An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum
Abstract
An automated high-throughput solid phase extraction (SPE) micro-elution method for 8 perfluorosulfonic acids, 11 perfluorocarboxylic acids and fluorooctane sulfonamide in human serum was developed. Importance was attached to the application of small volumes of reagents and solvents in addition to low sample volumes (50 μL) in order to save the highly valuable sample material for follow-up and other studies. Instrumental analysis was performed by ultra high pressure liquid chromatography coupled to triple quadrupole mass spectrometry (UHPLC-MS/MS). The recoveries of perfluoroalkyl substances (PFASs) were satisfactory and between 70 and 120% for most of the compounds at the three investigated spike concentrations. Perfluorobutane sulfonate (PFBS) was slightly underestimated at high concentrations (20 ng/mL; 67%), whereas perfluoropentanoate (PFPA), perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were overestimated with 134, 131 and 133% respectively, at low spike concentrations (0.2 ng/mL). The precision of the method was below 20% coefficient of variation (CV%) for all target compounds with the only exception of PFOS (22%) at low spike concentrations. Method detection limits ranged from 0.006 to 0.34 ng/mL. High sensitivity, accuracy, repeatability and robustness have been demonstrated for an appropriate concentration range. The applicability for real samples was satisfactory demonstrated by analysis of 40 sera samples from the general population from Tromsø, Norway.
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Many studies have improved quantitation results using isotope dilution and matrix-matched calibration curve approaches.
“many studies have improved quantitation results using isotope dilution [83,87,88] and matrix-matched calibration curve approaches [84].”
From Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment (2019) · cites this paper as [88]
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“In a murine model of asthma (47), exposure to immunosuppressant PFOA enhanced the hypersensitivity response to ovalbumin suggesting that PFOA may augment the IgE response to some allergens (25).”
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BackgroundResultInfluentialImpaired gross motor development in infants with higher PFAS concentrations
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- Authors
- Huber, S., & Brox, J.
- Affiliations
- University Hospital of North Norway (NO)
- Corresponding author
- Huber, Sandra
- Venue
- Analytical and Bioanalytical Chemistry
- Published
- 2015-03-21
- Volume
- 407
- Issue
- 13
- Pages
- 3751-3761
- ISSN
- 1618-2642 (ISSN-L)
- 1618-2650
- OpenAlex
- W2060795038
- Cited by
- 46
- References
- 39
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Analytical and Bioanalytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- perfluorinated compounds, perfluorosulfonic acid, perfluorocarboxylic acids, human serum, automated sample preparation, PFOS, perfluorooctanoic acid, PFBS, UPLC-MS/MS, biomonitoring
- MeSH terms
- Alkanes, Blood Chemical Analysis, Chromatography, High Pressure Liquid, Environmental Pollutants, Fluorocarbons, Humans, Robotics, Sensitivity and Specificity, Mass Spectrometry, Reproducibility of Results, Endocrine Disruptors, Automation, Laboratory, Liquid Phase Microextraction
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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