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Cited by 226Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and DiseasePancreatic function and diabetes

Insulin resistance and coronary artery disease

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Bressler, P., Bailey, S. R., Matsuda, M., DeFronzo, R. A.·1996·Diabetologia
DOI 10.1007/s001250050581
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Abstract

The purpose of the present study was to quantitate insulin-mediated glucose disposal in normal glucose tolerant patients with angiographically documented coronary artery disease (CAD) and to define the pathways responsible for the insulin resistance. We studied 13 healthy, normal weight, normotensive subjects with angiographically documented CAD and 10 age-, weight-matched control subjects with an oral glucose tolerance test and a 2-h euglycaemic insulin (40 mU.m-2.min-1) clamp with tritiated glucose and indirect calorimetry. Lean body mass was measured with tritiated water. All CAD and control subjects had a normal oral glucose tolerance test. Fasting plasma insulin concentration (66 +/- 6 vs 42 +/- 6 pmol/l, p < 0.05) and area under the plasma insulin curve following glucose ingestion (498 +/- 54 vs 348 +/- 42 pmol.l-1.min-1, p < 0.001) were increased in CAD vs control subjects. Insulin-mediated whole body glucose disposal (27.8 +/- 3.9 vs 38.3 +/- 4.4 mumol.kg fat free mass (FFM)-1.min-1, p < 0.01) was significantly decreased in CAD subjects and this was entirely due to diminished non-oxidative glucose disposal (8.9 +/- 2.8 vs 20.0 +/- 3.3 mumol.kg FFM-1.min-1, p < 0.001). The magnitude of insulin resistance was positively correlated with the severity of CAD (r = 0.480, p < 0.05). In the CAD subjects basal and insulin-mediated rates of glucose and lipid oxidation were normal and insulin caused a normal suppression of hepatic glucose production. In conclusion, subjects with angiographically documented CAD are characterized by moderate-severe insulin resistance and hyperinsulinaemia and should be included in the metabolic and cardiovascular cluster of disorders that comprise the insulin resistance syndrome or "syndrome X'.

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  • Skeletal muscle insulin resistance can develop without a family history of type 2 diabetes.

    “Insulin resistance in skeletal muscle also can develop independent of family history of T2DM.”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [36]

  • Obese normal-glucose-tolerant subjects without a family history of type 2 diabetes, individuals with essential hypertension, and individuals with ischaemic heart disease have a 35-50% decrease in whole-body insulin-mediated glucose disposal.

    “Thus, obese NGT subjects without a family history for T2DM [33, 34] and individuals with essential hypertension [35] and ischemic heart disease [36] also have a 35–50% decrease in whole body insulin-mediated glucose disposal (Figure 3).”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [36]

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Authors
Bressler, P., Bailey, S. R., Matsuda, M., & DeFronzo, R. A.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
1996-10-23
Volume
39
Issue
11
Pages
1345-1350
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s001250050581
OpenAlex
W2017443146
Cited by
226
References
47
Citations by year
2026: 1 · 2025: 11 · 2024: 6 · 2023: 6 · 2022: 21 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 5
FWCI
8.06
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsches Krebsforschungszentrum
  • National Institutes of Health (AM 24 092, 5r01am024092-06)
  • Geriatric Research Education and Clinical Center
  • National Center for Research Resources (M01RR01346, M01RR001346)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
insulin resistance, coronary artery disease, insulin-stimulated glucose disposal, hyperinsulinemia, metabolic syndrome, hepatic glucose production, glucose oxidation, lipid oxidation, fasting insulin
MeSH terms
Blood Glucose, Coronary Disease, Coronary Vessels, Fatty Acids, Nonesterified, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Triglycerides, Lipid Peroxidation, Body Mass Index, Case-Control Studies

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