The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Wnt signaling and cellular metabolism in osteoblasts
Open accessAbstract
The adult human skeleton is a multifunctional organ undergoing continuous remodeling. Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone resorption by osteoclasts and bone formation by osteoblasts; disturbance of such balance is the root cause for various bone disorders including osteoporosis. To develop effective and safe therapeutics to modulate bone formation, it is essential to elucidate the molecular mechanisms governing osteoblast differentiation and activity. Due to their specialized function in collagen synthesis and secretion, osteoblasts are expected to consume large amounts of nutrients. However, studies of bioenergetics and building blocks in osteoblasts have been lagging behind those of growth factors and transcription factors. Genetic studies in both humans and mice over the past 15 years have established Wnt signaling as a critical mechanism for stimulating osteoblast differentiation and activity. Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. Such findings therefore reveal an important regulatory axis between bone anabolic signals and cellular bioenergetics. A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Wnt proteins bind to their receptors (Frizzled) and coreceptors (LRP5/6) to promote the stabilization of β-catenin in the cytoplasm, which translocates to the nucleus, where it induces the expression of osteogenesis-related genes.38,39”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,281
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–293 of 293
Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma
Iannozzi, N. T., Marchica, V., Toscani, D., Burroughs-Garcìa, J., Giuliani, N., & Storti, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415448 · Cited by 7
Li, H., Liu, S., Miao, C., Lv, Y., & Hu, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1117111 · Cited by 7
Li, H., Yin, C., Li, J., Huang, Q., Huai, Y., Chu, X., Ji, M., Tian, Y., Qian, A., & Li, D. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230301150350 · Cited by 7
Wang, Y., Gan, Y., Dong, Y., Zhou, J., Zhu, E., Yuan, H., Li, X., & Wang, B. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17702 · Cited by 7
Alteration of m6A-Tagged RNA Profiles in Bone Originated from Periprosthetic Joint Infection
Cai, Y., Chen, X., Huang, C., Chen, Y., Zhang, C., Huang, Z., Zhang, W., Tang, Y., & Fang, X. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082863 · Cited by 7
Jagga, S., Sharma, A. R., Lee, Y. H., Nam, J., & Lee, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.666295 · Cited by 7
Extending the Therapeutic Potential: Romosozumab in Osteoporosis Management
Liu, L. Q., Clifton-Bligh, R. J., Girgis, C. M., & Gild, M. L. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae160 · Cited by 7
Shao, B., Fu, Y., Li, B., Huo, S., Du, J., Zhang, X., Yin, X., Li, Y., Cao, Z., & Song, M. (2024) · Journal of Biomaterials Applications · doi:10.1177/08853282241288323 · Cited by 6
Jalilinejad, N., Baheiraei, N., Azami, M., Ramezani, M., Haramshahi, S. M. A., & Shahrezaee, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-13449-7 · Cited by 6
Bone-Targeting HUVEC-Derived Exosomes Containing miR-503-5p for Osteoporosis Therapy
Huang, H., Feng, X., Feng, Y., Peng, Z., Jiao, C., Chen, H., Fu, C. R., Xu, F., Wang, Y., Su, X., et al. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c05056 · Cited by 6
Emerging roles and biomarker potential of WNT6 in human cancers
Ferreira, J. M., Gonçalves, C. S., & Costa, B. M. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01892-4 · Cited by 6
Liu, J., Dong, S., Lv, J., Li, Y., Sun, B., Guo, Y., Deng, M., Liu, D., & Liu, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212450 · Cited by 7
Li, Q., Wang, X., Cao, L., Chen, L., & Xiang, H. (2024) · Nano Energy · doi:10.1016/j.nanoen.2024.110542 · Cited by 6
Huang, T., Zhou, Y., Yu, Q., Chen, Y., Jiang, Z., Wang, Y., & Yang, G. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35085 · Cited by 6
Zhan, J., Luo, D., Zhao, B., Chen, S., Luan, J., Luo, J., Hou, Y., Hou, Y., Xu, W., Yan, W., et al. (2022) · Aging · doi:10.18632/aging.204382 · Cited by 7
Nimiritsky, P., Novoseletskaya, E. S., Eremichev, R. Y., Alexandrushkina, N. A., Karagyaur, M. N., Vetrovoy, O. V., Basalova, N. A., Khrustaleva, A. M., Tyakht, A., Efimenko, A. Y., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9091192 · Cited by 6
Chang, Y.-L., Lin, G., Lin, S., Huang, R., Kuo, P., Chang, N. N.-S., & Tsai, K. (2025) · World Journal of Clinical Cases · doi:10.12998/wjcc.v13.i23.105762 · Cited by 6
The relationship between OPLL and metabolic disorders
Wang, J., Wei, Z., Kong, Q., Sun, Y., Zhang, Z., Yang, H., & Chen, X. (2025) · Bone Research · doi:10.1038/s41413-025-00446-9 · Cited by 5
Goel, B., Virmani, T., Jain, V., Kumar, G., Sharma, A., & Noman, A. A. (2024) · BioMed Research International · doi:10.1155/2024/5594542 · Cited by 5
Epigenetic Mechanisms in Osteoporosis: Exploring the Power of m6A RNA Modification
Tian, S., Song, Y., Guo, L., Hui, Z., Bai, M., & Miao, M. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70344 · Cited by 5
Costa, R., Bellesso, S., Lualdi, S., Manzoli, R., Pistorio, V., Filocamo, M., & Moro, E. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz293 · Cited by 5
Parra-Torres, A. Y., Enríquez, J., Jiménez-Ortega, R. F., Patiño, N., Castillejos-López, M. D. J., Espíndola, L. M. T., Ramírez-Salazar, E. G., & Velázquez‐Cruz, R. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9384 · Cited by 5
The effect of overexpression of Lrp5 on orthodontic tooth movement
Holland, R., Bain, C., AlRasheed, R., Robling, A. G., & Utreja, A. (2020) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12459 · Cited by 5
Evolutionary conservation and cancer implications of the WNT signaling pathway
Prajapati, D., Ambere, G. D., Mathure, D. M., Karati, D., & Kumar, D. (2025) · Medical Oncology · doi:10.1007/s12032-025-02950-8 · Cited by 5
Comprehensive ceRNA network for MACF1 regulates osteoblast proliferation
Jiang, S., Yin, C., Dang, K., Zhang, W., Huai, Y., & Qian, A. (2022) · BMC Genomics · doi:10.1186/s12864-022-08910-0 · Cited by 4
Hyperin up-regulates miR-7031-5P to promote osteogenic differentiation of MC3T3-E1 cells.
Qian, D., Chen, Y., Qiu, X., Zhu, B., Zhang, L., Yan, Y., & Chen, Y. (2023) · PubMed · doi:10.14670/hh-18-579 · Cited by 4
Shan, L., Liao, X., Yang, X., Zhu, E., Yuan, H., Zhou, J., Li, X., & Wang, B. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101209 · Cited by 4
Kobayashi-Sun, J., Kobayashi, I., Kashima, M., Hirayama, J., Kakikawa, M., Yamada, S., & Suzuki, N. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1340089 · Cited by 4
Yang, S., Chen, M., Yang, D., Deng, F., & Guo, X. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04019-x · Cited by 4
Mohanty, P., Pathi, J., Ranjan, R., Manohar, B., Chatterjee, S., Dash, S., Verma, S., & Alam, M. K. (2022) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v21i2.58085 · Cited by 4
Carroll, M., Alliston, T. N., & Dole, N. S. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00802-w · Cited by 5
Zhang, G., Guan, Q., Zhao, Y., Wang, S., & Li, H. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00811-1 · Cited by 4
Pathak, J. L., Liu, L., Zhu, Y., & Bureik, M. (2020) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2227 · Cited by 4
Radiolabeled Amino Acid Uptake Assays in Primary Bone Cells and Bone Explants
Shen, L., & Karner, C. M. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1028-2_28 · Cited by 4
Self-citationMetabolic Control of Stem Cell Function: Insights into Amino Acid-Driven Mechanisms
Zeng, J., Liu, X., Bi, J., Mo, C., Zhang, H., Chai, Y., Lin, Y., Li, S., Liu, Z., Yao, M., et al. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10967-9 · Cited by 3
The Lymphatic Endothelial Cell Secretome Inhibits Osteoblast Differentiation and Bone Formation
Ernesto Solorzano, Z., Alejo, A. L., Ball, H. C., Robinson, G. T., Solorzano, A. L., Safadi, R., Douglas, J., Kelly, M., & Safadi, F. F. (2023) · Cells · doi:10.3390/cells12202482 · Cited by 3
Shen, C., Oh, H. R., Park, Y. R., Chen, J. H., Park, B., & Park, J. H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31245 · Cited by 3
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
Pan, Z., Ke, C., Zheng, H., Guo, X., Gao, W., Huang, X., Chen, C., Xiong, Y., Zheng, S., Zheng, F., et al. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05859-3 · Cited by 3
The anti-HIV drug abacavir stimulates β-catenin activity in osteoblast lineage cells
Olali, A. Z., Wallace, J., Gonzalez, H., Carpenter, K. A., Patel, N., Winchester, L. C., Podany, A. T., Venkatesh, I., Narasipura, S. D., Al‐Harthi, L., et al. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae037 · Cited by 3
Povoroznyuk, V. V., Dedukh, N. V., Bystrytska, M. А., & Shapovalov, V. S. (2021) · Regulatory Mechanisms in Biosystems · doi:10.15421/022130 · Cited by 4
Meng, F., Zhu, P., Ren, X., Wang, L., Ding, D., Yan, J., Zhang, Y., Yang, S., & Ning, B. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.25842 · Cited by 2
Association of nuclear magnetic resonance-based metabolomics with bone health in the UK Biobank
Cai, J., Huang, H., Hu, H., Qi, L., & Zhou, T. (2025) · Bone · doi:10.1016/j.bone.2025.117460 · Cited by 2
Zhou, C., Wang, K., Dai, C., Chen, J., Jin, X., Yan, Y., Wang, Z., Bai, J., Wu, X., Chen, E., et al. (2026) · Small · doi:10.1002/smll.202509368 · Cited by 2
Ai, C., Wang, L., Ye, X., Ren, X., Song, S., & Li, X. (2026) · Food Research International · doi:10.1016/j.foodres.2026.120150 · Cited by 2
Collagen-based Mineralization of Bones, Teeth, and Other Vertebrate Skeletal Tissues
Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_7 · Cited by 2
Yang, H., Zhang, Y., Zhang, L., Tan, X., Zhi, M., & Wang, C. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13327 · Cited by 2
Wu, Y., Ye, Q., Zhang, L., Cheng, Z., Xiao, K., Zhu, L. K., Yin, Y., & Dong, H. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16172 · Cited by 2
Chen, X., Yang, J., Lv, H., Che, J., Wang, J., Zhang, B., & Shang, P. (2022) · Acta Astronautica · doi:10.1016/j.actaastro.2022.10.020 · Cited by 2
Upmanyu, V., Sapra, L., & Srivastava, R. K. (2022) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91250-1.00005-7 · Cited by 2
Hwang, S. (2018) · Journal of dental hygiene science · doi:10.17135/jdhs.2018.18.2.130 · Cited by 2
Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
Shen, L., & Karner, C. M. (2022) · Journal of Visualized Experiments · doi:10.3791/62995 · Cited by 2
Self-citationHong, G., Xie, W., Ahmed, K., Oborn, C., Soltys, C.-L. M., & Kannus, P. (2024) · The FASEB Journal · doi:10.1096/fj.202400075rr · Cited by 1
Jin, Z., Da, W., Shen, Y. X., Zhao, Y., Xu, H., Wan, H., Wu, X., Gao, X., Li, Y., Shi, Q., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04642-6 · Cited by 1
Li, S., Liang, P., Chen, J., Zhang, Y., Miao, H., & Wang, T. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616070 · Cited by 1
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
Li, J. M., Liu, Y., Li, Y., Hua, Y., Jiang, X., & Zhou, M. (2026) · Open Research (University of Surrey) · doi:10.1002/viw.20250214 · Cited by 2
Li, T., Zeng, X., Yang, S., Bonewald, L. F., & Duan, P. (2026) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400637 · Cited by 1
Zhai, Y., Zhang, J., Yang, J.-X., Wang, T., Gao, J., Wang, W., & Han, W. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109768 · Cited by 1
Wang, Z., & Kamioka, H. (2017) · Journal of Oral Biosciences · doi:10.1016/j.job.2017.11.001 · Cited by 1
Identification of Candidate Genes for Osteoporosis via Integrated Bioinformatics Analysis
Xie, H. X., Cao, L., Ye, L. L., Shan, G., Jiang, C. J., & Song, W. (2021) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.spl.244 · Cited by 1
Avramets, D., Macewicz, L. L., & Piven, O. O. (2023) · Cytology and Genetics · doi:10.3103/s0095452723010024 · Cited by 1
Li, J., Liu, Z., Ren, Y., Shao, H., & Li, S. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03829-y · Cited by 1
Wnt pathway in bone: knowledge structure and hot spots from 1993 to 2022
Liu, T., Zhao, J., Zhang, X., Wang, Y., Wang, W., & Song, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1279423 · Cited by 1
Low Serum Levels of DKK2 Predict Incident Low‐Impact Fracture in Older Women
Rodrigues, A. M., Eusébio, M., Rodrigues, A. B., Caetano‐Lopes, J., Lopes, I., Lopes, A. G. B., Mendes, J. M., Coelho, P. S., Fonseca, J. E., Branco, J., et al. (2019) · JBMR Plus · doi:10.1002/jbm4.10179 · Cited by 1
Wnt signaling and bone cell activity
Williams, B. O., & Johnson, M. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00008-7 · Cited by 1
Xue, D., Bai, J., Xu, J., Hang, K., Kuang, Z., Zhou, C., Li, Y., & Wang, Y. (2020) · doi:10.22541/au.159593960.07846882 · Cited by 1
OSTEOCYTE SIGNALING AND ITS EFFECTS ON THE ACTIVITES OF OSTEOBLASTS AND BREAST CANCER CELLS
Ahandoust, S. (2021) · Purdue University Indianapolis (Indiana University) · doi:10.25394/pgs.14502360
Research Progress of Micro-RNAs in Apoptosis of OsteosarcomaPreprint
Cai, X., Yin, W., Tang, C., Lu, Y., & He, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-922088/v1
Avramets, D., Macewicz, L. L., & Piven, O. O. (2021) · Research Square · doi:10.21203/rs.3.rs-957426/v1
Febriyanti, K. D., Arimbawa, I. M., Yuda, I. M. D., & Margiani, N. N. (2023) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2023.16.1.0305
Hong, G., Tang, L., Zhou, T., Xie, Y., Wang, J., Ge, D., Dong, Q., & Sun, P. (2024) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-024-01516-4
Xu, L., & Zeng, Z. (2024) · Highlights in Science Engineering and Technology · doi:10.54097/ddt58253
Bone cancer: Current status in preclinical research
Ofori, E. K., & Amponsah, S. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-31656-2.00002-5
The evolution of the human diet
Herrera, R. J., & Garcia‐Bertrand, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-28919-4.00013-1
Luyao, L. I., Afang, L. I., Zhu, L., Gan, L., & Zuo, L. (2022) · Figshare · doi:10.6084/m9.figshare.19808969
Additional file 1 of METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
Zhang, Y., Kong, Y., Zhang, W., He, J., Zhang, Z., Cai, Y., Zhao, Y., & Xu, Q. (2024) · Figshare · doi:10.6084/m9.figshare.25059416
Rewiring of RNA–protein coupling in osteocytes in response to hyperglycemic levels of glucosePreprint
Marahleh, A., Rashad, S., Kanao, E., Fan, Z., Ohori, F., & Kitaura, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.25.696466
Nanocarrier armor for siRNA delivery to address fracture risk in osteoporosis
Kumari, A., Kaur, A., & Aggarwal, G. (2026) · AAPS Open · doi:10.1186/s41120-025-00143-1
Goodarzizadeh, N., Shahrjerdi, A., Begum, K., & Amani, R. (2026) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_114_23
Liu, J., Ren, H. W., Zhang, S., & Yu, G. (2026) · Mammalian Genome · doi:10.1007/s00335-026-10208-5
Boyce, B. F., Zuscik, M. J., & Xing, L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13683-2.00003-7
The role of sensory nervous system in the regulation of bone formation, remodeling, and repair
Silva, D. (2017) · theses.fr (ABES) · doi:10.70675/4216a1c9z5df6z4e80z9fcaz0ffed4a18391
Cerqueira, A. C. D. S. G. (2019) · theses.fr (ABES) · doi:10.70675/4853a6f7z81b9z4328zb416z005bc9fd5560
Rhotekin contributes to osteoblast differentiation and bone homeostasis by interacting with Chibby 1
Wang, Y., Shi, L., Yang, Y., Wang, S., Chen, M., Xie, Y., Li, X., & Wang, B. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112542
Rosenberg, A. M., & Jariwala, M. P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-11980-4.00002-7
Wang, L., Liu, Y., Wu, A., Cao, J., Zhao, Y., Wang, Y., Ning, W., Lian, Z., & Yu, K. (2026) · Cells · doi:10.3390/cells15131136
Bai, J., Zhang, Y., Jin, M., Qiao, M., Li, L., An, J., Xinsai, L., Li, S., Yang, Y., Wang, A., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118190
Genome-wide association study reveals loci associated with cytokine levels in chicken serum
Zhang, H., Yang, Y., 霞, 竜., & Yang, X. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107541
Effects of Stromal Cell‐Derived Factor 1 on Osteoblast Activity During Orthodontic Tooth Movement
Hamada, Y., Ishida, Y., Huang, A. C.-S., Hamahara, K., Rintanalert, D., Li, K., Hatano-sato, K., Hosomichi, J., Usumi‐Fujita, R., & Ono, T. (2026) · Clinical and Experimental Dental Research · doi:10.1002/cre2.70425
Li, Y., Chen, Z., Li, G., Ji, S., Yin, R., & Wang, S. (2026) · Comprehensive physiology · doi:10.1002/cph4.70242
Cuproptosis in age-related orthopedic diseases: mechanisms and therapeutic prospects
Hu, L., Xu, D., Zhou, J., Ban, K., Shen, T., Liu, C., & Zhu, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117419
Murray, J. S., Kim, P. S., Lehmann, P., Mitov, M. I., & Deevska, G. M. (2026) · Lipidology · doi:10.3390/lipidology3040026
The Role of Glucose Metabolic Reprogramming in Exercise-Attenuated Osteoporosis: a Narrative Review
Li, C., He, Y., Weng, K., Zhang, S., Weng, X., & Yuan, Y. J. (2026) · Sports Medicine - Open · doi:10.1186/s40798-026-01121-x
Metadata
- Authors
- Karner, C. M., & Long, F.
- Affiliations
- Duke University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Long, Fanxin
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-11-26
- Volume
- 74
- Issue
- 9
- Pages
- 1649-1657
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC5380548
- OpenAlex
- W2552658430
- Cited by
- 295
- References
- 151
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 39 · 2023: 35 · 2022: 39 · 2021: 36 · 2020: 46 · 2019: 27 · 2018: 19 · 2017: 14
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR060456, AR060674)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- Wnt signaling, osteoblasts, cellular metabolism, osteogenic differentiation, bone formation, bone remodeling, aerobic glycolysis, glutamine catabolism, fatty acid oxidation, bioenergetics, osteoporosis, bone anabolic therapy
- MeSH terms
- Animals, Bone and Bones, Humans, Models, Biological, Osteoblasts, Signal Transduction, Wnt Proteins, Wnt Signaling Pathway
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
