NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

α-Synuclein in Lewy bodies

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α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

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The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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Identification of two distinct synucleins from human brain

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Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

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Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)

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Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

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α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

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Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

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Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

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Histochemical detection of apoptosis in Parkinson's disease

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Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

Takeda, A., Mallory, M. E., Sundsmo, M. P., Honer, W. G., Hansen, L. A., & Masliah, E. (1998) · Europe PMC (PubMed Central) · Cited by 403

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

Irizarry, M. C., Growdon, W., Gomez-isla, T., Newell, K., George, J. M., Clayton, D. F., & Hyman, B. T. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199804000-00005 · Cited by 394

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

Wakabayashi, K., Hayashi, S., Kakita, A., Yamada, M., Toyoshima, Y., Yoshimoto, M., & Takahashi, H. (1998) · Acta Neuropathologica · doi:10.1007/s004010050918 · Cited by 347

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

Wakabayashi, K., Matsumoto, K., Takayama, K., Yoshimoto, M., & Takahashi, H. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00891-4 · Cited by 331

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

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Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

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NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., & Kawai, M. (1998) · Acta Neuropathologica · doi:10.1007/s004010050917 · Cited by 239

Multiple-system atrophy: a new α-synuclein disease?

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Human brainstem catecholamine neuronal anatomy as indicated by immunocytochemistry with antibodies to tyrosine hydroxylase

Pearson, J., Goldstein, M., Markey, K., & Brandeis, L. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90023-4 · Cited by 213

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

Yoshimoto, M., Iwai, A., Kang, D., Otero, D. A., Xia, Y., & Saitoh, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9141 · Cited by 203

Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue

Yamada, T., McGeer, P. L., & McGeer, E. G. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90145-w · Cited by 193

Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?

Mezey, E., Dehejia, A., Harta, G., Papp, M. I., Polymeropoulos, M. H., & Brownstein, M. J. (1998) · Nature Medicine · doi:10.1038/nm0798-755 · Cited by 184

Oligodendroglial Microtubular Tangles in Olivopontocerebellar Atrophy

Nakazato, Y., Yamazaki, H., Hirato, J., Ishida, Y., & Yamaguchi, H. (1990) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199009000-00007 · Cited by 182

Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein

Arawaka, S., Saito, Y., Murayama, S., & Mori, H. (1998) · Neurology · doi:10.1212/wnl.51.3.887 · Cited by 172

Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy

Komori, T., Arai, N., Oda, M., Nakayama, H., Mori, H., Yagishita, S., Takahashi, T., Amano, N., Murayama, S., Murakami, S., et al. (1998) · Acta Neuropathologica · doi:10.1007/s004010050911 · Cited by 165

Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations

Wakabayashi, K., Oyanagi, K., Makifuchi, T., Ikuta, F., Homma, A., Homma, Y., Horikawa, Y., & Tokiguchi, S. (1994) · Acta Neuropathologica · doi:10.1007/bf00293314 · Cited by 157

On the question of apoptosis in the parkinsonian substantia nigra

Kösel, S., Egensperger, R., Eitzen, U. V., Mehraein, P., & Graeber, M. B. (1997) · Acta Neuropathologica · doi:10.1007/s004010050590 · Cited by 145

Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy

Arima, K., Murayama, S., Mukoyama, M., & Inose, T. (1992) · Acta Neuropathologica · doi:10.1007/bf00310020 · Cited by 121

Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

Ikeda, K., Akiyama, H., Kondo, H., Haga, C., Tanno, E., Tokuda, T., & Ikeda, S. (1995) · Acta Neuropathologica · doi:10.1007/bf00318575 · Cited by 119

Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal Tangles

Ikeda, K., Akiyama, H., Arai, T., & Nishimura, T. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00034-7 · Cited by 113

Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis.

Kato, S., Hayashi, H., Nakashima, K., Nanba, E., Kato, M., Hirano, A., Nakano, I., Asayama, K., & Ohama, E. (1997) · PubMed · Cited by 112

Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics

Iwatsubo, T., Hasegawa, M., & Ihara, Y. (1994) · Acta Neuropathologica · doi:10.1007/bf00294505 · Cited by 110

Cortical Degeneration in Progressive Supranuclear Palsy. A Comparison with Cortical-Basal Ganglionic Degeneration

Bergeron, C., Pollanen, Weyer, L., & Lang, A. E. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199706000-00010 · Cited by 110

Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain

Hayashi, Y., Kakita, A., Yamada, M., Koide, R., Igarashi, S., Takano, H., Ikeuchi, T., Wakabayashi, K., Egawa, S., Tsuji, S., et al. (1998) · Acta Neuropathologica · doi:10.1007/s004010050933 · Cited by 94

Do oligodendrocytes mediate iron regulation in the human brain?

Gerber, M. R., & Connor, J. R. (1989) · Annals of Neurology · doi:10.1002/ana.410260115 · Cited by 87

Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein

Arai, T., Uéda, K., Ikeda, K., Akiyama, H., Haga, C., Kondo, H., Kuroki, N., Niizato, K., Iritani, S., & Tsuchiya, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00890-8 · Cited by 85

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease

Cairns, N. J., Atkinson, P. F., Hanger, D. P., Anderton, B. H., Daniel, S. E., & Lantos, P. L. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00474-6 · Cited by 85

Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy)

Kato, S., Nakamura, H., Hirano, A., Itô, H., Llena, J. F., & Yen, S. H. (1991) · Acta Neuropathologica · doi:10.1007/bf00293383 · Cited by 79

Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease

Nakano, I., Iwatsubo, T., Otsuka, N., Kamei, M., Matsumura, K., & Mannen, T. (1992) · Acta Neuropathologica · doi:10.1007/bf00296783 · Cited by 53

Neuroaxonal dystrophy in young adults: A clinicopathological study of two unrelated cases

Williamson, K., Anders, A. F. S., Curry, B., & Ludwin, S. K. (1982) · Annals of Neurology · doi:10.1002/ana.410110403 · Cited by 44

Tau immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

Takeda, A., Arai, N., Komori, T., Iseki, E., Kato, S., & Oda, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00676-9 · Cited by 37

Neuroaxonal dystrophy combined with diffuse Lewy body disease in a young adult.

Sugiyama, H., Hainfellner, J. A., Schmid-Siegel, B., & Budka, H. (1993) · PubMed · Cited by 29

Untitled work

Price (1999) · doi:10.1002/1531-8249(199903)45:3

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877

Parkinson's Disease and Parkinsonism: Neuropathology

Dickson, D. W. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009258 · Cited by 847

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701

Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697