ATM protein kinase: the linchpin of cellular defenses to stress

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075

Shelterin: the protein complex that shapes and safeguards human telomeres

de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Schultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

Kinner, A., Wu, W., Staudt, C., & Iliakis, G. E. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn550 · Cited by 1,303

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 2×

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

Stucki, M., Clapperton, J. A., Mohammad, D. H., Yaffe, M. B., Smerdon, S. J., & Jackson, S. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.038 · Cited by 1,164

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Telomeres: protecting chromosomes against genome instability

O’Sullivan, R. J., & Karlseder, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2848 · Cited by 1,043

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 932

Structural Biology of Rad50 ATPase

Hopfner, K., Kärcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., & Tainer, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80890-9 · Cited by 924

The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

Paull, T. T., & Gellert, M. F. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80097-0 · Cited by 919

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 888

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836

Radiosensitivity in ataxia-telangiectasia: a new explanation.

Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 795

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762

Systematic Discovery of In Vivo Phosphorylation Networks

Linding, R., Jensen, L. J., Ostheimer, G. J., van Vugt, M. A. T. M., Jørgensen, C., Miron, I. M., Diella, F., Colwill, K., Taylor, L., Elder, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.052 · Cited by 739

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1446 · Cited by 735

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 668

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Zhu, X., Küster, B., Mann, M., Petrini, J. H. J., & de Lange, T. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 619

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613 · cited 1×

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

Hopfner, K., Craig, L., Moncalián, G., Zinkel, R. A., Usui, T., Owen, B. A. L., Kärcher, A., Henderson, B., Bodmer, J.-L., McMurray, C. T., et al. (2002) · Nature · doi:10.1038/nature00922 · Cited by 571

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M., Guan, A. S., Hesley, J., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 564

Sequential Modification of NEMO/IKKγ by SUMO-1 and Ubiquitin Mediates NF-κB Activation by Genotoxic Stress

Huang, T. T., Wuerzberger‐Davis, S. M., Wu, Z., & Miyamoto, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00895-x · Cited by 560

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545

Crosstalk between histone modifications during the DNA damage response

van Attikum, H., & Gasser, S. M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.03.001 · Cited by 542

Insulin resistance is a cellular antioxidant defense mechanism

Hoehn, K. L., Salmon, A. B., Hohnen-Behrens, C., Turner, N., Hoy, A. J., Maghzal, G. J., Stocker, R., Van Remmen, H., Kraegen, E. W., Cooney, G. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902380106 · Cited by 540

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

Baskaran, R., Wood, L. D., Whitaker, L. L., Canman, C. E., Morgan, S. E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A. J., Kastan, M. B., et al. (1997) · Nature · doi:10.1038/387516a0 · Cited by 538

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 535

Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

Hopfner, K., Kärcher, A., Craig, L., Woo, T. T., Carney, J. P., & Tainer, J. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00335-x · Cited by 531

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 523

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Williams, R. S., Moncalián, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L., Cahill, D., Hitomi, C., Guenther, G., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.017 · Cited by 520

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 519

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510015 · Cited by 518

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515

High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., & Legube, G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.38 · Cited by 515

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

de Jager, M., van Noort, J., van Gent, D. C., Dekker, C., Kanaar, R., & Wyman, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00381-1 · Cited by 512

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

Lehner, B., Crombie, C., Tischler, J., Fortunato, A., & Fraser, A. G. (2006) · Nature Genetics · doi:10.1038/ng1844 · Cited by 502

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482

ATM associates with and phosphorylates p53: mapping the region of interaction

Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S. P., Gatei, M. H., Hobson, K., Taya, Y., Gabrielli, B. G., Chan, D. W., Lees‐Miller, S. P., et al. (1998) · Nature Genetics · doi:10.1038/3882 · Cited by 481

Interaction between ATM protein and c-Abl in response to DNA damage

Shafman, T. D., Khanna, K. K., Kedar, P. S., Spring, K. J., Kozlov, S., Yen, T. J., Hobson, K., Gatei, M. H., Zhang, N., Watters, D. J., et al. (1997) · Nature · doi:10.1038/387520a0 · Cited by 478

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454

Characteristics of γ-H2AX foci at DNA double-strand breaks sites

Pilch, D. R., Sedelnikova, O. A., Redon, C. E., Celeste, A., Nussenzweig, A., & Bonner, W. M. (2003) · Biochemistry and Cell Biology · doi:10.1139/o03-042 · Cited by 452

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

You, Z., Chahwan, C., Bailis, J. M., Hunter, T. R., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5363-5379.2005 · Cited by 449

DNA end resection: Many nucleases make light work

Mimitou, E. P., & Symington, L. S. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.017 · Cited by 440

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L., & Reinberg, D. (2007) · Nature · doi:10.1038/nature06268 · Cited by 439

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

Xiao, A., Li, H., Shechter, D., Ahn, S. H., Fabrizio, L. A., Erdjument‐Bromage, H., Ishibe-Murakami, S., Wang, B., Tempst, P., Hofmann, K., et al. (2008) · Nature · doi:10.1038/nature07668 · Cited by 430

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Karlseder, J., Hoke, K., Mirzoeva, O. K., Bakkenist, C. J., Kastan, M. B., Petrini, J. H. J., & de Lange, T. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020240 · Cited by 418

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Ayoub, N., Jeyasekharan, A. D. D., Bernal, J. A., & Venkitaraman, A. R. (2008) · Nature · doi:10.1038/nature06875 · Cited by 417

TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 398

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Falck, J., Petrini, J. H. J., Williams, B. R., Lukas, J., & Bartek, J. (2002) · Nature Genetics · doi:10.1038/ng845 · Cited by 392

Proposed mechanisms for the induction of insulin resistance by oxidative stress

Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388

DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N. K., Amunugama, R., Yoder, K. E., Izumi, S., Kuraoka, I., Tanaka, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00579-07 · Cited by 387

ATM Activation and DNA Damage Response

Lavin, M. F., & Kozlov, S. (2007) · Cell Cycle · doi:10.4161/cc.6.8.4180 · Cited by 386

Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

Inomata, K., Aoto, T., Binh, N. T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.037 · Cited by 368

A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

Meetei, A. R., Sechi, S., Wallisch, M., Yang, D., Young, M. K., Joenje, H., Hoatlin, M. E., & Wang, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3417-3426.2003 · Cited by 361

ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

Stiff, T., Walker, S. A., Cerosaletti, K., Goodarzi, A. A., Petermann, E., Concannon, P., O'Driscoll, M., & Jeggo, P. A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601446 · Cited by 360

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

Barzilai, A. (2002) · DNA Repair · doi:10.1016/s1568-7864(01)00007-6 · Cited by 359

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

Shreeram, S., Demidov, O. N., Hee, W. K., Yamaguchi, H., Onishi, N., Kek, C., Timofeev, O. N., Dudgeon, C., Fornace, A. J., Anderson, C. W., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.010 · Cited by 358

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Shiotani, B., & Zou, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.024 · Cited by 353

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

Williams, R. S., Dodson, G. E., Limbo, O., Yamada, Y., Williams, J. S., Guenther, G., Classen, S., Glover, J. N. M., Iwasaki, H., Russell, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.07.033 · Cited by 322

DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319

FAT: a novel domain in PIK-related kinases

Bosotti, R., Isacchi, A., & Sonnhammer, E. L. L. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01563-2 · Cited by 313

Emerging common themes in regulation of PIKKs and PI3Ks

Lempiäinen, H., & Halazonetis, T. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.281 · Cited by 312

A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1

Keller, D. M., Zeng, X., Wang, Y., Zhang, Q. H., Kapoor, M., Shu, H., Goodman, R. H., Lozano, G., Zhao, Y., & Lu, H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00176-9 · Cited by 308

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Kruhlak, M., Crouch, E. E., Orlov, M., Montaño, C., Gorski, S. A., Nussenzweig, A., Misteli, T., Phair, R. D., & Casellas, R. (2007) · Nature · doi:10.1038/nature05842 · Cited by 305

Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break

Chen, B. P. C., Uematsu, N., Kobayashi, J., Lerenthal, Y., Krempler, A., Yajima, H., Löbrich, M., Shiloh, Y., & Chen, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m611605200 · Cited by 304

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 303

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 303

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299

Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Chapman, J. R., & Jackson, S. P. (2008) · EMBO Reports · doi:10.1038/embor.2008.103 · Cited by 299

Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells

Armstrong, L., Tilgner, K., Saretzki, G. C., Atkinson, S. P., Stojković, M., Moreno, R., Przyborski, S. A., & Lako, M. (2010) · Stem Cells · doi:10.1002/stem.307 · Cited by 292

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

Bensimon, A., Schmidt, A., Ziv, Y., Elkon, R., Wang, S., Chen, D. J., Aebersold, R. H., & Shiloh, Y. (2010) · Science Signaling · doi:10.1126/scisignal.2001034 · Cited by 290

Mammalian SWI/SNF complexes facilitate DNA double‐strand break repair by promoting γ‐H2AX induction

Park, J., Park, E., Lee, H.-S., Kim, S. J., Hur, S.-K., Imbalzano, A. N., & Kwon, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601291 · Cited by 288

Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

Verdun, R. E., Crabbe, L., Haggblom, C., & Karlseder, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.024 · Cited by 284

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Preprint

Keegan, K. S., Holtzman, D. A., Plug, A. W., Christenson, E., Brainerd, E. E., Flaggs, G., Bentley, N. J., Taylor, E. M., Meyn, M. S., Moss, S. B., et al. (1996) · Genes & Development · doi:10.1101/gad.10.19.2423 · Cited by 283

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

Hinz, M., Stilmann, M., Arslan, S. Ç., Khanna, K. K., Dittmar, G., & Scheidereit, C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.008 · Cited by 280

The ATRs, ATMs, and TORs Are Giant HEAT Repeat Proteins

Perry, J., & Kleckner, N. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00033-3 · Cited by 279

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1

Yang, D., & Kastan, M. B. (2000) · Nature Cell Biology · doi:10.1038/35046542 · Cited by 278

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

Moreno‐Herrero, F., de Jager, M., Dekker, N. H., Kanaar, R., Wyman, C., & Dekker, C. (2005) · Nature · doi:10.1038/nature03927 · Cited by 278

Common mechanisms of PIKK regulation

Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.006 · Cited by 277

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

Waltes, R., Kalb, R., Gatei, M. H., Kijas, A. W., Stümm, M., Sobeck, A., Wieland, B., Varon, R., Lerenthal, Y., Lavin, M. F., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.04.010 · Cited by 277

SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein

Yuan, Z., Zhang, X. M., Sengupta, N., Lane, W. S., & Seto, E. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.029 · Cited by 277

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

Andegeko, Y., Moyal, L., Rotman, G., Shiloh, Y., Mittelman, L., & Tsarfaty, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102986200 · Cited by 276

Heterochromatin is refractory to γ-H2AX modification in yeast and mammals

Kim, J., Kruhlak, M. J., Dotiwala, F., Nussenzweig, A., & Haber, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612031 · Cited by 276

Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM

Viniegra, J. G., Martínez, N., Modirassari, P., Hernández‐Losa, J., Cobo, C. P., Lobo, V. J. S.-A., Luquero, C. I. A., Álvarez‐Vallina, L., y Cajal, S. R., Rojas, J. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410344200 · Cited by 275

Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

Goodarzi, A. A., Jonnalagadda, J. C., Douglas, P., Young, D., Ye, R., Moorhead, G. B. G., Lees‐Miller, S. P., & Khanna, K. K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600455 · Cited by 269

A cooperative activation loop among SWI/SNF, γ‐H2AX and H3 acetylation for DNA double‐strand break repair

Lee, H.-S., Park, J., Kim, S., Kwon, S.-J., & Kwon, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.27 · Cited by 269

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

Cam, H., Easton, J. B., High, A., & Houghton, P. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.030 · Cited by 266

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

Houldsworth, J., & Lavin, M. F. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.16.3709 · Cited by 265

Ataxia Telangiectasia Mutated (ATM) Signaling Network Is Modulated by a Novel Poly(ADP-ribose)-dependent Pathway in the Early Response to DNA-damaging Agents

Haince, J.-F., Kozlov, S., Dawson, V. L., Dawson, T. M., Hendzel, M. J., Lavin, M. F., & Poirier, G. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608406200 · Cited by 261

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

Spycher, C., Miller, E. S., Townsend, K., Pavic, L., Morrice, N. A., Janščák, P., Stewart, G. S., & Stucki, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709008 · Cited by 259

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

Richard, D. J., Bolderson, E., Cubeddu, L., Wadsworth, R. I. M., Savage, K. I., Sharma, G. G., Nicolette, M. L., Tsvetanov, S., McIlwraith, M. J., PANDITA, R. K., et al. (2008) · Nature · doi:10.1038/nature06883 · Cited by 257

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S.-I., Natsume, T., & Mizushima, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121699 · Cited by 255

Methylation of a Histone Mimic within the Histone Methyltransferase G9a Regulates Protein Complex Assembly

Sampath, S. C., Marazzi, I., Yap, K. L., Sampath, S. C., Krutchinsky, A. N., Mecklenbräuker, I., Viale, A. J., Rudensky, E., Zhou, M., Chait, B. T., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.026 · Cited by 249

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

Yalcin, S., Zhang, X., Luciano, J. P., Mungamuri, S. K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., & Ghaffari, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800517200 · Cited by 247

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint controlPreprint

Boisvert, F., Déry, U., Masson, J., & Richard, S. (2005) · Genes & Development · doi:10.1101/gad.1279805 · Cited by 241

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

Bennetzen, M. V., Larsen, D. H., Bunkenborg, J., Bártek, J., Lukas, J., & Andersen, J. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900616-mcp200 · Cited by 240

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 234

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

Cowell, I. G., Sunter, N. J., Singh, P. B., Austin, C. A., Durkacz, B. W., & Tilby, M. J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001057 · Cited by 234

A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.

Stilmann, M., Hinz, M., Arslan, S. Ç., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.032 · Cited by 232

Insulin receptor signaling in the development of neuronal structure and function

Chiu, S., & Cline, H. T. (2010) · Neural Development · doi:10.1186/1749-8104-5-7 · Cited by 231

Tel2 Regulates the Stability of PI3K-Related Protein Kinases

Takai, H., Wang, R. C., Takai, K., Yang, H., & de Lange, T. (2007) · Cell · doi:10.1016/j.cell.2007.10.052 · Cited by 226

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

Sibanda, B. L., Chirgadze, D. Y., & Blundell, T. L. (2009) · Nature · doi:10.1038/nature08648 · Cited by 225

Rapamycin-Sensitive Pathway Regulates Mitochondrial Membrane Potential, Autophagy, and Survival in Irradiated MCF-7 Cells

Paglin, S., Lee, N.-Y., Nakar, C. T., Fitzgerald, M. L., Plotkin, J., Deuel, B., Hackett, N., McMahill, M., Sphicas, E., Lampen, N., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1083 · Cited by 223

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

So, S., Davis, A. J., & Chen, D. J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200906064 · Cited by 222

Autophosphorylation and ATM Activation

Kozlov, S., Graham, M. E., Jakob, B., Tobias, F., Kijas, A. W., Tanuji, M., Chen, P., Robinson, P. J., Taucher-Scholz, G., Suzuki, K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204065 · Cited by 221

CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability

Hořejší, Z., Takai, H., Adelman, C. A., Collis, S. J., Flynn, H. R., Maslen, S., Skehel, M. J., de Lange, T., & Boulton, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.037 · Cited by 219

When repair meets chromatin

Green, C., & Almouzni, G. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf005 · Cited by 214

Functional interaction between FOXO3a and ATM regulates DNA damage response

Tsai, W.-B., Chung, Y. M., Takahashi, Y. K., Xu, Z., & Hu, M. C. ‐. (2008) · Nature Cell Biology · doi:10.1038/ncb1709 · Cited by 210

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

Hurov, K. E., Cotta-Ramusino, C., & Elledge, S. J. (2010) · Genes & Development · doi:10.1101/gad.1934210 · Cited by 210

Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential

Lechner, M. S., Begg, G. E., Speicher, D. W., & Rauscher, F. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6449-6465.2000 · Cited by 210

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 209

Multiple roles for MRE11 at uncapped telomeres

Deng, Y., Guo, X., Ferguson, D. O., & Chang, S. S. (2009) · Nature · doi:10.1038/nature08196 · Cited by 204

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

Savic, V., Yin, B., Maas, N. L., Bredemeyer, A. L., Carpenter, A. C., Helmink, B. A., Yang-Iott, K. S., Sleckman, B. P., & Bassing, C. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.012 · Cited by 204

The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci

Poot, R. A., Bozhenok, L., van den Berg, D. L. C., Steffensen, S., Ferreira, F., Grimaldi, M., Gilbert, N., Ferreira, J. A., & Varga‐Weisz, P. (2004) · Nature Cell Biology · doi:10.1038/ncb1196 · Cited by 203

Chk2 Activation Dependence on Nbs1 after DNA Damage

Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5214-5222.2001 · Cited by 201

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesPreprint

Takai, H., Xie, Y., de Lange, T., & Pavletich, N. P. (2010) · Genes & Development · doi:10.1101/gad.1956410 · Cited by 197

Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

Desai-Mehta, A., Cerosaletti, K. M., & Concannon, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2184-2191.2001 · Cited by 196

ATM activation in the presence of oxidative stress

Guo, Z., Deshpande, R. A., & Paull, T. T. (2010) · Cell Cycle · doi:10.4161/cc.9.24.14323 · Cited by 191

Characterization of ATM Expression, Localization, and Associated DNA-dependent Protein Kinase Activity

Gately, D. P., Hittle, J. C., Chan, G. K. T., & Yen, T. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2361 · Cited by 191

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

Peng, G., Yim, E.-K., Dai, H., Jackson, A. P., van der Burgt, I., Pan, M., Hu, R., Li, K., & Lin, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1895 · Cited by 191

ATR-dependent radiation-induced γH2AX foci in bystander primary human astrocytes and glioma cells

Burdak‐Rothkamm, S., Short, S. C., Folkard, M., Rothkamm, K., & Prise, K. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209863 · Cited by 190

Localization of a Portion of Extranuclear ATM to Peroxisomes

Watters, D. J., Kedar, P. S., Spring, K. J., Björkman, J., Chen, P., Gatei, M. H., Birrell, G. W., Garrone, B., Srinivasa, P., Crane, D. I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34277 · Cited by 190

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

Aguilar‐Quesada, R., Muñoz‐Gámez, J. A., Martín‐Oliva, D., Peralta, A., Valenzuela, M. T., Matínez-Romero, R., Quiles, R., Murcia, J. M., de MURCIA, G., de Almodóvar, J. M. R., et al. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-29 · Cited by 186

The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM

Paull, T. T., & Lee, J. (2005) · Cell Cycle · doi:10.4161/cc.4.6.1715 · Cited by 185

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

Tian, B., Yang, Q., & Mao, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1829 · Cited by 184

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

Fu, X., Wan, S., Lyu, Y. L., Liu, L. F., & Qi, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002009 · Cited by 183

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

Rossetto, D., Truman, A. W., Kron, S. J., & Côté, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0513 · Cited by 183

Extreme Insulin Resistance in Ataxia Telangiectasia

Bar, R. S., Levis, W. R., Rechler, M. M., Harrison, L. C., Siebert, C., Podskalny, J. M., Roth, J., & Muggeo, M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805252982103 · Cited by 180

HIF-1 and tumour radiosensitivity

Moeller, B. J., & Dewhirst, M. W. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603201 · Cited by 178

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

Ali, A., Zhang, J., Bao, S., Liu, I., Otterness, D. M., Dean, N. M., Abraham, R. T., & Wang, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1176004 · Cited by 175

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

Barlow, C., Ribaut‐Barassin, C., Zwingman, T. A., Pope, A. J., Brown, K. D., Owens, J. W., Larson, D. M., Harrington, E. A., Haeberlé, A., Mariani, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.871 · Cited by 170

Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression

Li, X., Lee, Y.-K., Jeng, J.-C., Yen, Y., Schultz, D. C., Shih, H.-M., & Ann, D. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706912200 · Cited by 168

Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

Kumar, A., Fernández-Capetillo, Ó., & Carrera, A. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914242107 · Cited by 167

Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of Telomeres

Zhong, Z.-H., Jiang, W.-Q., Cesare, A. J., Neumann, A. A., Wadhwa, R., & Reddel, R. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701413200 · Cited by 166

ATM function and telomere stability

Pandita, T. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205060 · Cited by 164

Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells

Ambrose, M., Goldstine, J. V., & Gatti, R. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm166 · Cited by 163

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

Wu, L., Luo, K., Lou, Z., & Chen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802885105 · Cited by 162

Identification of a Novel Protein Kinase Mediating Akt Survival Signaling to the ATM Protein

Suzuki, A., Kusakai, G.-I., Kishimoto, A., Lu, J., Ogura, T., Lavin, M. F., & Esumi, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206025200 · Cited by 161

Inhibition of Transforming Growth Factor-β1 Signaling Attenuates Ataxia Telangiectasia Mutated Activity in Response to Genotoxic Stress

Kirshner, J., Jobling, M. F., Pajares, M. J., Ravani, S. A., Glick, A. B., Lavin, M. F., Koslov, S., Shiloh, Y., & Barcellos‐Hoff, M. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2565 · Cited by 161

Ataxia telangiectasia mutated is essential during adult neurogenesisPreprint

Allen, D. M., van Praag, H., Ray, J., Ohler, Z. W., Winrow, C. J., Carter, T. A., Braquet, R., Harrington, E. A., Ried, T., Brown, K. D., et al. (2001) · Genes & Development · doi:10.1101/gad.869001 · Cited by 159

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

Rai, R., Dai, H., Multani, A. S., Li, K., Chin, K., Gray, J. W., Lahad, J. P., Liang, J., Mills, G. B., Meric‐Bernstam, F., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.07.002 · Cited by 154

53BP1 promotes ATM activity through direct interactions with the MRN complex

Lee, J., Goodarzi, A. A., Jeggo, P. A., & Paull, T. T. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.372 · Cited by 147

Phosphorylation of Huntingtin by Cyclin-Dependent Kinase 5 Is Induced by DNA Damage and Regulates Wild-Type and Mutant Huntingtin Toxicity in Neurons

Anne, S. L., Saudou, F., & Humbert, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1831-07.2007 · Cited by 147

ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response

Peretz, S., Jensen, R. B., Baserga, R., & Glazer, P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1676 · Cited by 146

The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM

Jiang, X., Sun, Y., Chen, S., Roy, K., & Price, B. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513172200 · Cited by 145

Ionizing Radiation Induces Ataxia Telangiectasia Mutated-Dependent Checkpoint Signaling and G2 But Not G1 Cell Cycle Arrest in Pluripotent Human Embryonic Stem Cells

Momčilović, O., Choi, S., Varum, S., Bakkenist, C. J., Schatten, G. P., & Navara, C. S. (2009) · Stem Cells · doi:10.1002/stem.123 · Cited by 142

ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress

Yajima, H., Lee, K. J., & Chen, B. P. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00048-06 · Cited by 142

Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling

Kim, J., & Wong, P. K. Y. (2009) · Stem Cells · doi:10.1002/stem.125 · Cited by 141

Mre11–Rad50–Nbs1‐dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

Jazayeri, A. R., Balestrini, A., Garner, E., Haber, J. E., & Costanzo, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.128 · Cited by 141

Regulation of Protein Synthesis by Ionizing Radiation

Braunstein, S. E., Badura, M. L., Xi, Q., Formenti, S. C., & Schneider, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00711-09 · Cited by 141

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

Kim, Y., Gerlitz, G., Furusawa, T., Catez, F., Nussenzweig, A., Oh, K., Kraemer, K. H., Shiloh, Y., & Bustin, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1817 · Cited by 139

The role of the DNA damage response in neuronal development, organization and maintenance

Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 139

Nonaminoglycoside compounds induce readthrough of nonsense mutations

Du, L., Damoiseaux, R. D., Nahas, S., Gao, K., Hu, H., Pollard, J. M., Goldstine, J. V., Jung, M. E., Henning, S. M., Bertoni, C., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081940 · Cited by 139

DNMT3B mutations and DNA methylation defect define two types of ICF syndrome

Jiang, Y., Rigolet, M., Bourc’his, D., Nigon, F., Bökesoy, I., Fryns, J. P., Hultén, M. A., Jonveaux, P., Maraschio, P., Mégarbané, A., et al. (2004) · Human Mutation · doi:10.1002/humu.20113 · Cited by 138

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Hilz, H., Hickey, R. J., Malkas, L. H., Applegren, N., Wu, Y. Q., Bers, G., & Smulson, M. E. (1996) · Biochemistry · doi:10.1021/bi953010z · Cited by 137

Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells

Tomimatsu, N., Mukherjee, B., & Burma, S. (2009) · EMBO Reports · doi:10.1038/embor.2009.60 · Cited by 135

Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice

Chen, P., Peng, C., Luff, J., Spring, K. J., Watters, D. J., Bottle, S. E., Furuya, S., & Lavin, M. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11453.2003 · Cited by 134

Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response: Figure 1.Preprint

Zou, L. (2007) · Genes & Development · doi:10.1101/gad.1550307 · Cited by 133

TATA Binding Protein-Associated CK2 Transduces DNA Damage Signals to the RNA Polymerase III Transcriptional Machinery

Ghavidel, A., & Schultz, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00473-1 · Cited by 131

Cytoplasmic ATM in Neurons Modulates Synaptic Function

Li, J., Han, Y. R., Plummer, M. R., & Herrup, K. (2009) · Current Biology · doi:10.1016/j.cub.2009.10.039 · Cited by 130

The Solution Structure of the FATC Domain of the Protein Kinase Target of Rapamycin Suggests a Role for Redox-dependent Structural and Cellular Stability

Dames, S. A., Mulet, J. M., Rathgeb–Szabo, K., Hall, M. N., & Grzesiek, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501116200 · Cited by 130

The Product of the ATM Gene Is a 370-kDa Nuclear Phosphoprotein

Chen, G., & Lee, E. Y.-H. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33693 · Cited by 129

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

Macaulay, V. M., Salisbury, A. J., Bohula, E. A., Playford, M. P., Smorodinsky, N. I., & Shiloh, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204565 · Cited by 128

The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain

Douglas, P., Cui, X., Block, W. D., Yu, Y., Gupta, S., Ding, Q., Ye, R., MORRICE, N. A., Lees‐Miller, S. P., & Meek, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01962-06 · Cited by 127

Proteomic analysis of synaptosomes using isotope‐coded affinity tags and mass spectrometry

Schrimpf, S., Meskenaïte, V., Brunner, E., Rutishauser, D., Walther, P., Eng, J. K., Aebersold, R. H., & Sonderegger, P. (2005) · PROTEOMICS · doi:10.1002/pmic.200401198 · Cited by 125

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage

Dong, Z., Zhong, Q., & Chen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19513 · Cited by 123

Rad50 Adenylate Kinase Activity Regulates DNA Tethering by Mre11/Rad50 Complexes

Bhaskara, V., Dupré, A., Lengsfeld, B. M., Hopkins, B. B., Chan, A., Lee, J., Zhang, X., Gautier, J., Zakian, V. A., & Paull, T. T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.028 · Cited by 123

Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2

Dimitrova, N., & de Lange, T. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00476-09 · Cited by 122

Purification and Characterization of ATM from Human Placenta

Chan, D. W., Son, S.-C., Block, W. D., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P., Goodarzi, A. A., Pelley, J. L., Taya, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7803 · Cited by 122

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM

Beamish, H., Kedar, P. S., Kaneko, H., Chen, P., Fukao, T., Peng, C., Beresten, S., Gueven, N., Purdie, D. M., Lees‐Miller, S. P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203801200 · Cited by 121

PATHOLOGICAL OBSERVATIONS IN ATAXIA-TELANGIECTASIA A REPORT ON FIVE CASES

Aguilar, M. J., Kamoshita, S., Landing, B. H., et al. (1968) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196810000-00009 · Cited by 119

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants

Adams, B. R., Golding, S. E., Rao, R. R., & Valerie, K. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010001 · Cited by 115

Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)

Rivera-Calzada, Á., Maman, J. P., Spagnolo, L., Pearl, L. H., & Llorca, Ó. (2005) · Structure · doi:10.1016/j.str.2004.12.006 · Cited by 113

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

Daniel, J. A., Pellegrini, M., Lee, J., Paull, T. T., Feigenbaum, L., & Nussenzweig, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805154 · Cited by 113

Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks

Takemura, H., Rao, V. A., Sordet, O., Furuta, T., Miao, Z., Meng, L., Zhang, H., & Pommier, Y. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603747200 · Cited by 112

Rapid activation of ATM on DNA flanking double-strand breaks

You, Z., Bailis, J. M., Johnson, S. A., Dilworth, S. M., & Hunter, T. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1651 · Cited by 107

Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains

Costes, S. V., Ponomarev, A. L., Chen, J. L., Nguyen, D. H. A., Cucinotta, F. A., & Barcellos‐Hoff, M. H. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030155 · Cited by 106

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

Costanzo, V., Paull, T., Gottesman, M., & Gautier, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020110 · Cited by 106

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

Petersen, A. J., Rimkus, S. A., & Wassarman, D. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110470109 · Cited by 139

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116

Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

Zimmermann, M., Don, A. S. A., Donaldson, M. S., Dallapiazza, R. F., Cowan, C. E., & Horne, M. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.376855 · Cited by 63

Chk1 and Chk2 as Checkpoint Targets

Zhang, H., Xiao, Z., & Sowin, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_16 · Cited by 1

Chapter 16 Chk1 and Chk2 as Checkpoint Targets

Zhang, H., Xiao, Z., & Sowin, T. (2009)

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

Lee, M., Kim, H., Kim, M.-A., Jee, H. J., Kim, A. J., Bae, Y., Park, J., Chung, J. H., & Yun, J. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6551 · Cited by 65

p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

Reinhardt, H. C., Aslanian, A., Lees, J. A., & Yaffe, M. B. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.024 · Cited by 614