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Cited by 560

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Mobile genetic elements of Staphylococcus aureus

Open access
Malachowa, Natalia, DeLeo, Frank R.·2010·Cellular and Molecular Life Sciences

Abstract

Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host. Mobile genetic elements (MGEs) play a central role in this adaptation process and are a means to transfer genetic information (DNA) among and within bacterial species. Importantly, MGEs encode putative virulence factors and molecules that confer resistance to antibiotics, including the gene that confers resistance to beta-lactam antibiotics in methicillin-resistant S. aureus (MRSA). Inasmuch as MRSA infections are a significant problem worldwide and continue to emerge in epidemic waves, there has been significant effort to improve diagnostic assays and to develop new antimicrobial agents for treatment of disease. Our understanding of S. aureus MGEs and the molecules they encode has played an important role toward these ends and has provided detailed insight into the evolution of antimicrobial resistance mechanisms and virulence.

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Metadata

Authors
Malachowa, N., & DeLeo, F. R.
Venue
Cellular and Molecular Life Sciences
Published
2010-07-29
Volume
67
Issue
18
Pages
3057-3071
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2111662072
Cited by
560
References
6
FWCI
13.26
Type
journal article
Language
en
Open access
hybrid

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