Cited by 99Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsInfant Health and Development

Altered esophageal pain threshold in irritable bowel syndrome

Costantini, Mario, Sturniolo, Giacomo Carlo, Zaninotto, Giovanni, D'Inc�, Renata, Polo, Rita, Naccarato, Remo, Ancona, Ermanno·1993·Digestive Diseases and Sciences

Abstract

Gut motility disorders and altered pain perception were reported in patients with irritable bowel syndrome (IBS). To verify foregut involvement in IBS, we studied 30 patients using esophageal manometry and 24-hr pH monitoring of the distal esophagus. Two subgroups of patients underwent esophageal provocative tests (bethanechol 50 micrograms/kg subcutaneously and esophageal balloon distension test). Twelve healthy volunteers formed a control group. A pain threshold on esophageal distension significantly lower than in healthy subjects (11.5 +/- 1 ml vs 22.2 +/- 1.7 ml, P < 0.01) was found in IBS patients. On the other hand, no differences between patients and controls were detected in lower esophageal sphincter pressure and length, esophageal body motility, or GER pattern; furthermore, bethanechol stimulation elicited similar esophageal body motility changes. Our study could confirm no detectable basal or bethanechol-induced esophageal motility disorders in IBS patients, nor enhanced GER. Esophageal involvement in IBS consists of a lower pain threshold on esophageal distension, possibly reflecting an altered visceral receptor sensitivity or modulation throughout the gut.

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Crossref · 10.1007/bf01307536

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Authors
Costantini, M., Sturniolo, G. C., Zaninotto, G., D'Inc�, R., Polo, R., Naccarato, R., & Ancona, E.
Affiliations
University of Padua (IT)
Venue
Digestive Diseases and Sciences
Published
1993-02
Volume
38
Issue
2
Pages
206-212
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
OpenAlex
W2080716197
Cited by
99
References
50
Citations by year
2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
4.31
Type
journal article
Language
en
Open access
closed
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords
irritable bowel syndrome, esophageal distension, esophageal motility, lower esophageal sphincter pressure, gastroesophageal reflux, bethanechol
MeSH terms
Adult, Aged, Analysis of Variance, Bethanechol Compounds, Colonic Diseases, Functional, Esophagus, Female, Gastroesophageal Reflux, Humans, Hydrogen-Ion Concentration, Male, Manometry, Middle Aged, Peristalsis, Pain Threshold, Bethanechol

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