Cited by 158DNA Repair MechanismsGenomics and Chromatin DynamicsCancer-related Molecular Pathways

Identification and functional analysis of TopBP1 and its homologs

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Garcia, Valerie, Furuya, Kanji, Carr, Antony M.·2005·DNA Repair

Abstract

The multiple BRCT-domain protein TopBP1 and its yeast homologs have been implicated in many aspects of DNA metabolism, but their molecular functions remain elusive. In this review, we first summarise how the yeast homologs were identified and characterised. We next review the data available from metazoan systems and finally draw parallels with the yeast models. TopBP1 plays important functions in the initiation of DNA replication in all organisms and participates in checkpoint responses both within S phase and following DNA damage. In metazoan systems there is accumulating evidence for additional roles in transcriptional regulation that have not been reported in yeast. Overall, TopBP1 appears to play a key role in integrating different aspects of DNA metabolism, but the mechanistic basis for this remains to be fully explained.

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Crossref · 10.1016/j.dnarep.2005.04.001

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Authors
Garcia, V., Furuya, K., & Carr, A. M.
Affiliations
University of Sussex (GB)
Corresponding author
Carr, Antony M.
Venue
DNA Repair
Publisher
Elsevier BV
Published
2005-11
Volume
4
Issue
11
Pages
1227-1239
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2052410309
Cited by
158
References
102
Citations by year
2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 13 · 2012: 9
FWCI
1.16
Type
journal article
Language
en
Open access
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Sussex Research Online (University of Sussex) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
TopBP1, BRCT domain, DNA replication initiation, DNA damage checkpoint, S-phase checkpoint, transcriptional regulation, DNA metabolism, yeast homolog
MeSH terms
Animals, Carrier Proteins, DNA-Binding Proteins, Humans, Nuclear Proteins, Saccharomyces cerevisiae, Schizosaccharomyces, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, Structural Homology, Protein

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