The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
Abstract
Rationale High blockade of dopamine D2 receptors in the ventral striatum including the nucleus accumbens may interfere with reward anticipation and cause secondary negative symptoms such as apathy or anhedonia. This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor.Objectives We used functional magnetic resonance imaging to assess the blood oxygenation level dependent response in the ventral striatum of schizophrenics medicated with typical neuroleptics (T1) and after switching them to olanzapine (T2) and of healthy control subjects at corresponding time points during reward anticipation.Materials and methods Ten schizophrenics, while medicated with typical neuroleptics (T1) and after having been switched to olanzapine (T2), and ten matched healthy volunteers participated in a monetary incentive delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus would either result in monetary gain or have no consequence.Results During reward anticipation, healthy volunteers showed significantly higher ventral striatal activation compared to schizophrenic patients treated with typical neuroleptics but not olanzapine, which was reflected in a significant interaction between group and session. In patients treated with typical neuroleptics, but not with olanzapine, decreased left ventral striatal activation was correlated with negative symptoms.Conclusions Failure to activate the ventral striatum during reward anticipation was pharmacologically state-dependent and observed only in patients treated with typical neuroleptics but not with olanzapine, which may indicate that this drug did not induce secondary negative symptoms via interference with reward anticipation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A handful of studies also suggest that striatal responses during monetary anticipation in schizophrenia are partially normalized by the antipsychotic, olanzapine [279,417,423] but not by other antipsychotics [418]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [423]
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Self-citationDopamine-dependent prediction errors underpin reward-seeking behaviour in humans
Pessiglione, M., Seymour, B., Flandin, G., Dolan, R. J., & Frith, C. D. (2006) · Nature · doi:10.1038/nature05051 · Cited by 1,584
(1997) · American Psychiatric Press eBooks · Cited by 1,436
Farde, L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070032005 · Cited by 1,420
Functional imaging of neural responses to expectancy and experience of monetary gains and losses
Breiter, H. C., Aharon, I., Kahneman, D., Dale, A., & Shizgal, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00303-8 · Cited by 1,404
Kapur, S., & Seeman, P. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.360 · Cited by 1,140
Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895 · cited 2×
“, lower blockade of and faster dissociation from the dopamine D2 receptor (Kapur and Seeman 2001) or the additional blockade of 5-HT2A receptors (Meltzer et al. 2003), may help to preserve some degree of dopaminergic neurotransmission in the ventral striatum, which then no longer differs significantly from healthy con…”
Serotonin receptors : their key role in drugs to treat schizophrenia
Meltzer, H. Y., Li, Z., Kaneda, Y., & Ichikawa, J. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.010 · Cited by 787
Parametric Analysis of fMRI Data Using Linear Systems Methods
Cohen, M. S. (1997) · NeuroImage · doi:10.1006/nimg.1997.0278 · Cited by 723
Complexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down
Callicott, J. H., Mattay, V. S., Verchinski, B. A., Marenco, S., Egan, M. F., & Weinberger, D. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2209 · Cited by 673
Dysfunction of ventral striatal reward prediction in schizophrenia
Juckel, G., Schlagenhauf, F., Koslowski, M., Wüstenberg, T., Villringer, A., Knutson, B., Wrase, J., & Heinz, A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.051 · Cited by 578
Self-citation(2023) · Elsevier eBooks · doi:10.1016/c2021-0-02248-3 · Cited by 542
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002058 · Cited by 532
Mapping context and content: the BrainMap model
Fox, P. T., & Lancaster, J. L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn789 · Cited by 473
Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions
Corlett, P. R., Murray, G. K., Honey, G. D., Aitken, M. R. F., Shanks, D. R., Robbins, T. W., Bullmore, E. T., Dickinson, A., & Fletcher, P. C. (2007) · Brain · doi:10.1093/brain/awm173 · Cited by 460
Juckel, G., Schlagenhauf, F., Koslowski, M., Filonov, D., Wüstenberg, T., Villringer, A., Knutson, B., Kienast, T., Gallinat, J., Wrase, J., et al. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0405-4 · Cited by 323
Self-citationReward prediction in primate basal ganglia and frontal cortex
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00071-9 · Cited by 318
Honey, G. D., Bullmore, E. T., Soni, W., Varatheesan, M., Williams, S., & Sharma, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13432 · Cited by 284
Bertolino, A., Caforio, G., Blasi, G., Candia, M. D., Latorre, V., Petruzzella, V., Altamura, M., Nappi, G., Papa, S., Callicott, J. H., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1798 · Cited by 283
Heinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00628-4 · Cited by 270
Self-citationNeural Mechanisms of Anhedonia in Schizophrenia
Crespo‐Facorro, B., Paradiso, S., Andreasen, N. C., OʼLeary, D. S., Watkins, G. L., Ponto, L. L. B., & Hichwa, R. D. (2001) · JAMA · doi:10.1001/jama.286.4.427 · Cited by 232
The formation of abnormal associations in schizophrenia: Neural and behavioral evidence
Jensen, J., Willeit, M., Zipursky, R. B., Savina, I., Smith, A. J., Menon, M., Crawley, A. P., & Kapur, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301437 · Cited by 225
Amphetamine modulates human incentive processing
Knutson, B., Bjork, J. M., Fong, G. W., Hommer, D., Mattay, V. S., & Weinberger, D. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.030 · Cited by 174
Self-citationDifferent neural systems adjust motor behavior in response to reward and punishment
Wrase, J., Kahnt, T., Schlagenhauf, F., Beck, A., Cohen, M. X., Knutson, B., & Heinz, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.001 · Cited by 172
Self-citationKumakura, Y., Cumming, P. D., Vernaleken, I., Buchholz, H., Siessmeier, T., Heinz, A., Kienast, T., Bartenstein, P., & Gründer, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-07.2007 · Cited by 158
Self-citationMenon, M., Jensen, J., Vitcu, I., Graff‐Guerrero, A., Crawley, A. P., Smith, M. A., & Kapur, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.020 · Cited by 145
Heinz, A., Knable, M. B., Coppola, R., Gorey, J. G., Jones, D. W., Lee, K.-S., & Weinberger, D. R. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00003-6 · Cited by 128
Self-citationAbler, B., Erk, S., & Walter, H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0690-y · Cited by 118
The role of dopamine for the pathophysiology of schizophrenia
Meisenzahl, E., Schmitt, G., Scheuerecker, J., & Möller, H. ‐. (2007) · International Review of Psychiatry · doi:10.1080/09540260701502468 · Cited by 110
Positive and Negative Symptoms: Historical and Conceptual Aspects1
Andreasen, N. C. (2015) · Modern problems of pharmacopsychiatry/Modern trends in pharmacopsychiatry · doi:10.1159/000418010 · Cited by 82
Nielsen, F. Å., & Hansen, L. K. (2008) · Cited by 74
de Haan, L., Lavalaye, J., van Bruggen, M., van Nimwegen, L. J. M., Booij, J., van Amelsvoort, T., & LINSZEN, D. H. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900503 · Cited by 69
Lahti, A. C., Weiler, M. A., Medoff, D. R., Tamminga, C. A., & Holcomb, H. H. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.02.006 · Cited by 65
The 5-HT hypothesis of schizophrenia.
Akhondzadeh, S. (2001) · PubMed · Cited by 63
Schizophrenia: Neural Mechanisms for Novel Therapies
Sawa, A., & Snyder, S. H. (2003) · Molecular Medicine · doi:10.1007/bf03402101 · Cited by 53
Siessmeier, T., Kienast, T., Wrase, J., Larsen, J. L., Braus, D. F., Smolka, M. N., Buchholz, H. G., Schreckenberger, M., Rösch, F., Cumming, P., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04903.x · Cited by 48
Self-citationPaquet, F., Soucy, J., Stip, É., Lévesque, M., Elie, A., & Bédard, M. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.1.47 · Cited by 46
Matsuoka, K., Miyamoto, Y., Ito, H., & Kurita, H. (2003) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2003.01168.x · Cited by 29
Dopamine and incentive learning: A framework for considering antipsychotic medication effects
Beninger, R. J. (2006) · Neurotoxicity Research · doi:10.1007/bf03033357 · Cited by 26
Dopamine D2 Receptor Blockade by Haloperidol 3H-Raclopride Reveals Much Higher Occupancy than EEDQ
Kapur, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00139-1 · Cited by 22
Glick, I. D., Lemmens, P., & Vester-Blokland, E. (2001) · International Clinical Psychopharmacology · doi:10.1097/00004850-200109000-00003 · Cited by 19
Bhaduri, A., Krishnaswamy, L., Ullal, G. R., Panicker, M. M., & Sowdhamini, R. (2003) · Journal of Molecular Modeling · doi:10.1007/s00894-002-0102-0 · Cited by 18
Müller, J. L., & Klein, H. E. (2000) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2000.00766.x · Cited by 16
Research works printed but not linked: 5
- First M, Spitzer R, Gibbon M, Williams J (1997) Structured clinical interview for DSM-IV personality disorders, (SCID-II). American Psychiatric, Washington, DC
- First MB, Spitzer RL, Gibbon M, Williams J (2001) Structured clinical interview for DSM-IV-TR Axis I disorders, research version, patient edition with psychotic screen (SCID-I/P W/ PSY SCREEN). New York State Psychiatric Institute, New York
- Heaton R (1981) A manual for the Wisconsin Card Sorting Test. Psychological Assessment Resources, Odessa, Florida
- Muller JL, Deuticke C, Putzhammer A, Roder CH, Hajak G, Winkler J (2003) Schizophrenia and Parkinson’s disease lead to equal motor-related changes in cortical and subcortical brain activation: an fMRI fingertapping study. Psychiatry Clin Neurosci 57:562–568
- Schmidt K, Metzler P (1992) Wortschatztest (WST). Beltz test, Weinheim
Cited by
Sorted by citations
Anticipatory affect: neural correlates and consequences for choice
Knutson, B. D., & Greer, S. M. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0155 · Cited by 720
Self-citationThobois, S., Ardouin, C., Lhommée, E., Klinger, H., Lagrange, C., Xie, J., Fraix, V., Braga, M.-C. C., Hassani, R., Kistner, A., et al. (2010) · Brain · doi:10.1093/brain/awq032 · Cited by 546
Barch, D. M., & Dowd, E. C. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq068 · Cited by 507
Oldham, S., Murawski, C., Fornito, A., Youssef, G. J., Yücel, M., & Lorenzetti, V. (2018) · Human Brain Mapping · doi:10.1002/hbm.24184 · Cited by 449
Dopaminergic dysfunction in schizophrenia: Salience attribution revisited
Heinz, A., & Schlagenhauf, F. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq031 · Cited by 412
Self-citation
Metadata
- Authors
- Schlagenhauf, F., Juckel, G., Koslowski, M., Kahnt, T., Knutson, B., Dembler, T., Kienast, T., Gallinat, J., Wrase, J., & Heinz, A.
- Affiliations
- Stiftung Charité (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Stanford University (US)
- Corresponding author
- Heinz, Andreas
- ORCID
- Venue
- Psychopharmacology
- Published
- 2007-12-21
- Volume
- 196
- Issue
- 4
- Pages
- 673-684
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2153437292
- Cited by
- 204
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 20 · 2015: 22 · 2014: 19 · 2013: 18 · 2012: 17
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, olanzapine, typical antipsychotics, reward anticipation, ventral striatum, nucleus accumbens, dopamine D2 receptor blockade, negative symptoms, anhedonia, apathy, monetary incentive delay task, antipsychotic switching, functional MRI
- MeSH terms
- Olanzapine, Adult, Analysis of Variance, Benzodiazepines, Female, Flupenthixol, Fluphenazine, Haloperidol, Humans, Magnetic Resonance Imaging, Male, Motivation, Nucleus Accumbens, Oxygen, Psychomotor Performance, Reaction Time, Reward, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Neostriatum, Receptors, Dopamine D2, Dopamine D2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
