Genetics of type 1 diabetes

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

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Classification and Diagnosis of Diabetes

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

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Untitled work

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2. Classification and Diagnosis of Diabetes

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Type 1 diabetes: new perspectives on disease pathogenesis and treatment

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Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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Positional cloning of the APECED gene

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

Dabelea, D., Mayer-Davis, E. J., Saydah, S., Imperatore, G., Linder, B., Divers, J., Bell, R., Badaru, A., Talton, J. W., Crume, T., et al. (2014) · JAMA · doi:10.1001/jama.2014.3201 · Cited by 1,412 · see citing works

Staging presymptomatic type 1 diabetes: A scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

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Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group

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The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945 · see citing works

Effects of insulin in relatives of patients with type 1 diabetes mellitus

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Differentiation of diabetes by pathophysiology, natural history, and prognosis

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

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The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

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Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

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The Rise of Childhood Type 1 Diabetes in the 20th Century

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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

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The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth Study

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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

Cooper, J. D., Smyth, D. J., Smiles, A. M., Plagnol, V., Walker, N. M., Allen, J. E., Downes, K., Barrett, J. C., Healy, B. C., Mychaleckyj, J. C., et al. (2008) · Nature Genetics · doi:10.1038/ng.249 · Cited by 531 · see citing works

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

Flanagan, S. E., Haapaniemi, E. M., Russell, M. A., Caswell, R. C., Allen, H. L., Franco, E. D., McDonald, T. J., Rajala, H. L. M., Ramelius, A., Barton, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3040 · Cited by 508 · see citing works

Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2050

Imperatore, G., Boyle, J. P., Thompson, T. J., Case, D., Dabelea, D., Hamman, R. F., Lawrence, J. M., Liese, A. D., Liu, L. L., Mayer‐Davis, E. J., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0669 · Cited by 485 · see citing works

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

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Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY)

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Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

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Definition, epidemiology, and classification of diabetes in children and adolescents

Craig, M. E., Jefferies, C., Dabelea, D., Balde, N. M., Seth, A., & Donaghue, K. C. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12186 · Cited by 385 · see citing works

Racial-ethnic disparities in management and outcomes among children with type 1 diabetes

Willi, S. M., Miller, K. M., DiMeglio, L. A., Klingensmith, G. J., Simmons, J. H., Tamborlane, W. V., Nadeau, K. J., Kittelsrud, J. M., Huckfeldt, P., Beck, R. W., et al. (2015) · Pediatrics · doi:10.1542/peds.2014-1774 · Cited by 367 · see citing works

Concordance for islet autoimmunity among monozygotic twins

Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S., & Orban, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0805398 · Cited by 353 · see citing works

Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

Vella, A. V., Cooper, J. D., Lowe, C. E., Walker, N. M., Nutland, S. L., Widmer, B., Jones, R. W., Ring, S. M., McArdle, W. L., Pembrey, M. E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429843 · Cited by 352 · see citing works

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

Oram, R. A., Patel, K. A., Hill, A., Shields, B. M., McDonald, T. J., Jones, A. G., Hattersley, A. T., & Weedon, M. N. (2015) · Diabetes Care · doi:10.2337/dc15-1111 · Cited by 351 · see citing works

Genetics of Type 1 Diabetes

Noble, J. A., & Erlich, H. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007732 · Cited by 335 · see citing works

Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus

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Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States

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Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

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Global epidemiology of type 1 diabetes in young adults and adults: a systematic review

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The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

Hu, X.-L., Deutsch, A., Lenz, T., Onengut-Gumuscu, S., Han, B., Chen, W.-M., Howson, J., Todd, J., de Bakker, P., Rich, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3353 · Cited by 272 · see citing works

The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants

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Extreme genetic risk for type 1A diabetes

Aly, T. A., Ide, A., Jahromi, M. M., Barker, J. M., Fernando, M. S., Babu, S. R., Yu, L., Miao, D., Erlich, H. A., Fain, P. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606349103 · Cited by 256 · see citing works

HLA Class I and Genetic Susceptibility to Type 1 Diabetes

Noble, J. A., Valdes, A. M., Varney, M. D., Carlson, J. A., Moonsamy, P., Fear, A. L., Lane, J. A., Lavant, E., Rappner, R., Louey, A., et al. (2010) · Diabetes · doi:10.2337/db10-0699 · Cited by 254 · see citing works

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study)

Zhou, Z., Xiang, Y., Ji, L., Jia, W., Ning, G., Huang, G., Yang, L., Lin, J., Liu, Z., Hagopian, W. A., et al. (2013) · Diabetes · doi:10.2337/db12-0207 · Cited by 251 · see citing works

Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes–indication of an increased environmental pressure?

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Immunogenetics of type 1 diabetes: a comprehensive review

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The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results

Mahon, J. L., Sosenko, J. M., Rafkin‐Mervis, L., Krause-Steinrauf, H. J., Lachin, J. M., Thompson, C. M., Bingley, P. J., Bonifacio, E. E., Palmer, J. P., Eisenbarth, G. S., et al. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2008.00464.x · Cited by 200 · see citing works

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

Patel, K. A., Oram, R. A., Flanagan, S. E., Franco, E. D., Colclough, K., Shepherd, M. H., Ellard, S., Weedon, M. N., & Hattersley, A. T. (2016) · Diabetes · doi:10.2337/db15-1690 · Cited by 196 · see citing works

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

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Genetics of type 1A diabetes

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Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study

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GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

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Genetic control of autoimmunity in Type I diabetes and associated disorders

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Lack of Association Between Early Exposure to Cow's Milk Protein and β-Cell Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)

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IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity

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Protein tyrosine phosphatase PTPN22 in human autoimmunity

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Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

Grant, S. F. A., Qu, H., Bradfield, J. P., Marchand, L., Kim, C., Glessner, J., Grabs, R., Taback, S. P., Frackelton, E. C., Eckert, A. W., et al. (2008) · Diabetes · doi:10.2337/db08-1022 · Cited by 161 · see citing works

Genetics of diabetes – Are we missing the genes or the disease?

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DNA methylation and its role in the pathogenesis of diabetes

Bansal, A., & Pinney, S. E. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12521 · Cited by 156 · see citing works

Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study

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HL-A ANTIGENS AND DIABETES MELLITUS

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A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families

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PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Santín, I., Moore, F., Colli, M. L., Gurzov, E. N., Marselli, L., Marchetti, P., & Eizirik, D. L. (2011) · Diabetes · doi:10.2337/db11-0758 · Cited by 138 · see citing works

The changing face of diabetes in youth: lessons learned from studies of type 2 diabetes

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Diabetes classification: grey zones, sound and smoke: Action LADA 1

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Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes

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Genetic and Epigenetic Factors in Etiology of Diabetes Mellitus Type 1

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Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity

Ilonen, J., Kiviniemi, M., Lempainen, J., Simell, O., Toppari, J., Veijola, R., Knip, M., & Register, T. F. P. D. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12327 · Cited by 134 · see citing works

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes

Yang, Y., & Chan, L. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1116 · Cited by 133 · see citing works

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

CONCANNON, P. J., Önengüt-Gümüşcü, S., Todd, J. A., Smyth, D. J., Pociot, F., Bergholdt, R., Akolkar, B., Erlich, H. A., Hilner, J. E., Julier, C., et al. (2008) · Diabetes · doi:10.2337/db08-0753 · Cited by 130 · see citing works

The HLA class I A locus affects susceptibility to type 1 diabetes

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Type 1 Diabetes TrialNet–An International Collaborative Clinical Trials Network

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BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

Marroquí, L., Santín, I., dos Santos, R. S., Marselli, L., Marchetti, P., & Eizirik, D. L. (2014) · Diabetes · doi:10.2337/db13-1443 · Cited by 113 · see citing works

Genetic epidemiology of type 1 diabetes

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HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus.

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Monogenic Diabetes Accounts for 6.3% of Cases Referred to 15 Italian Pediatric Diabetes Centers During 2007 to 2012

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Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen

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The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes.

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FREQUENCY OF DIABETES MELLITUS IN PATIENTS WITH COVID-19 INFECTION

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Investigation and analysis on the status of diabetes cognition among COPD patients complicated with diabetes mellitus

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Diabetes status affects long-term changes in coronal caries - The SHIP Study

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