Deficits in a sustained attention task following nicotine withdrawal in rats
Open accessAbstract
Objective Behavioural consequences of spontaneous and antagonist-precipitated withdrawal from nicotine upon performance of rats were compared alongside non-nicotinic antagonists in the 5-choice serial reaction time task (5-CSRTT).Methods Male hooded Lister rats were trained to detect and respond to brief flashes of light presented every 15 s in one of five holes until a stable level of performance was achieved.Results Surgical removal of osmotic minipumps from rats having received nicotine (3.16 mg/kg per day base SC) chronically for 7 days produced marked deficits in performance. Compared to saline-treated controls, deficits were apparent 10 h and 16 h following nicotine abstinence; the percentage of omission errors increased concomitantly with modest decreases in response accuracy. Tests conducted 34 h and 106 h post-withdrawal indicated a progressive and complete recovery in attention performance, respectively. In another experiment, following the exposure to the same nicotine regime, administration of the competitive nicotine receptor antagonist dihydro-beta-erythroidine precipitated immediate deficits in performance that were greater than those observed in saline-treated subjects. Methyllycaconitine, an alpha(7) nicotinic receptor antagonist failed to precipitate attention deficits in nicotine-treated rats. Tests with SCH23390 and raclopride produced impairments that were similar in profile to nicotine withdrawal contrasting with non-specific effects of dizocilpine.Conclusions These results provide evidence of a cognitive impairment resulting from nicotine deprivation in rodents. Specifically, blockade of D(1) receptors by SCH23390 produced decrements in performance that were qualitatively similar but greater in magnitude to the alterations observed following nicotine withdrawal. Overall, assessing nicotine withdrawal in the 5-CSRTT presents an animal model that exhibits robust construct and face validity.
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Spontaneous withdrawal from nicotine produces significant deficits in sustained attention in male rats.
“Significant deficits in sustained attention were seen after spontaneous withdrawal from nicotine in male rats [206]”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [206]
DHβE-precipitated withdrawal produces significant deficits in sustained attention in nicotine-treated rats.
“as well as during withdrawal precipitated with DHβE [206].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [206]
The 5-CSRTT is a visual attention task that can reliably detect cognitive aspects of nicotine withdrawal.
“The five-choice serial reaction time task (5-CSRTT) is a visual attention task [205] that can reliably detect cognitive aspects of nicotine withdrawal [206, 207].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [206]
MLA does not precipitate attention deficits in nicotine-treated rats.
“The α7 nAChR antagonist MLA failed to precipitate attention deficits in nicotine-treated rats [206]”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [206]
α4β2-containing nAChRs, but not α7-containing nAChRs, are important for 5-CSRTT performance.
“suggesting that α4β2-containing, but not α7-containing nAChRs are important for 5-CSRTT.”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [206]
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Bidirectional relationship between attentional deficits and escalation of nicotine intakePreprint
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- Authors
- Shoaib, M., & Bizarro, L.
- Affiliations
- King's College London (GB)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Shoaib, Mohammed
- Venue
- Psychopharmacology
- Published
- 2004-08-27
- Volume
- 178
- Issue
- 2-3
- Pages
- 211-222
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2070055547
- Cited by
- 87
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine withdrawal, sustained attention, 5-choice serial reaction time task, dihydro-beta-erythroidine, methyllycaconitine, alpha7 nicotinic acetylcholine receptor, dopamine D1 receptor, SCH 23390, raclopride, MK-801, cognitive impairment, nicotine dependence
- MeSH terms
- Animals, Attention, Choice Behavior, Male, Nicotine, Serial Learning, Substance Withdrawal Syndrome, Receptors, Dopamine D1, Rats
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