Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
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AIM: To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart. METHODS: Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories Ⅰ, Ⅱ and Ⅲ of the guidelines were examined. RESULTS: The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean ± SD) (mm) for a 10-year absolute risk of ≥ 2.0% and ≥ 5.0%: 0.88 ± 0.18 and 0.95 ± 0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean ± SD) (mm) for Categories Ⅰ, Ⅱ, and Ⅲ: 0.70 ± 0.11, 0.81 ± 0.16 and 0.88 ± 0.18, respectively; mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category Ⅲ participants with or without DM and CKD. CONCLUSIONS: Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.
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There is still a lack of sufficient evidence on the significance of noninvasive arterial wall assessment in Japan.
“Although there are reports on the significance of noninvasive arterial wall assessment in Japan34), there is still a lack of sufficient evidence.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [34]
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- Authors
- Kadota, A., Miura, K., Okamura, T., Fujiyoshi, A., Ohkubo, T., Kadowaki, T., Takashima, N., Hisamatsu, T., Nakamura, Y., Kasagi, F., Maegawa, H., Kashiwagi, A., & Ueshima, H.
- Affiliations
- Osaka Kyoiku University (JP)
- Shiga University of Medical Science (JP)
- Keio University (JP)
- Radiation Effects Association (JP)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2013
- Volume
- 20
- Issue
- 10
- Pages
- 755-766
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2048236527
- Cited by
- 51
- References
- 43
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (21249043, R01068220)
- Japan Society for the Promotion of Science (23590791)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- carotid intima-media thickness, carotid plaque, subclinical atherosclerosis, coronary artery disease mortality, cardiovascular risk stratification, diabetes mellitus, chronic kidney disease, Japanese men
- MeSH terms
- Adult, Aged, Blood Glucose, Cardiovascular Diseases, Glomerular Filtration Rate, Glycated Hemoglobin, Humans, Japan, Male, Middle Aged, Risk Factors, Tunica Intima, Plaque, Atherosclerotic
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