Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men
Open accessAbstract
Aims/hypothesis Type 2 diabetes mellitus is characterised by heightened inflammation and endothelial dysfunction. Moderate alcohol intake has been associated with a reduced risk of cardiovascular disease in type 2 diabetic patients. It remains to be determined whether there is an association between alcohol and inflammation in individuals with diabetes.Methods We investigated the relationship between alcohol intake and inflammation in 726 of 18,159 men who returned blood samples in the Health Professionals Follow-up Study and had confirmed type 2 diabetes at blood draw.Results In age-adjusted analyses, alcohol intake was associated with lower levels of HbA1c, fibrinogen, soluble tumour necrosis factor receptor-2 (sTNF-R2) and soluble vascular adhesion molecule-1 (sVCAM-1), and with higher levels of HDL cholesterol and adiponectin (p value for trends <0.05). After adjustment for age, HbA1c, insulin use, fasting status, smoking, BMI, physical activity, aspirin use, prevalence of cardiovascular disease and dietary factors, each additional drink per day was related to increased HDL cholesterol (0.053 mmol/l, p<0.0001) and adiponectin (0.8 microg/ml, p=0.01), and decreased sTNFR-2 (73 pg/ml, p=0.03), fibrinogen (0.302 micromol/l, p=0.02) and sVCAM-1 (33 ng/ml, p=0.02). The relationship between alcohol and inflammatory biomarkers persisted when subjects were stratified according to HbA1c levels.Conclusions/interpretation Moderate alcohol intake may have a beneficial effect on markers of inflammation and endothelial dysfunction in type 2 diabetic patients.
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Alcohol Consumption and Incident Heart Failure in Men and Women
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- Authors
- Shai, I., Rimm, E. B., Schulze, M. B., Rifai, N., Stampfer, M. J., & Hu, F. B.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Corresponding author
- Shai, I.
- Venue
- Diabetologia
- Published
- 2004-10
- Volume
- 47
- Issue
- 10
- Pages
- 1760-1767
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1974318561
- Cited by
- 83
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- American Heart Association
- Ben-Gurion University of the Negev
- National Institutes of Health (CA55075)
- National Institute on Alcohol Abuse and Alcoholism (AA-11181, R01AA011181)
- National Heart, Lung, and Blood Institute (HL 65582, R01HL065582, R01HL035464, HL35464)
- National Cancer Institute (CA-55075)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- moderate drinking, type 2 diabetes, inflammation, endothelial dysfunction, inflammatory markers, HDL cholesterol, adiponectin, fibrinogen, HbA1c, cardiovascular risk, men
- MeSH terms
- Adult, Aged, Alcohol Drinking, Diabetes Mellitus, Type 2, Endothelium, Vascular, Glycated Hemoglobin, Humans, Inflammation, Life Style, Lipids, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Smoking, Cohort Studies, Biomarkers
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