Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task demands
Open accessAbstract
Rationale Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. Objectives To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects further. Methods Rats were trained in a modified version of the five-choice serial reaction time task (5-CSRTT) to detect 1-s light stimuli with greater than 70% accuracy and fewer than 20% omission errors. Nicotine was tested under different task requirements by varying signal event rate, stimulus duration and stimulus predictability, and by introducing white-noise distractors. Results Nicotine (0.05-0.2 mg/kg, s.c.) repeatedly improved accuracy and reduced omission errors and reaction times, leading to increases in numbers of reinforcers earned. Anticipatory responding was increased. Parametric modifications intended to increase demands on sustained attention did not affect performance in a manner suggesting that this subtype of attention was being taxed, and the effects of nicotine were not more marked under such conditions. Shorter stimulus durations impaired performance, but this manipulation weakened the effect of nicotine on accuracy. In contrast, the presence of noise distractors facilitated the effects of nicotine to the extent that distractor-induced impairments were abolished by the drug. Conclusions The 5-CSRTT can provide a sensitive rodent model for the attention-enhancing effects of nicotine. Changes made to the procedure may have increased its sensitivity to nicotine, particularly with respect to accuracy. There were indications that the effects of nicotine were largest on processes of selective attention or on disengaging attention from irrelevant events and shifting it to behaviourally significant stimuli.
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Enhanced cognitive performance following acute nicotine exposure has been seen in rodent models of attention.
“Enhanced cognitive performance following acute nicotine exposure has also been seen in rodent models of attention (Hahn et al. 2002).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Hahn et al. 2002
In adult rodents, acute administration of alcohol, nicotine, or marijuana alters aspects of learning and memory associated with the FC and HC.
“In adult rodents, acute administration of alcohol, nicotine, or marijuana alters aspects of learning and memory associated with the FC and HC (Hahn et al. 2002; Gould 2003; Arguello and Jentsch 2004; Pamplona and Takahashi 2006; Semenova et al. 2007; Portugal et al. 2012), indicating that mechanisms responsible for learning and memory are sensitive to those substances.”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Hahn et al. 2002
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“In adult rodents, acute administration of alcohol, nicotine, ormarijuana alters aspects of learning andmemory associatedwith the FC and HC (Hahn et al. 2002; Gould 2003; Arguello and Jentsch 2004; Pamplona and Takahashi 2006; Semenova et al. 2007; Portugal et al. 2012), indicating that mechanisms…”
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- Authors
- Hahn, B., Shoaib, M., & Stolerman, I.
- Affiliations
- King's College London (GB)
- Venue
- Psychopharmacology
- Published
- 2002-03-23
- Volume
- 162
- Issue
- 2
- Pages
- 129-137
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1971270348
- Cited by
- 188
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 8
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, attention, 5-choice serial reaction time task, sustained attention, selective attention, distractor interference, omission errors, stimulus predictability, stimulus duration, attentional shift
- MeSH terms
- Analysis of Variance, Animals, Attention, Male, Nicotine, Noise, Serial Learning, Task Performance and Analysis, Rats
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