Modulation of rotavirus severe gastroenteritis by the combination of probiotics and prebiotics
Open accessAbstract
Annual mortality rates due to infectious diarrhea are about 2.2 million; children are the most vulnerable age group to severe gastroenteritis, representing group A rotaviruses as the main cause of disease. One of the main factors of rotavirus pathogenesis is the NSP4 protein, which has been characterized as a viral toxin involved in triggering several cellular responses leading to diarrhea. Furthermore, the rotavirus protein NSP1 has been associated with interferon production inhibition by inducing the degradation of interferon regulatory factors IRF3, IRF5, and IRF7. On the other hand, probiotics such as Bifidobacterium and Lactobacillus species in combination with prebiotics such as inulin, HMO, scGOS, lcFOS have been associated with improved generalized antiviral response and anti-rotavirus effect by the reduction of rotavirus infectivity and viral shedding, decreased expression of NSP4 and increased levels of specific anti-rotavirus IgAs. Moreover, these probiotics and prebiotics have been related to shorter duration and severity of rotavirus diarrhea, to the prevention of infection and reduced incidence of reinfections. In this review we will discuss in detail about the rotavirus pathogenesis and immunity, and how probiotics such as Lactobacillus and Bifidobacterium species in combination with prebiotics have been associated with the prevention or modulation of rotavirus severe gastroenteritis.
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Lacticaseibacillus casei and Bifidobacterium adolescentis indirectly maintain barrier permeability by producing metabolites associated with reduced expression of the rotavirus toxin NSP4.
“some species, including Lacticaseibacillus casei and Bifidobacterium adolescentis, have been found to indirectly maintain barrier permeability by producing metabolites associated with reduced expression of the rotavirus toxin NSP4, which acts to disrupt the structure and function of tight junctions during infection (Gonzalez-Ochoa et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Gonzalez-Ochoa et al., 2017
NSP4 is a viral toxin that affects intestinal mucosa structure, targeting tight junctional complexes, affecting electrolyte balance, and resulting in secretory diarrhea.
“NSP4 protein is a viral toxin which affects the structure of the intestinal mucosa (targeting tight junctional complexes) and affecting the relative intra- and extra-cellular electrolytes balance and ultimately result in secretory diarrhea.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Gonzalez-Ochoa et al., 2017
Rotavirus proteins NSP1 and NSP4 are important in pathogenesis of rotavirus gastroenteritis.
“The rotavirus proteins NSP1 and NSP4 have been shown to be important in the pathogenesis of rotavirus gastroenteritis (Gonzalez-Ochoa et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Gonzalez-Ochoa et al., 2017
Metabolites of Lacticaseibacillus casei and Bifidobacterium adolescentis were associated with reduced expression of the viral toxin NSP4.
“Recent research has also shown that metabolites of Lacticaseibacillus casei and Bifidobacterium adolescentis were associated with reduced expression of the viral toxin NSP4 (Gonzalez-Ochoa et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Gonzalez-Ochoa et al., 2017
NSP1 inhibits INF production, leading to down-regulation of inflammatory cytokines.
“NSP1 has been shown to inhibit INF production, leading to down-regulation of inflammatory cytokines (Gonzalez-Ochoa et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Gonzalez-Ochoa et al., 2017
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- Authors
- Gonzalez-Ochoa, G., Flores-Mendoza, L. K., Icedo-Garcia, R., Gomez-Flores, R., & Tamez-Guerra, P.
- Affiliations
- Universidad de Sonora (MX)
- Venue
- Archives of Microbiology
- Published
- 2017-06-20
- Volume
- 199
- Issue
- 7
- Pages
- 953-961
- ISSN
- 0003-9276 (ISSN-L)
- 0302-8933
- 1432-072X
- PMC
- PMC5548957
- OpenAlex
- W2694293442
- Cited by
- 82
- References
- 55
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 19 · 2020: 7 · 2019: 11 · 2018: 7
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Archives of Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- El Repositorio Academico Digital de la UANL (Universidad Autónoma de Nuevo León) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- rotavirus, severe gastroenteritis, probiotics, prebiotics, NSP4, Nsp1, interferon regulatory factors, Bifidobacterium, Lactobacillus, inulin, human milk oligosaccharides, galactooligosaccharides, fructooligosaccharides, rotavirus shedding, rotavirus pathogenesis, childhood diarrhea
- MeSH terms
- Antiviral Agents, Bifidobacterium, Child, Diarrhea, Female, Gastroenteritis, Glycoproteins, Humans, Infant, Inulin, Lactobacillus, Rotavirus Infections, Rotavirus, Toxins, Biological, Viral Nonstructural Proteins, Probiotics, Prebiotics
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