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Cited by 143Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesLipid metabolism and biosynthesis

Lipid Mediators in Acne

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Ottaviani, Monica, Camera, Emanuela, Picardo, Mauro·2010·Mediators of Inflammation
DOI 10.1155/2010/858176PMC PMC2943135
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Abstract

Multiple factors are involved in acne pathogenesis, and sebum secretion is one of the main ones. The role sebum plays in acne development has not been completely elucidated yet; however, increasing amounts of data seem to confirm the presence of alterations in sebum from acne patients. Altered ratio between saturated and unsaturated fatty acids has been indicated as an important feature to be considered in addition to the altered amount of specific fatty acids such as linoleic acid. Furthermore, particular attention has been focused on squalene peroxide that seems to be able to induce an inflammatory response beyond cytotoxicity and comedones formation. Moreover, recent data suggest that lipid mediators are able to interfere with sebocytes differentiation and sebogenesis through the activation of pathways related to peroxisome proliferators-activated receptors. Understanding the factors and mechanisms that regulate sebum production is needed in order to identify novel therapeutic strategies for acne treatment.

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  • An increase in the C16:0/C16:1 nutrition lipid ratio has been shown to improve acne, accompanied by diminishing levels of linoleic acid content.

    “An altered ratio between saturated and unsaturated fatty acids has been identified, and particularly, an increase in the C16:0/C16:1 nutrition lipid ratio has been shown to improve acne, accompanied by diminishing levels of linoleic acid content.24,26”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [24]

    Section 3.2 reports that the C16:0/C16:1 ratio in skin-surface lipids is higher in acne, not that increasing it improves acne. Section 3.1 likewise describes diminished linoleic acid in affected patients and links low levels to processes involved in comedone formation. (LLM, conf=0.88)

    Checked by a reasoning model — may be wrong.

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  • Sebocytes have been shown to exert inflammatory properties with the production of antimicrobial peptides, cytokines and chemokines.

    “sebocytes have been shown to exert inflammatory properties with the production of antimicrobial peptides, cytokines and chemokines24”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [24]

    Section 4 reports that 5-LOX activation induces IL-6 and IL-8 expression in human sebocytes, supporting an inflammatory role. Section 2 also describes antibacterial effects of certain sebaceous lipids, but the copy does not say that sebocytes produce antimicrobial peptides or chemokines. No page numbers are available in the supplied passages. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The leptin-induced changes in sebum lipids are characteristics for acne patients' sebum.

    “which altogether are also the characteristics for acne patients' sebum.24,25,44”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [24]

    Section 3 (Sebum Alterations and Acne; page unavailable) describes changes in acne patients’ sebum, including altered fatty-acid composition, and §3.3 reports increased squalene peroxide. The cited paper does not identify these changes as leptin-induced or establish that a leptin-induced lipid profile matches acne sebum. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • An altered ratio between saturated and unsaturated fatty acids has been identified in acne.

    “An altered ratio between saturated and unsaturated fatty acids has been identified, and particularly, an increase in the C16:0/C16:1 nutrition lipid ratio has been shown to improve acne, accompanied by diminishing levels of linoleic acid content.24,26”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [24]

  • Acne patients have a markedly altered sebum composition.

    “In the recent years numerous studies have showed, that in addition to an elevated sebum production, acne patients have a markedly altered sebum composition.24,25”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [24]

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Research works printed but not linked: 50

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Authors
Ottaviani, M., Camera, E., & Picardo, M.
Affiliations
San Gallicano Hospital (IT)
Corresponding author
Picardo, Mauro
ORCID
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2010
Volume
2010
Pages
1-6
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
DOI
10.1155/2010/858176
PMC
PMC2943135
OpenAlex
W2089559595
Cited by
143
References
4
Citations by year
2026: 8 · 2025: 14 · 2024: 8 · 2023: 17 · 2022: 9 · 2021: 14 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 4
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
acne, lipid mediators, sebum, sebocytes, saturated and unsaturated fatty acids, linoleic acid, inflammation, comedones, peroxisome proliferator-activated receptors, acne pathogenesis
MeSH terms
Acne Vulgaris, Cell Differentiation, Fatty Acids, Humans, Inflammation, Sebaceous Glands, Sebum, Molecular Structure, Oxidative Stress, Peroxisome Proliferator-Activated Receptors, Lipid Metabolism

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