Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis
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BACKGROUND: GG ATCC 53013 (LGG) has been used to treat diarrhea. However, recent randomized controlled trials (RCTs) found no evidence of a beneficial effect of LGG treatment. AIM: To evaluate the efficacy of LGG in treating acute diarrhea in children. METHODS: The EMBASE, MEDLINE, PubMed, Web of Science databases, and the Cochrane Central Register of Controlled Trials were searched up to April 2019 for meta-analyses and RCTs. The Cochrane Review Manager was used to analyze the relevant data. RESULTS: a lower dose. A similar reduction was found in Asian and European patients [MD -24.42 h, 95%CI (-47.01, -1.82); MD -32.02 h, 95%CI (-49.26, -14.79), respectively]. A reduced duration of diarrhea was confirmed in LGG participants with diarrhea for less than 3 d at enrollment [MD -15.83 h, 95%CI (-20.68, -10.98)]. High-dose LGG effectively reduced the duration of rotavirus-induced diarrhea [MD -31.05 h, 95%CI (-50.31, -11.80)] and the stool number per day [MD -1.08, 95%CI (-1.87, -0.28)]. CONCLUSION: High-dose LGG therapy reduces the duration of diarrhea and the stool number per day. Intervention at the early stage is recommended. Future trials are expected to verify the effectiveness of LGG treatment.
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Some systematic reviews and meta-analyses have supported that specific probiotic strains may be effective in certain areas.
“While there is limited evidence around many probiotics, some systematic reviews and meta-analyses have supported that specific strains may be effective in certain areas [43,44,45,46].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [44]
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Lactobacillus rhamnosus GG Evaluation in Acute Diarrhea (LEAD): An Observational Study
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Genetically Modified Lactic Acid Bacteria: a Promising Mucosal Delivery Vector for Vaccines
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Probiotics: current regulatory aspects of probiotics for use in different disease conditions
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Probiotic Preparations for Infantile Gastroenteritis: The Clinical and Economic Perspective
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Exploring the Therapeutic Landscape of Probiotics in Enteric and Respiratory Viral Infections
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РОЛЬ ПРОБИОТИКОВ В ЛЕЧЕНИИ КИШЕЧНЫХ ИНФЕКЦИЙ
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Lactic acid bacteria: Two sides of the same coin
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Impact of Probiotics on Children with Acute Gastroenteritis: Results from an Umbrella Meta-Analysis
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- Authors
- Li, Y.-T., Xu, H., Ye, J.-Z., Wu, W.-R., Shi, D., Fang, D.-Q., Liu, Y., & Li, L.-J.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Lund University (SE)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2019-09-07
- Volume
- 25
- Issue
- 33
- Pages
- 4999-5016
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC6737314
- OpenAlex
- W2971610165
- Cited by
- 77
- References
- 73
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 14 · 2021: 12 · 2020: 13 · 2019: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Lactobacillus rhamnosus GG, acute diarrhea, childhood diarrhea, probiotics, diarrhea duration, stool frequency, early intervention
- MeSH terms
- Child, Diarrhea, Humans, Severity of Illness Index, Time Factors, Randomized Controlled Trials as Topic, Treatment Outcome, Probiotics, Lacticaseibacillus rhamnosus, Time-to-Treatment
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