Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans
Open accessAbstract
Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at night and experience circadian misalignment (i.e. misalignment between the central circadian pacemaker and the environmental/behavioural cycles), have an increased risk of type 2 diabetes. To determine the separate and relative impacts of the circadian system, behavioural/environmental cycles, and their interaction (i.e. circadian misalignment) on insulin sensitivity and β‐cell function, the oral minimal model was used to quantitatively assess the major determinants of glucose control in 14 healthy adults using a randomized, cross‐over design with two 8‐day laboratory protocols. Both protocols involved 3 baseline inpatient days with habitual sleep/wake cycles, followed by 4 inpatient days with the same nocturnal bedtime (circadian alignment) or with 12‐hour inverted behavioural/environmental cycles (circadian misalignment). The data showed that circadian phase and circadian misalignment affect glucose tolerance through different mechanisms. While the circadian system reduces glucose tolerance in the biological evening compared to the biological morning mainly by decreasing both dynamic and static β‐cell responsivity, circadian misalignment reduced glucose tolerance mainly by lowering insulin sensitivity, not by affecting β‐cell function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The decrease in insulin sensitivity is mostly caused by the behavioral cycle, while the circadian system dominates the deterioration in glucose tolerance and b-cell responsivity.
“Furthermore, it has been shown that such a decrease in insulin sensitivity is mostly caused by the behavioral cycle, while the circadian system dominates the deterioration in glucose tolerance and b-cell responsivity (8,32).”
From Interplay of Dinner Timing and <i>MTNR1B</i> Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [32]
The Discussion (p. not supplied) says the behavioral cycle mostly accounts for the decline in insulin sensitivity, while the circadian system dominates the decline in β-cell responsivity. The Introduction (p. not supplied) says both circadian and behavioral cycles contribute to daily glucose control; it does not establish that the circadian system dominates the deterioration in glucose tolerance overall. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe circadian effect on glucose tolerance and b-cell responsivity appeared to be independent of melatonin signaling, because melatonin levels were low during the circadian evening in previous studies.
“The circadian effect appeared to be independent of melatonin signaling, because melatonin levels were low during the circadian evening ($2000-2200 h) in the previous studies (8,32).”
From Interplay of Dinner Timing and <i>MTNR1B</i> Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [32]
The Results section reports lower β-cell responsivity in the biological evening, and the paper reports a corresponding reduction in glucose tolerance. But our copy does not establish that this effect is independent of melatonin signaling or state that melatonin levels were low during the circadian evening (searched: melatonin, low melatonin levels). (LLM, conf=0.84)
Experimental — accuracy not yet measuredLonger sleep episodes correlate with an earlier intake of dinner/the last meal and a decreased consumption of free sugars.
“longer sleep episodes correlate with an earlier intake of dinner/the last meal (83) as well as a decreased consumption of free sugars (173).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [83]
Citation 83 is attached to the earlier-dinner claim; the free-sugars claim has a separate citation. The Methods (section 2.1) describe meals scheduled relative to waking, and the Results (section 3) compare metabolic responses to breakfast and dinner. Neither those passages nor the searched passages on sleep duration and meal timing report whether longer sleep episodes correlate with an earlier dinner or last meal. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Self-citationBuxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women
Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805 · cited 1× · see citing works
“The circadian regulation of β-cell function may provide an explanation for the increased risk of poor glycaemic control in late eaters and shift workers who often eat in the biological evening/night.(11,12) The results also support the findings that avoiding large meals with high glycaemic index in the late evening or…”
ResultCircadian misalignment increases cardiovascular disease risk factors in humans
Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691 · see citing works
Self-citationRoles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 611 · see citing works
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Van Cauter, E. (1997) · Endocrine Reviews · doi:10.1210/er.18.5.716 · Cited by 608 · see citing works
Leproult, R., Holmbäck, U., & Van Cauter, E. (2014) · Diabetes · doi:10.2337/db13-1546 · Cited by 607 · see citing works
Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523 · see citing works
Self-citationRizza, R. A., Mandarino, L. J., & Gerich, J. E. (1982) · Diabetes · doi:10.2337/diab.31.8.663 · Cited by 430 · cited 1× · see citing works
“decrease insulin sensitivity.(15,16) In the short-term circadian misalignment exposure (3 days), no evidence was found of altered β-cell function due to circadian misalignment.”
BackgroundPancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370 · see citing works
Self-citationOral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity
Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320 · see citing works
Self-citationCobelli, C., TOFFOLO, G. M., Man, C. D., Campioni, M., Denti, P., Caumo, A., Butler, P. C., & Rizza, R. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00421.2006 · Cited by 311 · see citing works
Self-citationDiurnal pattern to insulin secretion and insulin action in healthy individuals
Saad, A., Dalla Man, C., Nandy, D. K., Levine, J. A., Bharucha, A. E., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., Kudva, Y. C., et al. (2012) · Diabetes · doi:10.2337/db11-1478 · Cited by 297 · see citing works
Self-citationThe oral glucose minimal model: Estimation of insulin sensitivity from a meal test
Della Man, C., Caumo, A., & Cobelli, C. (2002) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.995680 · Cited by 241 · see citing works
Self-citationCobelli, C., Dalla Man, C., Toffolo, G., Basu, R., Vella, A., & Rizza, R. (2014) · Diabetes · doi:10.2337/db13-1198 · Cited by 216 · see citing works
Self-citationMorris, C. J., Garcia, J. I., Myers, S., Yang, J. N., Trienekens, N., & Scheer, F. A. J. L. (2015) · Obesity · doi:10.1002/oby.21189 · Cited by 167 · see citing works
Self-citationMorgan, L. M., Shi, J.-W., Hampton, S. M., & Frost, G. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511006507 · Cited by 145 · see citing works
Jakubowicz, D., Wainstein, J., Ahrén, B., Bar-Dayan, Y., Landau, Z., Rabinovitz, H. R., & Froy, O. (2015) · Diabetologia · doi:10.1007/s00125-015-3524-9 · Cited by 139 · see citing works
Qian, J., Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2013) · Diabetes · doi:10.2337/db12-1543 · Cited by 138 · see citing works
Self-citationDaily circadian misalignment impairs human cognitive performance task-dependently
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-20707-4 · Cited by 120 · see citing works
Self-citationGlucose metabolism during rotational shift-work in healthcare workers
Sharma, A. R., LAURENTI, M. C., Man, C. D., Varghese, R. T., Cobelli, C., Rizza, R. A., Matveyenko, A. V., & Vella, A. V. (2017) · Diabetologia · doi:10.1007/s00125-017-4317-0 · Cited by 113 · see citing works
Self-citationIsn’t This Just Bedtime Snacking?
Morse, S. A., Ciechanowski, P. S., Katon, W. J., & Hirsch, I. B. (2006) · Diabetes Care · doi:10.2337/dc06-0315 · Cited by 110 · see citing works
Four days of simulated shift work reduces insulin sensitivity in humans
Bescós, R., Boden, M. J., Jackson, M. L., Trewin, A. J., Marin, E. C., Levinger, I., GARNHAM, A. P., Hiam, D., Falcão‐Tebas, F., Conte, F., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13039 · Cited by 84 · see citing works
The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation
Tucker, M. A., Morris, C. J., Morgan, A., Yang, J. N., Myers, S. J., Pierce, J. G., Stickgold, R., & Scheer, F. A. J. L. (2017) · SLEEP · doi:10.1093/sleep/zsx036 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works
Self-citationCircadian disruption and human health
Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468 · see citing works
The circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428 · see citing works
Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes
Mason, I. C., Qian, J., Adler, G. K., & Scheer, F. A. J. L. (2020) · Diabetologia · doi:10.1007/s00125-019-05059-6 · Cited by 359 · see citing works
Self-citationMelatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193 · see citing works
Self-citationSex differences in the circadian misalignment effects on energy regulation
Qian, J., Morris, C. J., Caputo, R., Wang, W., Garaulet, M., & Scheer, F. A. J. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914003116 · Cited by 139 · see citing works
Self-citationBaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 138 · see citing works
Daytime eating prevents internal circadian misalignment and glucose intolerance in night work
Chellappa, S. L., Qian, J., Vujovic, N., Morris, C. J., Nedeltcheva, A., Nguyen, H., Rahman, N., Heng, S. W., Kelly, L., Kerlin-Monteiro, K., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg9910 · Cited by 135 · see citing works
Self-citationTiming of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121 · see citing works
Self-citationMammalian circadian systems: Organization and modern life challenges
Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117 · see citing works
Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans
Qian, J., Morris, C. J., Caputo, R., Garaulet, M., & Scheer, F. A. J. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0208-9 · Cited by 119 · see citing works
Self-citationCircadian rhythm and disease: Relationship, new insights, and future perspectives
Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. R. B. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30815 · Cited by 120 · see citing works
Research gaps and opportunities in precision nutrition: an NIH workshop report
Lee, B. Y., Ordovás, J. M., Parks, E. J., Anderson, C. A. M., Barabási, A.-Ĺ., Clinton, S. K., de la Haye, K., Duffy, V. B., Franks, P. W., Ginexi, E. M., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac237 · Cited by 122 · see citing works
Self-citationCoupled network of the circadian clocks: a driving force of rhythmic physiology
Finger, A., Dibner, C., & Kramer, A. (2020) · FEBS Letters · doi:10.1002/1873-3468.13898 · Cited by 99 · see citing works
Circadian misalignment increases mood vulnerability in simulated shift work
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-75245-9 · Cited by 98 · see citing works
Self-citationSondrup, N., Termannsen, A., Eriksen, J. N., Hjorth, M. F., Færch, K., Klingenberg, L., & Quist, J. S. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101594 · Cited by 105 · see citing works
Nagare, R., Woo, M. K., MacNaughton, P., Plitnick, B., Tinianov, B. D., & Figueiro, M. G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18199980 · Cited by 85 · see citing works
Garaulet, M., Lopez-Minguez, J., Dashti, H. S., Vetter, C., Hernández-Martínez, A. M., Pérez-Ayala, M., Baraza, J. C., Wang, W., Florez, J. C., Scheer, F. A. J. L., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1314 · Cited by 77 · see citing works
Self-citationMeal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72 · see citing works
“…of obesity (42), (2) reduced diet-induced thermogenesis in the evening (81), (3) diminished glucose tolerance due to circadian misalignment resulting from lower insulin sensitivity (82, 83), (4) adverse effects of elevated melatonin on glucose metabolism (84), and (5) an increase in body fat (69).”
BackgroundGenário, R., Cipolla‐Neto, J., Bueno, A. A., & Santos, H. O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105254 · Cited by 68 · see citing works
Physiological Closed-Loop Control (PCLC) Systems: Review of a Modern Frontier in Automation
Khodaei, M. J., Candelino, N. W., Mehrvarz, A., & Jalili, N. (2020) · IEEE Access · doi:10.1109/access.2020.2968440 · Cited by 66 · see citing works
Windred, D. P., Burns, A. C., Rutter, M. K., Yeung, C. H. C., Lane, J. M., Xiao, Q., Saxena, R., Cain, S. W., & Phillips, A. J. K. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.100943 · Cited by 59 · see citing works
Social jetlag, eating behaviours and BMI among adolescents in the USA
Mathew, G. M., Hale, L. E., & Chang, A. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001804 · Cited by 59 · see citing works
Liu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55 · see citing works
Brown, M., Sen, S., Mazzone, A., Her, T. K., Xiong, Y., Lee, J., Javeed, N., Colwell, C. S., Rakshit, K., LeBrasseur, N. K., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6856 · Cited by 55 · see citing works
Xiao, Q., Qian, J., Evans, D. S., Redline, S. S., Lane, N. E., Ancoli‐Israel, S., Scheer, F. A. J. L., & Stone, K. L. (2020) · Diabetes Care · doi:10.2337/dc20-0557 · Cited by 53 · see citing works
Self-citationA scoping review of intermittent fasting, chronobiology, and metabolism
Santos, H. O., Genário, R., Tinsley, G. M., de Carvalho, P. R., Carteri, R. B., Coelho‐Ravagnani, C. D. F., & Mota, J. F. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab433 · Cited by 53 · see citing works
Makarem, N., German, C. A., Zhang, Z., Diaz, K. M., Palta, P., Duncan, D. T., Castro‐Diehl, C., & Shechter, A. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.032073 · Cited by 47 · see citing works
The importance of being rhythmic: Living in harmony with your body clocks
Dibner, C. (2019) · Acta Physiologica · doi:10.1111/apha.13281 · Cited by 45 · see citing works
Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues
Khalyfa, A., Gaddameedhi, S., Crooks, E., Zhang, C., Li, Y., Qiao, Z., Trzépizur, W., Kay, S. A., Andrade, J., Satterfield, B. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176396 · Cited by 45 · see citing works
Aiello, E. M., Deshpande, S., Özaslan, B., Wolkowicz, K. L., Dassau, E., Pinsker, J. E., & Doyle, F. J. (2021) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2021.100312 · Cited by 44 · see citing works
Time for Exercise? Exercise and Its Influence on the Skeletal Muscle Clock
Martin, R. A., & Esser, K. A. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221122662 · Cited by 45 · see citing works
Mentzelou, M., Papadopoulou, S. Κ., Papandreou, D., Spanoudaki, M., Dakanalis, A., Vasios, G. K., Voulgaridou, G., Pavlidou, E., Mantzorou, M., & Giaginis, C. (2023) · Metabolites · doi:10.3390/metabo13030370 · Cited by 42 · see citing works
Association between circadian disruption and diseases: A narrative review
Hou, Y., Liu, L.-M., Chen, X., Li, Q., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118512 · Cited by 45 · see citing works
Shift Work and Metabolic Syndrome Updates: A Systematic Review
Schettini, M. A. S., Passos, R. F. D. N., & Koike, B. D. V. (2023) · Sleep Science · doi:10.1055/s-0043-1770798 · Cited by 47 · see citing works
de Goede, P., Foppen, E., Ritsema, W. I. G. R., Korpel, N. L., Yi, C., & Kalsbeek, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00554 · Cited by 41 · see citing works
Gao, C., Li, P., Morris, C. J., Zheng, X., Ulsa, M. C., Gao, L., Scheer, F. A. J. L., & Hu, K. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s373107 · Cited by 36 · see citing works
Self-citationBlunted rest–activity rhythms link to higher body mass index and inflammatory markers in children
Qian, J., Martínez-Lozano, N., Tvarijonaviciute, A., Ríos, R., Scheer, F. A. J. L., & Garaulet, M. (2020) · SLEEP · doi:10.1093/sleep/zsaa256 · Cited by 34 · see citing works
Self-citationDoes Insufficient Sleep Increase the Risk of Developing Insulin Resistance: A Systematic Review
Singh, T., Ahmed, T. H. E., Mohamed, N., Elhaj, M. S., Mohammed, Z., Paulsingh, C. N., Mohamed, M. B., & Khan, S. (2022) · Cureus · doi:10.7759/cureus.23501 · Cited by 41 · see citing works
Xiao, Q., Sampson, J. N., LaCroix, A. Z., Shadyab, A. H., Zeitzer, J. M., Ancoli‐Israel, S., Yaffe, K., Stone, K. L., & Osteoporotic Fractures in Men (MrOS) Study Group (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab275 · Cited by 33 · see citing works
Liang, F., Fu, J., Xu, Y., Wang, Y., Nan, Q., Ding, K., Zeng, J., Moore, J. B., & Li, R. (2022) · Nutrients · doi:10.3390/nu14030510 · Cited by 36 · see citing works
Molzof, H. E., Peterson, C. M., Thomas, S. J., Gloston, G. F., Johnson, R. L., & Gamble, K. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.876752 · Cited by 32 · see citing works
Remchak, M. E., Heiston, E. M., Ballantyne, A. C., Dotson, B. L., Stewart, N. R., Spaeth, A. M., & Malin, S. K. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac233 · Cited by 31 · see citing works
Age-related changes in circadian regulation of the human plasma lipidome
Rahman, S. A., Gathungu, R. M., Marur, V. R., Hilaire, M. A. S., Scheuermaier, K. D., Belenky, M., Struble, J. S., Czeisler, C. A., Lockley, S. W., Klerman, E. B., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05102-8 · Cited by 30 · see citing works
Rumanova, V. S., Okuliarová, M., Molčan, Ľ., Šutovská, H. M., & Zeman, M. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0043 · Cited by 31 · see citing works
Circadian de(regulation) in physiology: implications for disease and treatmentPreprint
de Assis, L. V. M., & Kramer, A. (2024) · Genes & Development · doi:10.1101/gad.352180.124 · Cited by 27 · see citing works
Chronic circadian disruption on a high-fat diet impairs glucose tolerance
Zitting, K., Vetrivelan, R., Yuan, R. K., Vujović, N., Wang, W., Bandaru, S. S., Quan, S. F., Klerman, E. B., Scheer, F. A. J. L., Buxton, O. M., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155158 · Cited by 27 · see citing works
Self-citationHebl, J. T., Velasco, J., & McHill, A. W. (2022) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2022.02.003 · Cited by 24 · see citing works
Sampieri, A., Paoli, A., Spinello, G., Santinello, E., & Moro, T. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05849-6 · Cited by 22 · see citing works
Astrocyte Clocks and Glucose Homeostasis
Barca‐Mayo, O., & López, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.662017 · Cited by 23 · see citing works
Endothelial Glycocalyx Preservation—Impact of Nutrition and Lifestyle
Franceković, P., & Gliemann, L. (2023) · Nutrients · doi:10.3390/nu15112573 · Cited by 21 · see citing works
Cobelli, C., & Man, C. D. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211015268 · Cited by 21 · see citing works
Self-citationDo Temporal Eating Patterns Differ in Healthy versus Unhealthy Overweight/Obese Individuals?
Mazri, F. H., Manaf, Z. A., Shahar, S., Ludin, A. F. M., Karim, N. A., Hazwari, N., Kek, Q., Basir, S. M. A., & Arifin, A. (2021) · Nutrients · doi:10.3390/nu13114121 · Cited by 21 · see citing works
Her, T. K., Li, J., Lin, H., Liu, D., Root, K. M., Regal, J. F., Alejandro, E. U., & Cao, R. (2024) · Metabolites · doi:10.3390/metabo14020126 · Cited by 21 · see citing works
Qian, J., Morris, C. J., Phillips, A. J. K., Li, P., Rahman, S. A., Wang, W., Hu, K., Arendt, J., Czeisler, C. A., & Scheer, F. A. J. L. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12791 · Cited by 19 · see citing works
Self-citationProcopio, S. B., & Esser, K. A. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.11.011 · Cited by 17 · see citing works
Multi-Omics Reveal Interplay between Circadian Dysfunction and Type2 Diabetes
Tiwari, A., Rathor, P., Trivedi, P. K., & Ch, R. (2023) · Biology · doi:10.3390/biology12020301 · Cited by 17 · see citing works
Evidence for Internal Desynchrony Caused by Circadian Clock Resetting.
Nicholls, S. K., Casiraghi, L. P., Wang, W., Weber, E. T., & Harrington, M. E. (2019) · PubMed Central · Cited by 18 · see citing works
de Goede, P., Hellings, T. P., Coopmans, T. V., Ritsema, W. I. G. R., & Kalsbeek, A. (2020) · Obesity · doi:10.1002/oby.22830 · Cited by 17 · see citing works
Stutz, B., Krueger, B., Goletzke, J., Jankovic, N., Alexy, U., Herder, C., Dierkes, J., Berg‐Beckhoff, G., Jakobsmeyer, R., Reinsberger, C., et al. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03372-4 · Cited by 18 · see citing works
Yuan, R. K., Zitting, K.-M., Duffy, J., Vujović, N., Wang, W., Quan, S. F., Klerman, E., Scheer, F., Buxton, O., Williams, J. S., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.764737 · Cited by 17 · see citing works
Self-citationWang, Q., Wu, S., Luo, Z., Pu, L., Wang, X., Guo, M., Zhang, M., Tang, H., Chen, M., Kong, L., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1307537 · Cited by 18 · see citing works
McDermott, J., Jacobs, J., Merrill, N. J., Mitchell, H. D., Arshad, O. A., McClure, R., Teeguarden, J., Gajula, R. P., Porter, K. I., Satterfield, B. C., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00418 · Cited by 15 · see citing works
Moreno, J. P., Crowley, S. J., Alfano, C. A., & Thompson, D. I. (2019) · Obesity Reviews · doi:10.1111/obr.12973 · Cited by 17 · see citing works
Guo, Y., Wang, Q., Zhang, K., Yao, C., Huang, J., Li, Q., Liu, Z., Zhang, Y., Shan, C., Liu, P., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001265rr · Cited by 15 · see citing works
Shift Workers at Risk for Metabolic Syndrome
Kulkarni, K., Schow, M., & Shubrook, J. H. (2020) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2020.020 · Cited by 15 · see citing works
Thambiliya, C. J. K. N., Agrawal, N., Sveistyte, A., Karatsoreos, I. N., Dongen, H. P. A. V., & Brandvold, K. R. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob02257e · Cited by 13 · see citing works
Davis, R., Murgia, C., Dordevic, A. L., Bonham, M. P., & Huggins, C. E. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.011 · Cited by 13 · see citing works
Sa'ari, A. S., Hamid, M. R. A., Azizan, N. A., & Ismail, N. H. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114562 · Cited by 11 · see citing works
Andriessen, C., Schrauwen, P., & Hoeks, J. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00719-9 · Cited by 13 · see citing works
Cincotta, A. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713255 · Cited by 11 · see citing works
Bidirectional Relationship Between Circadian Rhythm and Frailty
Pan, Y., Zhu, F., Yuan, Y., Hu, G. M., Jiang, Y., & Dong, J. C. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s436488 · Cited by 10 · see citing works
Leahy, S., Xiao, Q., Yeung, C. H. C., & Figueiro, M. G. (2024) · Scientific Reports · doi:10.1038/s41598-024-64309-9 · Cited by 10 · see citing works
Nrf2 modulates the benefits of evening exercise in type 2 diabetes
Fasipe, B., & Laher, I. (2023) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2023.09.001 · Cited by 11 · see citing works
The impact of training shifts in dancers’ chronotype and sleep patterns
Coirolo, N., Silva, A., & Tassino, B. (2020) · Sleep Science · doi:10.5935/1984-0063.20200010 · Cited by 10 · see citing works
Yang, L., Han, S., Miao, C., Lou, H., Gao, G., Lou, X., Hao, C., & Wang, X. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01324-2 · Cited by 9 · see citing works
Yeung, C. H. C., Wright, A. K., Windred, D. P., Burns, A. C., Phillips, A. J. K., Cain, S. W., Rutter, M. K., & Xiao, Q. (2025) · Diabetes Care · doi:10.2337/dc25-0309 · Cited by 8 · see citing works
Chen, W., & Yang, H. (2023) · Annals of Epidemiology · doi:10.1016/j.annepidem.2023.01.013 · Cited by 8 · see citing works
Influence of Chronotypes in Respiratory Pathology
Moreno, B. R., Riolobos, C. L., Díaz-García, J. M., López, C. M., & Fernández, A. A. (2022) · Open Respiratory Archives · doi:10.1016/j.opresp.2022.100228 · Cited by 7 · see citing works
Kim, J., Kenyon, J. D., Sargent, L. J., Kirkman, D. L., & Kim, Y. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae281 · Cited by 6 · see citing works
Circadian rhythms in ischemic stroke: From pathogenesis to chronotherapy
Fan, H., Wu, Z., Zhao, J., Kou, J., & Xu, Q. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108825 · Cited by 6 · see citing works
Zheng, N., Yin, F., Yu, Q., Zhong, J., Yang, J., Xu, Z.-F., Su, J., & Chen, X. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23713 · Cited by 6 · see citing works
Time‐restricted eating affects human adipose tissue fat mobilization
Zambrano, C., González‐Alvarado, E., Salmerón, D., Ruiz‐Ojeda, F. J., Luján, J., Scheer, F. A. J. L., & Garaulet, M. (2024) · Obesity · doi:10.1002/oby.24057 · Cited by 6 · see citing works
Self-citationHebl, J. T., Velasco, J., & McHill, A. W. (2024) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2024.07.006 · Cited by 6 · see citing works
Slebe, R., Splinter, J. J., Schoonmade, L. J., Blondin, D. P., Campbell, D. J. T., Carpentier, A. C., Després, J., Joris Hoeks, J., Kalsbeek, A., Raina, P. S., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16104 · Cited by 5 · see citing works
Exploring circadian and meal timing impacts on cortisol during simulated night shifts
Grosser, L., Yates, C., Dorrian, J., Centofanti, S. A., Heilbronn, L. K., Wittert, G., Kennaway, D. J., Coates, A. M., Gupta, C. C., Stepien, J. M., et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf249 · Cited by 5 · see citing works
Chronobiology in the wild: toolkit to study daily rhythms in free-living animals
Silvério, J. T., & Tachinardi, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200020 · Cited by 5 · see citing works
Almeida, G. D. S., Souza, M. O. D., & Pereira, L. M. (2023) · Journal Archives of Health · doi:10.46919/archv4n2-011 · Cited by 5 · see citing works
Fetal programming of adipose tissue function by gestational chronodisruption
Halabí, D., Ehrenfeld, P., Méndez, N., Hans, G. H. R., & Torres‐Farfan, C. (2020) · Sleep Science · doi:10.5935/1984-0063.20200014 · Cited by 5 · see citing works
Chronotype and Sleep Timing by Race-Gender: The CARDIA Sleep Study
Knutson, K. L., Reid, K. J., Wong, M., Alexandria, S. J., Thomas, S. J., Lewis, C. E., Schreiner, P. J., Sidney, S., Kershaw, K. N., & Carnethon, M. R. (2025) · Journal of Biological Rhythms · doi:10.1177/07487304251315596 · Cited by 4 · see citing works
Kim, J., Kirkman, D. L., Lü, J., Sargent, L. J., & Kim, Y. (2025) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70110 · Cited by 4 · see citing works
Pilot testing an electronic food diary among Registered Nurses working night shifts
Bigand, T. L., Cason, M., Diede, T., & Wilson, M. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1822857 · Cited by 4 · see citing works
Electrocortical temporal complexity during wakefulness and sleep: an updated account
González, J., Cavelli, M., Mondino, A., Pascovich, C., Castro‐Zaballa, S., Rubido, N., & Torterolo, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200013 · Cited by 6 · see citing works
Andreeva, E. N., & Absatarova, Y. S. (2022) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20222206148 · Cited by 4 · see citing works
Circadian control of white and brown adipose tissues
Yue, K., Rensen, P. C. N., & Kooijman, S. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102056 · Cited by 4 · see citing works
Sleep and maternal behavior in the postpartum rat after haloperidol and midazolam treatments
Peña, F., Rivas, M., González, J., Schwarzkopf, N., Torterolo, P., Ferreira, A., & Benedetto, L. (2020) · Sleep Science · doi:10.5935/1984-0063.20200019 · Cited by 4 · see citing works
Social modulation on daily variability in electric behavior
Gascue, V., da Silva, A. C. R., & Migliaro, A. (2020) · Sleep Science · doi:10.5935/1984-0063.20200012 · Cited by 4 · see citing works
Sleep and Circadian Effects on the Incretin System
Yuan, R. K., & Zitting, K. (2025) · Current Sleep Medicine Reports · doi:10.1007/s40675-025-00337-9 · Cited by 3 · see citing works
GLP-1 Receptor Agonists at the Crossroads of Circadian Biology, Sleep, and Metabolic Disease
Gandhi, A., Phyu, E. M., Koom‐Dadzie, K., Dickson, K. B., & Halm, J. K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062853 · Cited by 3 · see citing works
Role of circadian rhythms in metabolic syndrome
Bhatnagar, A., Puppala, A., Rankawat, S., Ray, S., & Ray, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00006-2 · Cited by 3 · see citing works
- Authors
- Qian, J., Dalla Man, C., Morris, C. J., Cobelli, C., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Department of Information Engineering University of Padova Padova Italy
- University of Padua (IT)
- Corresponding author
- Qian, Jingyi
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2018-07-02
- Volume
- 20
- Issue
- 10
- Pages
- 2481-2485
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- PMC
- PMC6167165
- OpenAlex
- W2807200695
- Cited by
- 170
- References
- 25
- Citations by year
- 2026: 25 · 2025: 11 · 2024: 19 · 2023: 30 · 2022: 19 · 2021: 15 · 2020: 38 · 2019: 10 · 2018: 3
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health (R01HL094806, R01HL118601, R01DK099512, R01DK102696, R01DK105072)
- Harvard University
- Brigham and Women's Hospital (UL1RR025758)
- American Diabetes Association (#1‐17‐PDF‐103)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian misalignment, circadian system, insulin sensitivity, beta-cell function, insulin secretion, glucose tolerance, shift work, oral minimal model, type 2 diabetes risk, circadian phase
- MeSH terms
- Insulin Secretion, Adult, Blood Glucose, Circadian Rhythm, Clinical Protocols, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Glucose Intolerance, Cross-Over Studies, Chronobiology Disorders, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
