Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
Open accessAbstract
Aims/hypothesis The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period.Methods All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture-recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied.Results Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half.Conclusions/interpretation The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted.
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The incidence of diabetes in England is still twice as high as in Lithuania.
“However, the incidence of diabetes in England is still twice as high as in Lithuania [ 1 ]”
From Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren (2020) · cites this paper as [1]
Table 1 (Discussion; page unavailable) reports childhood type 1 diabetes incidence of 25.1 and 25.5 per 100,000 in Oxford and Yorkshire, versus 14.2 in Lithuania in the latest period—roughly 1.8 times as high. The comparison is directionally supported, but the paper reports two English regions, not England as a whole, and concerns children under 15 with type 1 diabetes rather than diabetes generally. (LLM, conf=0.87)
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- Authors
- Patterson, C. C., Gyürüs, E., Rosenbauer, J., Cinek, O., Neu, A., Schober, E., Parslow, R. C., Joner, G., Svensson, J., Castell, C., Bingley, P. J., Schoenle, E., Jarosz-Chobot, P., Urbonaité, B., Rothe, U., Krzisnik, C., Ionescu-Tirgoviste, C., Weets, I., Kocova, M., Stipancic, G., Samardzic, M., de Beaufort, C. E., Green, A., Dahlquist, G. G., & Soltész, G.
- Affiliations
- Queen's University Belfast (GB)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Charles University (CZ)
- University Children's Hospital Tübingen (DE)
- Medical University of Vienna (AT)
- University of Leeds (GB)
- Oslo University Hospital (NO)
- University of Copenhagen (DK)
- Generalitat de Catalunya (ES)
- University of Bristol (GB)
- University Children's Hospital Zurich (CH)
- Medical University of Silesia (PL)
- Technische Universität Dresden (DE)
- Université Libre de Bruxelles (BE)
- University of Montenegro (ME)
- University of Southern Denmark (DK)
- Umeå University (SE)
- University of Pecs (HU)
- Corresponding author
- Patterson, C. C.
- ORCID
- Venue
- Diabetologia
- Published
- 2012-05-26
- Volume
- 55
- Issue
- 8
- Pages
- 2142-2147
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2017377709
- Cited by
- 470
- References
- 10
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 18 · 2022: 32 · 2021: 36 · 2020: 37 · 2019: 28 · 2018: 47 · 2017: 49 · 2016: 53 · 2015: 49 · 2014: 47 · 2013: 37 · 2012: 12
- FWCI
- 27.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Lithuanian University of Health Sciences (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Diabetes UK
- Bundesministerium für Bildung und Forschung (01GI0802, 01GI0859)
- Vetenskapsrådet (07531)
- Universität Ulm
- Helse Sør-Øst RHF
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes in children, incidence trends, temporal heterogeneity, mark-recapture, risk exposure, Europe
- MeSH terms
- Adolescent, Child, Child Welfare, Diabetes Mellitus, Type 1, Europe, Female, Health Planning, Health Services Needs and Demand, Humans, Male, Prospective Studies, Registries, Risk Factors, Incidence, Survival Rate, Age Distribution, Sex Distribution
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