Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes–indication of an increased environmental pressure?

The effect of infections on susceptibility to autoimmune and allergic diseases.

Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,714 · see citing works

Common West African HLA antigens are associated with protection from severe malaria

Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,554 · see citing works

Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group

Karvonen, M., Viik-Kajander, M., Moltchanova, E., Libman, I., LaPorte, R., & Tuomilehto, J. (2000) · Diabetes Care · doi:10.2337/diacare.23.10.1516 · Cited by 1,072 · see citing works

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

Nisticò, L. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.7.1075 · Cited by 807 · see citing works

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

Bell, G. I., Horita, S., & Karam, J. H. (1984) · Diabetes · doi:10.2337/diab.33.2.176 · Cited by 744 · see citing works

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

Noble, J. A., Valdes, A. M., Cook, M., Klitz, W., Thomson, G., & Erlich, H. A. (1996) · PubMed Central · Cited by 481 · see citing works

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

Marron, M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1275 · Cited by 406 · see citing works

Heterozygote advantage for HLA class-II type in hepatitis B virus infection

Thursz, M. R., Thomas, H. C., Greenwood, B. M., & Hill, A. V. S. (1997) · Nature Genetics · doi:10.1038/ng0997-11 · Cited by 311 · see citing works

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

Caillat‐Zucman, S., Garchon, H., Timsit, J., Assan, R., Boîtard, C., Djilali-Saiah, I., Bougneres, P. F., & Bach, J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116110 · Cited by 286 · see citing works

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

Lucassen, A., Julier, C., Beressi, J.-P., Boîtard, C., Froguel, P., Lathrop, M. G., & Bell, J. I. (1993) · Nature Genetics · doi:10.1038/ng0793-305 · Cited by 267 · see citing works

Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.

Komulainen, J., Kulmala, P., Savola, K., Lounamaa, R., Ilonen, J., Reijonen, H., Knip, M., & Åkerblom, H. K. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1950 · Cited by 198 · see citing works

Population‐based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA‐DQB1, HLA‐DQA1 and HLA‐DRB1 loci

Nejentsev, S., Sjöroos, M., Soukka, T., Knip, M., Simell, O., Lövgren, T. N.-E., & Ilonen, J. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00186.x · Cited by 164 · see citing works

Substitution of l -Fucose by l -Galactose in Cell Walls of Arabidopsis mur1

Zablackis, E., York, W. S., Pauly, M., Hantus, S. T., Reiter, W., Chapple, C. C. S., Albersheim, P., & Darvill, A. G. (1996) · Science · doi:10.1126/science.272.5269.1808 · Cited by 149 · see citing works

Markers on Distal Chromosome 2q Linked to Insulin-Dependent Diabetes Mellitus

Morahan, G., Huang, D., Tait, B. D., Colman, P. G., & Harrison, L. C. (1996) · Science · doi:10.1126/science.272.5269.1811 · Cited by 112 · see citing works

Genes of the Class II and Class III Major Histocompatibility Complex Are Associated with Typhoid Fever in Vietnam

Dunstan, S. J., Stephens, H. A. F., Blackwell, J. M., Duc, C. M., Lanh, M. N., Dudbridge, F., Phuong, C. X. T., Luxemburger, C., Wain, J. R., Ho, V. A., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/317940 · Cited by 101 · see citing works

Increasing trend in Type 1 (insulin-dependent) diabetes mellitus in childhood in Finland

Tuomilehto, J., Rewers, M., Reunanen, A., Lounamaa, P., Lounamaa, R., Tuomilehto‐Wolf, E., & �kerblom, H. K. (1991) · Diabetologia · doi:10.1007/bf00405089 · Cited by 98 · see citing works

Can enterovirus infections explain the increasing incidence of type 1 diabetes?

Viskari, H., Koskela, P. U., Lönnrot, M., Luonuansuu, S., Reunanen, A., Baer, M., & Hyöty, H. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.414 · Cited by 92 · see citing works

HLA class II associated risk and protection against multiple sclerosis—a Finnish family study

Laaksonen, M., Pastinen, T., Sjöroos, M., Kuokkanen, S., Ruutiainen, J., Sumelahti, M., Reijonen, H., Salonen, R., Wikstrom, J., Panelius, M., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00456-8 · Cited by 75 · see citing works

The Gut Immune System and Type 1 Diabetes

Vaarala, O. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02945.x · Cited by 59 · see citing works

The HLA-A,B gene frequencies in the world: Migration or selection?

Piazza, A., Menozzi, P., & Cavalli-Sforza, L. L. (1980) · Human Immunology · doi:10.1016/0198-8859(80)90105-6 · Cited by 49 · see citing works

Distribution of insulin‐dependent diabetes mellitus (IDDM)‐related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region

Nejentsev, S., Koskinen, S., Sjöroos, M., Reijonen, H., Schwartz, E. I., Kovalchuk, L., Sochnev, A., Adojaan, B., Podar, T., Knip, M., et al. (1998) · Tissue Antigens · doi:10.1111/j.1399-0039.1998.tb03074.x · Cited by 38 · see citing works

HLA alleles and IDDM in children in Hungary: a comparison with Finland

Hermann, R., Mijovic, C. H., Rayner, M., Croft, N., Kelly, M. A., Jenkins, D., Soltész, G., & Barnett, A. H. (2001) · Human Immunology · doi:10.1016/s0198-8859(01)00224-5 · Cited by 18 · see citing works

DIFFERENCES IN HLA TYPES IN CHILDREN WITH INSULIN-DEPENDENT DIABETES DIAGNOSED IN 1960s, 1970s, AND 1980s

Kontiainen, S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92320-3 · Cited by 17 · see citing works

Human leucocyte antigen and insulin gene regions and nephropathy in Type I diabetes

Chowdhury, T. A., Dyer, P., Mijovic, C. H., Dunger, D. B., Barnett, A. H., & Bain, S. C. (1999) · Diabetologia · doi:10.1007/s001250051262 · Cited by 16 · see citing works

Influence of genetic factors (HLA class II genes, insulin-gene region polymorphisms) and metabolic control on the development of diabetic nephropathy.

Rønningen, K. S., Hj, B., Undlien, D. E., & Thorsby, E. (1993) · PubMed · Cited by 12 · see citing works

Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990.

Mäenpää, A., Koskimies, S., Scheinin, T. M., Schlenzka, A., Hk, Å., Mäenpää, J., Reunanen, A., & Kontiainen, S. (1991) · PubMed · Cited by 3 · see citing works

Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854 · see citing works

Epidemiology of type 1 diabetes

Maahs, D. M., West, N. A., Lawrence, J. M., & Mayer-Davis, E. J. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.011 · Cited by 1,092 · see citing works

Incidence and trends of childhood type 1 diabetes worldwide 1990–1999

The DIAMOND Project Group (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01925.x · Cited by 1,085 · see citing works

ISPAD Clinical Practice Consensus Guidelines 2018: Definition, epidemiology, and classification of diabetes in children and adolescents

Mayer‐Davis, E. J., Kahkoska, A. R., Jefferies, C., Dabelea, D., Balde, N. M., Gong, C., Aschner, P. J., & Craig, M. E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12773 · Cited by 695 · see citing works

Pathogenesis of autoimmune disease

Pisetsky, D. S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00720-1 · Cited by 656 · see citing works

Environmental Triggers and Determinants of Type 1 Diabetes

Knip, M., Veijola, R., Virtanen, S. M., Hyöty, H., Vaarala, O., & Åkerblom, H. K. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s125 · Cited by 496 · see citing works

The heterogeneous pathogenesis of type 1 diabetes mellitus

Ilonen, J., Lempainen, J., & Veijola, R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0254-y · Cited by 497 · see citing works

Definition, epidemiology and classification of diabetes in children and adolescents

Craig, M. E., Hattersley, A. T., & Donaghue, K. C. (2009) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00568.x · Cited by 463 · see citing works

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Kent, S. C., Chen, Y., Bregoli, L., Clemmings, S. M., Kenyon, N. S., Ricordi, C., Hering, B. J., & Hafler, D. A. (2005) · Nature · doi:10.1038/nature03625 · Cited by 409 · see citing works

Type 1 diabetes: pathogenesis and prevention

Gillespie, K. M. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.060244 · Cited by 384 · see citing works

Definition, epidemiology, and classification of diabetes in children and adolescents

Craig, M. E., Jefferies, C., Dabelea, D., Balde, N. M., Seth, A., & Donaghue, K. C. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12186 · Cited by 366 · see citing works

Fall in C-Peptide During First 2 Years From Diagnosis

Greenbaum, C. J., Beam, C. A., Boulware, D., Gitelman, S. E., Gottlieb, P. A., Herold, K. C., Lachin, J. M., McGee, P., Palmer, J. P., Pescovitz, M. D., et al. (2012) · Diabetes · doi:10.2337/db11-1538 · Cited by 319 · see citing works

The Pathogenesis and Natural History of Type 1 DiabetesPreprint

Atkinson, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007641 · Cited by 318 · see citing works

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

Gillespie, K. M., Bain, S. C., Barnett, A. H., Bingley, P. J., Christie, M. R., Gill, G. V., & Gale, E. A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17357-1 · Cited by 304 · see citing works

Genetics of Type 1 Diabetes: What's Next?

Pociot, F., Akolkar, B., CONCANNON, P. J., Erlich, H. A., Julier, C., Morahan, G., Nierras, C. R., Todd, J. A., Rich, S. S., & Nerup, J. (2010) · Diabetes · doi:10.2337/db10-0076 · Cited by 301 · see citing works

Diabetes in Europe: An update

Tamayo, T., Rosenbauer, J., Wild, S. H., Spijkerman, A. M. W., Baan, C. A., Forouhi, N. G., Herder, C., & Rathmann, W. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.11.007 · Cited by 252 · see citing works

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

Fourlanos, S., Varney, M. D., Tait, B. D., Morahan, G., Honeyman, M. C., Colman, P. G., & Harrison, L. C. (2008) · Diabetes Care · doi:10.2337/dc08-0239 · Cited by 228 · see citing works

Genetics of type 1 diabetes

Redondo, M. J., Steck, A. K., & Pugliese, A. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12597 · Cited by 216 · see citing works

Environmental Triggers of Type 1 DiabetesPreprint

Knip, M., & Simell, O. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007690 · Cited by 206 · see citing works

The changing epidemiology of type 1 diabetes: why is it going through the roof?

Vehik, K., & Dabelea, D. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1141 · Cited by 175 · see citing works

Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity

Watad, ‬., Azrielant, S., Bragazzi, N. L., Sharif, Κ., David, P., Katz, I., Aljadeff, G., Quaresma, M., Tanay, G., Adawi, M., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.06.001 · Cited by 167 · see citing works

Genetics of diabetes – Are we missing the genes or the disease?

Groop, L., & Pociot, F. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.002 · Cited by 158 · see citing works

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents

Couper, J., Haller, M. J., Greenbaum, C. J., Ziegler, A., Wherrett, D. K., Knip, M., & Craig, M. E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12734 · Cited by 146 · see citing works

HLA DR‐DQ‐encoded genetic determinants of childhood‐onset type 1 diabetes in Finland: An analysis of 622 nuclear families

Hermann, R., Turpeinen, H., Laine, A.-P., Veijola, R., Knip, M., Simell, O., Sipilä, I., Åkerblom, H. K., & Ilonen, J. (2003) · Tissue Antigens · doi:10.1034/j.1399-0039.2003.00071.x · Cited by 146 · see citing works

The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes

Wilkin, T. J. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.97 · Cited by 158 · see citing works

Viruses in type 1 diabetes

Hyöty, H. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12370 · Cited by 127 · see citing works

Synthetic surfactant food additives can cause intestinal barrier dysfunction

Csáki, K. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.01.030 · Cited by 126 · see citing works

Molecular Mechanisms in Autoimmune Type 1 Diabetes: a Critical Review

Xie, Z., Chang, C., & Zhou, Z. (2014) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8422-2 · Cited by 121 · see citing works

Leptin in autoimmune diseases

Procaccini, C., Pucino, V., Mantzoros, C. S., & Matarese, G. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.014 · Cited by 116 · see citing works

Early-life factors contributing to type 1 diabetes

Craig, M. E., Kim, K. W., Isaacs, S. R., Penno, M. A. S., Hamilton‐Williams, E. E., Couper, J., & Rawlinson, W. D. (2019) · Diabetologia · doi:10.1007/s00125-019-4942-x · Cited by 114 · see citing works

The prenatal environment and type 1 diabetes

Stene, L. C., & Gale, E. (2013) · Diabetologia · doi:10.1007/s00125-013-2929-6 · Cited by 95 · see citing works

Coffee and autoimmunity: More than a mere hot beverage!

Sharif, Κ., Watad, ‬., Bragazzi, N. L., Adawi, M., Amital, H., & Shoenfeld, Y. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.007 · Cited by 98 · see citing works

Cellular and molecular pathogenesis of type 1A diabetes

Jahromi, M., & Eisenbarth, G. S. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6469-4 · Cited by 91 · see citing works

Spring harvest? Reflections on the rise of type 1 diabetes

Gale, E. A. M. (2005) · Diabetologia · doi:10.1007/s00125-005-0028-z · Cited by 90 · see citing works

HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk

Helminen, O., Aspholm, S., Pokka, T. M.-L., Hautakangas, M., Haatanen, N., Lempainen, J., Ilonen, J., Simell, O., Knip, M., & Veijola, R. (2014) · Diabetes · doi:10.2337/db14-0497 · Cited by 85 · see citing works

The genetic basis for type 1 diabetes

Mehers, K. L., & Gillespie, K. M. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn045 · Cited by 83 · see citing works

Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes

Vehik, K., Hamman, R. F., Lezotte, D., Norris, J. M., Klingensmith, G. J., Rewers, M., & Dabelea, D. (2008) · Diabetes Care · doi:10.2337/dc07-2210 · Cited by 82 · see citing works

Addressing insulin resistance in Type 1 diabetes

Pang, T. T. L., & Narendran, P. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02493.x · Cited by 78 · see citing works

Phases of type 1 diabetes in children and adolescents

Couper, J., Haller, M. J., Ziegler, A., Knip, M., Ludvigsson, J., & Craig, M. E. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12188 · Cited by 78 · see citing works

Age-Dependent Influences on the Origins of Autoimmune Diabetes

Leslie, R. D., & Castelli, M. D. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3033 · Cited by 73 · see citing works

Psychological stress and type 1 diabetes mellitus: what is the link?

Sharif, Κ., Watad, ‬., Coplan, L., Amital, H., Shoenfeld, Y., & Afek, A. B. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1538787 · Cited by 71 · see citing works

Epidemiology of Type 1 Diabetes

Vanderniet, J. A., Jenkins, A. J., & Donaghue, K. C. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01762-w · Cited by 74 · see citing works

Pathogenesis of type 1 diabetes: lessons from natural history studies of high‐risk individuals

Nokoff, N., & Rewers, M. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12021 · Cited by 66 · see citing works

The multiple origins of Type 1 diabetes

Pugliese, A. (2012) · Diabetic Medicine · doi:10.1111/dme.12081 · Cited by 66 · see citing works

Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies

Delli, A. J., Lindblad, B., Carlsson, A., Forsander, G., Ivarsson, S. A., Ludvigsson, J., Marcus, C., Lernmark, Å., & for the Better Diabetes Diagnosis (BDD) Study Group (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00637.x · Cited by 65 · see citing works

Beyond the Hormone: Insulin as an Autoimmune Target in Type 1 Diabetes

Brezar, V., Carel, J., Boîtard, C., & Mallone, R. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0010 · Cited by 66 · see citing works

Immunology and genetics of type 1 diabetes

Morran, M. P., Omenn, G. S., & Pietropaolo, M. (2008) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20052 · Cited by 63 · see citing works

Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden

for the Swedish Better Diabetes Diagnosis Study Group, Carlsson, A., Kockum, I. S., Lindblad, B., Engleson, L., Nilsson, A. C., Forsander, G., Karlsson, A., Kernell, A., Ludvigsson, J., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.122 · Cited by 62 · see citing works

Diabetes in the young: a paediatric and epidemiological perspective

Soltész, G. (2003) · Diabetologia · doi:10.1007/s00125-003-1101-0 · Cited by 62 · see citing works

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk

Mustonen, N., Siljander, H., Peet, A., Tillmann, V., Härkönen, T., Ilonen, J., Hyöty, H., Knip, M., & The DIABIMMUNE Study Group (2017) · Pediatric Diabetes · doi:10.1111/pedi.12547 · Cited by 61 · see citing works

Early-Onset, Coexisting Autoimmunity and Decreased HLA-Mediated Susceptibility Are the Characteristics of Diabetes in Down Syndrome

Aitken, R. J., Mehers, K. L., Williams, A. J. K., Brown, J., Bingley, P. J., Holl, R. W., Rohrer, T. R., Schober, E., Abdul-Rasoul, M. M., Hamilton-Shield, J. P., et al. (2012) · Diabetes Care · doi:10.2337/dc12-1712 · Cited by 61 · see citing works

Type 1 diabetes: Lessons for other autoimmune diseases?

Harrison, L. C., Honeyman, M. C., Morahan, G., Wentworth, J. M., Elkassaby, S., Colman, P. G., & Fourlanos, S. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.026 · Cited by 60 · see citing works

Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years

Steck, A. K., Armstrong, T. K., Babu, S. R., Eisenbarth, G. S., & the Type 1 Diabetes Genetics Consortium (2011) · Diabetes · doi:10.2337/db10-1419 · Cited by 60 · see citing works

Introduction to ISPAD Clinical Practice Consensus Guidelines 2014 Compendium

Acerini, C. L., Craig, M. E., de Beaufort, C. E., Maahs, D. M., & Hanås, R. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12182 · Cited by 59 · see citing works

OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis

Helminen, O., Aspholm, S., Pokka, T. M.-L., Ilonen, J., Simell, O., Veijola, R., & Knip, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3621-9 · Cited by 57 · see citing works

Obesity in late adolescence and incident type 1 diabetes in young adulthood

Zucker, I., Zloof, Y., Bardugo, A., Tsur, A. M., Lutski, M., Cohen, Y., Cukierman‐Yaffe, T., Minsky, N. C., Derazne, E., Tzur, D., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05722-5 · Cited by 57 · see citing works

Double or hybrid diabetes associated with an increase in type 1 and type 2 diabetes in children and youths

Pozzilli, P., Guglielmi, C., Pronina, E. A., & Petryaykina, E. E. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00338.x · Cited by 57 · see citing works

The convergence of type 1 and type 2 diabetes in childhood

Wilkin, T. J. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00831.x · Cited by 56 · see citing works

Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes

Aarnisalo, J., Veijola, R., Vainionpää, R., Simell, O., Knip, M., & Ilonen, J. (2008) · Diabetologia · doi:10.1007/s00125-008-0945-8 · Cited by 56 · see citing works

Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications

Zhang, J., Xiao, Y., Hu, J., Liu, S., Zhou, Z., & Xie, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.999108 · Cited by 53 · see citing works

Epidemiology of type 1 diabetes mellitus in children and adolescents: A 50‐year, single‐center experience

Kandemir, N., Vurallı, D., Özön, A., Gonc, N. E., Ardıçlı, D., Jalilova, L., Gülçek, Ö. N., & Alikaşifoğlu, A. (2024) · Journal of Diabetes · doi:10.1111/1753-0407.13562 · Cited by 53 · see citing works

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes

Lempainen, J., Vaarala, O., Mäkelä, M., Veijola, R., Simell, O., Knip, M., Hermann, R., & Ilonen, J. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.04.003 · Cited by 53 · see citing works

Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area

Urakami, T., Suzuki, J., Yoshida, A., Saito, H., & Mugishima, H. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.01.029 · Cited by 50 · see citing works

Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis

Wilkin, T. J. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00343.x · Cited by 48 · see citing works

BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children

Lauria, A., Barker, A., Schloot, N. C., Hosszúfalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., der Schueren, B. V., Mandrup-Poulsen, T. R., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0522 · Cited by 50 · see citing works

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease

Awdeh, Z., Yunis, E. J., Audeh, M. W., Fici, D. A., Pugliese, A., Larsen, C. E., & Alper, C. A. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.08.004 · Cited by 50 · see citing works

Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence

Hermann, R., Bartsocas, C. S., Soltész, G., Vazeou, A., Paschou, P., Bozas, E., Malamitsi‐Puchner, A., Simell, O., Knip, M., & Ilonen, J. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.455 · Cited by 50 · see citing works

Environmental Triggering of Type 1 Diabetes Autoimmunity

Houeiss, P., Luce, S., & Boîtard, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.933965 · Cited by 50 · see citing works

Type 1 diabetes mellitus and multiple sclerosis: common etiological features

Handel, A. E., Handunnetthi, L., Ebers, G. C., & Ramagopalan, S. V. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.216 · Cited by 49 · see citing works

At the crossroad of T cells, adipose tissue, and diabetes

Matarese, G., Procaccini, C., & Rosa, V. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01154.x · Cited by 47 · see citing works

Higher abundance of enterovirus A species in the gut of children with islet autoimmunity

Kim, K. W., Horton, J. L., Pang, C. N. I., Jain, K., Leung, P., Isaacs, S. R., Bull, R. A., Luciani, F., Wilkins, M. R., Catteau, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38368-8 · Cited by 48 · see citing works

Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis

Hekkala, A., Ilonen, J., Knip, M., Veijola, R., & _, _. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0376 · Cited by 47 · see citing works

C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277

Buzzetti, R., Cernea, S., Petrone, A., Capizzi, M., Spoletini, M., Zampetti, S., Guglielmi, C., Venditti, C., Pozzilli, P., & on behalf of the DiaPep Trialists Group (2011) · Diabetes · doi:10.2337/db10-0560 · Cited by 46 · see citing works

Metabolic Syndrome: Maladaptation to a Modern World

Wilkin, T. J., & Voss, L. D. (2004) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.97.11.511 · Cited by 46 · see citing works

The interplay of autoimmunity and insulin resistance in type 1 diabetes.

Nokoff, N., Rewers, M. J., & Cree‐Green, M. (2012) · PubMed · Cited by 44 · see citing works

Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus

Helminen, O., Pokka, T. M.-L., Tossavainen, P. H., Ilonen, J., Knip, M., & Veijola, R. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.07.027 · Cited by 41 · see citing works

How robust is the evidence for viruses in the induction of type 1 diabetes?

Honeyman, M. C. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.09.007 · Cited by 41 · see citing works

Prevention or acceleration of type 1 diabetes by viruses

Ghazarian, L., Diana, J., Simoni, Y., Beaudoin, L., & Lehuen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1042-1 · Cited by 40 · see citing works

What causes type 1 diabetes? Lessons from animal models

Buschard, K. (2011) · Apmis · doi:10.1111/j.1600-0463.2011.02765.x · Cited by 39 · see citing works

Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic: A case report

Cabrera‐Rode, E., Sarmiento, L., Molina, G., Pérez, C., Arranz, C., Cabrera, J. A. G., Prieto, M., Barrios, J., Palomera, R., Fonseca, M. C., et al. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20368 · Cited by 39 · see citing works

Common ground: shared risk factors for type 1 diabetes and celiac disease

Verdu, E. F., & Danska, J. S. (2018) · Nature Immunology · doi:10.1038/s41590-018-0130-2 · Cited by 39 · see citing works

The rising tide of childhood type 1 diabetes—what is the elusive environmental trigger?

Rewers, M., & Zimmet, P. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17368-6 · Cited by 39 · see citing works

Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile

Yeung, W. G., Al-Shabeeb, A., Pang, C. N. I., Wilkins, M. R., Catteau, J., Howard, N. J., Rawlinson, W. D., & Craig, M. E. (2012) · Diabetes · doi:10.2337/db11-0264 · Cited by 38 · see citing works

Changing perspectives in diabetes: their impact on its classification

Wilkin, T. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0665-5 · Cited by 38 · see citing works

Type 1 diabetes is insulin −2221 MspI and CTLA‐4 +49 A/G polymorphism dependent

Haller, K., Kisand, K., Nemvalts, V., Laine, A., Ilonen, J., & Uibo, R. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01385.x · Cited by 37 · see citing works

Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes

Mäkelä, M., Öling, V., Marttila, J., Waris, M. E., Knip, M., Simell, O., & Ilonen, J. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03146.x · Cited by 36 · see citing works

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Marcovecchio, M. L., Hendriks, E., Delfin, C., Battelino, T., Danne, T., Evans, M. L., Johannesen, J., Kaur, S., Knip, M., Overbergh, L., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06124-5 · Cited by 35 · see citing works

Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk

Lindehammer, S. R., Larsson, K., Örtqvist, E., Carlsson, A., Cedervall, E., Cilio, C., Ivarsson, S. A., Jönsson, B., Larsson, H. E., Lynch, K. F., et al. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0048-5 · Cited by 35 · see citing works

Ketoacidosis at onset of type 1 diabetes in children up to 14 years of age and the changes over a period of 18 years in Saxony, Eastern-Germany: A population based register study

Manuwald, U., Schoffer, O., Hegewald, J., Große, J., Kügler, J., Kapellen, T. M., Kieß, W., & Rothe, U. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218807 · Cited by 33 · see citing works

Epidemiology of Type 1 Diabetes

Lamb, M. M., & Norris, J. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-478-4_16 · Cited by 33 · see citing works

Looking back at the TEDDY study: lessons and future directions

Lernmark, Å., Agardh, D., Akolkar, B., Gesualdo, P., Hagopian, W., Haller, M. J., Hyöty, H., Johnson, S. B., Larsson, H. E., Liu, E., et al. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01045-0 · Cited by 32 · see citing works

Viral Infections and Diabetes

Galleri, L., Sebastiani, G., Vendrame, F., Grieco, F. A., Spagnuolo, I., & Dotta, F. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_20 · Cited by 32 · see citing works

Bare lymphocyte syndrome: An opportunity to discover our immune system

Shrestha, D., Szöllõsi, J., & Jenei, A. (2011) · Immunology Letters · doi:10.1016/j.imlet.2011.10.007 · Cited by 32 · see citing works

An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes

Mehers, K. L., Long, A. E., van der Slik, A. R., Aitken, R. J., Nathwani, V., Wong, F. S., Bain, S., Gill, G. V., Roep, B. O., Bingley, P. J., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2299-x · Cited by 31 · see citing works

LADA and T1D in Estonian population — Two different genetic risk profiles

Kisand, K., & Uibo, R. (2012) · Gene · doi:10.1016/j.gene.2012.01.089 · Cited by 29 · see citing works

GDF15: a potential therapeutic target for type 1 diabetes

Sarkar, S., Melchior, J., Henry, H. R., Syed, F., Mirmira, R. G., Nakayasu, E. S., & Metz, T. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2029410 · Cited by 30 · see citing works

The microbiology of human hygiene and its impact on type 1 diabetes

Chapman, N. M., Coppieters, K. T., von Herrath, M., & Tracy, S. (2012) · Islets · doi:10.4161/isl.21570 · Cited by 30 · see citing works

Descriptive epidemiology of type 1 diabetes—is it still in?

Knip, M. (2012) · Diabetologia · doi:10.1007/s00125-012-2522-4 · Cited by 28 · see citing works

Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar

Haris, B., Ahmed, I., Syed, N., Almabrazi, H., Saraswathi, S., Al‐Khawaga, S., Saeed, A. Z., Mundekkadan, S., Mohammed, I., Sharari, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98460-4 · Cited by 28 · see citing works

Early life origin of type 1 diabetes

Knip, M., Luopajärvi, K., & Härkönen, T. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0665-6 · Cited by 27 · see citing works

Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk

Lindehammer, S. R., Larsson, K., Örtqvist, E., Carlsson, A., Cedervall, E., Cilio, C., Ivarsson, S. A., Jönsson, B., Larsson, H. E., Lynch, K. F., et al. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0048-5 · Cited by 35 · see citing works

Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes

Vehik, K., Hamman, R. F., Lezotte, D., Norris, J. M., Klingensmith, G. J., Rewers, M., & Dabelea, D. (2008) · Diabetes Care · doi:10.2337/dc07-2210 · Cited by 82 · see citing works

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

Gillespie, K. M., Bain, S. C., Barnett, A. H., Bingley, P. J., Christie, M. R., Gill, G. V., & Gale, E. A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17357-1 · Cited by 304 · see citing works

Temporal Trends of HLA, CTLA-4 and PTPN22 Genotype Frequencies among Type 1 Diabetes in Continental Italy

Spoletini, M., Zampetti, S., Campagna, G., Marandola, L., Capizzi, M., Buzzetti, R., & for the IMDIAB Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0061331 · Cited by 4 · see citing works

The rising tide of childhood type 1 diabetes—what is the elusive environmental trigger?

Rewers, M., & Zimmet, P. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17368-6 · Cited by 39 · see citing works