Cytokines and depression: fortuitous or causative association?
Abstract
There is an increasingly impressive database concerning the possible involvement of cytokines in depression and their role in the therapeutic effects of antidepressants. Based on the discussions which took place on these issues at a recent meeting held in Roscoff, France, this perspective summarizes in a critical way the evidence in favor of such a possibility, and points out the needs for further research to clarify both the nature of the subtle dysregulations that affect neuroendocrine-immune interactions in depressive disorders and their contribution to psychopathology.
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Stress and depression can permanently alter the responsiveness of the immune system.
“Stress and depression can permanently alter the responsiveness of the immune system (41-44).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [43]
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- Authors
- Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Dantzer, R
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 1999-07-01
- Volume
- 4
- Issue
- 4
- Pages
- 328-332
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2063650882
- Cited by
- 174
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- cytokines, depression, antidepressants, neuroendocrine-immune interaction, neuroinflammation, psychopathology, cytokine imbalance
- MeSH terms
- Antidepressive Agents, Brain, Depression, Depressive Disorder, Humans, Cytokines
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