Cited by 116DNA Repair MechanismsCancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

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ATM protein kinase: the linchpin of cellular defenses to stress

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Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin, Khanna, Kum Kum·2011·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-011-0683-9PMC PMC11115042

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Abstract

ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.

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Authors: Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K.
Affiliations: University of Lahore (PK)
QIMR Berghofer Medical Research Institute (AU)
Corresponding author: Kozlov, Sergei
ORCID: Bhatti, Shahzad
Lavin, Martin
Khanna, Kum Kum
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2011-05-02
Volume: 68
Issue: 18
Pages: 2977-3006
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-011-0683-9
PMC: PMC11115042
OpenAlex: W1971822253
Cited by: 116
References: 275
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 15 · 2013: 24 · 2012: 11
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: ATM kinase, DNA damage response, genome stability, DNA repair signaling, cell cycle arrest, carcinogenesis, metabolic syndrome, neurodegeneration, ataxia telangiectasia, stress response, therapeutic target
MeSH terms: MRE11 Homologue Protein, Ataxia Telangiectasia, DNA Damage, DNA-Binding Proteins, Enzyme Activation, Humans, Models, Molecular, Nuclear Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Acid Anhydride Hydrolases, Oxidative Stress, Cell Cycle Proteins, Tumor Suppressor Proteins, Chromatin Assembly and Disassembly, DNA Repair Enzymes, Multiprotein Complexes, Ataxia Telangiectasia Mutated Proteins

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ATM protein kinase: the linchpin of cellular defenses to stress

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