Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

Microtubules as a target for anticancer drugs

Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

Axelrod, D., Koppel, D. E., Schlessinger, J., Elson, E. L., & Webb, W. W. (1976) · Biophysical Journal · doi:10.1016/s0006-3495(76)85755-4 · Cited by 2,717 · see citing works

Stages in the development of Parkinson’s disease-related pathology

Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563 · see citing works

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Li, J.-Y., Englund, E., Holton, J. L., Soulet, D., Hagell, P., Lees, A. J., Lashley, T., Quinn, N. P., Rehncrona, S., Björklund, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1746 · Cited by 1,845 · see citing works

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine · doi:10.1038/nm1747 · Cited by 1,722 · see citing works

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683 · see citing works

In vivo demonstration that α-synuclein oligomers are toxic

Winner, B., Jappelli, R., Maji, S. K., Desplats, P., Boyer, L. F., Aigner, S., Hetzer, C., Loher, T., Vilar, M., Campioni, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100976108 · Cited by 1,494 · see citing works

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

Desplats, P., Lee, H.-J., Bae, E.-J., Patrick, C., Rockenstein, E., Crews, L., Spencer, B., Masliah, E., & Lee, S.-J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903691106 · Cited by 1,485 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,087 · see citing works

Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

Luk, K. C., Song, C., O’Brien, P., Stieber, A., Branch, J. R., Brunden, K. R., Trojanowski, J. Q., & Lee, V. M. ‐. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908005106 · Cited by 957 · see citing works

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

Hansen, C., Angot, E., Bergström, A.-L., Steiner, J. A., Pieri, L., Paul, G., Outeiro, T. F., Melki, R., Kallunki, P., Fog, K., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43366 · Cited by 842 · see citing works

Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding

Danzer, K. M., Haasen, D., Karow, A. R., Moussaud, S., Habeck, M., Giese, A., Kretzschmar, H. A., Hengerer, B., & Kostka, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2617-07.2007 · Cited by 798 · see citing works

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

Ellenberg, J., Siggia, E. D., Moreira, J. E., Smith, C. L., Presley, J. F., Worman, H. J., & Lippincott‐Schwartz, J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1193 · Cited by 770 · see citing works

Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

Recasens, A., Dehay, B., Bové, J., Carballo‐Carbajal, I., Doveró, S., Pérez‐Villalba, A., Fernagut, P., Blesa, J., Parent, A., Perier, C., et al. (2013) · Annals of Neurology · doi:10.1002/ana.24066 · Cited by 629 · see citing works

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

Aguzzi, A., & Rajendran, L. (2009) · Neuron · doi:10.1016/j.neuron.2009.12.016 · Cited by 447 · see citing works

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

Pan-Montojo, F., Schwarz, M., Winkler, C., Arnhold, M., O'Sullivan, G. A., Pal, A., Said, J., Marsico, G., Verbavatz, J.-M., Rodrigo-Angulo, M., et al. (2012) · Scientific Reports · doi:10.1038/srep00898 · Cited by 405 · see citing works

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Outeiro, T. F., Putcha, P., Tetzlaff, J. E., Spoelgen, R., Koker, M., Carvalho, F. L. F., Hyman, B. T., & McLean, P. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001867 · Cited by 400 · see citing works

Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport

Freundt, E. C., Maynard, N., Clancy, E. K., Roy, S., Bousset, L., Sourigues, Y., Covert, M. W., Melki, R., Kirkegaard, K., & Brahic, M. (2012) · Annals of Neurology · doi:10.1002/ana.23747 · Cited by 370 · see citing works

Measurement of Dynamic Protein Binding to Chromatin In Vivo, Using Photobleaching Microscopy

Phair, R. D., Gorski, S. A., & Misteli, T. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)75025-3 · Cited by 360 · see citing works

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

Parkkinen, L., Pirttilä, T., & Alafuzoff, I. I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0346-6 · Cited by 357 · see citing works

Seeded Aggregation and Toxicity of α-Synuclein and Tau

Nonaka, T., Watanabe, S., Iwatsubo, T., & Hasegawa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148460 · Cited by 330 · see citing works

α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia

Parkkinen, L., Kauppinen, T., Pirttilä, T., Autere, J. M., & Alafuzoff, I. I. (2004) · Annals of Neurology · doi:10.1002/ana.20321 · Cited by 315 · see citing works

Parkinson's Disease: The Dual Hit Theory Revisited

Hawkes, C. H., Del Tredici, K., & Braak, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04365.x · Cited by 303 · see citing works

Axonal transport of the cytoplasmic matrix.

Lasek, R. J., Garner, J. A., & Brady, S. T. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.1.212s · Cited by 299 · see citing works

Neuroanatomy and Pathology of Sporadic Parkinson's Disease

Braak, H., & Tredici, K. D. (2008) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-540-79850-7 · Cited by 297 · see citing works

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

Kordower, J. H., Chu, Y., Hauser, R. A., Olanow, C. W., & Freeman, T. B. (2008) · Movement Disorders · doi:10.1002/mds.22369 · Cited by 286 · see citing works

Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

Tan, T. Z., Miow, Q. H., Huang, R. Y., Wong, M. K., Ye, J., Lau, J. A., Wu, M., Hadi, L. A., Soong, R., Choolani, M. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201823 · Cited by 281 · see citing works

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

Rey, N. L., Petit, G. H., Bousset, L., Melki, R., & Brundin, P. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1160-3 · Cited by 267 · see citing works

The second brain and Parkinson’s disease

Lebouvier, T., Chaumette, T., Paillusson, S., Duyckaerts, C. J., Varannes, S. B. D., Neunlist, M., & Derkinderen, P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06873.x · Cited by 258 · see citing works

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

Ulusoy, A., Rusconi, R., Pérez‐Revuelta, B. I., Musgrove, R. E., Helwig, M., Winzen‐Reichert, B., & Monte, D. A. D. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302475 · Cited by 250 · see citing works

A critical reappraisal of current staging of Lewy-related pathology in human brain

Jellinger, K. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0406-y · Cited by 229 · see citing works

Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon

Ahmad, F. J., Echeverri, C. J., Vallee, R. B., & Baas, P. W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.2.391 · Cited by 216 · see citing works

Characterization of Lewy body pathology in 12‐ and 16‐year‐old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

Li, J., Englund, E. M., Widner, H., Rehncrona, S., Björklund, A., Lindvall, O., & Brundin, P. (2010) · Movement Disorders · doi:10.1002/mds.23012 · Cited by 214 · see citing works

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

Phillips, R. J., Walter, G. C., Wilder, S. L., Baronowsky, E. A., & Powley, T. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.074 · Cited by 189 · see citing works

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

Prots, I., Veber, V., Brey, S., Campioni, S., Buder, K., Riek, R., Böhm, K. J., & Winner, B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.451815 · Cited by 140 · see citing works

Axonal transport of actin: Slow component b is the principal source of actin for the axon

Black, M. M., & Lasek, R. J. (1979) · Brain Research · doi:10.1016/0006-8993(79)91045-x · Cited by 138 · see citing works

Signs of Degeneration in 12–22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson's Disease

Kurowska, Z., Englund, E. M., Widner, H., Lindvall, O., Li, J., & Brundin, P. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11004 · Cited by 120 · see citing works

Mechanistic Logic Underlying the Axonal Transport of Cytosolic Proteins

Scott, D. A., Das, U., Tang, Y., & Roy, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.022 · Cited by 119 · see citing works

Measuring Protein Mobility by Photobleaching GFP Chimeras in Living Cells

Snapp, E. L., Altan, N., & Lippincott‐Schwartz, J. (2003) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb2101s19 · Cited by 117 · see citing works

Rapid and Intermittent Cotransport of Slow Component-b Proteins

Roy, S., Winton, M. J., Black, M. M., Trojanowski, J. Q., & Lee, V. M. ‐. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4999-06.2007 · Cited by 105 · see citing works

Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ‘permissive templating’ as a general mechanism underlying neurodegeneration

Hardy, J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330578 · Cited by 105 · see citing works

Axonal transport of synucleins is mediated by all rate components

Jensen, P. H., Li, J., Dahlström, A. B., & Dotti, C. G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00754.x · Cited by 102 · see citing works

PA700, the regulatory complex of the 26S proteasome, interferes with α‐synuclein assembly

Ghee, M., Melki, R., Michot, N., & Mallet, J. J. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04776.x · Cited by 96 · see citing works

Olfactory pathogenesis of idiopathic Parkinson disease revisited

Lerner, A., & Bagic, A. I. (2008) · Movement Disorders · doi:10.1002/mds.22066 · Cited by 73 · see citing works

Kinesin, dynein and neurofilament transport

Shea, T. B., & Flanagan, L. A. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01919-6 · Cited by 67 · see citing works

Cytoskeletal Requirements in Axonal Transport of Slow Component-b

Roy, S., Winton, M. J., Black, M. M., Trojanowski, J. Q., & Lee, V. M. ‐. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0309-08.2008 · Cited by 52 · see citing works

Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

Lee, H.-J., Suk, J., Lee, K.-W., Park, S.-H., Blumbergs, P. C., Gai, W., & Lee, S. (2011) · Experimental Neurobiology · doi:10.5607/en.2011.20.4.181 · Cited by 42 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Kim, S., Kwon, S.-H., Kam, T.-I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.035 · Cited by 1,397 · see citing works

The gut microbiome in neurological disorders

Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works

Colonic bacterial composition in Parkinson's disease

Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders · doi:10.1002/mds.26307 · Cited by 1,281 · see citing works

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Peelaerts, W., Bousset, L., Van der Perren, A., Moskalyuk, A., Pulizzi, R., Giugliano, M., Van den Haute, C., Melki, R., & Baekelandt, V. (2015) · Nature · doi:10.1038/nature14547 · Cited by 1,130 · see citing works

Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

Goedert, M. (2015) · Science · doi:10.1126/science.1255555 · Cited by 977 · see citing works

The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders

Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works

Vagotomy and subsequent risk of <scp>P</scp> arkinson's disease

Svensson, E., Horváth‐Puhó, E., Thomsen, R. W., Djurhuus, J. C., Pedersen, L., Borghammer, P., & Sørensen, H. T. (2015) · Annals of Neurology · doi:10.1002/ana.24448 · Cited by 806 · see citing works

Spreading of pathology in neurodegenerative diseases: a focus on human studies

Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706 · see citing works

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

Parker, A., Fonseca, S., & Carding, S. R. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1638722 · Cited by 722 · see citing works

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598 · see citing works

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works

Brain-Gut-Microbiota Axis in Parkinson’s Disease

Mulak, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10609 · Cited by 583 · see citing works

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1(-/-) mice

Matheoud, D., Cannon, T., Voisin, A., Penttinen, A.-M., Ramet, L., Fahmy, A. M., Ducrot, C., Laplante, A., Bourque, M.-J., Zhu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1405-y · Cited by 496 · see citing works

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Ghaisas, S., Maher, J. M., & Kanthasamy, A. G. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.012 · Cited by 519 · see citing works

Analysis of Gut Microbiota in Patients with Parkinson’s Disease

Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., et al. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3700-7 · Cited by 487 · see citing works

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works

Microbiota and the social brain

Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445 · see citing works

Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study

Liu, B., Fang, F., Pedersen, N. L., Tillander, A., Ludvigsson, J. F., Ekbom, A., Svenningsson, P., Chen, H., & Wirdefeldt, K. (2017) · Neurology · doi:10.1212/wnl.0000000000003961 · Cited by 447 · see citing works

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Sampson, T. R., Challis, C., Jain, N., Moiseyenko, A., Ladinsky, M. S., Shastri, G. G., Thron, T., Needham, B. D., Horvath, I., Debelius, J. W., et al. (2020) · eLife · doi:10.7554/elife.53111 · Cited by 439 · see citing works

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

Schmidt, H. B., & Görlich, D. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.11.001 · Cited by 413 · see citing works

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

Qian, Y., Yang, X., Xu, S., Wu, C., Song, Y., Qin, N., Chen, S.-D., & Xiao, Q. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.016 · Cited by 409 · see citing works

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Challis, C., Hori, A., Sampson, T. R., Yoo, B. B., Challis, R. C., Hamilton, A. M., Mazmanian, S. K., Volpicelli-Daley, L. A., & Gradinaru, V. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0589-7 · Cited by 405 · see citing works

The progress of gut microbiome research related to brain disorders

Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works

Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis

Borghammer, P., & Van Den Berge, N. (2019) · Journal of Parkinson’s Disease · doi:10.3233/jpd-191721 · Cited by 419 · see citing works

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes

Abounit, S., Bousset, L., Loria, F., Zhu, S., de Chaumont, F., Pieri, L., Olivo‐Marin, J., Melki, R., & Zurzolo, C. (2016) · The EMBO Journal · doi:10.15252/embj.201593411 · Cited by 414 · see citing works

Fecal Microbiota Transplantation in Neurological Disorders

Vendrik, K. E. W., Ooijevaar, R. E., de Jong, P. R. C., Laman, J. D., van Oosten, B. W., van Hilten, J. J., Ducarmon, Q. R., Keller, J. J., Kuijper, E. J., & Contarino, M. F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00098 · Cited by 413 · see citing works

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., et al. (2019) · Movement Disorders · doi:10.1002/mds.27581 · Cited by 393 · see citing works

Review: Sporadic Parkinson's disease: development and distribution ofα‐synuclein pathology

Tredici, K. D., & Braak, H. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12298 · Cited by 396 · see citing works

Exploring Braak’s hypothesis of Parkinson’s disease

Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00037 · Cited by 395 · see citing works

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392 · see citing works

Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT

Barichella, M., Pacchetti, C., Bolliri, C., Cassani, E., Iorio, L., Pusani, C., Pinelli, G., Privitera, G., Cesari, I., Faierman, S. A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003127 · Cited by 390 · see citing works

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

Ingelsson, M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00408 · Cited by 374 · see citing works

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372 · see citing works

Alzheimer’s disease and gut microbiota

Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371 · see citing works

Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment

Chen, Z., Li, G., & Liu, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104700 · Cited by 364 · see citing works

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

Subramaniam, S., & Federoff, H. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00176 · Cited by 343 · see citing works

Neuropathology and molecular diagnosis of Synucleinopathies

Koga, S., Sekiya, H., Kondru, N. C., Ross, O. A., & Dickson, D. W. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00501-z · Cited by 345 · see citing works

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Uemura, N., Yagi, H., Uemura, M. T., Hatanaka, Y., Yamakado, H., & Takahashi, R. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0257-5 · Cited by 328 · see citing works

Recent developments in understanding the role of the gut microbiota in brain health and disease

Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

Van Den Berge, N., Ferreira, N., Gram, H., Mikkelsen, T. W., Alstrup, A. K. O., Casadei, N., Tsung-Pin, P., Riess, O., Nyengaard, J. R., Tamgüney, G., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02040-w · Cited by 300 · see citing works

Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases

Gerhardt, S., & Mohajeri, M. H. (2018) · Nutrients · doi:10.3390/nu10060708 · Cited by 298 · see citing works

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

Walsh, D. M., & Selkoe, D. J. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.13 · Cited by 290 · see citing works

α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies

Henderson, M. X., Trojanowski, J. Q., & Lee, V. M. ‐. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134316 · Cited by 291 · see citing works

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Matsumoto, J., Stewart, T., Sheng, L., Li, N., Bullock, K. M., Song, N., Shi, M. Y., Banks, W. A., & Zhang, J. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0470-4 · Cited by 294 · see citing works

Human gut microbiota: the links with dementia development

Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 283 · see citing works

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

Stolzenberg, E. D., Berry, D. L., Yang, D., Lee, E. Y., Kroemer, A., Kaufman, S. S., Wong, G. C. L., Oppenheim, J. J., Sen, S., Fishbein, T., et al. (2017) · Journal of Innate Immunity · doi:10.1159/000477990 · Cited by 285 · see citing works

The vermiform appendix impacts the risk of developing Parkinson’s disease

Killinger, B. A., Madaj, Z., Sikora, J. W., Rey, N. L., Haas, A. J., Vepa, Y., Lindqvist, D., Chen, H., Thomas, P. M., Brundin, P., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar5280 · Cited by 274 · see citing works

The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System

Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 278 · see citing works

Prying into the Prion Hypothesis for Parkinson's Disease

Brundin, P., & Melki, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1788-16.2017 · Cited by 274 · see citing works

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

Spielman, L. J., Gibson, D. L., & Klegeris, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.005 · Cited by 266 · see citing works

Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases

Han, Y., Wang, B., Gao, H., He, C., Hua, R., Liang, C., Zhang, S., Wang, Y., Xin, S., & Xu, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s384949 · Cited by 265 · see citing works

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

Borghammer, P. (2021) · Journal of Parkinson's Disease · doi:10.3233/jpd-202481 · Cited by 259 · see citing works

Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

Palma, J., & Kaufmann, H. (2018) · Movement Disorders · doi:10.1002/mds.27344 · Cited by 246 · see citing works

The Role of α-Synuclein Oligomers in Parkinson’s Disease

Du, X.-Y., Xie, X.-X., & Liu, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228645 · Cited by 242 · see citing works

Network structure of brain atrophy in de novo Parkinson's disease

Zeighami, Y., Ulla, M., Iturria‐Medina, Y., Dadar, M., Zhang, Y., Larcher, K. M.-H., Fonov, V., Evans, A. C., Collins, D. L., & Dagher, A. (2015) · eLife · doi:10.7554/elife.08440 · Cited by 232 · see citing works

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function

Schneider, S., Wright, C. M., & Heuckeroth, R. O. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121515 · Cited by 239 · see citing works

Animal models of α-synucleinopathy for Parkinson disease drug development

Koprich, J. B., Kalia, L. V., & Brotchie, J. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.75 · Cited by 235 · see citing works

α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease

Chandra, R., Hiniker, A., Kuo, Y.-M., Nussbaum, R. L., & Liddle, R. A. (2017) · JCI Insight · doi:10.1172/jci.insight.92295 · Cited by 236 · see citing works

The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Vegeto, E., Villa, A. M., Torre, S. D., Crippa, V., Rusmini, P., Cristofani, R., Galbiati, M., Maggi, A. C., & Poletti, A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz005 · Cited by 231 · see citing works

<i>APOE</i> genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

Tran, T. T. T., Corsini, S., Kellingray, L., Hegarty, C., Le Gall, G., Narbad, A., Müller, M., Tejera, N., O'Toole, P. W., Minihane, A.-M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900071r · Cited by 233 · see citing works

The Microbiome as a Modifier of Neurodegenerative Disease Risk

Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works

Parkinson’s disease from the gut

Liddle, R. A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.01.010 · Cited by 219 · see citing works

Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Murros, K. E., Huynh, V. A., Takala, T. M., & Saris, P. E. J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.652617 · Cited by 218 · see citing works

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Borghammer, P., Horsager, J., Andersen, K. B., Berge, N. V. D., Raunio, A., Murayama, S., Parkkinen, L., & Myllykangas, L. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105557 · Cited by 216 · see citing works

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Herath, M., Hosie, S., Bornstein, J. C., Franks, A. E., & Hill‐Yardin, E. L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00248 · Cited by 214 · see citing works

α‐synuclein assemblies sequester neuronal α3‐Na+/K+‐ATPase and impair Na+ gradient

Shrivastava, A. N., Redeker, V., Fritz, N., Pieri, L., Almeida, L. G., Spolidoro, M., Liebmann, T., Bousset, L., Renner, M. L., Léna, C., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591397 · Cited by 206 · see citing works

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

Arotcarena, M.-L., Dovero, S., Prigent, A., Bourdenx, M., Camus, S., Porras, G., Thiolat, M.-L., Tasselli, M., Aubert, P., Kruse, N., et al. (2020) · Brain · doi:10.1093/brain/awaa096 · Cited by 210 · see citing works

Review: Parkinson's disease: from synaptic loss to connectome dysfunction

Bellucci, A., Mercuri, N. B., Venneri, A., Faustini, G., Longhena, F., Pizzi, M., Missale, C., & Spano, P. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12297 · Cited by 203 · see citing works

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

Chen, C., Ahn, E. H., Kang, S. S., Liu, X., Alam, A., & Ye, K. (2020) · Science Advances · doi:10.1126/sciadv.aba0466 · Cited by 205 · see citing works

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism &amp; Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works

Organ-specific protection mediated by cooperation between vascular and epithelial barriers

Spadoni, I., Fornasa, G., & Rescigno, M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.100 · Cited by 203 · see citing works

The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies

Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Manfredsson, F. P., Luk, K. C., Benskey, M. J., Gezer, A., Garcia, J., Kuhn, N. C., Sandoval, I. M., Patterson, J. R., O'Mara, A., Yonkers, R., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.008 · Cited by 199 · see citing works

Gut–brain axis and the spread of α‐synuclein pathology: Vagal highway or dead end?

Breen, D. P., Halliday, G. M., & Lang, A. E. (2019) · Movement Disorders · doi:10.1002/mds.27556 · Cited by 193 · see citing works

Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease

Troncoso-Escudero, P., Parra, A., Nassif, M., & Vidal, R. L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00860 · Cited by 191 · see citing works

Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities

Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 197 · see citing works

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

Musgrove, R. E., Helwig, M., Bae, E.-J., Aboutalebi, H., Lee, S., Ulusoy, A., & Monte, D. A. D. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127330 · Cited by 189 · see citing works

Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management

Warnecke, T., Schäfer, K., Claus, I., Tredici, K. D., & Jost, W. H. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00295-x · Cited by 189 · see citing works

Altered gut microbiome in parkinson’s disease and the influence of lipopolysaccharide in a human α-synuclein over-expressing mouse model

Gorecki, A. M., Preskey, L., Bakeberg, M. C., Kenna, J. E., Gildenhuys, C., MacDougall, G., Dunlop, S. A., Mastaglia, F. L., Akkari, P. A., Koengten, F., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00839 · Cited by 184 · see citing works

The concept of alpha-synuclein as a prion-like protein: ten years after

Steiner, J. A., Quansah, E., & Brundin, P. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2814-1 · Cited by 183 · see citing works

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Guix, F. X., Corbett, G. T., Cha, D., Mustapić, M., Liu, W., Mengel, D., Chen, Z., Aïkawa, E., Young‐Pearse, T. L., Kapogiannis, D., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030663 · Cited by 182 · see citing works

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance

Travagli, R. A., Browning, K. N., & Camilleri, M. (2020) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-020-0339-z · Cited by 181 · see citing works

Alpha-synuclein spreading in Parkinson’s disease

Recasens, A., & Dehay, B. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00159 · Cited by 179 · see citing works

Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation

Kuai, X.-Y., Yao, X.-H., Xu, L.-J., Zhou, Y.-Q., Zhang, L.-P., Liu, Y., Pei, S.-F., & Zhou, C.-L. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01589-0 · Cited by 179 · see citing works

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

Ulusoy, A., Phillips, R. J., Helwig, M., Klinkenberg, M., Powley, T. L., & Di Monte, D. A. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1661-y · Cited by 179 · see citing works

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works

Neuropathobiology of non-motor symptoms in Parkinson disease

Jellinger, K. A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1405-5 · Cited by 177 · see citing works

Does Parkinson’s disease start in the gut?

Lionnet, A., Leclair‐Visonneau, L., Neunlist, M., Murayama, S., Takao, M., Adler, C. H., Derkinderen, P., & Beach, T. G. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1777-8 · Cited by 176 · see citing works

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Harischandra, D. S., Rokad, D., Neal, M. P., Ghaisas, S., Manne, S., Sarkar, S., Panicker, N., Zenitsky, G. D., Jin, H., Lewis, M. M., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aau4543 · Cited by 170 · see citing works

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

Sánchez-Guajardo, V., Tentillier, N., & Romero‐Ramos, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.008 · Cited by 171 · see citing works

Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

Choi, J. G., Kim, N., Ju, I. G., Eo, H., Lim, S.-M., Jang, S.-E., Kim, D.-H., & Oh, M. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19646-x · Cited by 170 · see citing works

Synaptic failure and α‐synuclein

Calò, L., Węgrzynowicz, M., Santivañez‐Perez, J., & Spillantini, M. G. (2016) · Movement Disorders · doi:10.1002/mds.26479 · Cited by 170 · see citing works

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162 · see citing works

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

Visanji, N. P., Brotchie, J. M., Kalia, L. V., Koprich, J. B., Tandon, A., Watts, J. C., & Lang, A. E. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.003 · Cited by 161 · see citing works

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Uemura, N., Yagi, H., Uemura, M. T., Hatanaka, Y., Yamakado, H., & Takahashi, R. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0257-5 · Cited by 328 · see citing works

A new Perspective on Parkinson's disease: exploring the involvement of intestine and vagus lysates in α-synucleinopathy propagation

Ullah, R., Dawson, V. L., & Dawson, T. M. (2023) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2023.07 · Cited by 4 · see citing works

Inoculation of alpha-synuclein fibrils into the mouse gastrointestinal tract induces Lewy-like pathology in the brain via the vagal nerve

Uemura, N., Uemura, M. T., Takahashi, R., & Yagi, H. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.08.244

The Gut–Brain Axis Based on α-Synuclein Propagation—Clinical, Neuropathological, and Experimental Evidence

Takahashi, R., Yamakado, H., Uemura, N., Taguchi, T., & Ueda, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093994 · Cited by 14 · see citing works

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Kim, S., Kwon, S.-H., Kam, T.-I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.035 · Cited by 1,397 · see citing works