CoChat
Sign Up
Cited by 29Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Regulation of peroxisomal trafficking and distribution

Open access
Covill-Cooke, Christian, Toncheva, Viktoriya S., Kittler, Josef T.·2021·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-020-03687-5PMC PMC7966214
Open this paper in CoChat — free accountOpen PDF

Abstract

Peroxisomes are organelles that perform a wide range of essential metabolic processes. To ensure that peroxisomes are optimally positioned in the cell, they must be transported by both long- and short-range trafficking events in response to cellular needs. Here, we review our current understanding of the mechanisms by which the cytoskeleton and organelle contact sites alter peroxisomal distribution. Though the focus of the review is peroxisomal transport in mammalian cells, findings from flies and fungi are used for comparison and to inform the gaps in our understanding. Attention is given to the apparent overlap in regulatory mechanisms for mitochondrial and peroxisomal trafficking, along with the recently discovered role of the mitochondrial Rho-GTPases, Miro, in peroxisomal dynamics. Moreover, we outline and discuss the known pathological and pharmacological conditions that perturb peroxisomal positioning. We conclude by highlighting several gaps in our current knowledge and suggest future directions that require attention.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00018-020-03687-5

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Peroxisomes are few in neuron perikarya or dendrites, rare within axons, and absent in synaptic terminals in the spinal cord except during early development.

    “While mitochondria fill dendrites and axons, peroxisomes are few in neuron perikarya or dendrites, rare within axons [251,253,254,255,292,293], and absent in synaptic terminals in the spinal cord [255] except during early development [255].”

    From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [292]

    In “Factors that modulate peroxisomal transport and distribution” (page unavailable), the paper says neuronal peroxisomes are largely absent from axons and that their localisation likely changes during development. It instead describes them as predominantly located in somata and proximal dendrites; it does not establish that they are few there or absent from spinal-cord synaptic terminals except during early development. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 120

  1. [1]Agrawal G Subramani S De novo peroxisome biogenesis: Evolving concepts and conundrums Biochim Biophys Acta 2016 1863 892 901 10.1016/j.bbamcr.2015.09.014 26381541 PMC4791208 · DOI
  2. [2]Fujiki Y Okumoto K Mukai S Peroxisome biogenesis in mammalian cells Front Physiol 2014 5 307 10.3389/fphys.2014.00307 25177298 PMC4133648 · DOI
  3. [3]Costello JL Schrader M Unloosing the Gordian knot of peroxisome formation Curr Opin Cell Biol 2018 50 50 56 10.1016/j.ceb.2018.02.002 29475136 PMC6525147 · DOI
  4. [4]Braverman NE D’Agostino MD Maclean GE Peroxisome biogenesis disorders: biological, clinical and pathophysiological perspectives Dev Disabil Res Rev 2013 17 187 196 10.1002/ddrr.1113 23798008 · DOI
  5. [5]Klouwer FCC Berendse K Ferdinandusse S Zellweger spectrum disorders: clinical overview and management approach Orphanet J Rare Dis 2015 10 151 10.1186/s13023-015-0368-9 26627182 PMC4666198 · DOI
  6. [6]Smith JJ Aitchison JD Peroxisomes take shape Nat Rev Mol Cell Biol 2013 14 803 817 10.1038/nrm3700 24263361 PMC4060825 · DOI
  7. [7]Schrader M Costello JL Godinho LF Proliferation and fission of peroxisomes—an update Biochim Biophys Acta 2016 1863 971 983 10.1016/j.bbamcr.2015.09.024 26409486 · DOI
  8. [8]Huber N Guimaraes S Schrader M Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission EMBO Rep 2013 14 545 552 10.1038/embor.2013.56 23628762 PMC3674444 · DOI
  9. [9]Ebberink MS Koster J Visser G A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11β gene J Med Genet 2012 49 307 313 10.1136/jmedgenet-2012-100778 22581968 · DOI
  10. [10]Chao Y-H Robak LA Xia F Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila Hum Mol Genet 2016 25 1846 1856 10.1093/hmg/ddw059 26931468 PMC5007591 · DOI
  11. [11]Nasca A Nardecchia F Commone A Clinical and biochemical features in a patient with mitochondrial fission factor gene alteration Front Genet 2018 9 625 10.3389/fgene.2018.00625 30581454 PMC6292958 · DOI
  12. [12]Nasca A Legati A Baruffini E Biallelic mutations in DNM1L are associated with a slowly progressive infantile encephalopathy Hum Mutat 2016 37 898 903 10.1002/humu.23033 27328748 PMC5108486 · DOI
  13. [13]Cho D-H Kim YS Jo DS Pexophagy: molecular mechanisms and implications for health and diseases Mol Cells 2018 41 55 64 10.14348/molcells.2018.2245 29370694 PMC5792714 · DOI
  14. [14]Schrader M King SJ Stroh TA Schroer TA Real time imaging reveals a peroxisomal reticulum in living cells J Cell Sci 2000 113 Pt 20 3663 3671 11017881
  15. [15]Wali G Sutharsan R Fan Y Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with hereditary spastic paraplegia Sci Rep 2016 6 27004 10.1038/srep27004 27229699 PMC4882512 · DOI
  16. [16]Rapp S Saffrich R Anton M Microtubule-based peroxisome movement J Cell Sci 1996 109 Pt 4 837 849 8718675
  17. [17]Huber C Saffrich R Anton M A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells J Cell Sci 1997 110 Pt 23 2955 2968 9359881
  18. [18]Huber CM Saffrich R Ansorge W Just WW Receptor-mediated regulation of peroxisomal motility in CHO and endothelial cells EMBO J 1999 18 5476 5485 10.1093/emboj/18.20.5476 10523292 PMC1171616 · DOI
  19. [19]Wiemer EA Wenzel T Deerinck TJ Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules J Cell Biol 1997 136 71 80 10.1083/jcb.136.1.71 9008704 PMC2132450 · DOI
  20. [20]Kulic IM Brown AEX Kim H The role of microtubule movement in bidirectional organelle transport Proc Natl Acad Sci USA 2008 105 10011 10016 10.1073/pnas.0800031105 18626022 PMC2481308 · DOI
  21. [21]Schrader M Burkhardt JK Baumgart E Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs Eur J Cell Biol 1996 69 24 35 8825021
  22. [22]Nguyen T Bjorkman J Paton BC Crane DI Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance J Cell Sci 2006 119 636 645 10.1242/jcs.02776 16449325 · DOI
  23. [23]Bharti P Schliebs W Schievelbusch T PEX14 is required for microtubule-based peroxisome motility in human cells J Cell Sci 2011 124 1759 1768 10.1242/jcs.079368 21525035 · DOI
  24. [24]Okumoto K Ono T Toyama R New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes J Cell Biol 2018 217 619 633 10.1083/jcb.201708122 29222186 PMC5800816 · DOI
  25. [25]Covill-Cooke C Toncheva VS Drew J Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2 EMBO Rep 2020 21 e49865 10.15252/embr.201949865 31894645 PMC7001505 · DOI
  26. [26]Castro IG Richards DM Metz J A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes Traffic 2018 19 229 242 10.1111/tra.12549 29364559 PMC5888202 · DOI
  27. [27]Thiemann M Schrader M Völkl A Interaction of peroxisomes with microtubules. In vitro studies using a novel peroxisome-microtubule binding assay Eur J Biochem 2000 267 6264 6275 10.1046/j.1432-1327.2000.01713.x 11012681 · DOI
  28. [28]Kural C Kim H Syed S Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Science 2005 308 1469 1472 10.1126/science.1108408 15817813 · DOI
  29. [29]Ally S Larson AG Barlan K Opposite-polarity motors activate one another to trigger cargo transport in live cells J Cell Biol 2009 187 1071 1082 10.1083/jcb.200908075 20038680 PMC2806283 · DOI
  30. [30]Dietrich D Seiler F Essmann F Dodt G Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells Biochim Biophys Acta 2013 1833 3013 3024 10.1016/j.bbamcr.2013.08.002 23954441 · DOI
  31. [31]Kong J Ji Y Jeon YG Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5 Nat Commun 2020 11 578 10.1038/s41467-019-14176-0 31996685 PMC6989686 · DOI
  32. [32]Miyamoto T Hosoba K Itabashi T Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome EMBO J 2020 39 e103499 10.15252/embj.2019103499 32368833 PMC7298307 · DOI
  33. [33]Cao Y Lipka J Stucchi R Microtubule minus-end binding protein CAMSAP2 and kinesin-14 motor KIFC3 Control dendritic microtubule organization Curr Biol 2020 30 899 908.e6 10.1016/j.cub.2019.12.056 32084403 PMC7063570 · DOI
  34. [34]Baker A Lanyon-Hogg T Warriner SL Peroxisome protein import: a complex journey Biochem Soc Trans 2016 44 783 789 10.1042/BST20160036 27284042 PMC4900764 · DOI
  35. [35]Passmore JB Carmichael RE Schrader TA Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation Biochim Biophys Acta Mol Cell Res 2020 1867 118709 10.1016/j.bbamcr.2020.118709 32224193 PMC7262603 · DOI
  36. [36]Barros-Barbosa A Ferreira MJ Rodrigues TA Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes FEBS J 2019 286 205 222 10.1111/febs.14697 30414318 · DOI
  37. [37]Brocard CB Boucher KK Jedeszko C Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis Traffic 2005 6 386 395 10.1111/j.1600-0854.2005.00283.x 15813749 · DOI
  38. [38]Birsa N Norkett R Higgs N Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins Biochem Soc Trans 2013 41 1525 1531 10.1042/BST20130234 24256248 · DOI
  39. [39]Dixit E Boulant S Zhang Y Peroxisomes are signaling platforms for antiviral innate immunity Cell 2010 141 668 681 10.1016/j.cell.2010.04.018 20451243 PMC3670185 · DOI
  40. [40]Lodhi IJ Semenkovich CF Peroxisomes: a nexus for lipid metabolism and cellular signaling Cell Metab 2014 19 380 392 10.1016/j.cmet.2014.01.002 24508507 PMC3951609 · DOI · Paper page
  41. [41]Schrader M Costello J Godinho LF Islinger M Peroxisome-mitochondria interplay and disease J Inherit Metab Dis 2015 38 681 702 10.1007/s10545-015-9819-7 25687155 · DOI
  42. [42]Schrader M Fahimi HD Peroxisomes and oxidative stress Biochim Biophys Acta 2006 1763 1755 1766 10.1016/j.bbamcr.2006.09.006 17034877 · DOI · Paper page
  43. [44]Neuspiel M Schauss AC Braschi E Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers Curr Biol 2008 18 102 108 10.1016/j.cub.2007.12.038 18207745 · DOI
  44. [45]Gandre-Babbe S van der Bliek AM The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells Mol Biol Cell 2008 19 2402 2412 10.1091/mbc.E07-12-1287 18353969 PMC2397315 · DOI · Paper page
  45. [46]Koch J Brocard C PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission J Cell Sci 2012 125 3813 3826 10.1242/jcs.102178 22595523 · DOI
  46. [48]Marcassa E Kallinos A Jardine J Dual role of USP30 in controlling basal pexophagy and mitophagy EMBO Rep 2018 10.15252/embr.201745595 29895712 PMC6030704 · DOI · Paper page
  47. [49]Costello JL Castro IG Camões F Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells J Cell Sci 2017 130 1675 1687 10.1242/jcs.200204 28325759 PMC5450235 · DOI
  48. [50]Koch A Thiemann M Grabenbauer M Dynamin-like protein 1 is involved in peroxisomal fission J Biol Chem 2003 278 8597 8605 10.1074/jbc.M211761200 12499366 · DOI · Paper page
  49. [51]Smirnova E Griparic L Shurland DL van der Bliek AM Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells Mol Biol Cell 2001 12 2245 2256 10.1091/mbc.12.8.2245 11514614 PMC58592 · DOI
  50. [52]Kamerkar SC Kraus F Sharpe AJ Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission Nat Commun 2018 9 5239 10.1038/s41467-018-07543-w 30531964 PMC6286342 · DOI
  51. [53]Losón OC Song Z Chen H Chan DC Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission Mol Biol Cell 2013 24 659 667 10.1091/mbc.E12-10-0721 23283981 PMC3583668 · DOI · Paper page
  52. [54]Fransson A Ruusala A Aspenström P Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis J Biol Chem 2003 278 6495 6502 10.1074/jbc.M208609200 12482879 · DOI
  53. [55]Klosowiak JL Focia PJ Chakravarthy S Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro EMBO Rep 2013 14 968 974 10.1038/embor.2013.151 24071720 PMC3818075 · DOI
  54. [56]Eberhardt EL Ludlam AV Tan Z Cianfrocco MA Miro: a molecular switch at the center of mitochondrial regulation Protein Sci 2020 10.1002/pro.3839 32056317 PMC7255519 · DOI
  55. [57]Lee S Lee K-S Huh S Polo kinase phosphorylates Miro to control ER-mitochondria contact sites and mitochondrial Ca(2+) homeostasis in neural stem cell development Dev Cell 2016 37 174 189 10.1016/j.devcel.2016.03.023 27093086 PMC4839004 · DOI
  56. [58]Modi S López-Doménech G Halff EF Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery Nat Commun 2019 10 4399 10.1038/s41467-019-12382-4 31562315 PMC6764964 · DOI
  57. [59]Safiulina D Kuum M Choubey V Miro proteins prime mitochondria for Parkin translocation and mitophagy EMBO J 2019 10.15252/embj.201899384 30504269 PMC6331716 · DOI
  58. [60]Niescier RF Hong K Park D Min K-T MCU interacts with Miro1 to modulate mitochondrial functions in neurons J Neurosci 2018 38 4666 4677 10.1523/JNEUROSCI.0504-18.2018 29686046 PMC6596018 · DOI
  59. [61]López-Doménech G Covill-Cooke C Ivankovic D Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution EMBO J 2018 37 321 336 10.15252/embj.201696380 29311115 PMC5793800 · DOI
  60. [62]Norkett R Lesept F Kittler JT DISC1 regulates mitochondrial trafficking in a Miro1-GTP-dependent manner Front Cell Dev Biol 2020 8 449 10.3389/fcell.2020.00449 32637409 PMC7317294 · DOI
  61. [63]Norkett R Modi S Birsa N DISC1-dependent regulation of mitochondrial dynamics controls the morphogenesis of complex neuronal dendrites J Biol Chem 2016 291 613 629 10.1074/jbc.M115.699447 26553875 PMC4705382 · DOI
  62. [64]Birsa N Norkett R Wauer T Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase J Biol Chem 2014 289 14569 14582 10.1074/jbc.M114.563031 24671417 PMC4031514 · DOI
  63. [65]Wang X Winter D Ashrafi G PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility Cell 2011 147 893 906 10.1016/j.cell.2011.10.018 22078885 PMC3261796 · DOI
  64. [66]Lopez-Domenech G Covill-Cooke C Howden JH Miro ubiquitination is critical for efficient damage-induced PINK1/Parkin-mediated mitophagy BioRxiv 2018 10.1101/414664 · DOI
  65. [67]Stephen T-L Higgs NF Sheehan DF Miro1 regulates activity-driven positioning of mitochondria within astrocytic processes apposed to synapses to regulate intracellular calcium signaling J Neurosci 2015 35 15996 16011 10.1523/JNEUROSCI.2068-15.2015 26631479 PMC4666922 · DOI
  66. [68]Sheng Z-H The interplay of axonal energy homeostasis and mitochondrial trafficking and anchoring Trends Cell Biol 2017 27 403 416 10.1016/j.tcb.2017.01.005 28228333 PMC5440189 · DOI · Paper page
  67. [69]Pilling AD Horiuchi D Lively CM Saxton WM Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons Mol Biol Cell 2006 17 2057 2068 10.1091/mbc.e05-06-0526 16467387 PMC1415296 · DOI
  68. [71]MacAskill AF Kittler JT Control of mitochondrial transport and localization in neurons Trends Cell Biol 2010 20 102 112 10.1016/j.tcb.2009.11.002 20006503 · DOI
  69. [72]van Spronsen M Mikhaylova M Lipka J TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites Neuron 2013 77 485 502 10.1016/j.neuron.2012.11.027 23395375 · DOI · Paper page
  70. [73]Stowers RS Megeath LJ Górska-Andrzejak J Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein Neuron 2002 36 1063 1077 10.1016/s0896-6273(02)01094-2 12495622 · DOI
  71. [74]Glater EE Megeath LJ Stowers RS Schwarz TL Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent J Cell Biol 2006 173 545 557 10.1083/jcb.200601067 16717129 PMC2063864 · DOI
  72. [75]Brickley K Stephenson FA Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons J Biol Chem 2011 286 18079 18092 10.1074/jbc.M111.236018 21454691 PMC3093881 · DOI
  73. [76]Henrichs V Grycova L Barinka C Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments Nat Commun 2020 11 3123 10.1038/s41467-020-16972-5 32561740 PMC7305210 · DOI
  74. [77]López-Doménech G Higgs NF Vaccaro V Loss of dendritic complexity precedes neurodegeneration in a mouse model with disrupted mitochondrial distribution in mature dendrites Cell Rep 2016 17 317 327 10.1016/j.celrep.2016.09.004 27705781 PMC5067282 · DOI
  75. [78]Guo X Macleod GT Wellington A The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses Neuron 2005 47 379 393 10.1016/j.neuron.2005.06.027 16055062 · DOI
  76. [79]Lee CA Chin L-S Li L Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion Protein Cell 2018 9 693 716 10.1007/s13238-017-0469-4 28924745 PMC6053349 · DOI
  77. [80]Oeding SJ Majstrowicz K Hu X-P Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX J Cell Sci 2018 10.1242/jcs.219469 30111583 · DOI
  78. [81]Wang X Schwarz TL The mechanism of Ca2+-dependent regulation of kinesin-mediated mitochondrial motility Cell 2009 136 163 174 10.1016/j.cell.2008.11.046 19135897 PMC2768392 · DOI · Paper page
  79. [82]Saotome M Safiulina D Szabadkai G Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase Proc Natl Acad Sci USA 2008 105 20728 20733 10.1073/pnas.0808953105 19098100 PMC2634948 · DOI · Paper page
  80. [83]Macaskill AF Rinholm JE Twelvetrees AE Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses Neuron 2009 61 541 555 10.1016/j.neuron.2009.01.030 19249275 PMC2670979 · DOI
  81. [84]Pekkurnaz G Trinidad JC Wang X Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase Cell 2014 158 54 68 10.1016/j.cell.2014.06.007 24995978 PMC4224014 · DOI
  82. [85]Cichocki BA Krumpe K Vitali DG Rapaport D Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes Traffic 2018 19 770 785 10.1111/tra.12604 30033679 · DOI
  83. [86]Russo GJ Louie K Wellington A Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport J Neurosci 2009 29 5443 5455 10.1523/JNEUROSCI.5417-08.2009 19403812 PMC2693725 · DOI · Paper page
  84. [87]Nguyen TT Oh SS Weaver D Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease Proc Natl Acad Sci USA 2014 111 E3631 E3640 10.1073/pnas.1402449111 25136135 PMC4156725 · DOI
  85. [88]Kanfer G Courthéoux T Peterka M Mitotic redistribution of the mitochondrial network by Miro and Cenp-F Nat Commun 2015 6 8015 10.1038/ncomms9015 26259702 PMC4538849 · DOI
  86. [89]Valm AM Cohen S Legant WR Applying systems-level spectral imaging and analysis to reveal the organelle interactome Nature 2017 546 162 167 10.1038/nature22369 28538724 PMC5536967 · DOI · Paper page
  87. [90]Barel O Malicdan MCV Ben-Zeev B Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy Brain 2017 140 568 581 10.1093/brain/awx002 28364549 PMC6075218 · DOI
  88. [91]Vlahou G Eliáš M von Kleist-Retzow J-C The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum Eur J Cell Biol 2011 90 342 355 10.1016/j.ejcb.2010.10.012 21131095 · DOI
  89. [92]Yamaoka S Hara-Nishimura I The mitochondrial Ras-related GTPase Miro: views from inside and outside the metazoan kingdom Front Plant Sci 2014 5 350 10.3389/fpls.2014.00350 25076955 PMC4100572 · DOI
  90. [93]Kustatscher G Grabowski P Schrader TA Co-regulation map of the human proteome enables identification of protein functions Nat Biotechnol 2019 37 1361 1371 10.1038/s41587-019-0298-5 31690884 PMC6901355 · DOI
  91. [95]Gennerich A Schild D Finite-particle tracking reveals submicroscopic-size changes of mitochondria during transport in mitral cell dendrites Phys Biol 2006 3 45 53 10.1088/1478-3975/3/1/005 16582469 · DOI
  92. [96]Cagalinec M Safiulina D Liiv M Principles of the mitochondrial fusion and fission cycle in neurons J Cell Sci 2013 126 2187 2197 10.1242/jcs.118844 23525002 · DOI
  93. [97]Misko A Jiang S Wegorzewska I Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex J Neurosci 2010 30 4232 4240 10.1523/JNEUROSCI.6248-09.2010 20335458 PMC2852190 · DOI
  94. [98]Wang Y Metz J Costello JL Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression PLoS ONE 2018 13 e0209507 10.1371/journal.pone.0209507 30589881 PMC6307868 · DOI · Paper page
  95. [99]Liao P-C Tandarich LC Hollenbeck PJ ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila PLoS ONE 2017 12 e0178105 10.1371/journal.pone.0178105 28542430 PMC5436889 · DOI
  96. [100]Debattisti V Gerencser AA Saotome M ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak Cell Rep 2017 21 1667 1680 10.1016/j.celrep.2017.10.060 29117569 PMC5710826 · DOI
  97. [101]Egan MJ McClintock MA Reck-Peterson SL Microtubule-based transport in filamentous fungi Curr Opin Microbiol 2012 15 637 645 10.1016/j.mib.2012.10.003 23127389 PMC3518651 · DOI
  98. [102]Egan MJ Tan K Reck-Peterson SL Lis1 is an initiation factor for dynein-driven organelle transport J Cell Biol 2012 197 971 982 10.1083/jcb.201112101 22711696 PMC3384415 · DOI
  99. [103]Guimaraes SC Schuster M Bielska E Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes J Cell Biol 2015 211 945 954 10.1083/jcb.201505086 26620910 PMC4674278 · DOI
  100. [104]Lin C Schuster M Guimaraes SC Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells Nat Commun 2016 7 11814 10.1038/ncomms11814 27251117 PMC4895713 · DOI
  101. [105]Salogiannis J Egan MJ Reck-Peterson SL Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA J Cell Biol 2016 212 289 296 10.1083/jcb.201512020 26811422 PMC4748578 · DOI
  102. [106]Zhang J Qiu R Arst HN HookA is a novel dynein-early endosome linker critical for cargo movement in vivo J Cell Biol 2014 204 1009 1026 10.1083/jcb.201308009 24637327 PMC3998793 · DOI
  103. [107]Hua R Cheng D Coyaud É VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis J Cell Biol 2017 216 367 377 10.1083/jcb.201608128 28108526 PMC5294787 · DOI · Paper page
  104. [108]Costello JL Castro IG Schrader TA Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations Cell Cycle 2017 16 1039 1045 10.1080/15384101.2017.1314422 28463579 PMC5499832 · DOI
  105. [109]Costello JL Castro IG Hacker C ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER J Cell Biol 2017 216 331 342 10.1083/jcb.201607055 28108524 PMC5294785 · DOI
  106. [110]Neuhaus A Eggeling C Erdmann R Schliebs W Why do peroxisomes associate with the cytoskeleton? Biochim Biophys Acta 2016 1863 1019 1026 10.1016/j.bbamcr.2015.11.022 26616035 · DOI
  107. [111]Schollenberger L Gronemeyer T Huber CM RhoA regulates peroxisome association to microtubules and the actin cytoskeleton PLoS ONE 2010 5 e13886 10.1371/journal.pone.0013886 21079737 PMC2975642 · DOI
  108. [112]Vaccaro V Devine MJ Higgs NF Kittler JT Miro1-dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity EMBO Rep 2017 18 231 240 10.15252/embr.201642710 28039205 PMC5286383 · DOI
  109. [113]Kassmann CM Quintes S Rietdorf J A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity FEBS Lett 2011 585 2205 2211 10.1016/j.febslet.2011.05.032 21620837 · DOI · Paper page
  110. [114]Arnold G Holtzman E Microperoxisomes in the central nervous system of the postnatal rat Brain Res 1978 155 1 17 10.1016/0006-8993(78)90300-1 688002 · DOI
  111. [115]Ferdinandusse S Falkenberg KD Koster J ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism J Med Genet 2017 54 330 337 10.1136/jmedgenet-2016-104132 27799409 · DOI · Paper page
  112. [116]Nishimura AL Mitne-Neto M Silva HCA A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis Am J Hum Genet 2004 75 822 831 10.1086/425287 15372378 PMC1182111 · DOI
  113. [117]Abrahamsen G Fan Y Matigian N A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations Dis Model Mech 2013 6 489 502 10.1242/dmm.010884 23264559 PMC3597030 · DOI
  114. [118]Fan Y Wali G Sutharsan R Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in hereditary spastic paraplegia Biol Open 2014 3 494 502 10.1242/bio.20147641 24857849 PMC4058084 · DOI
  115. [119]Koutsis G Lynch DS Tucci A A novel ABCD1 mutation detected by next generation sequencing in presumed hereditary spastic paraplegia: a 30-year diagnostic delay caused by misleading biochemical findings J Neurol Sci 2015 355 199 201 10.1016/j.jns.2015.05.031 26049658 · DOI
  116. [120]Chang C-L Weigel AV Ioannou MS Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III J Cell Biol 2019 218 2583 2599 10.1083/jcb.201902061 31227594 PMC6683741 · DOI · Paper page
  117. [121]Stamer K Vogel R Thies E Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress J Cell Biol 2002 156 1051 1063 10.1083/jcb.200108057 11901170 PMC2173473 · DOI · Paper page
  118. [122]Yamashita S Abe K Tatemichi Y Fujiki Y The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy Autophagy 2014 10 1549 1564 10.4161/auto.29329 25007327 PMC4206534 · DOI
  119. [123]Narendra D Kane LA Hauser DN p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy 2010 6 1090 1106 10.4161/auto.6.8.13426 20890124 PMC3359490 · DOI
  120. [124]Jongsma MLM Berlin I Wijdeven RHM An ER-associated pathway defines endosomal architecture for controlled cargo transport Cell 2016 166 152 166 10.1016/j.cell.2016.05.078 27368102 PMC4930482 · DOI

Cited by

Sorted by citations

Authors
Covill-Cooke, C., Toncheva, V. S., & Kittler, J. T.
Affiliations
University College London (GB)
Corresponding author
Kittler, Josef T.
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2020-11-03
Volume
78
Issue
5
Pages
1929-1941
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-020-03687-5
PMC
PMC7966214
OpenAlex
W3095512444
Cited by
29
References
4
Citations by year
2025: 7 · 2024: 10 · 2023: 3 · 2022: 5 · 2021: 4
FWCI
0.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Medical Research Council (1368635, 2180679, G0802377, MR/N025644/1)
  • European Research Council (282430)
  • University College London
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
peroxisomes, cytoskeleton, membrane contact sites, mitochondrial trafficking, Miro, Rho GTPases, peroxisome biogenesis disorders
MeSH terms
Animals, Biological Transport, Humans, Microtubules, Mitochondria, Models, Biological, Peroxisomes, rho GTP-Binding Proteins, Mitochondrial Proteins, Mitochondrial Dynamics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review