Wnt signaling and cellular metabolism in osteoblasts

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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The Wnt Signaling Pathway in Development and Disease

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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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ATP-citrate lyase links cellular metabolism to histone acetylation

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Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis

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Neural EGF-like protein 1 (NELL-1): Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine

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Betulin Promotes Differentiation of Human Osteoblasts In Vitro and Exerts an Osteoinductive Effect on the hFOB 1.19 Cell Line Through Activation of JNK, ERK1/2, and mTOR Kinases

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Research progress on sarcopenia in the musculoskeletal system

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Increased osteogenic differentiation potential of MSCs cultured on nanofibrous structure through activation of Wnt/β-catenin signalling by inorganic polyphosphate

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Four cases of pulmonary nodular eosinophilic granulomatosis in dogs.

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Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation

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The Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis

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Cinnamtannin B-1 Prevents Ovariectomy-Induced Osteoporosis via Attenuating Osteoclastogenesis and ROS Generation

Li, M., Li, H., Li, L., Liu, L., Chen, G., Jiang, W., Xu, W., Zhu, C., Yao, G., & Fang, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01023 · Cited by 29

Blue Mussel-Derived Peptides PIISVYWK and FSVVPSPK Trigger Wnt/β-Catenin Signaling-Mediated Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells

Oh, Y., Ahn, C., & Je, J. (2020) · Marine Drugs · doi:10.3390/md18100510 · Cited by 29

MiR-34a suppresses osteoblast differentiation through glycolysis inhibition by targeting lactate dehydrogenase-A (LDHA)

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CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice

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MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation

Zhang, Y., Yin, C., Hu, L., Chen, Z., Zhao, F., Li, D., Ma, J., Ma, X., Su, P., Qiu, W., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.153 · Cited by 28

Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway

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Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation

Ohnishi, T., Kusuyama, J., Bandow, K., & Matsuguchi, T. (2020) · Biochemical Journal · doi:10.1042/bcj20190888 · Cited by 28

Circulating microRNAs, miR-10b-5p, miR-328-3p, miR-100 and let-7, are associated with osteoblast differentiation in osteoporosis.

Chen, R., Liao, X., Chen, F., Wang, B., Huang, J., Jian, G., Huang, Z., Yin, G., Liu, H., & Jin, D. (2018) · PubMed Central · Cited by 26

Novel Peptides Derived from Sea Cucumber Intestine Promotes Osteogenesis by Upregulating Integrin-Mediated Transdifferentiation of Growth Plate Chondrocytes to Osteoblasts

Yue, H., Tian, Y., Feng, X., Bo, Y., Xue, C., Dong, P., & Wang, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03458 · Cited by 27

The Aqueous Extract of Eucommia Leaves Promotes Proliferation, Differentiation, and Mineralization of Osteoblast-Like MC3T3-E1 Cells

Guan, M., Pan, D., Zhang, M., Leng, X., & Yao, B. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/3641317 · Cited by 26

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Li, L., Li, A., Zhu, L., Gan, L., & Zuo, L. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-03162-w · Cited by 26

Extracellular Vesicle Clicking on Osteoimplants Through Biomimetic Molecular Adhesion Enables Immune‐Enhanced Osseointegration in Diabetics

Ge, G., Wang, W., Wang, Q., Wang, M., Wang, T., Yu, L., Zhang, X., Zhu, C., Xu, Y., Yang, H., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202315849 · Cited by 26

Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/β-catenin signaling pathway

Sun, Z., Yan, K., Liu, S., Yu, X., Xu, J., Liu, J., & Li, S. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-020-09941-1 · Cited by 25

The role of TGF-β1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride

Qi, Y., Wang, H., Chen, X., & Zhu, Y. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103613 · Cited by 25

Bone-modifying Agents (BMAs) in Breast Cancer

Shapiro, C. L. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.04.009 · Cited by 26

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass

Doolittle, M. L., Calabrese, G. M., Mesner, L. D., Godfrey, D. A., Maynard, R. D., Ackert‐Bicknell, C. L., & Farber, C. R. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008805 · Cited by 28

Bone and Inflammatory Responses to Training in Female Rowers over an Olympic Year

Kurgan, N., Logan-Sprenger, H. M., Falk, B., & Klentrou, P. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001640 · Cited by 24

Enhanced Osteogenesis of Injectable Calcium Phosphate Bone Cement Mediated by Loading Chondroitin Sulfate

Shi, H., Ye, X., Zhang, J., & Ye, J. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00871 · Cited by 24

A 3D Printed Porous Titanium Alloy Rod with Diamond Crystal Lattice for Treatment of the Early-Stage Femoral Head Osteonecrosis in Sheep

Wang, C., Liu, D., Xie, Q., Liu, J., Deng, S., Gong, K., Huang, C., Yin, L., Xie, M., Guo, Z., et al. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.30832 · Cited by 23

Hesperidin promotes differentiation of alveolar osteoblasts via Wnt/β-Catenin signaling pathway

Hong, W., & Zhang, W. (2020) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2020.1752718 · Cited by 23

Inhibition of osteogenic and adipogenic potential in bone marrow-derived mesenchymal stem cells under osteoporosis

Huang, T., Zhou, Y., Yu, Q., Wang, Y., Jiang, Z., Wang, H., & Yang, G. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.035 · Cited by 23

Bone Marrow Microvasculature

Prisby, R. D. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190009 · Cited by 30

ANKRD1 activates the Wnt signaling pathway by modulating CAV3 expression and thus promotes BMSC osteogenic differentiation and bone formation in ovariectomized mice

Zhang, Y., Zhou, L., Fu, Q., & Liu, Z. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166693 · Cited by 23

Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT

Lu, W., Duan, Y., Li, K., Qiu, J., & Cheng, Z. (2023) · Bone Research · doi:10.1038/s41413-023-00268-7 · Cited by 24

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Müller, D. I. H., Stoll, C., Palumbo‐Zerr, K., Böhm, C., Krishnacoumar, B., Ipseiz, N., Taubmann, J., Zimmermann, M., Böttcher, M., Mougiakakos, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65305-5 · Cited by 22

Glycyrrhizic Acid Promotes Osteogenic Differentiation of Human Bone Marrow Stromal Cells by Activating the Wnt/β-Catenin Signaling Pathway

Bai, J., Xu, J., Hang, K., Kuang, Z., Li, Y., Zhou, C., Ni, L., Wang, Y., & Xue, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.607635 · Cited by 23

FGF19 protects against obesity-induced bone loss by promoting osteogenic differentiation

Guo, A., Li, K., Tian, H., Tao, B., Xiao, Q., & Jiang, D. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112524 · Cited by 21

The role of the Wnt signalling pathway in the energy metabolism of bone remodelling

Zhu, M., & Fan, Z. (2022) · Cell Proliferation · doi:10.1111/cpr.13309 · Cited by 20

Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments

Endo, T., Takahata, M., Fujita, R., Koike, Y., Suzuki, R., Hasegawa, Y., Murakami, T., Ishii, M., Yamada, K., Sudo, H., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-27136-4 · Cited by 21

The role and mechanism of RNA-binding proteins in bone metabolism and osteoporosis

Wu, J., Niu, L., Yang, K., Xu, J., Zhang, D., Ling, J., Xia, P., Wu, Y., Liu, X., Liu, J., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102234 · Cited by 23

Osteoporosis y calcificación vascular: un escenario compartido

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Ark shell protein‐derived bioactive peptides promote osteoblastic differentiation through upregulation of the canonical Wnt/β‐catenin signaling in human bone marrow‐derived mesenchymal stem cells

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Wnt signaling in bone metastasis: mechanisms and therapeutic opportunities

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Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis

Chang, G. R., Lin, W., Fan, H., Tu, M., Liu, Y.-H., Yen, C., Cidem, A., Chen, W., & Chen, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113859 · Cited by 20

Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament

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METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis

Zhang, Y., Kong, Y., Zhang, W., He, J., Zhang, Z., Cai, Y., Zhao, Y., & Xu, Q. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01628-8 · Cited by 20

Foxk1 promotes bone formation through inducing aerobic glycolysis

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Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways

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Phosphate glass fibers facilitate proliferation and osteogenesis through Runx2 transcription in murine osteoblastic cells

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Autophagy was involved in tumor necrosis factor-α-inhibited osteogenic differentiation of murine calvarial osteoblasts through Wnt/β-catenin pathway

Chen, L., Bao, J., Yang, Y., Wang, Z., Xia, M., Tan, J., Zhou, L., Wu, Y., & Sun, W. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101401 · Cited by 20

Osteoclast-derived exosomes inhibit osteogenic differentiation through Wnt/β-catenin signaling pathway in simulated microgravity model

Huyan, T., Du, Y., Dong, D., Li, Q., Zhang, R., Yang, J., Yang, Z., Li, J., & Shang, P. (2018) · Acta Astronautica · doi:10.1016/j.actaastro.2018.08.044 · Cited by 19

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality

Shao, Y., Zielinski, E., Childress, P., Adaway, M., Misra, J., Klunk, A. J., Burr, D. B., Wek, R. C., Mosley, A. L., Liu, Y., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2018 · Cited by 20

Aging and Bone Metabolism

Pignolo, R. J. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220012 · Cited by 48

Role of extracellular vesicles associated with microRNAs and their interplay with cuproptosis in osteoporosis

Sun, Y., Chen, P., & Zhao, B. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.03.002 · Cited by 18

Cistanche Deserticola for Regulation of Bone Metabolism: Therapeutic Potential and Molecular Mechanisms on Postmenopausal Osteoporosis

Wang, C., Li, F., Yang, L., Feng, H., Zhao, M.-W., Tu, P., & Tian, H. (2022) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-022-3518-z · Cited by 18

YAP / WNT5A / FZD4 axis regulates osteogenic differentiation of human periodontal ligament cells under cyclic stretch

Zhang, X., Chang, M., Wang, B., Liu, X., Zhang, Z., & Han, G. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13143 · Cited by 18

Metabolic bone disorders and the promise of marine osteoactive compounds

Carletti, A., Gavaia, P. J., Cancela, M. L., & Laizé, V. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05033-x · Cited by 18

Typing characteristics of metabolism-related genes in osteoporosis

Guo, J., Huang, Q., Zhou, Y., Xu, Y., Zong, C., Shen, P., Ma, Y., Zhang, J., Cui, Y., Yu, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.999157 · Cited by 16

Cornus officinalis: a potential herb for treatment of osteoporosis

Tang, X., Huang, Y., Fang, X., Tong, X., Qian, Y., Zheng, W., & Fu, F. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1289144 · Cited by 17

Pharmacological inhibition of S6K1 impairs self‐renewal and osteogenic differentiation of bone marrow stromal cells

Gu, X., Fu, X., Lu, J., Saijilafu, Li, B., Luo, Z., & Chen, J. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26272 · Cited by 16

FAM20C plays a critical role in the development of mouse vertebra

Huang, Y., Chen, H., Zhang, H., Lu, Y., & Qin, C. (2021) · The Spine Journal · doi:10.1016/j.spinee.2021.07.022 · Cited by 15

miR-21-5p and canonical Wnt signaling pathway promote osteoblast function through a feed-forward loop induced by fluoride

Guo, N., Yu, Y., Chu, Y., Lou, Q., Huang, W., Wu, L., Fan, C., Su, M., Zhang, M., Yin, F., et al. (2021) · Toxicology · doi:10.1016/j.tox.2021.153079 · Cited by 15

Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications

Weng, Y., Jian, Y., Huang, W., Xie, Z., Zhou, Y. M., & Pei, X. (2023) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35246 · Cited by 15

A review: the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts

Ren, M., Ahmed, A. F., Li, M., Li, M., Yan, Z., & Wang, J. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2023.07.001 · Cited by 14

Axin 1 knockdown inhibits osteoblastic apoptosis induced by Porphyromonas gingivalis lipopolysaccharide

Zhang, K., He, S.-H., Dai, Z., Cao, L., Yue, S., Bai, Y., & Zheng, M. H. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104667 · Cited by 14

Integrated renal metabolomic and metallomic profiling revealed protective effect and metabolic mechanism of Gushudan on glucocorticoid-induced osteoporotic rat based on GC-MS and ICP-MS

Jia, H., Yuan, X., Liu, S., Feng, Q., Zhao, J., Zhao, L., & Xiong, Z. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113705 · Cited by 14

Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures

Wu, Y.-Z., Huang, H., Cheng, T., Lu, Y., Lin, S., Ho, C.-J., Lee, T., Hsu, C., Huang, P.-J., Huang, H. H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105232 · Cited by 14

Application of porcupine inhibitors in stem cell fate determination

Kalantary‐Charvadeh, A., Hosseini, V., Mehdizadeh, A., & Darabi, M. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13704 · Cited by 13

The extracellular matrix protein Agrin is expressed by osteoblasts and contributes to their differentiation

Souza, A. T. P., Lopes, H. B., Oliveira, F. S., Weffort, D., Freitas, G. P., Adolpho, L. F., Fernandes, R. R., Rosa, A. L., & Beloti, M. M. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03494-9 · Cited by 14

The effects and mechanism of paeoniflorin in promoting osteogenic differentiation of MC3T3-E1

Guo, W., Yang, X.-G., Shi, Y.-L., & Wang, H. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-02965-1 · Cited by 12

WNT7B overexpression rescues bone loss caused by glucocorticoids in mice

Chen, H., Song, F., & Long, F. (2021) · The FASEB Journal · doi:10.1096/fj.202100151rr · Cited by 13

The bone nonunion microenvironment: A place where osteogenesis struggles with osteoclastic capacity

Cheng, K., Gao, S., Mei, Y., Zhou, D., Song, C., Guo, D., Hou, Y., & Liu, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31314 · Cited by 12

Biomineralized Piezoelectrically Active Scaffolds for Inducing Osteogenic Differentiation

Ma, Z., Hu, X., Zhang, Y., Li, X., Chen, B., An, Q., Zhao, Y., & Zhang, Y. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202203166 · Cited by 12

Monosodium Glutamate Supplementation Improves Bone Status in Mice Under Moderate Protein Restriction

Blais, A., Rochefort, G. Y., Moreau, M., Calvez, J., Wu, X., Matsumoto, H., & Blachier, F. (2019) · JBMR Plus · doi:10.1002/jbm4.10224 · Cited by 12

MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 α inhibitor (HIF1AN)

Zhou, L., Qiu, M. R., Yang, L., Yang, L., Zhang, Y., Mu, S., & Song, H. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103613 · Cited by 13

Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling

Jun, J.-Y., Kim, J., Kim, M., Hong, S., Kim, M., Ryu, G.-H., Park, J. H., Jung, H., & Sohn, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087388 · Cited by 11

Sodium Selenite Promotes Osteoblast Differentiation via The WNT/ß-Catenin Signaling Pathway.

Sharma, A. R., Sharma, G., Lee, Y., Chakraborty, C., Lee, S., & Seo, E.-M. (2022) · PubMed Central · doi:10.22074/cellj.2022.8314 · Cited by 11

Biology of Bone and Cartilage

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Amyloid-β neuropathology induces bone loss in male mice by suppressing bone formation and enhancing bone resorption

Jung, Y., Ay, B., Cyr, S. M., Tognoni, C. M., Klovdahl, K., Matthias, J., Cui, Q., Brooks, D. J., Bouxsein, M., Carreras, I., et al. (2024) · Bone Reports · doi:10.1016/j.bonr.2024.101771 · Cited by 11

Targeting the Wnt/β-catenin cascade in osteosarcoma: The potential of ncRNAs as biomarkers and therapeutics

Fuloria, S., Yadav, G., Menon, S. V., Ali, H., Pant, K., Kaur, M., Deorari, M., Sekar, M., Narain, K., Kumar, S., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155346 · Cited by 11

Sera and lungs metabonomics reveals key metabolites of resveratrol protecting against PAH in rats

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Molecular mechanism of microRNAs regulating apoptosis in osteosarcoma

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