Cited by 122Pharmacological Effects and Toxicity StudiesEpilepsy research and treatmentAnesthesia and Neurotoxicity Research

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Antiepileptic drugs and the developing brain

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Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. v.d., Turski, L., Ikonomidou, C.·2006·Cellular and Molecular Life Sciences CMLS

DOI 10.1007/s00018-005-5348-0PMC PMC11136147

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Abstract

Epilepsy is the most common neurological disorder in young humans. Antiepileptic drugs (AEDs) which are used to treat seizures in infants, children and pregnant women can cause cognitive impairment, microcephaly and birth defects. Ion channels, neurotransmitters and second messenger systems constitute molecular targets of AEDs. The same targets regulate brain processes essential both for propagation of seizures and for learning, memory and emotional behavior. Thus, AEDs can influence brain function and brain development in undesired ways. Here we review mechanisms of action of AEDs, examine clinical evidence for their adverse effects in the developing human brain, and present studies on cognitive and behavioral effects in animal models. Furthermore, we discuss mechanisms responsible for adverse effects of AEDs in the developing mammalian brain, including interference with cell proliferation and migration, axonal arborization, synaptogenesis, synaptic plasticity and physiological apoptotic cell death.

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Authors: Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. V. D., Turski, L., & Ikonomidou, C.
Affiliations: Stiftung Charité (DE)
Technische Universität Dresden (DE)
Solvay (Netherlands) (NL)
Corresponding author: Ikonomidou, C.
ORCID: Kaindl, A. M.
Hagen, M. v.d.
Ikonomidou, C.
Venue: Cellular and Molecular Life Sciences CMLS
Publisher: Springer Science and Business Media LLC
Published: 2006-01-02
Volume: 63
Issue: 4
Pages: 399-413
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-005-5348-0
PMC: PMC11136147
OpenAlex: W1963567657
Cited by: 121
References: 179
Citations by year: 2026: 4 · 2025: 6 · 2024: 5 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 12 · 2014: 5 · 2013: 6 · 2012: 7
FWCI: 8.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords: antiepileptic drugs, adverse drug reactions, developing brain, epilepsy, cognitive impairment, microcephaly, congenital malformations, ion channels, neurotransmitters, second messenger signaling, seizure propagation, learning and memory, behavioral effects, cell proliferation, neuronal migration, axonal arborization, synaptogenesis, synaptic plasticity, apoptosis, prenatal drug exposure
MeSH terms: Animals, Anticonvulsants, Brain, Epilepsy, Humans, Neurons, Apoptosis

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Antiepileptic drugs and the developing brain

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