Cited by 304Advanced Glycation End Products researchGalectins and Cancer BiologyBiomarkers in Disease Mechanisms

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RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

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Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., Schmidt, A. M.·2002·Cellular and Molecular Life Sciences (CMLS)

DOI 10.1007/s00018-002-8491-xPMC PMC11337527

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Abstract

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

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Authors: Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., & Schmidt, A. M.
Affiliations: Columbia University (US)
ORCID: Bucciarelli, L. G.
Lalla, E.
Taguchi, A.
Yan, S. F.
Venue: Cellular and Molecular Life Sciences (CMLS)
Publisher: Springer Science and Business Media LLC
Published: 2002-07-01
Volume: 59
Issue: 7
Pages: 1117-1128
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-002-8491-x
PMC: PMC11337527
OpenAlex: W1979731419
Cited by: 304
References: 56
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 15 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 20 · 2015: 14 · 2014: 13 · 2013: 14 · 2012: 20
FWCI: 9.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: receptor for advanced glycation end products, RAGE, immunoglobulin superfamily, advanced glycation end products, amyloid-beta, β-sheet fibrils, S100/calgranulins, amphoterin, diabetes mellitus, inflammation, neurodegenerative diseases, tumors, homeostasis, chronic disease
MeSH terms: Receptor for Advanced Glycation End Products, Alzheimer Disease, Amyloidosis, Animals, Arteriosclerosis, Cell Movement, Chronic Disease, Diabetic Angiopathies, Homeostasis, Humans, Immunoglobulins, Inflammation, Neoplasms, Receptors, Immunologic, Signal Transduction, Mice

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RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

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