Long-Term Enhancement of Neuronal Excitability and Temporal Fidelity Mediated by Metabotropic Glutamate Receptor Subtype 5
Open accessAbstract
The cellular substrate for memory is generally attributed to long-lasting changes in synaptic strength. We report here that synaptic or pharmacological activation of the metabotropic glutamate receptor subtype 5 (mGluR5) induces long-term potentiation of intrinsic excitability (LTP-IE) in layer V pyramidal neurons. mGluR5-dependent LTP-IE was associated with a persistent reduction of the afterhyperpolarization (AHP) outward current (IAHP), resulting in the potentiation of EPSP-spike coupling. Apamin occluded induction of LTP-IE, indicating that downregulation of small conductance calcium-dependent potassium (SK) channels mediates this process. In addition to the improved reliability of the input-output function, LTP-IE led to increased temporal precision. The induced reduction of IAHP accelerated the rate of membrane depolarization preceding each action potential and subsequently decreased the jitter of the neuronal discharge. We conclude that mGluR5-dependent LTP-IE not only promotes the spread of excitation in the cortical network but also persistently enhances the temporal fidelity of the neuronal message.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Persistent mGluR5 activation has been shown to increase the excitability of pyramidal cells.
“While persistent mGluR5 activation has been shown to increase the excitability of pyramidal cells 106 ,”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · cited 2× · see citing works
“…activity-dependent, long-lasting bi-directional changes in synaptic strength, referred to as long-term potentiation (LTP) and long-term depression (LTD), two processes that may underlie certain forms of memory (Bliss and Collingridge, 1993; Sourdet and Debanne, 1999; Abbott and Nelson, 2000).”
Gasparini, F., Lingenhöhl, K., Stoehr, N., Flor, P. J., Heinrich, M., Vranesic, I., Biollaz, M., Allgeier, H., Heckendorn, R., Urwyler, S., et al. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00082-9 · Cited by 725 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Abeles M (1991) Corticonics: neural circuits of the cerebral cortex. Cam- bridge, UK: Cambridge UP.
Cited by
Sorted by citations
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works
Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Plasticity of intrinsic neuronal excitability
Debanne, D., Inglebert, Y., & Russier, M. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.09.001 · Cited by 272 · see citing works
Self-citationPedarzani, P., & Stocker, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8216-x · Cited by 173 · see citing works
Lamsa, K., Heeroma, J. H., & Kullmann, D. M. (2005) · Nature Neuroscience · doi:10.1038/nn1486 · Cited by 158 · see citing works
Campanac, E., Gasselin, C., Baude, A., Rama, S., Ankri, N., & Debanne, D. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.020 · Cited by 150 · see citing works
Self-citationCudmore, R. H., Fronzaroli-Molinieres, L., Giraud, P., & Debanne, D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0740-10.2010 · Cited by 106 · see citing works
Self-citationCarvalho, T. P., & Buonomano, D. V. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.013 · Cited by 100 · see citing works
The contribution of ion channels in input-output plasticity
Debanne, D., & Russier, M. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107095 · Cited by 38 · see citing works
Self-citationImpairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats
Clausen, B., Schachtman, T. R., Mark, L. T., Reinholdt, M., & Christoffersen, G. R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.069 · Cited by 41 · see citing works
Neural ensembles: role of intrinsic excitability and its plasticity
Hansel, C., & Yuste, R. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1440588 · Cited by 33 · see citing works
Regional and temporal specificity of intrinsic plasticity mechanisms in rodent primary visual cortex
Nataraj, K., & Turrigiano, G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4455-11.2011 · Cited by 23 · see citing works
Soldado-Magraner, S., Brandalise, F., Honnuraiah, S., Pfeiffer, M., Moulinier, M., Gerber, U., & Douglas, R. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00506.2019 · Cited by 25 · see citing works
- Authors
- Sourdet, V., Russier, M., Daoudal, G., Ankri, N., & Debanne, D.
- Affiliations
- Inserm (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-11-12
- Volume
- 23
- Issue
- 32
- Pages
- 10238-10248
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741009
- OpenAlex
- W1955958386
- Cited by
- 171
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion, other-oa)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- metabotropic glutamate receptor 5, mGluR5, layer 5 pyramidal neurons, afterhyperpolarization, small conductance calcium-activated potassium channels, apamin, temporal precision, neuronal jitter, input-output function, synaptic plasticity, memory
- MeSH terms
- Action Potentials, Animals, Neurons, Reaction Time, Synapses, Reproducibility of Results, Long-Term Potentiation, Receptors, Metabotropic Glutamate, Patch-Clamp Techniques, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Neocortex, Excitatory Postsynaptic Potentials, Rats, Receptor, Metabotropic Glutamate 5, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
