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Cited by 267Frailty in Older AdultsPharmaceutical Practices and Patient OutcomesChronic Disease Management Strategies

Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians

Jones, David, Song, Xiaowei, Mitnitski, Arnold, Rockwood, Kenneth·2005·Aging Clinical and Experimental Research
DOI 10.1007/bf03327413
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Abstract

Background and aims Objectives were to develop a frailty index (FI) based on a standard comprehensive geriatric assessment (CGA) derived from a clinical examination; to assess the validity of the FI-CGA and to compare its precision with other frailty measures. Methods Design Secondary analysis of a prospective cohort study, with five-year follow-up data. Setting Second phase of the Canadian Study of Health and Aging (CSHA-2); clinical examinations were performed in clinics, nursing homes, and patients' homes. Participants People selected (as either cognitively impaired cases or unimpaired controls) to receive the CSHA-2 clinical examination (n = 2305; women = 1431). Measurements Clinical and performance-based measures and diagnostic data were extracted to correspond to the 10 impairment domains and the single comorbidity domain of a CGA. The proportion of deficits accumulated in each domain was calculated to yield the FI-CGA. The FI-CGA was validated and its predictive ability compared with other frailty measures. Results Within the seven grades of fitness/frailty identified, subjects with greater frailty were older, less educated, and more likely to be women. The FI-CGA correlated highly with a previously validated, empirically-derived frailty index (r = 0.76). Frailty was associated with higher risk of death (for each increment in frailty, the hazard ratio, adjusted for age, sex and education, was 1.23 (95% CI 1.18-1.29) and institutionalization (HR 1.20; 1.10-1.32). Conclu…

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  • The FI-CGA still requires a comprehensive geriatric assessment (CGA), which limits its potential for routine application.

    “Similarly, the FI-CGA [19] still requires a CGA, which also limits its potential for routine application.”

    From Validity and reliability of the Edmonton Frail Scale (2006) · cites this paper as [19]

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Authors
Jones, D., Song, X., Mitnitski, A., & Rockwood, K.
Affiliations
  • Memorial University of Newfoundland (CA)
  • Queen Elizabeth II Health Sciences Centre (CA)
  • Dalhousie University (CA)
ORCID
Venue
Aging Clinical and Experimental Research
Publisher
Springer Science and Business Media LLC
Published
2005-12
Volume
17
Issue
6
Pages
465-471
ISSN
  • 1594-0667 (ISSN-L)
  • 1720-8319
DOI
10.1007/bf03327413
OpenAlex
W1998940826
Cited by
267
References
3
Citations by year
2026: 4 · 2025: 9 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 17 · 2019: 25 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 18
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Aging Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Keywords
frailty index, comprehensive geriatric assessment, frailty assessment, Canadian Study of Health and Aging, mortality risk, institutionalization, cognitive impairment, functional disability, comorbidities
MeSH terms
Aged, Aged, 80 and over, Aging, Canada, Cognition Disorders, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Predictive Value of Tests, Risk Factors, Cohort Studies, Geriatric Assessment, Comorbidity, Frail Elderly

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