Cited by 344Alzheimer's disease research and treatmentsRedox biology and oxidative stressDementia and Cognitive Impairment Research

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Causes of oxidative stress in Alzheimer disease

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Zhu, X., Su, B., Wang, X., Smith, M. A., Perry, G.·2007·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-007-7218-4PMC PMC11136009

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Abstract

Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

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Authors: Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G.
Affiliations: Case Western Reserve University (US)
The University of Texas at San Antonio (US)
Corresponding author: Perry, G.
ORCID: Zhu, X.
Su, B.
Wang, X.
Smith, M. A.
Perry, G.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2007-07-02
Volume: 64
Issue: 17
Pages: 2202-2210
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-007-7218-4
PMC: PMC11136009
OpenAlex: W2064625375
Cited by: 336
References: 117
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 17 · 2019: 12 · 2018: 16 · 2017: 16 · 2016: 10 · 2015: 26 · 2014: 28 · 2013: 11 · 2012: 38
FWCI: 20.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: oxidative stress, Alzheimer's disease, reactive oxygen species, mitochondrial dysfunction, neurodegeneration, neuronal injury, pathogenesis
MeSH terms: Alzheimer Disease, Astrocytes, Copper, Glycosylation, Humans, Iron, Mitochondria, Oxidation-Reduction, Glycation End Products, Advanced, Reactive Oxygen Species, Microglia, Oxidative Stress

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