Mechanisms of protein toxicity in neurodegenerative diseases

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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The role of autophagy in neurodegenerative disease

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Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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5′ UTR m6A Promotes Cap-Independent Translation

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Transmission and spreading of tauopathy in transgenic mouse brain

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Principles and Properties of Stress Granules

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

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Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Toxic Proteins in Neurodegenerative Disease

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The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

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Selective neuronal vulnerability in Parkinson disease

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Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

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Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

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Review Article: Genetics of Alzheimer Disease

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Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

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Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

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Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

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Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease

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Prion-like spreading of pathological α-synuclein in brain

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Mitochondria and Mitochondrial Cascades in Alzheimer’s disease

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

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Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons

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G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

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Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

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Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

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Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

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Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

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The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

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