Daddy Issues: Paternal Effects on Phenotype

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429 · see citing works

The thrifty phenotype hypothesis

Hales, C. N., & Barker, D. J. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.5 · Cited by 2,749 · see citing works

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563 · see citing works

Environmental epigenomics and disease susceptibility

Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works

Small silencing RNAs: an expanding universe

Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,314 · see citing works

Transposable elements and the epigenetic regulation of the genome

Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044 · see citing works

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka, E., & Raz, G. (2009) · The Quarterly Review of Biology · doi:10.1086/598822 · Cited by 1,659 · see citing works

Epigenetic inheritance at the agouti locus in the mouse

Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476 · see citing works

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327 · see citing works

Distinctive chromatin in human sperm packages genes for embryo development

Hammoud, S. S., Nix, D. A., Zhang, H., Purwar, J., Carrell, D. T., & Cairns, B. R. (2009) · Nature · doi:10.1038/nature08162 · Cited by 1,326 · see citing works

Epigenome-wide association studies for common human diseases

Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3000 · Cited by 1,272 · see citing works

Epigenetic Reprogramming in Plant and Animal Development

Feng, S., Jacobsen, S. E., & Reik, W. (2010) · Science · doi:10.1126/science.1190614 · Cited by 1,171 · see citing works

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

Carone, B. R., Fauquier, L., Habib, N., Shea, J. M., Hart, C. E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.12.008 · Cited by 1,157 · see citing works

Sex-specific, male-line transgenerational responses in humans

The ALSPAC Study Team, Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., & Golding, J. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201538 · Cited by 1,150 · see citing works

Insect Seminal Fluid Proteins: Identification and Function

Avila, F. W., Sirot, L. K., LaFlamme, B. A., Rubinstein, C. D., & Wolfner, M. F. (2010) · Annual Review of Entomology · doi:10.1146/annurev-ento-120709-144823 · Cited by 920 · see citing works

Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period

Kaati, G., Bygren, L., & Edvinsson, S. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200859 · Cited by 896 · see citing works

Gardening the genome: DNA methylation in Arabidopsis thaliana

Chan, S. W.-L., Henderson, I. R., & Jacobsen, S. E. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1601 · Cited by 892 · see citing works

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

Brykczynska, U., Hisano, M., Erkek, S., Ramos, L., Oakeley, E. J., Roloff, T. C., Beisel, C., Schübeler, D., Stadler, M. B., & Peters, A. H. F. M. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1821 · Cited by 680 · see citing works

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

Wu, H., & Zhang, Y. (2011) · Genes & Development · doi:10.17615/800j-yk16 · Cited by 665 · see citing works

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works

Transgenerational Epigenetic Effects

Youngson, N. A., & Whitelaw, E. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164445 · Cited by 575 · see citing works

Mammalian genomic imprinting

Bartolomei, M. S., & Ferguson-Smith, A. C. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002592 · Cited by 518 · see citing works

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

Nakamura, T., Liu, Y.-J., Nakashima, H., Umehara, H., Inoue, K., Matoba, S., Tachibana, M., Ogura, A., Shinkai, Y., & Nakano, T. (2012) · Nature · doi:10.1038/nature11093 · Cited by 466 · see citing works

Timescales of Genetic and Epigenetic Inheritance

Rando, O. J., & Verstrepen, K. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.023 · Cited by 461 · see citing works

Genetic Requirements for Inheritance of RNAi in C. elegans

Grishok, A., Tabara, H., & Mello, C. C. (2000) · Science · doi:10.1126/science.287.5462.2494 · Cited by 450 · see citing works

Epigenetics and the origins of paternal effects

Curley, J. P., Rahia Mashoodh, A., & Champagne, F. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.018 · Cited by 415 · see citing works

Epigenetic programming of stress responses through variations in maternal care

FISH, E. W., SHAHROKH, D., BAGOT, R., CALDJI, C., BREDY, T., SZYF, M., & MEANEY, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.011 · Cited by 361 · see citing works

Paternal Transmission of Stress-Induced Pathologies

Dietz, D. M., LaPlant, Q., Watts, E. L., Hodes, G. E., Russo, S. J., Feng, J., Oosting, R. S., Vialou, V., & Nestler, E. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.005 · Cited by 346 · see citing works

A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory

Katz, D. J., Edwards, T. M., Reinke, V., & Kelly, W. G. (2009) · Cell · doi:10.1016/j.cell.2009.02.015 · Cited by 336 · see citing works

Animal traditions: behavioural inheritance in evolution

(2001) · Choice Reviews Online · doi:10.5860/choice.39-0310 · Cited by 334 · see citing works

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

Seong, K.-H., Li, D., Shimizu, H., Nakamura, R., & Ishii, S. (2011) · Cell · doi:10.1016/j.cell.2011.05.029 · Cited by 322 · see citing works

Transgenerational epigenetic inheritance in plants

Hauser, M., Aufsatz, W., Jonak, C., & Luschnig, C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.03.007 · Cited by 304 · see citing works

RNAi-dependent formation of heterochromatin and its diverse functions

Grewal, S. I. S. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.003 · Cited by 236 · see citing works

Epigenetic control of an endogenous gene family is revealed by a novel blue fluorescent mutant of arabidopsis

Bender, J., & Fink, G. R. (1995) · Cell · doi:10.1016/0092-8674(95)90185-x · Cited by 235 · see citing works

Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring: Evidence from Animal Models

Li, M.-L., Sloboda, D., & Vickers, M. (2011) · International Journal of Experimental Diabetes Research · doi:10.1155/2011/592408 · Cited by 211 · see citing works

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA inCaenorhabditis elegans

Alcazar, R., Lin, R., & Fire, A. Z. (2008) · Genetics · doi:10.1534/genetics.108.089433 · Cited by 195 · see citing works

Preconceptional fasting of fathers alters serum glucose in offspring of mice

Anderson, L. M., Riffle, L. A., Wilson, R., Travlos, G. S., Lubomirski, M. S., & Alvord, W. G. (2006) · Nutrition · doi:10.1016/j.nut.2005.09.006 · Cited by 177 · see citing works

Assisted reproduction treatment and epigenetic inheritance

van Montfoort, A. P. A., Hanssen, L. L. P., Sutter, P. D., Viville, S., Geraedts, J. P. M., & de Boer, P. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr047 · Cited by 175 · see citing works

Modifiers of epigenetic reprogramming show paternal effects in the mouse

Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., et al. (2007) · Nature Genetics · doi:10.1038/ng2031 · Cited by 166 · see citing works

Small RNAs in early mammalian development: from gametes to gastrulation

Suh, N., & Blelloch, R. H. (2011) · Development · doi:10.1242/dev.056234 · Cited by 166 · see citing works

Germline histone dynamics and epigenetics

Ooi, S. L., & Henikoff, S. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.015 · Cited by 141 · see citing works

Paramutation in maize: RNA mediated trans-generational gene silencing

Arteaga-Vazquez, M. A., & Chandler, V. L. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.01.008 · Cited by 134 · see citing works

An Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming

Radford, E. J., ISGANAITIS, E. M., Jiménez‐Chillarón, J. C., Schroeder, J., Molla, M. N., Andrews, S., Didier, N., Charalambous, M., McEwen, K. R., Marazzi, G., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002605 · Cited by 116 · see citing works

Environmental and epigenetic effects upon preimplantation embryo metabolism and development

Chason, R. J., Csokmay, J. M., Segars, J. H., DeCherney, A. H., & Armant, D. R. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.05.005 · Cited by 115 · see citing works

Genetic Incompatibility Drives Sex Allocation and Maternal Investment in a Polymorphic Finch

Pryke, S. R., & Griffith, S. C. (2009) · Science · doi:10.1126/science.1168928 · Cited by 91 · see citing works

Isolation and Proteomic Characterization of the Mouse Sperm Acrosomal Matrix

Guyonnet, B., Zabet‐Moghaddam, M., SanFrancisco, S., & Cornwall, G. A. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.020339 · Cited by 60 · see citing works

Transgenerational Genetic Effects of the Paternal Y Chromosome on Daughters‘ Phenotypes

Nelson, V. R., Spiezio, S. H., & Nadeau, J. H. (2010) · Epigenomics · doi:10.2217/epi.10.26 · Cited by 59 · see citing works

Sociology and Biology: Can’t We Just Be Friends?Animal Traditions: Behavioural Inheritance in Evolution. By Eytan Avital and Eva Jablonka. Cambridge: Cambridge University Press, 2000. 432p.+xiv.

Heuveline, P. (2004) · American Journal of Sociology · doi:10.1086/421567 · Cited by 47 · see citing works

Oligomerization and Transglutaminase Cross-linking of the Cystatin CRES in the Mouse Epididymal Lumen

von Horsten, H. H., Johnson, S., SanFrancisco, S., Hastert, M. C., Whelly, S., & Cornwall, G. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703956200 · Cited by 26 · see citing works

Hemochromatosis: a genetic defect in iron metabolism

Jazwinska, E. C. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 15 · see citing works

The making of an organ

Rassoulzadegan, M., & Cuzin, F. (2010) · Organogenesis · doi:10.4161/org.6.1.11094 · Cited by 10 · see citing works

Transgenerational epigenetic inheritance: myths and mechanisms

Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864 · see citing works

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

Chen, Q., Yan, M., Cao, Z., Li, X., Zhang, Y., Shi, J., Feng, G.-H., Peng, H., Zhang, X., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aad7977 · Cited by 1,470 · see citing works

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., et al. (2016) · Science · doi:10.1126/science.aad6780 · Cited by 1,275 · see citing works

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-13.2013 · Cited by 814 · see citing works

Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

Yehuda, R., & Lehrner, A. (2018) · World Psychiatry · doi:10.1002/wps.20568 · Cited by 730 · see citing works

Intergenerational and transgenerational epigenetic inheritance in animals

Perez, M. F., & Lehner, B. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0242-9 · Cited by 528 · see citing works

Sex-Specific Placental Responses in Fetal Development

Rosenfeld, C. S. (2015) · Endocrinology · doi:10.1210/en.2015-1227 · Cited by 473 · see citing works

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406 · see citing works

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.023 · Cited by 429 · see citing works

High-Fat Diet Reprograms the Epigenome of Rat Spermatozoa and Transgenerationally Affects Metabolism of the Offspring

de Castro Barbosa, T., Ingerslev, L. R., Alm, P. S., Versteyhe, S., Massart, J., Rasmussen, M., Donkin, I., Sjögren, R., Mudry, J. M., Vetterli, L., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.002 · Cited by 417 · see citing works

DNA methylation contributes to natural human variation

Heyn, H., Moran, S., Hernando-Herraez, I., Sayols, S., Gomez, A., Sandoval, J., Monk, D., Hata, K., Marques-Bonet, T., Wang, L., et al. (2013) · Genome Research · doi:10.1101/gr.154187.112 · Cited by 408 · see citing works

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring

Bromfield, J. J., Schjenken, J. E., Chin, P. Y., Care, A. S., Jasper, M. J., & Robertson, S. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305609111 · Cited by 374 · see citing works

The presence, role and clinical use of spermatozoal RNAs

Jodar, M., Selvaraju, S., Sendler, E. D., Diamond, M. P., Krawetz, S. A., & for the Reproductive Medicine Network (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt031 · Cited by 371 · see citing works

Transgenerational inheritance: Models and mechanisms of non–DNA sequence–based inheritance

Miska, E. A., & Ferguson-Smith, A. C. (2016) · Science · doi:10.1126/science.aaf4945 · Cited by 367 · see citing works

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

Soubry, A., Hoyo, C., Jirtle, R. L., & Murphy, S. K. (2014) · BioEssays · doi:10.1002/bies.201300113 · Cited by 354 · see citing works

Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice

Conine, C. C., Sun, F., Song, L., Rivera‐Pérez, J. A., & Rando, O. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.024 · Cited by 353 · see citing works

Transgenerational Epigenetic Inheritance

Bošković, A., & Rando, O. J. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031404 · Cited by 348 · see citing works

Stability, delivery and functions of human sperm RNAs at fertilization

Sendler, E. D., Johnson, G. D., Mao, S., Goodrich, R. J., Diamond, M. P., Hauser, R. B., & Krawetz, S. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt132 · Cited by 326 · see citing works

Parenting from before conception

Lane, M., Robker, R. L., & Robertson, S. A. (2014) · Science · doi:10.1126/science.1254400 · Cited by 289 · see citing works

Mechanisms of epigenetic memory

D’Urso, A., & Brickner, J. H. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.004 · Cited by 281 · see citing works

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

Rando, O. J., & Simmons, R. A. (2015) · Cell · doi:10.1016/j.cell.2015.02.021 · Cited by 271 · see citing works

Innate immune memory: a paradigm shift in understanding host defense

Netea, M. G., Latz, E., Mills, K. H. G., & O'Neill, L. A. J. (2015) · Nature Immunology · doi:10.1038/ni.3178 · Cited by 269 · see citing works

Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment

Chan, J. C., Nugent, B. M., & Bale, T. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.005 · Cited by 241 · see citing works

Entangled lives: Implications of the developmental origins of health and disease hypothesis for bioarchaeology and the life course

Gowland, R. L. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22820 · Cited by 232 · see citing works

Animal models of in utero exposure to a high fat diet: A review

Williams, L., Seki, Y., Vuguin, P. M., & Charron, M. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.07.006 · Cited by 223 · see citing works

The Female Response to Seminal Fluid

Schjenken, J. E., & Robertson, S. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2018 · Cited by 208 · see citing works

What is a paternal effect?

Crean, A. J., & Russell Bonduriansky, A. (2014) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2014.07.009 · Cited by 209 · see citing works

Mitochondria: their role in spermatozoa and in male infertility

Boguenet, M., Bouet, P., Spiers, A., Reynier, P., & May‐Panloup, P. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab001 · Cited by 189 · see citing works

Metabolism and Epigenetics

Janke, R., Dodson, A. E., & Rine, J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125544 · Cited by 192 · see citing works

Epigenetic marking of sperm by post-translational modification of histones and protamines

Brunner, A. M., Nanni, P., & Mansuy, I. M. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-2 · Cited by 181 · see citing works

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

Conine, C. C., Moresco, J. J., Gu, W., Shirayama, M., Conte, D., Yates, J. R., & Mello, C. C. (2013) · Cell · doi:10.1016/j.cell.2013.11.032 · Cited by 177 · see citing works

The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo

Castillo, J., Jodar, M., & Oliva, R. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy017 · Cited by 177 · see citing works

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvágner, G., Humphreys, D. T., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.008 · Cited by 171 · see citing works

Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information

Sharma, U. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00215 · Cited by 165 · see citing works

Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.

Day, J., Savani, S., Krempley, B. D., Nguyen, M. H., & Kitlinska, J. B. (2016) · Europe PMC (PubMed Central) · Cited by 155 · see citing works

Maternal age generates phenotypic variation in Caenorhabditis elegans

Perez, M. F., Francesconi, M., Hidalgo-Carcedo, C., & Lehner, B. (2017) · Nature · doi:10.1038/nature25012 · Cited by 151 · see citing works

Elements of morphology: General terms for congenital anomalies

Hennekam, R. C. M., Biesecker, L. G., Allanson, J. E., Hall, J. G., Opitz, J. M., Temple, I. K., & Carey, J. C. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36249 · Cited by 154 · see citing works

Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

Cossetti, C., Lugini, L., Astrologo, L., Saggio, I., Fais, S., & Spadafora, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101629 · Cited by 151 · see citing works

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

Shea, J. M., Serra, R. W., Carone, B. R., Shulha, H. P., Kucukural, A., Ziller, M. J., Vallaster, M. P., Gu, H., Tapper, A. R., Gardner, P. D., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.024 · Cited by 137 · see citing works

Fathers Matter: Why It’s Time to Consider the Impact of Paternal Environmental Exposures on Children’s Health

Braun, J. M., Messerlian, C., & Hauser, R. B. (2017) · Current Epidemiology Reports · doi:10.1007/s40471-017-0098-8 · Cited by 125 · see citing works

Intergenerational Transfer of Epigenetic Information in SpermPreprint

Rando, O. J. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022988 · Cited by 126 · see citing works

Occurrence and functional significance of the transcriptome in bovine (Bos taurus) spermatozoa

Selvaraju, S., Parthipan, S., Somashekar, L., Kolte, A. P., Binsila, B. K., Arangasamy, A., & Ravindra, J. P. (2017) · Scientific Reports · doi:10.1038/srep42392 · Cited by 121 · see citing works

Recent advances in vertebrate and invertebrate transgenerational immunity in the light of ecology and evolution

Roth, O., Beemelmanns, A., Barribeau, S. M., & Sadd, B. M. (2018) · Heredity · doi:10.1038/s41437-018-0101-2 · Cited by 119 · see citing works

Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds

Rissman, E. F., & Adli, M. (2014) · Endocrinology · doi:10.1210/en.2014-1123 · Cited by 113 · see citing works

A history of why fathers’ RNA matters†

Gòdia, M., Swanson, G., & Krawetz, S. A. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy007 · Cited by 113 · see citing works

The protein and transcript profiles of human semen

Jodar, M., Sendler, E. D., & Krawetz, S. A. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2237-1 · Cited by 104 · see citing works

Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary

Morán, S., Martínez‐Cardús, A., Boussios, S., & Esteller, M. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.97 · Cited by 104 · see citing works

Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model

Rahman, M. S., Pang, W., Ryu, D., Park, Y.-J., & Pang, M. (2020) · Human Reproduction · doi:10.1093/humrep/deaa139 · Cited by 105 · see citing works

Roles of male reproductive tract extracellular vesicles in reproduction

Tamessar, C. T., Trigg, N. A., Nixon, B., Skerrett-Byrne, D. A., Sharkey, D. J., Robertson, S. A., Bromfield, E. G., & Schjenken, J. E. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13338 · Cited by 97 · see citing works

Integrating Ecological and Evolutionary Context in the Study of Maternal Stress

Sheriff, M. J., Bell, A. M., Boonstra, R., Dantzer, B., Lavergne, S. G., McGhee, K. E., MacLeod, K. J., Winandy, L., Zimmer, C., & Love, O. P. (2017) · Integrative and Comparative Biology · doi:10.1093/icb/icx105 · Cited by 95 · see citing works

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

Oliva, R., Castillo, J., Estanyol, J. M., & Ballescà, J. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.153302 · Cited by 92 · see citing works

Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience

Rodgers, A. B., & Bale, T. L. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.018 · Cited by 91 · see citing works

Consequences of Paternal Nutrition on Offspring Health and Disease

Dimofski, P., Meyre, D., Dreumont, N., & Leininger‐Muller, B. (2021) · Nutrients · doi:10.3390/nu13082818 · Cited by 89 · see citing works

Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk

Heyn, H., Sayols, S., Moutinho, C., Vidal, E., Sanchez-Mut, J. V., Stefánsson, Ó. A., Nadal, E., Morán, S., Eyfjord, J. E., González‐Suárez, E., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.016 · Cited by 87 · see citing works

Epigenetic Mechanisms Affecting Regulation of Energy Balance: Many Questions, Few Answers

Waterland, R. A. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105315 · Cited by 87 · see citing works

Paternal impact on the life course development of obesity and type 2 diabetes in the offspring

Sharp, G. C., & Lawlor, D. A. (2019) · Diabetologia · doi:10.1007/s00125-019-4919-9 · Cited by 84 · see citing works

Sperm epigenomics: challenges and opportunities

Casas, E., & Vavouri, T. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00330 · Cited by 81 · see citing works

Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status

Javurek, A. B., Spollen, W. G., Ali, A. M. M., Johnson, S., Lubahn, D. B., Bivens, N. J., Bromert, K. H., Ellersieck, M. R., Givan, S. A., & Rosenfeld, C. S. (2016) · Scientific Reports · doi:10.1038/srep23027 · Cited by 81 · see citing works

Paternal epigenetic programming: evolving metabolic disease risk

Hur, S. S. J., Cropley, J. E., & Suter, C. M. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0236 · Cited by 80 · see citing works

Programming of stress pathways: A transgenerational perspective

Constantinof, A., Moisiadis, V. G., & Matthews, S. G. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.10.008 · Cited by 82 · see citing works

Sperm and seminal plasma RNAs: what roles do they play beyond fertilization?

Jodar, M. (2019) · Reproduction · doi:10.1530/rep-18-0639 · Cited by 78 · see citing works

Soma-to-germline RNA communication

Conine, C. C., & Rando, O. J. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00412-1 · Cited by 76 · see citing works

Role of miRNA in the Transmission of Metabolic Diseases Associated With Paternal Diet-Induced Obesity

Dupont, C., Kappeler, L., Saget, S., Grandjean, V., & Lévy, R. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00337 · Cited by 75 · see citing works

Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring

Vallaster, M., Kukreja, S., Bing, X., Ngolab, J., Zhao-Shea, R., Gardner, P. D., Tapper, A. R., & Rando, O. J. (2017) · eLife · doi:10.7554/elife.24771 · Cited by 75 · see citing works

Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis

Jia, Y., Tan, W., & Zhou, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-2797 · Cited by 73 · see citing works

What are parental condition‐transfer effects and how can they be detected?

Russell Bonduriansky, A., & Crean, A. J. (2017) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12848 · Cited by 73 · see citing works

Characterization of Genetic and Epigenetic Variation in Sperm and Red Blood Cells from Adult Hatchery and Natural-Origin Steelhead, Oncorhynchus mykiss

Gavery, M. R., Nichols, K. M., Goetz, G., Middleton, M. A., & Swanson, P. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200458 · Cited by 73 · see citing works

The Cell Biology of Genomes: Bringing the Double Helix to Life

Misteli, T. (2013) · Cell · doi:10.1016/j.cell.2013.02.048 · Cited by 71 · see citing works

Current status of sperm functional genomics and its diagnostic potential of fertility in bovine (Bos taurus)

Selvaraju, S., Parthipan, S., Somashekar, L., Binsila, B. K., Kolte, A. P., Arangasamy, A., Ravindra, J. P., & Krawetz, S. A. (2018) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2018.1444816 · Cited by 71 · see citing works

Maternal and paternal preconception exposure to bisphenols and size at birth

Mustieles, V., Williams, P. L., Fernández, M. F., Mínguez‐Alarcón, L., Ford, J. B., Calafat, A. M., Hauser, R. B., Messerlian, C., & Environment and Reproductive Health (EARTH) Study Team (2018) · Human Reproduction · doi:10.1093/humrep/dey234 · Cited by 69 · see citing works

An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome

Ahmed, T., Auble, D., Berkley, J. A., Black, R. E., Ahern, P. P., Hossain, M., Hsieh, A. T., Ireen, S., Arabi, M., & Gordon, J. I. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12487 · Cited by 69 · see citing works

Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species

Agarwal, A. K., Ayaz, A., Samanta, L., Sharma, R. K., Assidi, M., Abuzenadah, A. M., & Sabanegh, E. (2015) · Clinical Proteomics · doi:10.1186/s12014-015-9094-5 · Cited by 68 · see citing works

Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study

Messerlian, C., Mustieles, V., Mínguez‐Alarcón, L., Ford, J. B., Calafat, A. M., Souter, I. C., Williams, P. L., & Hauser, R. B. (2018) · Environment International · doi:10.1016/j.envint.2018.02.017 · Cited by 68 · see citing works

Oncogenesis as a Selective Force: Adaptive Evolution in the Face of a Transmissible Cancer

Russell, T., Madsen, T. R. L., Frédéric Thomas, A., Raven, N., Hamede, R., & Újvári, B. (2018) · BioEssays · doi:10.1002/bies.201700146 · Cited by 67 · see citing works

Genomic and proteomic dissection and characterization of the human sperm chromatin

Castillo, J., Amaral, A., Azpiazu, R., Vavouri, T., Estanyol, J. M., Ballescà, J. L., & Oliva, R. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau079 · Cited by 64 · see citing works

Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders

Risal, S., Manti, M., Lu, H., Fornes, R., Larsson, H., Benrick, A., Deng, Q., Cesta, C. E., Rosenqvist, M. A., & Stener‐Victorin, E. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01183-9 · Cited by 60 · see citing works

Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development

Nicolella, H. D., & de Assis, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094671 · Cited by 57 · see citing works

Cancer and life-history traits: lessons from host–parasite interactions

Újvári, B., Beckmann, C., Biro, P. A., Arnal, A., Tasiemski, A., Massol, F., Salzet, M., Mery, F., Boidin‐Wichlacz, C., Missé, D., et al. (2016) · Parasitology · doi:10.1017/s0031182016000147 · Cited by 51 · see citing works

Consumption of a high-fat diet alters the seminal fluid and gut microbiomes in male mice

Javurek, A. B., Spollen, W. G., Johnson, S., Bivens, N. J., Bromert, K. H., Givan, S. A., & Rosenfeld, C. S. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16119 · Cited by 52 · see citing works

The Current State of Cephalopod Science and Perspectives on the Most Critical Challenges Ahead From Three Early-Career Researchers

O’Brien, C. E., Roumbedakis, K., & Winkelmann, I. E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00700 · Cited by 51 · see citing works

Sperm miRNAs— potential mediators of bull age and early embryo development

Wu, C., Blondin, P., Vigneault, C., Labrecque, R., & Sirard, M. (2020) · BMC Genomics · doi:10.1186/s12864-020-07206-5 · Cited by 50 · see citing works

Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances

Jiménez‐Chillarón, J. C., Ramon‐Krauel, M., Ribó, S., & Díaz, R. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004231 · Cited by 47 · see citing works

Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples

Messerlian, C., Braun, J. M., Mínguez‐Alarcón, L., Williams, P. L., Ford, J. B., Mustieles, V., Calafat, A. M., Souter, I. C., Toth, T. L., & Hauser, R. B. (2017) · Environment International · doi:10.1016/j.envint.2017.06.015 · Cited by 46 · see citing works

Understanding the molecular mechanisms of bisphenol A action in spermatozoa

Rahman, M. S., & Pang, M. (2019) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2019.00276 · Cited by 46 · see citing works

Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress

Christoforou, E. R., & Sferruzzi-Perri, A. N. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03566-z · Cited by 44 · see citing works

Spectacular role of epididymis and bio-active cargo of nano-scale exosome in sperm maturation: A review

Ali, W., Deng, K., Bian, Y., Liu, Z., & Zou, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114889 · Cited by 46 · see citing works

Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior

Messerlian, C., Bellinger, D. C., Mínguez‐Alarcón, L., Romano, M. E., Ford, J. B., Williams, P. L., Calafat, A. M., Hauser, R. B., & Braun, J. M. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.032 · Cited by 44 · see citing works

Epigenetic control of variation and stochasticity in metabolic disease

Panzeri, I., & Pospisilik, J. A. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.010 · Cited by 50 · see citing works

Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model

Fontelles, C. C., Carney, E., Clarke, J., Nguyen, N. M., Yin, C., Lu, J., Cruz, M. I., Ong, T. P., Hilakivi-Clarke, L. A., & de Assis, S. (2016) · Scientific Reports · doi:10.1038/srep28602 · Cited by 42 · see citing works

Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center

Mínguez‐Alarcón, L., Bellavia, A., Gaskins, A. J., Chavarro, J. E., Ford, J. B., Souter, I. C., Calafat, A. M., Hauser, R. B., & Williams, P. L. (2020) · Environment International · doi:10.1016/j.envint.2020.106171 · Cited by 43 · see citing works

Paternal epigenetic effects of population density on locust phase‐related characteristics associated with heat‐shock protein expression

Chen, B., Li, S., Ren, Q., Tong, X., Zhang, X., & Kang, L. (2015) · Molecular Ecology · doi:10.1111/mec.13072 · Cited by 41 · see citing works

Paternal smoking and germ cell death: A mechanistic link to the effects of cigarette smoke on spermatogenesis and possible long-term sequelae in offspring

Esakky, P., & Moley, K. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.015 · Cited by 41 · see citing works

High-fat Diet Alters Male Seminal Plasma Composition to Impair Female Immune Adaptation for Pregnancy in Mice

Schjenken, J. E., Moldenhauer, L. M., Sharkey, D. J., Chan, H. Y., Chin, P. Y., Fullston, T., McPherson, N. O., & Robertson, S. A. (2021) · Endocrinology · doi:10.1210/endocr/bqab123 · Cited by 41 · see citing works

Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner

Emborski, C. A., & Mikheyev, A. S. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0181 · Cited by 40 · see citing works

Sperm RNA Payload: Implications for Intergenerational Epigenetic Inheritance

Liu, S., & Sharma, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065889 · Cited by 41 · see citing works

Non-genetic inheritance via the male germline in mammals

Baxter, F., & Drake, A. J. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0118 · Cited by 40 · see citing works

Mapping the past, present and future research landscape of paternal effects

Rutkowska, J., Lagisz, M., Russell Bonduriansky, A., & Nakagawa, S. (2020) · BMC Biology · doi:10.1186/s12915-020-00892-3 · Cited by 38 · see citing works

Insights into the sperm chromatin and implications for male infertility from a protein perspective

de la Iglesia, A., Jodar, M., Oliva, R., & Castillo, J. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1588 · Cited by 38 · see citing works

Puberty and the Evolution of Developmental Science

Worthman, C. M., Dockray, S., & Marceau, K. (2019) · Journal of Research on Adolescence · doi:10.1111/jora.12411 · Cited by 37 · see citing works

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

Soubry, A., Hoyo, C., Jirtle, R. L., & Murphy, S. K. (2014) · BioEssays · doi:10.1002/bies.201300113 · Cited by 354 · see citing works

Paternal epigenetic inheritance

Rahia Mashoodh, A., & Champagne, F. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816363-4.00006-7 · Cited by 7 · see citing works

Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance

Champagne, F. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000808 · Cited by 80 · see citing works

Exploring paternal epigenetic inheritance in mice

Bras, A. L. (2025) · Lab Animal · doi:10.1038/s41684-025-01646-w

Lamarck rises from his grave: parental environment‐induced epigenetic inheritance in model organisms and humans

Wang, Y., Liu, H., & Sun, Z. S. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12322 · Cited by 192 · see citing works