Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Adams, K E; Medhurst, A L; Dart, D A; Lakin, N D

doi:10.1038/sj.onc.1209426

Cited by 164DNA Repair MechanismsEffects of Radiation ExposureProtein Kinase Regulation and GTPase Signaling

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Open access

Adams, K E, Medhurst, A L, Dart, D A, Lakin, N D·2006·Oncogene

DOI 10.1038/sj.onc.1209426PMC PMC1852851

Open this paper in CoChat — free account

Abstract

ATM and ATR are two related kinases essential for signalling DNA damage. Although ATM is thought to be the principle kinase responsible for signalling ionising radiation (IR)-induced DNA damage, ATR also contributes to signalling this form of genotoxic stress. However, the molecular basis of differential ATM and ATR activation in response to IR remains unclear. Here, we report that ATR is recruited to sites of IR-induced DNA damage significantly later than activation of ATM. We show that ATR is recruited to IR-induced nuclear foci in G(1) and S phase of the cell cycle, supporting a role for ATR in detecting DNA damage outside of S phase. In addition, we report that recruitment of ATR to sites of IR-induced DNA damage is concomitant with appearance of large tracts of single-stranded DNA (ssDNA) and that this event is dependent on ATM and components of the Mre11/Rad50/Nbs1 (MRN) protein complex.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1209426

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ATR can also be recruited to DSBs, and this binding depends on ATM.
“The situation is somewhat complicated by the finding that ATR can be also recruited to DSBs and this binding depends upon ATM [41,42].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [42]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works
Chk1 and Chk2 kinases in checkpoint control and cancer
Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513 · see citing works
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works
The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response
Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220 · see citing works
Requirement of the MRN complex for ATM activation by DNA damage
Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064 · see citing works
The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder
Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works
A role for ATR in the DNA damage-induced phosphorylation of p53
Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,010 · see citing works
<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works
Choreography of the DNA Damage Response
Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874 · see citing works
A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786 · see citing works
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667 · see citing works
MCM Proteins in DNA Replication
Tye, B. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.649 · Cited by 666 · see citing works
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
Santocanale, C., & Diffley, J. F. X. (1998) · Nature · doi:10.1038/27001 · Cited by 663 · see citing works
Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.
Celis, J. E., & Celis, A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3262 · Cited by 636 · see citing works
Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints
Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
Brown, E. J., & Baltimore, D. (2003) · Genes & Development · doi:10.1101/gad.1067403 · Cited by 511 · see citing works
The Mre11 complex is required for ATM activation and the G2/M checkpoint
Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502 · see citing works
ATM-dependent phosphorylation of nibrin in response to radiation exposure
Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468 · see citing works
A unified view of the DNA-damage checkpoint
Melo, J. A., & Toczyski, D. P. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00312-5 · Cited by 457 · see citing works
The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance
Moreau, S., Ferguson, J. R., & Symington, L. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.556 · Cited by 445 · see citing works
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 437 · see citing works
DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex
Mirzoeva, O. K., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.281-288.2001 · Cited by 387 · see citing works
An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication
Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K. A., Gottesman, M. E., & Gautier, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00799-2 · Cited by 355 · see citing works
Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage
Raderschall, E., Golub, E. I., & Haaf, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1921 · Cited by 350 · see citing works
ATM: from gene to function
Rotman, G. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.10.1555 · Cited by 322 · see citing works
ATR inhibition selectively sensitizes G <sub>1</sub> checkpoint-deficient cells to lethal premature chromatin condensation
Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works
Mutations in XRS2 and RAD50 Delay but Do Not Prevent Mating-Type Switching in Saccharomyces cerevisiae
Ivanov, E. L., Sugawara, N., White, C. I., Fabre, F., & Haber, J. E. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.5.3414-3425.1994 · Cited by 240 · see citing works
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1270 · Cited by 227 · see citing works
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
Wright, J. A., Keegan, K. S., Herendeen, D. R., Bentley, N. J., Carr, A. M., Hoekstra, M. F., & Concannon, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7445 · Cited by 226 · see citing works
A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis
Tsubouchi, H., & Ogawa, H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.260 · Cited by 223 · see citing works
The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells
Brumbaugh, K. M., Otterness, D. M., Geisen, C., Oliveira, V. A., Brognard, J., Li, X., Lejeune, F., Tibbetts, R. S., Maquat, L. E., & Abraham, R. T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.005 · Cited by 222 · see citing works
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410873200 · Cited by 216 · see citing works
Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest
Davies, S. L., North, P. S., Dart, D. A., Lakin, N. D., & Hickson, I. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1279-1291.2004 · Cited by 208 · see citing works
Self-citation
UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress
Ward, I. M., Minn, K. T., & Chen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300554200 · Cited by 205 · see citing works
Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17
Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
Hekmat-Nejad, M., You, Z., Yee, M., Newport, J. W., & Cimprich, K. A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00855-1 · Cited by 193 · see citing works
Nbs1 is required for ATR‐dependent phosphorylation events
Stiff, T., Reis, C., Alderton, G. K., Woodbine, L. J., O’Driscoll, M., & Jeggo, P. A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600504 · Cited by 169 · see citing works
A requirement for replication in activation of the ATR-dependent DNA damage checkpointPreprint
Lupardus, P. J., Byun, T. S., Yee, M., Hekmat-Nejad, M., & Cimprich, K. A. (2002) · Genes & Development · doi:10.1101/gad.1013502 · Cited by 163 · see citing works
Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans
García‐Muse, T., & Boulton, S. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600896 · Cited by 161 · see citing works
The Mre11 Nuclease Is Not Required for 5′ to 3′ Resection at Multiple HO-Induced Double-Strand Breaks
Llorente, B., & Symington, L. S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9682-9694.2004 · Cited by 160 · see citing works
Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase
Dart, D. A., Adams, K. E., Akerman, I., & Lakin, N. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314212200 · Cited by 124 · see citing works
Self-citation
The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage
Dong, Z., Zhong, Q., & Chen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19513 · Cited by 118 · see citing works
The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint
You, Z., Kong, L., & Newport, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204120200 · Cited by 114 · see citing works
Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113 · see citing works
ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint
Nghiem, P., Park, P. K., Kim, Y.-S., Desai, B. N., & Schreiber, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106113200 · Cited by 98 · see citing works
DNA Replication Defects, Spontaneous DNA Damage, and ATM-dependent Checkpoint Activation in Replication Protein A-deficient Cells
Dodson, G. E., Shi, Y., & Tibbetts, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400242200 · Cited by 96 · see citing works
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks
Lavin, M. F. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.07.001 · Cited by 78 · see citing works
Rad50 depletion impacts upon ATR-dependent DNA damage responses
Zhong, H., Bryson, A., Eckersdorff, M., & Ferguson, D. O. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi302 · Cited by 60 · see citing works
Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism
Yuan, S. F., Chang, H.-L., Hou, M., Chan, T., Kao, Y. H., Wu, Y., & Su, J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00220-2 · Cited by 29 · see citing works
Protective packaging for DNA
Downs, J. A., & Jackson, S. P. (2003) · Nature · doi:10.1038/424732a · Cited by 20 · see citing works

Flagged first, then by citations

1 of the 62 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

D'Amours D Jackson SP Nat Rev Mol Cell Biol 2002 3 317 327 11988766
Garcia-Muse T Boulton SJ Embo J 2005 24 4345 4355 16319925 PMC1356337
O'Driscoll M Ruiz-Perez VL Woods CG Jeggo PA Goodship JA Nat Genet 2003 33 497 501 12640452

Sorted by citations

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Blackford, A. N., & Jackson, S. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.015 · Cited by 1,953 · see citing works
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works
DNA Damage Sensing by the ATM and ATR Kinases
Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works
Human CtIP promotes DNA end resection
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works
The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer
Smith, J., Tho, L. M., Xu, N., & Gillespie, D. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00003-0 · Cited by 1,279 · see citing works
DNA damage checkpoints: from initiation to recovery or adaptation
Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784 · see citing works
The ATM-mediated DNA-damage response: taking shape
Shiloh, Y. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.05.004 · Cited by 539 · see citing works
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
Shen, J., Peng, Y., Wei, L., Zhang, W., Yang, L., Lan, L., Kapoor, P., Ju, Z., Mo, Q., Shih, I.-M., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0849 · Cited by 522 · see citing works
Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
Batchelor, E., Mock, C. S., Bhan, I., Loewer, A., & Lahav, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.016 · Cited by 422 · see citing works
DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B
Palii, S. S., Emburgh, B. O. V., Sankpal, U. T., Brown, K. D., & Robertson, K. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01799-07 · Cited by 382 · see citing works
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works
DNA Repair in Mammalian Cells
Pardo, B., Gómez‐González, B., & Aguilera, A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8740-3 · Cited by 323 · see citing works
ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
Lavin, M. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210880 · Cited by 301 · see citing works
Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy
Hammad, M., Raftari, M., Cesário, R., Salma, R., Godoy, P. R. D. V., Emami, S. N., & Haghdoost, S. (2023) · Antioxidants · doi:10.3390/antiox12071371 · Cited by 245 · see citing works
CtIP Links DNA Double-Strand Break Sensing to Resection
You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y.-W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., & Hunter, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.002 · Cited by 231 · see citing works
DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells
Sturzenegger, A., Burdová, K., Kanagaraj, R., Levikova, M., Pinto, C., Ćejka, P., & Janščák, P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578823 · Cited by 216 · see citing works
Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review
Arjunan, K. P., Sharma, V. K., & Ptasińska, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022971 · Cited by 196 · see citing works
DNA damage response at functional and dysfunctional telomeresPreprint
Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 180 · see citing works
Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit
Leung‐Pineda, V., Ryan, C. E., & Piwnica-Worms, H. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00447-06 · Cited by 178 · see citing works
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
You, Z., & Bailis, J. M. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.04.002 · Cited by 176 · see citing works
MRE11 UFMylation promotes ATM activation
Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz110 · Cited by 167 · see citing works
Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation
Niida, H., Katsuno, Y., Banerjee, B., Hande, M. P., & Nakanishi, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01611-06 · Cited by 166 · see citing works
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
Xu, X., Vaithiyalingam, S., Glick, G. G., Mordes, D. A., Chazin, W., & Cortez, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01079-08 · Cited by 166 · see citing works
Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand
Mei, L., Zhang, J., He, K., & Zhang, J. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0733-6 · Cited by 157 · see citing works
Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer‐predisposing gene
Bártková, J., Tommiska, J., Oplustilova, L., Aaltonen, K., Tamminen, A., Heikkinen, T., Mistrík, M., Aittomäki, K., BLOMQVIST, C. P., Heikkilä, P., et al. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.09.007 · Cited by 156 · see citing works
The role of the DNA damage response in neuronal development, organization and maintenance
Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 135 · see citing works
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
Biton, S., Barzilai, A., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.006 · Cited by 133 · see citing works
Eukaryotic DNA damage checkpoint activation in response to double-strand breaks
Finn, K., Lowndes, N. F., & Grenon, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0875-3 · Cited by 127 · see citing works
Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells
Tomimatsu, N., Mukherjee, B., & Burma, S. (2009) · EMBO Reports · doi:10.1038/embor.2009.60 · Cited by 127 · see citing works
ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells
Burdak‐Rothkamm, S., Rothkamm, K., & Prise, K. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0545 · Cited by 124 · see citing works
Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status
Mirzayans, R., Andrais, B., Scott, A., Wang, Y., & Murray, D. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122409 · Cited by 119 · see citing works
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery
Ha, K., Lee, G. E., Palii, S. S., Brown, K. D., Takeda, Y., Liu, K., Bhalla, K. N., & Robertson, K. D. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq451 · Cited by 119 · see citing works
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks
Mantiero, D., Clerici, M., Lucchini, G., & Longhese, M. P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400911 · Cited by 118 · see citing works
Review of Chromium (VI) Apoptosis, Cell-Cycle-Arrest, and Carcinogenesis
Chiu, A. O. S., Shi, X., LEE, W. K. P., Hill, R., Wakeman, T. P., Katz, A. J., Xu, B., Dalal, N. S., Robertson, J. D., Chen, C., et al. (2010) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2010.504980 · Cited by 117 · see citing works
The Intra-S Checkpoint Responses to DNA Damage
Iyer, D., & Rhind, N. (2017) · Genes · doi:10.3390/genes8020074 · Cited by 113 · see citing works
Distinct Roles of the ATR Kinase and the Mre11-Rad50-Nbs1 Complex in the Maintenance of Chromosomal Stability in Arabidopsis
Amiard, S., Charbonnel, C., Allain, E., Depeiges, A., White, C. I., & Gallego, M. E. (2010) · The Plant Cell · doi:10.1105/tpc.110.078527 · Cited by 109 · see citing works
Loss of ATM kinase activity leads to embryonic lethality in mice
Daniel, J. A., Pellegrini, M., Lee, B.-S., Guo, Z., Filsuf, D., Belkina, N. V., You, Z., Paull, T. T., Sleckman, B. P., Feigenbaum, L., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201204035 · Cited by 107 · see citing works
Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
Takemura, H., Rao, V. A., Sordet, O., Furuta, T., Miao, Z., Meng, L., Zhang, H., & Pommier, Y. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603747200 · Cited by 107 · see citing works
Targeting DNA repair in cancer: current state and novel approaches
Klinakis, A., Karagiannis, D., & Rampias, T. N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03299-8 · Cited by 105 · see citing works
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair
Korsholm, L. M., Gál, Z., Lin, L., Quevedo, O., Ahmad, D. A., Dulina, E., Luo, Y., Bártek, J., & Larsen, D. H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz518 · Cited by 102 · see citing works
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest
Sun, X., Wang, Y., Ji, K., Liu, Y., Kong, Y., Nie, S., Li, N., Hao, J., Xie, Y., Xu, C., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa631 · Cited by 102 · see citing works
ATM-Mediated Transcriptional and Developmental Responses to γ-rays in Arabidopsis
Ricaud, L., Proux, C., Renou, J., Pichon, O., Fochesato, S., Ortet, P., & Montané, M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000430 · Cited by 102 · see citing works
Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM -Defective Tumors
Riabinska, A., Daheim, M., Herter-Sprie, G. S., Winkler, J., Fritz, C., Hallek, M. J., Thomas, R. K., Kreuzer, K., Frenzel, L. P., Monfared, P., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005814 · Cited by 99 · see citing works
Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks
Gobbini, E., Cesena, D., Galbiati, A., Lockhart, A., & Longhese, M. P. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.07.009 · Cited by 98 · see citing works
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Mooser, C., Symeonidou, I.-E., Leimbacher, P.-A., Ribeiro, A., Shorrocks, A.-M. K., Jungmichel, S., Buch-Larsen, S. C., Knechtle, K., Jasrotia, A., Zurbriggen, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13981-x · Cited by 95 · see citing works
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker‐Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bártek, J., Lukas, J., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.15 · Cited by 93 · see citing works
Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro
Koppensteiner, R., Samartzis, E. P., Noske, A., von Teichman, A., Dedes, I., Gwerder, M., Imesch, P., Ikenberg, K., Moch, H., Fink, D. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100041 · Cited by 90 · see citing works
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
Kulkarni, A., & Wilson, D. M. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.009 · Cited by 87 · see citing works
Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
Walker, M., Black, E. J., Oehler, V., Gillespie, D. A., & Scott, M. T. (2009) · Oncogene · doi:10.1038/onc.2009.102 · Cited by 86 · see citing works
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation
Badie, S., Liao, C., Thanasoula, M., Barber, P. R., Hill, M. A., & Tarsounas, M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811079 · Cited by 86 · see citing works
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death
Saini, S., & Gurung, P. (2024) · Immunological Reviews · doi:10.1111/imr.13409 · Cited by 76 · see citing works
Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability
Broderick, S., Rehmet, K., Concannon, C., & Nasheuer, H. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_8 · Cited by 76 · see citing works
Regulation of the DNA Damage Response by Cyclin-Dependent Kinases
Trovesi, C., Manfrini, N., Falcettoni, M., & Longhese, M. P. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.04.013 · Cited by 74 · see citing works
Gene regulation in response to DNA damage
Mannuß, A., Trapp, O., & Puchta, H. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.08.003 · Cited by 70 · see citing works
The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma
Lowery, C. D., VanWye, A. B., Dowless, M. S., Blosser, W. D., Falcón, B. L., Stewart, J. A., Stephens, J. R., Beckmann, R. P., Bence, A. K., & Stancato, L. F. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2876 · Cited by 69 · see citing works
E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair
So, C. C., Ramachandran, S., & Martín, A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00488-18 · Cited by 68 · see citing works
Mec1/ATR regulates the generation of single‐stranded DNA that attenuates Tel1/ATM signaling at DNA ends
Clerici, M., Trovesi, C., Galbiati, A., Lucchini, G., & Longhese, M. P. (2013) · The EMBO Journal · doi:10.1002/embj.201386041 · Cited by 67 · see citing works
Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase
Mladenov, E., Fan, X., Dueva, R., Soni, A., & Iliakis, G. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-44771-6 · Cited by 67 · see citing works
RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy
Liu, W., Zheng, M., Zhang, R., Jiang, Q., Du, G., Wu, Y., Yang, C., Li, F., Li, W., Wang, L., et al. (2022) · Advanced Science · doi:10.1002/advs.202203884 · Cited by 64 · see citing works
The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast
Dubrana, K., van Attikum, H., Hediger, F., & Gasser, S. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.018366 · Cited by 64 · see citing works
Polo-like kinase-1 in DNA damage response
Hyun, S., Hwan, H.-I., & Jang, Y. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.5.061 · Cited by 63 · see citing works
The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition
Thompson, R. H., Montano, R. E., & Eastman, A. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044021 · Cited by 61 · see citing works
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
Bigot, N., Day, M., Baldock, R. A., Watts, F. Z., Oliver, A. W., & Pearl, L. H. (2019) · eLife · doi:10.7554/elife.44353 · Cited by 59 · see citing works
Host DNA Damage Response Factors Localize to Merkel Cell Polyomavirus DNA Replication Sites To Support Efficient Viral DNA Replication
Tsang, S. H., Wang, X., Li, J., Buck, C. B., & You, J. (2014) · Journal of Virology · doi:10.1128/jvi.03656-13 · Cited by 58 · see citing works
Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation
Hurley, P. J., Wilsker, D. F., & Bunz, F. (2006) · Oncogene · doi:10.1038/sj.onc.1210049 · Cited by 57 · see citing works
ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression
Fallone, F., Britton, S., Nieto, L., Salles, B., & Muller, C. (2012) · Oncogene · doi:10.1038/onc.2012.462 · Cited by 56 · see citing works
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A. K., Banerjee, B., Hande, M. P., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.218 · Cited by 56 · see citing works
The DNA-damage response: new molecular insights and new approaches to cancer therapy
Jackson, S. P. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370483 · Cited by 56 · see citing works
Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss
Sankunny, M., Parikh, R. A., Lewis, D. W., Gooding, W. E., Saunders, W. S., & Gollin, S. M. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22125 · Cited by 53 · see citing works
Mouse models of DNA double-strand break repair and neurological disease
Frappart, P., & McKinnon, P. J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.007 · Cited by 52 · see citing works
Decision Making by p53: Life versus Death.
Jiang, L., Sheikh, M. S., & Huang, Y. K. (2010) · PubMed · Cited by 50 · see citing works
"ATR activation in response to ionizing radiation: still ATM territory"
Cuadrado, M., Martínez-Pastor, B., & Fernández-Capetillo, Ó. (2006) · Cell Division · doi:10.1186/1747-1028-1-7 · Cited by 50 · see citing works
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase
Köcher, S., Rieckmann, T., Rohaly, G., Mansour, W. Y., Dikomey, E., Dornreiter, I., & Dahm‐Daphi, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks604 · Cited by 47 · see citing works
Mechanisms of ATR-mediated checkpoint signalling
Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 45 · see citing works
MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
Kamisugi, Y., Schaefer, D. G., Kozák, J., Charlot, F., Vrielynck, N., Holá, M., Angelis, K. J., Cuming, A. C., & Nogué, F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1272 · Cited by 45 · see citing works
Src Family Kinases Promote Silencing of ATR-Chk1 Signaling in Termination of DNA Damage Checkpoint
Fukumoto, Y., Morii, M., Miura, T., Kubota, S., Ishibashi, K., Honda, T., Okamoto, A., Yamaguchi, N., Iwama, A., Nakayama, Y., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.533752 · Cited by 44 · see citing works
Mind the gap: keeping UV lesions in check
Novarina, D., Amara, F., Lazzaro, F., Plevani, P., & Muzi-Falconi, M. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.04.030 · Cited by 43 · see citing works
Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death
Chen, L.-H., Chu, P., Lee, Y., Tu, P., Chi, C., Lee, H., & Chiou, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13011209 · Cited by 42 · see citing works
Ku70/80 Modulates ATM and ATR Signaling Pathways in Response to DNA Double Strand Breaks
Tomimatsu, N., Tahimic, C. G. T., Otsuki, A., Burma, S., Fukuhara, A., Sato, K., Shiota, G., Oshimura, M., Chen, D. J., & Kurimasa, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611880200 · Cited by 40 · see citing works
ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage
Medhurst, A. L., Warmerdam, D. O., Akerman, İ., Verwayen, E. H., Kanaar, R., Smits, V. A. J., & Lakin, N. D. (2008) · Journal of Cell Science · doi:10.1242/jcs.033688 · Cited by 37 · see citing works
Self-citation
RAD18 lives a double life: Its implication in DNA double-strand break repair
Liu, T., Jun, H., & Junjie, C. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.016 · Cited by 37 · see citing works
C. elegans: A model of Fanconi anemia and ICL repair
Youds, J. L., Barber, L. J., & Boulton, S. J. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.11.007 · Cited by 37 · see citing works
DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Arlander, S. J. H., Greene, B. T., Innes, C. L., & Paules, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-0675 · Cited by 36 · see citing works
Coupling end resection with the checkpoint response at DNA double-strand breaks
Villa, M., Cassani, C., Gobbini, E., Bonetti, D., & Longhese, M. P. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2262-6 · Cited by 34 · see citing works
DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells
Mladenov, E., Fan, X., Paul‐Konietzko, K., Soni, A., & Iliakis, G. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-51071-6 · Cited by 34 · see citing works
Targeting ATM-deficient CLL through interference with DNA repair pathways
Knittel, G., Liedgens, P., & Reinhardt, H. C. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00207 · Cited by 33 · see citing works
Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients
Chiker, S., Pennaneach, V., Loew, D., Dingli, F., Biard, D. S. F., Cordelières, F. P., Gemble, S., Vacher, S., Bièche, I., Hall, J. A., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1078020 · Cited by 32 · see citing works
Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress
Umar, S. A., & Tasduq, S. A. (2020) · RSC Advances · doi:10.1039/d0ra05819j · Cited by 31 · see citing works
Dominant TEL1-hy Mutations Compensate for Mec1 Lack of Functions in the DNA Damage Response
Baldo, V., Testoni, V., Lucchini, G., & Longhese, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01214-07 · Cited by 30 · see citing works
Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells
Beishline, K., & Azizkhan‐Clifford, J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_3 · Cited by 29 · see citing works
And-1 is required for homologous recombination repair by regulating DNA end resection
Li, Y., Li, Z., Wu, R., Han, Z., & Zhu, W. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1241 · Cited by 29 · see citing works
Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum
Dar, I., Yosha, G., Elfassy, R., Galron, R., Wang, Z., Shiloh, Y., & Barzilai, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204172 · Cited by 26 · see citing works
N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells
Bodakuntla, S., Anandi, L., V, Sural, S., Trivedi, P., & Lahiri, M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-287 · Cited by 25 · see citing works
DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets
Lozinski, M., Bowden, N. A., Graves, M. C., Fay, M. F., & Tooney, P. A. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00613-0 · Cited by 25 · see citing works
Similarities and Differences in the In Vivo Response of Mouse Neonatal Gonocytes and Spermatogonia to Genotoxic Stress1
Forand, A., Fouchet, P., Lahaye, J.-B., Chicheportiche, A., Habert, R., & Bernardino-Sgherri, J. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.072884 · Cited by 22 · see citing works
ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response
Vega-Muñoz, I., Herrera‐Estrella, A., Martínez, O., & Heil, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175786 · Cited by 21 · see citing works
Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain
Kirshner, M., Galron, R., Frenkel, D., Mandelbaum, G., Shiloh, Y., Wang, Z., & Barzilai, A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9643-y · Cited by 19 · see citing works
DNA damage pathways and B-cell lymphomagenesis
Knittel, G., Rehkämper, T., Nieper, P., Schmitt, A., Flümann, R., & Reinhardt, H. C. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000433 · Cited by 18 · see citing works
How do cells sense DNA lesions?
Colombo, C. V., Gnugnoli, M., Gobbini, E., & Longhese, M. P. (2020) · Biochemical Society Transactions · doi:10.1042/bst20191118 · Cited by 17 · see citing works
A Kinase-Independent Role for the Rad3ATR-Rad26ATRIP Complex in Recruitment of Tel1ATM to Telomeres in Fission Yeast
Subramanian, L., & Nakamura, T. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000839 · Cited by 16 · see citing works

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11
Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 294 · see citing works
Distinct Roles of the ATR Kinase and the Mre11-Rad50-Nbs1 Complex in the Maintenance of Chromosomal Stability in Arabidopsis
Amiard, S., Charbonnel, C., Allain, E., Depeiges, A., White, C. I., & Gallego, M. E. (2010) · The Plant Cell · doi:10.1105/tpc.110.078527 · Cited by 109 · see citing works
ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage
Gamper, A. M., Rofougaran, R., Watkins, S. C., Greenberger, J. S., Beumer, J. H., & Bakkenist, C. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt833 · Cited by 69 · see citing works
Interplay between ATM and ATR for the regulation of cellular responses to DNA damage
Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)
The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:
Cuadrado, M., Martínez-Pastor, B., Murga, M., & Toledo, L. I. (2013)

Authors: Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D.
Affiliations: University of Oxford (GB)
Corresponding author: Lakin, N D
ORCID: Dart, D A
Lakin, N D
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-02-13
Volume: 25
Issue: 28
Pages: 3894-3904
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1209426
PMC: PMC1852851
OpenAlex: W2008280357
Cited by: 164
References: 62
Citations by year: 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 9
FWCI: 8.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: Cancer Research Institute
Wellcome Trust
Cancer Research UK (A5207)
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: ATR kinase, ATM kinase, ionizing radiation, DNA damage signaling, MRN complex, MRE11, RAD50, NBS1, single-stranded DNA, nuclear foci, G1 phase, S phase, DNA double-strand breaks
MeSH terms: MRE11 Homologue Protein, Animals, Base Sequence, DNA Damage, DNA-Binding Proteins, DNA, Single-Stranded, HeLa Cells, Humans, Radiation, Ionizing, S Phase, 3T3 Cells, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, RNA, Small Interfering, DNA Repair Enzymes, Mice, Ataxia Telangiectasia Mutated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks