Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

GUNDERSEN, H. J. G., BENDTSEN, T. F., KORBO, L., MARCUSSEN, N., MØLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B., SØRENSEN, F. B., VESTERBY, A., et al. (1988) · APMIS · doi:10.1111/j.1699-0463.1988.tb05320.x · Cited by 2,929 · see citing works

Autism as a strongly genetic disorder: evidence from a British twin study

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works

A clinicopathological study of autism

Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works

Histoanatomic observations of the brain in early infantile autism

Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964 · see citing works

New stereological methods for counting neurons

West, M. J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90112-o · Cited by 940 · see citing works

Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat.

Bayer, S. A., Altman, J., Russo, R. J., & Zhang, X. (1993) · PubMed · Cited by 912 · see citing works

Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report

(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.862 · Cited by 590 · see citing works

AUTISM IN THALIDOMIDE EMBRYOPATHY: A POPULATION STUDY

Strömland, K., Nordin, V., Miller, M. T., Åkerström, B., & Gillberg, C. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11856.x · Cited by 453 · see citing works

Development of the brainstem and cerebellum in autistic patients

Hashimoto, T., Tayama, M., Murakawa, K., Yoshimoto, T., Miyazaki, M., Harada, M., & Kuroda, Y. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02178163 · Cited by 381 · see citing works

Fetal Valproate Syndrome: Clinical and Neuro‐developmental Features in Two Sibling Pairs

Christianson, A. L., Chester, N., & Kromberg, J. G. R. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11858.x · Cited by 340 · see citing works

The brain in infantile autism

Courchesne, E., Townsend, J., & Saitoh, O. (1994) · Neurology · doi:10.1212/wnl.44.2.214 · Cited by 296 · see citing works

A male with fetal valproate syndrome and autism

Williams, P. G., & Hersh, J. H. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07500.x · Cited by 182 · see citing works

The development of the purkinje cells and of the cortical layers in the cerebellum of the albino rat

Addison, W. H. F. (1911) · The Journal of Comparative Neurology · doi:10.1002/cne.900210503 · Cited by 169 · see citing works

Fetal valproate syndrome.

Clayton‐Smith, J., & Donnai, D. (1995) · Journal of Medical Genetics · doi:10.1136/jmg.32.9.724 · Cited by 165 · see citing works

Total numbers of various cell types in rat cerebellar cortex estimated using an unbiased stereological method

Korbo, L., Andersen, B. B., Ladefoged, O., & Møller, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90881-m · Cited by 147 · see citing works

Autism in Fetal Alcohol Syndrome: A Report of Six Cases

Nanson, J. L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01417.x · Cited by 147 · see citing works

Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats

Binkerd, P. E. (1988) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(88)90112-1 · Cited by 140 · see citing works

Cerebellar Structure in Autism

Gaffney, G. (1987) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1987.04460120096044 · Cited by 131 · see citing works

Unusual Magnetic Resonance and Neuropathological Findings in Hemimegalencephaly: Report of a Case Following Hemispherectomy

Renowden, S. A., & Squier, M. V. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11857.x · Cited by 43 · see citing works

Time of Origin of the Neurons in the Caudal Brain Stem of Rat

Nornes, H. O., & Morita, M. (2007) · Developmental Neuroscience · doi:10.1159/000112444 · Cited by 40 · see citing works

Olivocerebellar lesions in infants born prematurely

Takashima, S. (1982) · Brain and Development · doi:10.1016/s0387-7604(82)80020-x · Cited by 25 · see citing works

Untitled work

Rodier (1996) · doi:10.1002/(sici)1096-9861(19960624)370:2

Untitled work

Burger (1998) · doi:10.1002/(sici)1098-2779(1998)4:2

The Epidemiology of Autism Spectrum Disorders

Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., Reaven, J., et al. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.28.021406.144007 · Cited by 1,228 · see citing works

Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism

Schneider, T., & Przewłocki, R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300518 · Cited by 959 · see citing works

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism

Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662 · see citing works

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Bourassa, M. W., Alim, I., Bultman, S. J., & Ratan, R. R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.009 · Cited by 636 · see citing works

Autism spectrum disorder: neuropathology and animal models

Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works

Mouse Behavioral Assays Relevant to the Symptoms of Autism*

Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541 · see citing works

The immune response in autism: a new frontier for autism research

Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works

Valproic acid in pregnancy: how much are we endangering the embryo and fetus?

Ornoy, A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.014 · Cited by 526 · see citing works

Designing mouse behavioral tasks relevant to autistic‐like behaviors

Crawley, J. N. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20039 · Cited by 520 · see citing works

The Intense World Theory – A Unifying Theory of the Neurobiology of Autism

Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 522 · see citing works

Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

MACFABE, D., CAIN, D., RODRIGUEZCAPOTE, K., FRANKLIN, A., HOFFMAN, J., BOON, F., TAYLOR, A., KAVALIERS, M., & OSSENKOPP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.025 · Cited by 497 · see citing works

GABA system dysfunction in autism and related disorders: From synapse to symptoms

Coghlan, S., Horder, J., Inkster, B., Méndez, M. A., Murphy, D., & Nutt, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.005 · Cited by 437 · see citing works

Consensus Paper: Cerebellum and Social Cognition

Overwalle, F. V., Manto, M. U., Cattaneo, Z., Clausi, S., Ferrari, C., Gabrieli, J. D. E., Guell, X., Heleven, E., Lupo, M., Ma, Q., et al. (2020) · The Cerebellum · doi:10.1007/s12311-020-01155-1 · Cited by 436 · see citing works

Autism as a disorder of neural information processing: Directions for research and targets for therapy

Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001499 · Cited by 442 · see citing works

In utero exposure to valproic acid and autism — A current review of clinical and animal studies

Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 425 · see citing works

The CHARGE Study: An Epidemiologic Investigation of Genetic and Environmental Factors Contributing to Autism

Hertz‐Picciotto, I., Croen, L., Hansen, R. L., Jones, C. R., de Water, J. V., & Pessah, I. N. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8483 · Cited by 420 · see citing works

Cerebro-cerebellar circuits in autism spectrum disorder

D’Mello, A. M., & Stoodley, C. J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00408 · Cited by 406 · see citing works

The intense world syndrome-an alternative hypothesis for autism

Markram, H. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.006.2007 · Cited by 394 · see citing works

Abnormal Fear Conditioning and Amygdala Processing in an Animal Model of Autism

Markram, H., Barkat, T. R., Mendola, D. L., Sandi, C., & Markram, H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301453 · Cited by 382 · see citing works

The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs

Bromley, R. L., Mawer, G. E., Briggs, M., Cheyne, C., Clayton-Smith, J., Garcia-Finana, M., Kneen, R., Lucas, S. B., Shallcross, R., Baker, G. A., et al. (2013) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304270 · Cited by 367 · see citing works

The teratology of autism

Arndt, T. L., Stodgell, C., & Rodier, P. M. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.11.001 · Cited by 369 · see citing works

Developmental Neuropathology of Environmental Agents

Costa, L. G., Aschner, M., Vitalone, A., Syversen, T. L. M., & Soldin, O. P. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121424 · Cited by 363 · see citing works

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

Kataoka, S., Takuma, K., Hara, Y., Maeda, Y., Ago, Y., & Matsuda, T. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001714 · Cited by 341 · see citing works

Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid

Schneider, T., Roman, A., Basta‐Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., & Przewłocki, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.011 · Cited by 335 · see citing works

Validating γ oscillations and delayed auditory responses as translational biomarkers of autism

Gandal, M. J., Edgar, J. C., Ehrlichman, R. S., Mehta, M., Roberts, T. P. L., & Siegel, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.031 · Cited by 314 · see citing works

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Rinaldi, T., Kulangara, K., Antoniello, K., & Markram, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704391104 · Cited by 290 · see citing works

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Schneider, T., Turczak, J., & Przewłocki, R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300767 · Cited by 298 · see citing works

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294 · see citing works

Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms

Tordjman, S., Somogyi, E., Coulon, N., Kermarrec, S., Cohen, D., Bronsard, G., Bonnot, O., Weismann-Arcache, C., Botbol, M., Lauth, B., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00053 · Cited by 283 · see citing works

The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats

Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., Shin, C. Y., & Ko, K. H. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.018 · Cited by 285 · see citing works

A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate

Wagner, G. C., Reuhl, K. R., Cheh, M. A., McRae, P. A., & Halladay, A. K. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0117-y · Cited by 278 · see citing works

Autism spectrum disorder and the cerebellum.

Becker, E. B. E., & Stoodley, C. J. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00001-0 · Cited by 248 · see citing works

AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

Bromley, R. L., Mawer, G., Clayton-Smith, J., & Baker, G. A. (2008) · Neurology · doi:10.1212/01.wnl.0000339399.64213.1a · Cited by 269 · see citing works

The neuroanatomy of autism – a developmental perspective

Donovan, A. P. A., & Basson, M. A. (2016) · Journal of Anatomy · doi:10.1111/joa.12542 · Cited by 269 · see citing works

Animal models of restricted repetitive behavior in autism.

Lewis, M., Tanimura, Y., Lee, L. W., & Bodfish, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.023 · Cited by 270 · see citing works

Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders

MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.28177 · Cited by 260 · see citing works

Prenatal factors associated with autism spectrum disorder (ASD)

Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.05.007 · Cited by 238 · see citing works

Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders

Heyer, D. B., & Meredith, R. M. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.10.017 · Cited by 237 · see citing works

Nicotinic receptor abnormalities in the cerebellar cortex in autism

Lee, M. (2002) · Brain · doi:10.1093/brain/awf160 · Cited by 232 · see citing works

The pathophysiology of restricted repetitive behavior

Lewis, M. H., & Kim, S. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9019-6 · Cited by 233 · see citing works

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Krug, A. K., Kolde, R., Gaspar, J. A., Rempel, E., Balmer, N. V., Meganathan, K., Vojnits, K., Baquié, M., Waldmann, T., Enseñat‐Waser, R., et al. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0967-3 · Cited by 228 · see citing works

The ups and downs of Wnt signaling in prevalent neurological disorders

Ferrari, G. V. D., & Moon, R. T. (2006) · Oncogene · doi:10.1038/sj.onc.1210064 · Cited by 221 · see citing works

The Neuropathology of Autism

Casanova, M. F. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00100.x · Cited by 216 · see citing works

Male‐specific alteration in excitatory post‐synaptic development and social interaction in pre‐natal valproic acid exposure model of autism spectrum disorder

Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Park, J. H., Kim, H. J., Jeon, S. J., dela Pena, I. C., Han, S., Cheong, J. H., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12147 · Cited by 212 · see citing works

The Neurobiology of Autism

Bauman, M. L. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3225 · Cited by 215 · see citing works

The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism

Rinaldi, T. (2008) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.004.2008 · Cited by 210 · see citing works

Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

Won, H., Mah, W., & Kim, E. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00019 · Cited by 204 · see citing works

Increased Monoamine Concentration in the Brain and Blood of Fetal Thalidomide- and Valproic Acid-Exposed Rat: Putative Animal Models for Autism

Narita, N., Kato, M., Tazoe, M., Miyazaki, K., Narita, M., & Okado, N. (2002) · Pediatric Research · doi:10.1203/00006450-200210000-00018 · Cited by 205 · see citing works

Advances in behavioral genetics: mouse models of autism

Moy, S. S., & Nadler, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002082 · Cited by 197 · see citing works

Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid

Roullet, F., Wollaston, L., deCatanzaro, D., & Foster, J. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.069 · Cited by 200 · see citing works

Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism

Miyazaki, K., Narita, N., & Narita, M. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.004 · Cited by 195 · see citing works

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Rinaldi, T., Silberberg, G., & Markram, H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm117 · Cited by 184 · see citing works

Alterations in the endocannabinoid system in the rat valproic acid model of autism

Kerr, D. M., Downey, L., Conboy, M., Finn, D. P., & Roche, M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.043 · Cited by 183 · see citing works

Improving basic and translational science by accounting for litter-to-litter variation in animal modelsPreprint

Lazic, S. E., & Essioux, L. (2016) · Cited by 182 · see citing works

Genetics of glutamate and its receptors in autism spectrum disorder

Nisar, S., Bhat, A. A., Masoodi, T., Hashem, S., Akhtar, S., Ali, T. A., Amjad, S., Chawla, S., Bagga, P., Frenneaux, M. P., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01506-w · Cited by 173 · see citing works

Molecular mechanisms of autism: a possible role for Ca2+ signaling

Krey, J. F., & Dolmetsch, R. E. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.010 · Cited by 169 · see citing works

Autism and environmental genomics

Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M. F., Kahler, S. G., Cremer, L., & Hatchwell, E. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.03.017 · Cited by 166 · see citing works

Fetal exposure to teratogens: Evidence of genes involved in autism

Dufour‐Rainfray, D., Vourc’h, P., Tourlet, S., Guilloteau, D., Chalon, S., & Andres, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.013 · Cited by 167 · see citing works

Heritable and Nonheritable Risk Factors for Autism Spectrum Disorders

Newschaffer, C. J. (2002) · Epidemiologic Reviews · doi:10.1093/epirev/mxf010 · Cited by 164 · see citing works

Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters

Bambini-Júnior, V., Rodrigues, L., Behr, G. A., Moreira, J. C. F., Riesgo, R. D. S., & Gottfried, C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.015 · Cited by 164 · see citing works

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Halsey, N. A., Hyman, S. L., & Panel, T. C. W. (2001) · PEDIATRICS · doi:10.1542/peds.107.5.e84 · Cited by 154 · see citing works

Antiepileptic drugs and brain development

Ikonomidou, C., & Turski, L. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.09.019 · Cited by 148 · see citing works

Imbalanced genomic imprinting in brain development: an evolutionary basis for the aetiology of autism

Badcock, C., & Crespi, B. J. (2006) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2006.01091.x · Cited by 148 · see citing works

Astrocytes as new targets to improve cognitive functions

Dallérac, G. M., & Rouach, N. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.003 · Cited by 143 · see citing works

Animal Models Relevant to Schizophrenia and Autism: Validity and Limitations

Tordjman, S., Drapier, D., Bonnot, O., Graignic-Philippe, R., Fortes, S., Cohen, D., Millet, B., Laurent‐Levinson, C., & Roubertoux, P. L. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9120-5 · Cited by 144 · see citing works

Behavior and serotonergic disorders in rats exposed prenatally to valproate: A model for autism

Dufour-Rainfray, D., Vourc’h, P., Le Guisquet, A.-M., Garreau, L., Ternant, D., Bodard, S., Jaumain, E., Gulhan, Z., Belzung, C., Andres, C. R., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.054 · Cited by 168 · see citing works

General developmental health in the VPA-rat model of autism

Favre, M., Barkat, T. R., Mendola, D. L., Khazen, G., Markram, H., & Markram, H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00088 · Cited by 139 · see citing works

Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research

Rogers, T. D., McKimm, E. J., Dickson, P., Goldowitz, D., Blaha, C., & Mittleman, G. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00015 · Cited by 141 · see citing works

Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism

Al-Amin, M. M., Rahman, M., Khan, F. R., Zaman, F., & Reza, H. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.041 · Cited by 132 · see citing works

Neuroteratogens in man: An overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy

Ornoy, A. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.03.014 · Cited by 130 · see citing works

Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD)

Ornoy, A., Weinstein‐Fudim, L., & Ergaz, Z. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00316 · Cited by 130 · see citing works

Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder

Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works

Antiepileptic drugs and the developing brain

Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. V. D., Turski, L., & Ikonomidou, C. (2006) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-005-5348-0 · Cited by 121 · see citing works

Molecular genetics and animal models in autistic disorder

Andres, C. R. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00642-6 · Cited by 121 · see citing works

Genetic and non-genetic animal models for autism spectrum disorders (ASD)

Ergaz, Z., Weinstein‐Fudim, L., & Ornoy, A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.04.024 · Cited by 116 · see citing works

Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder

Bringas, M. E., Carvajal-Flores, F. N., López-Ramírez, T. A., Atzori, M., & Flores, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.030 · Cited by 114 · see citing works

Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach?

Macfarlane, A., & Greenhalgh, T. (2018) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-018-1842-x · Cited by 121 · see citing works

Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders

Thomas, R., Foley, K. A., Mepham, J. R., Tichenoff, L. J., Possmayer, F., & MacFabe, D. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06614.x · Cited by 117 · see citing works

Autism: An Emerging Public Health Problem

Newschaffer, C. J., & Curran, L. K. (2003) · Public Health Reports · doi:10.1093/phr/118.5.393 · Cited by 116 · see citing works

Differential Local Connectivity and Neuroinflammation Profiles in the Medial Prefrontal Cortex and Hippocampus in the Valproic Acid Rat Model of Autism

Codagnone, M. G., Podestá, M. F., Uccelli, N. A., & Reinés, A. (2015) · Developmental Neuroscience · doi:10.1159/000375489 · Cited by 115 · see citing works

The Neurobiological Context of Autism

Keller, F., & Persico, A. M. (2003) · Molecular Neurobiology · doi:10.1385/mn:28:1:1 · Cited by 114 · see citing works

A Developmental Study of Abnormal Behaviors and Altered GABAergic Signaling in the VPA-Treated Rat Model of Autism

Hou, Q.-L., Wang, Y., Li, Y., Chen, D., Yang, F., & Wang, S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00182 · Cited by 113 · see citing works

A Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat Brain

MacFabe, D. F., Rodríguez-Capote, K., Hoffman, J. E., Franklin, A. E., Mohammad-A, Y., Taylor, A. R., Boon, F. H., Cain, D. P., Kavaliers, M., Possmayer, F., et al. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.146.166 · Cited by 114 · see citing works

The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders

Mosconi, M. W., Wang, Z., Schmitt, L. M., Tsai, P., & Sweeney, J. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00296 · Cited by 112 · see citing works

Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

Moldrich, R. X., Leanage, G., She, D. T., Dolan‐Evans, E., Nelson, M., Reza, N., & Reutens, D. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.049 · Cited by 111 · see citing works

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

Nicolini, C., Ahn, Y., Michalski, B., Rho, J. M., & Fahnestock, M. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0184-4 · Cited by 109 · see citing works

Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice

Kolozsi, E., Mackenzie, R. N., Roullet, F. I., Decatanzaro, D., & Foster, J. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.021 · Cited by 110 · see citing works

Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway.

Go, H. S., Kim, K. C., Choi, C. S., Jeon, S., Kwon, K., Han, S.-H., Lee, J., Cheong, J., Ryu, J., Kim, C.-H., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.028 · Cited by 110 · see citing works

VPA-induced apoptosis and behavioral deficits in neonatal mice

Yochum, C. L., Dowling, P. C., Reuhl, K. R., Wagner, G. C., & Ming, X. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.055 · Cited by 108 · see citing works

Bacopa monniera (L.) Wettst Ameliorates Behavioral Alterations and Oxidative Markers in Sodium Valproate Induced Autism in Rats

Sandhya, T., Sowjanya, J., & Veeresh, B. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0717-1 · Cited by 103 · see citing works

Macrocephaly and the control of brain growth in autistic disorders

McCaffery, P. J. A., & Deutsch, C. K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.10.005 · Cited by 99 · see citing works

Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism

Conciatori, M., Stodgell, C., Hyman, S. L., O’Bara, M. A., Militerni, R., Bravaccio, C., Trillo, S., Montecchi, F., Schneider, C., Melmed, R. D., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.005 · Cited by 101 · see citing works

Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism

Schneider, T., Ziółkowska, B., Gieryk, A., Tyminska, A., & Przewłocki, R. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0795-y · Cited by 93 · see citing works

Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat

Narita, M., Oyabu, A., Imura, Y., Kamada, N., Yokoyama, T., Tano, K., Uchida, A., & Narita, N. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.09.001 · Cited by 91 · see citing works

The Ketogenic Diet Modifies Social and Metabolic Alterations Identified in the Prenatal Valproic Acid Model of Autism Spectrum Disorder

Ahn, Y., Narous, M., Tobias, R., Rho, J. M., & Mychasiuk, R. (2014) · Developmental Neuroscience · doi:10.1159/000362645 · Cited by 89 · see citing works

Observation of fetal brain in a rat valproate‐induced autism model: a developmental neurotoxicity study

Kuwagata, M., Ogawa, T., Shioda, S., & Nagata, T. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.01.006 · Cited by 86 · see citing works

Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors

Kang, J., & Kim, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00017 · Cited by 81 · see citing works

Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder

Foley, A., Gannon, S. P., Rombach, N., Prendergast, A., Barry, C. E., Cassidy, A. W., & Regan, C. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.042 · Cited by 84 · see citing works

Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia

Main, S. L., & Kulesza, R. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.052 · Cited by 80 · see citing works

Changes of cerebellar cortex in a valproic acid‐induced rat model of autism

Alpay, M., & Yücel, F. (2022) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10213 · Cited by 3 · see citing works

The cerebellum in Austim

Perez‐Pouchoulen, M., Miquel, M., Saft, P., Brug, B., Toledo‐Cárdenas, M. R., Hernández‐Aguilar, M. E., & Manzo, J. G. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

The cerebellum in autism

Pouchoulen, M. P., Salgado-Araujo, M. M., Saft, P., Brug, B., Toledo, R. T., Hernández‐Aguilar, M. E., & Manzo, J. G. (2012) · eNeurobiología · Cited by 3 · see citing works

The Effects of Prenatal Exposure of Valproic Acid on Cranial Nerve Nuclei: A Rat Model for an Autistic Phenotype

Pickup, S. (2009) · Syracuse University Libraries (Syracuse University)