Development and Validation of an LC-MS/MS Method for the Quantitation of 30 Legacy and Emerging per- and Polyfluoroalkyl Substances (PFASs) in Human Plasma, Including HFPO-DA, DONA, and CC6O4

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PFAS and their association with the increased risk of cardiovascular disease in postmenopausal women

Eve, A. A., Tunc, E. P., Mehta, D., Yoo, J. Y., Yılmaz, H. E., Emren, S. V., Akçay, F. A., & Madak‐Erdogan, Z. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae065 · Cited by 24 · see citing works

Emerging Contaminants in Water Systems: Detection, Environmental Impacts, and Sustainable Removal Solutions

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An overview of the impact of PFAS on animals, humans, and the environment using a One Health approach

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Quality assurance and quality control for human biomonitoring data—focus on matrix reference materials

Tadić, Đ., de Lima, A. P., & Ricci, M. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-05859-3 · Cited by 18 · see citing works

Monitoring of per- and polyfluoroalkyl substances (PFAS) in human blood samples collected in three regions with known PFAS releases in the environment and three control regions in South Germany

Hron, L. M. C., Wöckner, M., Fuchs, V., Fembacher, L., Aschenbrenner, B., Herr, C., Schöber, W., Heinze, S., & Völkel, W. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03843-x · Cited by 18 · see citing works

Effects of polyamide microplastics on the adsorption of perfluoroalkyl substances in soil

Sun, J., Xiang, H., Jiang, X., Wang, X., Luo, X., Fu, J., & Fan, J. (2023) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2023.100391 · Cited by 15 · see citing works

Optimization for the analysis of 42 per- and polyfluorinated substances in human plasma: A high-throughput method for epidemiological studies

Román, A. S., Abilleira, E., Irizar, A., Santa‐Marina, L., González-Gaya, B., & Etxebarría, N. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464481 · Cited by 13 · see citing works

Interrogation of a fluoropolymer dispersion manufactured with a non-fluorinated polymerization aid for targeted and non-targeted fluorinated residuals by liquid chromatography high resolution mass spectrometry

Sworen, J. C., Morken, P. A., Smith, A. P., Boyle, J. E., Garcia, M. D. C., Kramer, J., Wadsley, M. P., & Davis, M. C. (2024) · Journal of Chromatography A · doi:10.1016/j.chroma.2024.465369 · Cited by 13 · see citing works

Pretreatment and detection of per- and polyfluoroalkyl substances (PFAS): A review of current advancements, development challenges, and perspectives

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Association of prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances with fetal growth trajectories.

Yang, Y., Teng, S., Lin, L., Li, W., Zhu, Z., Chen, T., Li, L., Peng, F., Peng, D., & Gao, X. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121331 · Cited by 11 · see citing works

An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches

Engelhardt, J. A., Plassmann, M. M., & Weiss, J. M. (2024) · Environment International · doi:10.1016/j.envint.2024.109214 · Cited by 8 · see citing works

A validated single-step saliva and serum sample extraction LC-MS/MS method for the analysis of nicotine, cotinine and 3’-hydroxycotinine for clinical vaping studies

van der Velpen, V., Liakoni, E., Hirt, M. B., Vonwyl, C., Christen, S. E., Duthaler, U., Jacob, P., & Haschke, M. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116703 · Cited by 8 · see citing works

A comprehensive review of detection techniques for PFAS compounds in aqueous solution

Sankhla, L., Ramamurthy, P. C., Wickramasinghe, S. R., & Thamaraiselvan, C. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.108569 · Cited by 8 · see citing works

Environmental exposure and ecotoxicological properties of a new-generation fluorosurfactant (cC6O4): A comparison with selected legacy perfluoroalkyl acids

Bizzotto, E. C., Bonetto, A., Marcomini, A., & Vighi, M. (2023) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.4794 · Cited by 7 · see citing works

Analysis and fate of per- and polyfluoroalkyl substances (PFAS) in the global aquatic environment: perspectives and combined risks with microplastics

Mallek, M., & Barceló, ‪. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-06264-6 · Cited by 6 · see citing works

The evolution and research hotspots of perfluorinated compounds (PFCs): Health risks, environmental behavior, and collaborative effort

Zhou, J.-X., Liu, X.-B., Zheng, Z.-Y., Qiao, L.-C., Hu, Y., Hu, K., Liu, X.-M., Jia, X., & Qi, W.-H. (2025) · Journal of Environmental Chemical Engineering · doi:10.1016/j.jece.2025.117792 · Cited by 11 · see citing works

Kinetics of Excretion of the Perfluoroalkyl Surfactant cC6O4 in Humans

Fustinoni, S., Mercadante, R., Lainati, G., Cafagna, S., & Consonni, D. (2023) · Toxics · doi:10.3390/toxics11030284 · Cited by 6 · see citing works

Per- and poly-fluoroalkyl substances: A review of sources, properties, chromatographic detection, and toxicological implications

Issaka, E., Adams, M., Agyekum, E. A., Baffoe, J., & Tornyeava, B. (2025) · AIMS Environmental Science · doi:10.3934/environsci.2025015 · Cited by 5 · see citing works

Volume-Corrected Free Energy as a New Criterion for Structural Elucidation in Chemical-Tagging-Based Metabolomics

Xiao, H., Peng, X., Rao, D. R., Zhao, S., Hussain, D., Chen, J., Luo, D., Wang, D., Lv, X., Wang, X., et al. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00722 · Cited by 5 · see citing works

Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cancer therapy

Nasrine, A., Mohanto, S., Narayana, S., & Ahmed, M. G. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2024.2449486 · Cited by 5 · see citing works

Environmental occurance, human exposure, and metabolism of per- and polyfluoroalkyl substances—a review

Cao, Y., Huang, Y., Ma, Y., Nie, J., Hu, C., Chen, Y., Xu, J., & Lu, L. (2025) · Environmental Research Communications · doi:10.1088/2515-7620/add0fa · Cited by 4 · see citing works

UHPLC-MS/MS analysis of PFAS in the serum of patients with Alzheimer's disease, mild cognitive impairment and controls: A preliminary study

Deda, O., Adams, S., Tsolaki, M., Lioupi, A., Tsolaki, A., Theodoridis, G. A., Wilson, I. D., Plumb, R. S., & Gika, H. (2025) · Journal of Chromatography B · doi:10.1016/j.jchromb.2025.124738 · Cited by 4 · see citing works

High-throughput screening of per- and polyfluoroalkyl substances in human plasma using biocompatible solid-phase microextraction coupled with mass spectrometry via microfluidic open interface

Li, Y., Nazdrajić, E., Zhou, W., & Pawliszyn, J. B. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344940 · Cited by 4 · see citing works

Multiple linear regression modeling with values below a lower limit of quantification – a statistical method comparison

Hafermann, L., Yokota, I., Kalski, L., Wolfarth, B., & Herrmann, C. (2026) · BMC Medical Research Methodology · doi:10.1186/s12874-026-02770-y · Cited by 3 · see citing works

Direct Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Plasma by Liquid Chromatography Coupled to Mass Spectrometry (LC–MS) for Biomonitoring Purposes

Fornasari, A., Fais, P., Luca, A. D., Lago, G. D., Santelli, S., Pelletti, G., Piva, E., & Pascali, J. P. (2026) · Exposure and Health · doi:10.1007/s12403-026-00763-2 · Cited by 3 · see citing works

Per- and polyfluoroalkyl substances (PFAS) analysis in plastics and other polymer-based materials for recycling: Progress, limitations, and regulatory implications

Sauvageot, P., Chainet, F., Berlioz‐Barbier, A., de Vega, R. G., Feldmann, J., & Lienemann, C.-P. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141977 · Cited by 3 · see citing works

Factors Contributing to Lower Surrogate Recoveries in PFAS Analysis Based on ISO 21675 and the River Survey of PFAS in Osaka City, Japan

Ichihara, M., Asakawa, D., Tojo, T., Taniyasu, S., & Yamashita, N. (2024) · Journal of Environmental Chemistry · doi:10.5985/jec.34.48 · Cited by 2 · see citing works

Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health

Qu, H., Han, Y., Wang, C., Zheng, D., Ni, Y., & Xiao, X. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-82990-1_7 · Cited by 2 · see citing works

Per- and Polyfluoroalkyl Substance (PFAS) Levels in Human Plasma Samples Originating from Four Regions with Known Environmental Pollution Compared To Four Nearby Control Regions in Bavaria

Aschenbrenner, B., Wöckner, M., Fuchs, V., Hron, L. M. C., Herr, C., Schober, W., Nowak, D., Graw, M., Heinze, S., & Völkel, W. (2025) · Exposure and Health · doi:10.1007/s12403-025-00742-z · Cited by 2 · see citing works

Evaluation of isotope-dilution mass spectrometry, internal standard, and external standard methods for PFAS quantification in tap water and soil

Yamazaki, E., Hanari, N., & Nakamura, K. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06447-9 · Cited by 2 · see citing works

Determination of Per- and Polyfluoroalkyl Substances in Food and Feed by Enhanced Matrix Removal LC-MS/MS Method, AOAC Official Method 2025.11, First Action

Zhao, L., Giardina, M., Parry, E., & Leoz, M. L. A. D. (2026) · Journal of AOAC International · doi:10.1093/jaoacint/qsag029 · Cited by 2 · see citing works

Current and Emerging Detection/Monitoring Techniques for Per‐ and Polyfluoroalkyl Substances Quantification in Environmental Samples

Ou, J., Zhong, H., Kao, C., Surampalli, R. Y., Zhang, T. C., & Al‐Hashimi, B. M. (2025) · Wiley eBooks · doi:10.1002/9781394343935.ch3 · Cited by 2 · see citing works

A novel automated micro solid phase extraction (µSPE) method to quantify 21 per- and polyfluoroalkyl substances compounds in biological samples

Zhang, G., Wawrzynczak, A., Tseng, G., Blais, A., Nong, A., Tayabali, A. F., Pelletier, G., Loan, A., Prescott, D. M., Eccles, K. M., et al. (2026) · Advances in Sample Preparation · doi:10.1016/j.sampre.2026.100230 · Cited by 1 · see citing works

Establishment and application of a QuEChERS-based high-performance liquid chromatography–mass spectrometry method for the analysis of 56 per- and polyfluoroalkyl substances in human plasma

Chuai, Y., Zhou, X., Zhang, Y., Zhang, J., Guo, J.-Q., Wang, Y., Zhou, Q., Xia, Y., Luo, C.-Y., Yong, L., et al. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06486-2 · Cited by 1 · see citing works

Achieving sub-part per trillion trace level PFAS quantification in drinking water using an optimized fast flow solid-phase extraction and UPLC-MS/MS method

Timalsina, D., Ramisetty, B. S., & Wang, M. Z. (2026) · PLOS Water · doi:10.1371/journal.pwat.0000501 · Cited by 1 · see citing works

Additional file 4 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949736

Additional file 3 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949733

Additional file 8 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949748

Additional file 5 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949739

Additional file 6 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949742

Additional file 7 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949745

Additional file 9 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949754

Perfluoroalkyl substances and preterm birth

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Determination of ten emerging poly- and perfluoroether carboxilates and sulfonates in food: Method development and validation

Barola, C., Bucaletti, E., Giusepponi, D., Moretti, S., Tavoloni, T., & Galarini, R. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145273

A Novel Automated Micro Solid Phase Extraction (µSPE) Method to Quantify 21 Per- and Polyfluoroalkyl Substances Compounds in Biological SamplesPreprint

Aranda‐Rodriguez, R., Zhang, G., Wawrzynczak, A., Tseng, G., Blais, A., Nong, A., Tayabali, A. F., Pelletier, G., Loan, A., Prescott, D. M., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5805698

Additional file 2 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949727

Additional file 1 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses

Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949724

Perfluorinated and Polyfluorinated Compounds

Fromme, H. (2026) · Springer eBooks · doi:10.1007/978-3-032-10036-8_4

Contaminants

Corsolini, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-90869-6.00001-3

Exposure to PFOA and GenX elicits cell typespecific impacts on p53 and TGF-β signaling pathways

Ding, H., Slack, M., McClure, H., Gu, W., Gu, H., Kappes, F., Schultz, T. F., Somarelli, J. A., & Tsigkou, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11571-x

Is direct probe electrospray ionization tandem mass spectrometry applicable for PFAS determination in human urine? An essay on circumventing the need for chromatographic separation

Vouzaxaki, E., Tzanetou, E. N., Machera, K. A., & Kasiotis, K. M. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.117636

Wavelet Transform for Frequency‐Division Multiplex Mass Spectrometry Combined With High‐Performance Liquid Chromatography

Suzuki, H., Iiguni, Y., & Kitagawa, S. (2026) · Journal of Separation Science · doi:10.1002/jssc.70397

Multiple contaminant detection in commercially available chicken-based cat kibbles in Italy

Öztürk, Y., Nicotra, M., Palermo, F. A., Marini, C., Öztürk, M., Tardugno, R., Pedretti, N., Marchegiani, A., Cerbo, A. D., Cocci, P., et al. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1846767

Carbonate radicals as the "Knocker" driving rapid PFOA removal in the VUV/SPC process: Performance and mechanism

Lai, Z., Li, Q., Deng, J., Zou, J., Yu, Y., Ma, X., Li, G., Du, E., Huang, H., & Wang, J. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142599

First Nationwide Survey of Legacy and Emerging Per- and Polyfluoroalkyl Substances in Japanese Rivers: Spatial Distribution and Riverine Loads

Ichihara, M., Asakawa, D., Tojo, T., Takakura, K., Taniyasu, S., & Yamashita, N. (2026) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2026.101456

Multi-class UHPLC–MS/MS method for the simultaneous determination of 32 endocrine-disrupting chemicals in the urine of pregnant women

Zhang, C., Liu, B., Jiang, T., Chen, C., Meng, Q., Sun, S., Li, S., Zhao, Z., Dai, Y., Di, D., et al. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06690-0

Determination of 13 per- and polyfluoroalkyl substances in human plasma samples using LC-MS/MS: application to capillary microsamples

da Luz, J. P., Dossena, A. J., Reichert, E. M., Ferreira, M. L., Ferrareze, C. W., Grando, A. P., Grassi, G. S., Hahn, R. Z., Charão, M. F., & Linden, R. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.125252

A simplified protein precipitation-based LC–MS/MS workflow for legacy and emerging PFAS determination in serum and whole blood

Acosta-Dacal, A. C., & Luzardo, O. P. (2026) · Advances in Sample Preparation · doi:10.1016/j.sampre.2026.100247

Trifluoroacetic Acid in Complex Matrices: A Critical Review of Analytical Strategies, Uncertainties, and Standardization Needs

Mottaghipisheh, J., Gautam, R. K., Tyka, M., & Ahrens, L. (2026) · Water · doi:10.3390/w18192385

Per- and polyfluoroalkyl substances in occupational settings: a review

Erb, A., Chalansonnet, M., Cosnier, F., Gaté, L., Rocca, B. L., Bousquenaud, M., Zerkeff, R., & Grova, N. (2026) · Environmental Chemistry Letters · doi:10.1007/s10311-026-01930-2

Single-nucleus transcriptomics reveals chronic GenX exposure-induced neurotoxicity and predicted alterations in microglia-neuron communication networks in mouse brain

Xu, Z., Xiang, K., Yang, Y., Fang, Z., Zhuo, L., Dai, C., Lin, X., Liu, J., & Sun, J. (2026) · Environment International · doi:10.1016/j.envint.2026.110553

Electrochemical Detection of PFAS Contaminants Across Environmental and Pharmaceutical Matrices:Sensing Mechanisms, Nanomaterial Platforms, Biological Monitoring, and Regulatory Convergence

(2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.72s.196

Electrochemical Detection of PFAS Contaminants Across Environmental and Pharmaceutical Matrices:Sensing Mechanisms, Nanomaterial Platforms, Biological Monitoring, and Regulatory Convergence

(2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.73s.190

Association of plasma legacy and emerging PFASs with HBV-related hepatocellular carcinoma risk: a case-control study with network toxicology and molecular simulation analyses

Wen, Q., Gong, R., Fan, Y., Liu, Y., Peng, J., Li, Y., Liu, H., Lu, Q., Wei, X., Li, R., et al. (2026) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2026.101715

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for Simultaneous Quantitation of Per- and Polyfluoroalkyl Substances (PFAS): Application to Rodents Plasma and TissuesPreprint

Yajima, T., Meisel, J. E., Pierfelice, J., Renyer, A., Stiffler, B., Sloop, J. T., & Suramya Waidyanatha, A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7417095

Direct Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Plasma by Liquid Chromatography Coupled to Mass Spectrometry (LC–MS) for Biomonitoring Purposes

Fornasari, A., Fais, P., Luca, A. D., Lago, G. D., Santelli, S., Pelletti, G., Piva, E., & Pascali, J. P. (2026) · Exposure and Health · doi:10.1007/s12403-026-00763-2 · Cited by 3 · see citing works

Determination of 13 per- and polyfluoroalkyl substances in human plasma samples using LC-MS/MS: application to capillary microsamples

da Luz, J. P., Dossena, A. J., Reichert, E. M., Ferreira, M. L., Ferrareze, C. W., Grando, A. P., Grassi, G. S., Hahn, R. Z., Charão, M. F., & Linden, R. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.125252

A novel high-throughput quantitative method for the determination of per- and poly-fluoroalkyl substances in human plasma based on UHPLC-Q/Orbitrap HRMS coupled with isotope internal standard

Zhang, W., Lu, Q., Chen, H., Li, Y., Hua, Y., Wang, J., Chen, F., & Zheng, R. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136138 · Cited by 7 · see citing works

A sensitive and robust method for the simultaneous determination of thirty-three legacy and emerging per- and polyfluoroalkyl substances in human plasma and serum

Ao, Y., Nian, M., Tang, W., Zhang, J., Zhang, Q., & Ao, J. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04426-4 · Cited by 25 · see citing works