanoni, M. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.09.009 · Cited by 22 · see citing works

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication

Feng, H., Lu, J., Song, X., Thongkum, A., Zhang, F., Lou, L., Reizes, O., Almasan, A., & Gong, Z. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa756 · Cited by 20 · see citing works

Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

Bai, L., Michael, W. M., & Yan, S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.006 · Cited by 19 · see citing works

Cancer-associated transcription factors in DNA damage response

Kciuk, M., Gielecińska, A., Kołat, D., Kałuzińska‐Kołat, Ż., & Kontek, R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188757 · Cited by 18 · see citing works

High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction

Wendel, S. O., Snow, J. A., Bastian, T., Brown, L. E., Hernandez, C., Burghardt, E., Kahn, A., Murthy, V., Neill, D., Smith, Z. C., et al. (2020) · Cancers · doi:10.3390/cancers13010028 · Cited by 17 · see citing works

Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer

Forma, E., Brzeziańska‐Lasota, E., Krześlak, A., Chwatko, G., Jóźwiak, P., Szymczyk, A., Smolarz, B., Romanowicz‐Makowska, H., Różański, W., & Bryś, M. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2424-z · Cited by 17 · see citing works

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

Yan, S., & Willis, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.144 · Cited by 16 · see citing works

Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation

Zluhan‐Martínez, E., Pérez‐Koldenkova, V., Ponce-Castañeda, M. V., Sánchez, M. D. L. P., García‐Ponce, B., Miguel-Hernández, S., Alvarez-Buylla, E. R., & Garay‐Arroyo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144925 · Cited by 10 · see citing works

TopBP1 in DNA Damage Response

Forma, E., Bryś, M., & Wanda, M. (2011) · InTech eBooks · doi:10.5772/22274 · Cited by 11 · see citing works

Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

Forma, E., Wójcik‐Krowiranda, K., Jóźwiak, P., Szymczyk, A., Bieńkiewicz, A., Bryś, M., & Krześlak, A. (2013) · Pathology & Oncology Research · doi:10.1007/s12253-013-9737-7 · Cited by 7 · see citing works

The impact of TOPBP1 mutations in human cancers on the DNA damage response

Yan, Z., Ge, X., Wang, J., Xu, F., Li, M., Liu, X., Yu, X., & Wu, C. (2022) · Genome Instability & Disease · doi:10.1007/s42764-022-00072-3 · Cited by 4 · see citing works

TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC

Tang, X.-M., Shi, M.-M., Wang, J., Gu, Y., Dai, Y.-T., Yang, Q.-X., Liu, J., Ren, L., Liu, X.-Y., Yang, C., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01350-9 · Cited by 3 · see citing works

The c.*229C > T gene polymorphism in 3′UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma

Starska, K., Forma, E., Nowacka‐Zawisza, M., Lewy‐Trenda, I., Ciesielski, P., Pietruszewska, W., Skóra, M., & Bryś, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-4276-3 · Cited by 3 · see citing works

Association between the c.*229C>T polymorphism of the topoisomerase IIb binding protein 1 (TopBP1) gene and breast cancer

FormaEwa, E. (2013)

Assembly of the Cdc45-MCM2-7-GINS Complex, the Replication Helicase

Pospiech, H., & Szambowska, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-24696-3_19

Epithelial Reprogramming and Transition during Pulmonary BioengineeringPreprint

Mizoguchi, S., Lee, V., Kim, H., Edelstein, S. E., Wang, N., Gracia, M. T., Danelski, C., Haynes, C. V., Rivero, R., Stitelman, D. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.24.701406

Evaluation of protein expression and oxidative stress index in Duchenne muscular dystrophy

Rizk, S. K., Ezzat, E. M., Abuhegazy, A., & El‐Ghlban, S. (2026) · Pediatric Research · doi:10.1038/s41390-025-04585-x

Importance of E3 Ligases for Preserving Genome Integrity: Progress and Challenges

Mahata, R., & Santra, M. (2026) · Molecular and Cellular Biology · doi:10.1080/10985549.2026.2638203

Rôles de la protéine E4F1 dans le contrôle de la réponse aux dommages de l’ADN dans le cancer du sein triple négatif

Batnini, K. (2019) · theses.fr (ABES) · doi:10.70675/1e6a4caaz593dz4037zb362z1237e393c1be

Human TopBP1 Ensures Genome Integrity during Normal S Phase

Kim, J., McAvoy, S., Smith, D. I., & Chen, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10907-10915.2005 · Cited by 72 · see citing works

Functions of TopBP1 in preserving genome integrity during mitosis

Bagge, J., Oestergaard, V. H., & Lisby, M. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.08.009 · Cited by 45 · see citing works

Identification and functional analysis of TopBP1 and its homologs

Garcia, V., Furuya, K., & Carr, A. M. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.04.001 · Cited by 158 · see citing works

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

Yamane, K., Wu, X., & Chen, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.555-566.2002 · Cited by 181 · see citing works

Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)

Reini, K. (2006)