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Cited by 184Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and HealthDiabetes Management and Research

No excess 12-year mortality in men with impaired glucose tolerance who participated in the Malm� Preventive Trial with diet and exercise

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Eriksson, K.-F., Lindg�rde, F.·1998·Diabetologia
DOI 10.1007/s001250051024
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Abstract

Impaired glucose tolerance (IGT) is associated with increased mortality due to ischaemic heart disease (IHD), but as it is not known whether this excess mortality can be reduced by preventing or delaying the development of non-insulin-dependent diabetes mellitus (NIDDM), a long-term NIDDM prevention trial of dietary counselling and physical exercise was launched at Malmö, Sweden, the 12-year follow-up of which is reported here. At 12-year follow-up of 6956 men who underwent health screening at 48 years of age, an IGT intervention group (n = 288) who participated in a long-term NIDDM prevention programme were compared with an IGT non-randomised routine treatment group (n = 135), a diabetic group (n = 144), and the remainder, the normal glucose tolerance (NGT) group (n = 6389). The variables studied included the levels of blood glucose, plasma insulin, blood pressure, blood lipids, lung function and maximum oxygen uptake. Subjects with IGT were characterised by overweight, poor vital capacity, hypertension, hypertriglyceridaemia and hyperinsulinaemia. The mortality rate in the IGT intervention group was similar to that in the NGT group (6.5 vs 6.2 per 1000 person years at risk) and lower than that in the IGT routine treatment group (6.5 vs 14.0, p = 0.009). In the two IGT groups taken together, intervention but not body mass index, systolic blood pressure, smoking, cholesterol or the 2-h glucose level predicted mortality. Systolic blood pressure was a predictor of IHD mortality among IGT subjects; and in the cohort as a whole, body mass index, systolic blood pressure, hypercholesterolaemica, diabetes and smoking were predictors of IHD mortality. The findings suggest that a long-term intervention programme, with an emphasis on lifestyle changes, including dietary counselling and physical exercise, will reduce mortality in subjects with IGT who are at an increased risk of both developing NIDDM and of premature death due to IHD and other causes.

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  • In the Malmö Preventive Project, the diet and exercise group had lower all-cause mortality than controls over 12 years.

    “All-cause mortality was lower in the diet and exercise intervention group compared to the control group during a 12-year follow-up in the Malmö Preventive Project”

    From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [121]

  • In the Malmö Preventive Project, participation in the intervention was not randomised.

    “but in this study participation in intervention was not randomised.121”

    From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [121]

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Authors
Eriksson, K.-F., & Lindg�rde, F.
Affiliations
Skåne University Hospital (SE)
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
1998-08-19
Volume
41
Issue
9
Pages
1010-1016
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s001250051024
OpenAlex
W1988913139
Cited by
184
References
32
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
5.81
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
impaired glucose tolerance, type 2 diabetes prevention, ischemic heart disease mortality, nutrition counseling, physical activity, lifestyle intervention, systolic blood pressure, body mass index, hyperinsulinemia, hypertriglyceridemia, cardiovascular risk factors
MeSH terms
Diabetes Mellitus, Type 2, Humans, Hypercholesterolemia, Hypertension, Male, Mass Screening, Middle Aged, Obesity, Primary Prevention, Risk Factors, Sweden, Cohort Studies, Exercise, Survival Rate, Glucose Intolerance, Diabetes Complications

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